EP2866784B1 - Stabile emulsion zur prävention von hautirritationen und artikel damit - Google Patents

Stabile emulsion zur prävention von hautirritationen und artikel damit Download PDF

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Publication number
EP2866784B1
EP2866784B1 EP13809933.8A EP13809933A EP2866784B1 EP 2866784 B1 EP2866784 B1 EP 2866784B1 EP 13809933 A EP13809933 A EP 13809933A EP 2866784 B1 EP2866784 B1 EP 2866784B1
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EP
European Patent Office
Prior art keywords
gum
emulsion
dimethicone
weight
clay
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EP13809933.8A
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English (en)
French (fr)
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EP2866784A4 (de
EP2866784A2 (de
Inventor
Corey Thomas Cunningham
Jeffery Richard Seidling
Lisa Marie Kroll
Stacy Averic Mundschau
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Kimberly Clark Worldwide Inc
Kimberly Clark Corp
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Kimberly Clark Worldwide Inc
Kimberly Clark Corp
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Publication of EP2866784A4 publication Critical patent/EP2866784A4/de
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Definitions

  • the present disclosure relates generally to a formulation in the form of an emulsion which includes a combination of a gum blend and an electrolyte tolerant polymer, and items using same.
  • the gum blend provides physical stability to an emulsion containing both clay and silicone oil.
  • the emulsion of the present disclosure is useful for rash prevention and may be applied to the skin with a wipe wetted therewith or by other various means.
  • wet wipes have been used for years for convenient skin cleansing between diaper changes. Much headway has been made in creating formulations for wet wipes. Such formulations are in the form of emulsions which provide a vehicle for the application of active ingredients to the skin. These ingredients may be used to treat and/or prevent diaper rash.
  • Diaper rash is a form of contact dermatitis which afflicts infants or incontinent persons whose wet and/or soiled absorbent garments are not promptly changed. Because of the practical impossibility of attending promptly to all of a person's needs, even those receiving a high level of care sometimes suffer from diaper rash. It has recently come to be understood that the initial stages of some types of diaper rash are the result of skin irritation caused by contact with digestive enzymes present in feces, particularly trypsin, chymotrypsin and elastase. These enzymes are proteolytic enzymes produced in the gastrointestinal tract to digest food. Similar conditions conducive to skin irritation by proteolytic enzymes present in feces are found in patients having colostomies.
  • Silicone oil is a commonly used active ingredient that acts as a skin barrier to prevent skin irritation.
  • a skin barrier alone is not enough to prevent skin irritation, especially when fecal matter is present. Therefore, it is also desirable to sequester irritants such as proteolytic enzymes away from the skin.
  • Clay is one substance that can bind the protease enzymes found in fecal matter.
  • the benefits of clay and silicone oil cannot be realized in the same product due to physical instability.
  • silicone oil e.g. dimethicone
  • an emulsion that contains silicone oil as an active ingredient and does not phase separate even in the presence of clay.
  • a further need to stabilize an emulsion containing silicone oil in a manner that is cost effective.
  • the formulation containing the emulsion and a sequestering solid such as clay would be suitable for spraying onto a substrate during the manufacture of a wet wipe.
  • preservatives to the emulsion, especially if it is to be applied to a natural substrate (e.g. cellulose) where there is more likelihood of microbe or fungal growth.
  • the gum blend contains one or more gums and propylene glycol alginate.
  • One or more of the following gum(s) may be suitable: xanthan gum, guar gum, gellan gum, acacia gum, cellulose gum, dehydroxanthan gum, sclerotium gum and locust bean gum.
  • the emulsion formed at about 95% water by weight is not only stable, but has a viscosity low enough to render it sprayable for the purpose of applying it to a wipe substrate.
  • propylene glycol alginate in combination with one or more gums provides an improved freeze-thaw stability by not only increasing the density of the water phase, but by imparting additional emulsification of the silicone oil. More specifically, large molecular-weight gums create a low viscosity network that bridges the silicate sheets (described herein) of the dissolved clay. Further, the gums are also salt tolerant as compared to typical rheology modifiers like acrylates, carbomer, polyquaternium-37, etc.
  • the present disclosure is directed to an oil-in-water emulsion including a glucoside-based emulsifier or a Gemini surfactant that is only present in the oil phase; a gum blend; a polymeric rheology modifier; 1% to 10% by weight silicone oil; 90% to 98% by weight water and a clay material in an effective mass amount to bind with the protease enzymes in a given amount of fecal mass.
  • the gum blend contains at least one gum and propylene glycol alginate, wherein the gum blend is less than or equal to 0.5% by weight of the emulsion.
  • the emulsion may be applied to a substrate to form a wet wipe.
  • Advantages due to the emulsion of the present disclosure include but are not limited to the following: cost effectiveness due to lower concentrations of emulsifier, the capability of being applied to a wipe substrate by spraying, and physical stability despite having both clay and silicone ingredients.
  • the present disclosure is directed to an emulsion for the prevention of skin irritation including among other ingredients, a stability enhancing system having a gum blend and an electrolyte tolerant polymer.
  • the gum blend includes one more gums and propylene glycol alginate.
  • the emulsion of the present disclosure contains a carrier medium, a barrier composition, an emulsifier system and a stability enhancing system. Additional ingredients, e.g. fragrance, botanicals, pH adjusting agents, buffers, preservatives, moisturizers and the like may be added to the emulsion.
  • water serves as a medium for carrying the silicone oil and clay to the skin in an esthetically pleasing manner and at a suitable viscosity as discussed herein.
  • water aids in the wetting of the substrate of the wipe product incorporating the emulsion.
  • the emulsions of the present disclosure include from about 90% by weight to about 98% by weight water, including from about 92% by weight to about 97% by weight, and including from about 94% by weight to about 96% by weight.
  • the emulsions of the present disclosure include a barrier composition that serves to protect the skin from the digestive enzymes.
  • Barrier composition components include silicone oil(s) and clay(s).
  • the emulsions include silicone oil which is an active ingredient that functions primarily as a skin protectant against moisture (urine, sweat and overall humidity), and functions secondarily as an emollient.
  • Desirable silicone oils are those that impart a tactile impression of softness and smoothness, and which do not impart an excessive tactile perception of greasiness, oiliness or coating when incorporated into the emulsion.
  • Non-volatile silicone oils may be desirable over volatile silicone oils.
  • Non-volatile silicone oils tend to remain stable when exposed to the environment, tend to provide a lasting tactile impression and tend to form a stable oil layer on the skin.
  • Mixtures of silicone oils may be used.
  • volatile silicone oils may be combined with non-volatile silicone oils to impart desired esthetic properties as long as the emulsion contains sufficient non-volatile silicone to provide a skin barrier layer that is effective for a given application.
  • the silicone oil is dimethicone (linear polydimethylsiloxane).
  • the emulsions of the present disclosure include from about 1 % by weight to about 10% by weight dimethicone, including from about 1 % by weight to about 5% by weight, and including from about 1 % by weight to about 3% by weight.
  • silicone oils that are suitable for use herein include dimethiconol, ethoxylated dimethicone (linear and pendant varieties), amodimethicone and derivatives thereof, cyclomethicone, alkyl substituted derivatives such as stearyl dimethicone and behenyl dimethicone, phenyl trimethicone and mixtures thereof.
  • Such silicones are commercially available, for example, from the Dow Corning Company of Midland, Mich.
  • oil droplets are solubilized by an emulsifier system.
  • the viscosity of the traditional emulsion arises from the relatively high concentration of oil droplets, and the use of a rheology/viscosity agent to provide a sufficient resistance to flow at all shear rates.
  • the rheology/viscosity agent prevents small emulsion oil droplets from forming larger, more unstable droplets that eventually result in complete separation of the oil phase, sometimes called Ostwald ripening.
  • the present disclosure utilizes the combination of clays to provide a significant yield (resistance to flow) without the concomitant increase in viscosity across all shear rates along with an emulsifying system that is capable of stabilizing relatively low levels of silicone oil in small droplets.
  • an emulsifying system that is capable of stabilizing relatively low levels of silicone oil in small droplets.
  • Suitable clays include natural smectite clays that have been water washed.
  • One such clay is magnesium aluminum silicate, available from R.T. Vanderbilt Company, Inc. under the VEEGUM ULTRA brand.
  • Additional commercial products for clays include Veegum PRO, Gel White H, Gelwhite GP, Gelwhite H also from R.T. Vanderbilt Company and Mineral Colloid BP from Southern Clay. Characteristics of smectite clays include the ability to swell in water to impart desirable rheological properties to aqueous compositions.
  • Smectite clays have a colloidal structure in water.
  • Each smectite particle can be thought of as a collection of submicroscopic platelets, each platelet having a negative charge at the face thereof, and positive charge at the edge. When hydrated, the cations diffuse away from the platelets, promoting delamination of same. The speed at which platelet separation occurs is directly related to the amount of energy introduced during hydration, both mechanical and thermal. High-shear mixing and warm water reduce hydration time.
  • Smectite dispersions are thixotropic and pseudoplastic. In addition, they have the ability to impart at low viscosity a certain minimum force known as a "yield value".
  • the yield value relates to the measure of resistance of the colloidal structure to breakdown. A force equal to the yield value is applied to start disruption of the colloidal structure. A force greater than the yield value is applied to enable movement through the emulsion. The greater the yield value, the more stable the emulsion.
  • Another desirable characteristic is that when mixed with salts and surfactants, the smectite viscosity and yield value will increase, and the thixotropy will decrease. However, the smectite will still provide a shear-thinning emulsion.
  • Smectite eliminates the tacky, gummy or stringy nature of organic gums and polymers. There is a synergistic effect between smectite clay and the organic gums/polymers. The smectite contributes to viscosity and yield value, while the gums/polymers collioidal action improves the clay stability in the presence of electrolytes, surfactants and other water soluble ingredients.
  • a desirable amount of clay is an amount that binds a desirable portion of the protease enzymes in a given sample of proteolytic digestive enzymes using the Test Method to Determine Binding of Fecal Protease.
  • bind means that the proteolytic enzymes possess an overall positive charge and are attracted/physisorbed to the anionic clay platelets through an electrostatic interaction.
  • an "effective amount" of clay maybe defined as an amount of clay in a formulation such that when a pre-determined amount of formulation is thoroughly mixed with a pre-determined amount of protease enzyme solution, the clay binds to at least about 50% of the protease enzymes present in the solution.
  • the amount of smectite clay in the emulsion is between about 0.1 % to about 3% by weight of the emulsion.
  • the emulsions of the present disclosure include an emulsifier system for forming oil-in-water emulsions.
  • the emulsifier system is a synergistic combination of specific ingredients which emulsify other formulation components that would not otherwise mix together in a stable manner. It is capable of de-emulsifying upon application of the complete formulation to the skin thereby forming a silicone oil film on the skin.
  • the emulsifier system does not tend to re-emulsify once the emulsion is applied to the skin and exposed to urine or other body fluids. This prevents the silicone oil from being washed away by urine.
  • the emulsifier system includes two components: (a) either a Gemini surfactant only present in the oil phase, a glucoside-based emulsifier or a combination thereof.
  • Gemini surfactants are a special class of surfactants that contain multiple hydrophobic tails and multiple hydrophilic head groups within the same molecule. Gemini surfactants can be ten to a thousand times more surface active than conventional surfactants with similar but singular hydrophilic and hydrophobic groups in the molecule. Gemini surfactants may reduce skin irritation in addition to serving as an emulsifier.
  • Gemini surfactants are believed to form liquid crystalline lamellar gel networks in the oil phase which result in the formation of very small oil droplets.
  • the small size and gel-like nature of the droplets provides resistance against coalescence of the droplets eventuating in complete oil phase separation.
  • Gemini surfactants have been shown to not have the HLB dependency for oil emulsification of typical ethoxylated fatty alcohols, ethoxylated fatty esters, and other common non-Gemini surfactant emulsifiers.
  • Gemini surfactants were explored in an effort to create a stable emulsion containing dimethicone and clay, and surprisingly, most did not work.
  • One Gemini surfactant that was found to work in an emulsion having 95.15% water was Disodium Ethylene Dicocamide PEG-15 Disulfate.
  • this Gemini surfactant is blended with Behenyl Alcohol (and) Glyceryl Stearate (and) Glyceryl Stearate Citrate, and is available from Sasol North America, Inc. as CERALUTION H.
  • a glucoside-based emulsifier may be used in lieu of or in addition to the Gemini surfactant.
  • Other non-ionic surfactants tested alone or in combination with other such surfactants, that failed to perform satisfactorily include: Glyceryl Stearate, PEG-100 Stearate, Sorbitan Sesquioleate, Undeceth-3, Undeceth-8, PEG-20 Methyl Glucose Sesquistearate, Tridedeceth-3, Tridedeceth -12, Laureth-9, Behenoyl Stearic Acid, Oleth-2, Oleth-20, Cetearyl Olivate, Sorbitan Olivate, Polawax A-31, Sorbitan Laurate, Sorbitan Palmitate, Sorbitan Oleate, Steric Acid, Sorbitan Trioleate , Steareth-2, Steareth-20, Steareth-21, Laureth-23,
  • Glucoside emulsifiers are generally formed by the condensation of glucose with varied fatty alcohols. More specifically, the glucoside emulsifiers are combined with a fatty alcohol, such as cetearyl alcohol, to create stable emulsions. Glucoside emulsifiers are known to promote liquid crystals around oil droplets in the continuous phase, thereby enhancing distribution on skin of the barrier forming materials such as dimethicone.
  • Specific glucoside based emulsifiers that are commercially available include but are not limited to MONTANOV 202, MONTANOV 68, MONTANOV 82, MONTANOV S, MONTANOV L, SEPISOFT 20-22, available from Seppic, Paris, France; and POLY SUGAPHOS 1000P, POLY SUGANATE 100P, SUGANATE 100 AND SUGANATE 160 available from Colonial Chemical, Inc, South Pittsburg, TN.
  • the stability enhancing system is defined by one or more gums and an electrolyte tolerant polymer.
  • the gum blend may be a single gum or multiple gums.
  • One desirable gum blend includes xanthan gum and/or guar gum. In certain applications, it may be advantageous to substitute the xanthan gum and/or guar gum with one or more of the following: gellan gum, acacia gum, cellulose gum, dehydroxanthan gum, sclerotium gum and locust bean gum.
  • the gum blend further includes propylene glycol alginate. Without being bound by theory, it is believed that propylene glycol alginate serves to improve freeze-thaw stability by not only increasing the density of the water phase, but by imparting additional emulsification of the silicone oil.
  • gums are rheological modifiers which are used in conjunction with the propylene glycol alginate.
  • Other classes of rheological modifiers such as starches may be used in combination with propylene glycol alginate provided that a stable emulsion is achieved using less than 0.5% by weight rheological modifiers and the viscosity of the formulation measures below 5,000 centipoise.
  • the gum blend is used in an amount between about 0.01 to about 0.5% by weight of the emulsion.
  • the emulsions of the present disclosure further include an electrolyte-tolerant polymeric serving as a rheology modifier to provide additional structure to the formulation and to prevent the oil droplets from coalescing.
  • electrolyte-tolerant polymers provide an increase in viscosity to the complete formulation without interfering with the clay, despite the presence of ionic species.
  • typical acrylate-based rheology modifiers the addition of clays and ionic surfactants results in the collapse of the polymer thereby removing all rheology imparted by the polymer. It has been found that certain classes of polymeric rheology modifiers can survive the ionic strength of formulations of the present disclosure and retain their rheological profile.
  • electrolyte-tolerant polymeric rheology modifiers include those utilizing the acryloyldimethyl taurate monomers, such as GRANSIL APK-1 available from Grant Industries, Inc., Elmwood Park, NJ; and SEPINOV EMT 10, SEPIPLUS S, SIMULGEL FL, SIMULGEL EG, SIMULGEL 800, AND SIMULGEL NS, all available from Seppic, Paris, France.
  • the emulsions of the present disclosure include from about 1% by weight to about 30% by weight of an electrolyte-tolerant polymeric rheology modifier utilizing an acryloyldimethyl taurate monomer, including from about 0.05% to about 0.50% by weight of the material as supplied, and including from about 0.1 % to about 0.25% by weight.
  • the emulsions of the present disclosure may further include a pH-adjusting agent.
  • a pH-adjusting agent Such agents are desirable for the creation of emulsions having a pH at or near that of human skin. Therefore, the pH will typically be adjusted as necessary so that the emulsion of the present disclosure has a pH of from 4 to 7, or more desirably, from 4.5 to 6.5.
  • the pH can be adjusted by adding one or more pH-adjusting agents in an amount effective to provide such pH values ("effective amount").
  • Agents that may be used to adjust the pH of the emulsions include organic and inorganic acids and bases.
  • Acid pH-adjusting agents include organic acids which are relatively non-irritating. Such acids include malic acid, citric acid acetic acid, propionic acid, oxalic acid, glycolic acid, malonic acid, lactic acid, succinic acid, tartaric acid, aspartic acid, maleic acid, glutaric acid, glutamic acid, gluconic acid, sorbic acid, benzoic acid, ascorbic acid, salicylic acid and mixtures thereof.
  • a desirable pH-adjusting agent is malic acid.
  • the amount of the pH-adjusting agent that is employed depends on the equivalent weight of the pH-adjusting agent and the desired pH. Typically, the pH-adjusting agent is used in an amount of from about 0.05% to about 0.5% by weight of the emulsion. Desirable emulsions of the present disclosure include from about 0.1% to about 0.5% percent, and typically about 0.2% to about 0.3% percent of the pH-adjusting agent.
  • Preservatives function in one or more ways to improve the shelf life of the emulsions and products incorporating same.
  • the preservative may be an anti-microbial agent, an anti-bacterial agent, an anti-fungal agent, or a combination thereof.
  • Preservatives herein include, but are not limited to, benzethonium chloride, benzisothiazolinone, benzoic acid, benzyl alcohol, 2-Bromo-2-nitropropane-1,3-diol, butylparaben, caprylyl glycol, chlorhexidine digluconate, DMDM hydantoin, diazolidinyl urea, dehydroacetic acid, ethylparaben, iodopropynyl butylcarbamate, methylchloroisothiazolinone, methylisothiazolinone, methyldibromo glutaronitrile, methylparaben, pentylene glycol, phenethyl alcohol, phenoxyethanol, propylparaben, polyaminopropyl biguanide, quaternium-15, salicylic acid, sodium benzoate, sodium methylparaben, sodium dehydroacetate, thymol
  • benzoic acid with or without phenoxyethanol, is effective in preventing the growth of a wide variety of microbes and fungi. Such protection tends to be particularly desirable where the wipe product contains a porous substrate, for example, nonwoven substrates.
  • wet wipes have a shelf life of at least two years under storage conditions of about 75 degrees Fahrenheit and 50 percent relative humidity.
  • Certain agents may be employed to achieve the desired term, one of which is an anti-microbial agent.
  • the anti-microbial agent may be used in an amount that is effective to provide the desired shelf life (storage stability, i.e., microorganisms do not grow to a significant extent) (herein alternatively referred to as "an effective amount"). This includes demonstrating sufficient anti-microbial activity in accordance with United States Pharmacopeia test entitled "Microbial Test, Antimicrobial Preservative --Effectiveness".
  • the emulsion may contain one or more chelating agents.
  • the chelating agent tends to bind metals (e.g., calcium ions, magnesium ions) that may be present in the emulsion so as to enhance the efficiency of the emulsifier and the anti-microbial agent.
  • the chelating agent may be considered to provide a level of anti-microbial activity to function as a preservative.
  • the chelating agent may be used in an amount that is effective to bind the aforementioned metals (hereinafter alternatively referred to as an "effective amount"), typically an amount ranging from about 0.01 percent to about 0.2 weight percent of the emulsion.
  • Particularly preferred emulsions include from about 0.05 % to about 0.2% by weight, more preferably from about 0.05% to about 0.10% by weight.
  • Chelating agents and their use in personal cleansing emulsions are well known in the art.
  • Exemplary chelating agents include disodium EDTA, trisodium EDTA, tetrasodium EDTA, and tetrasodium iminodisuccinate.
  • the emulsion of the present disclosure may optionally include other ingredients, e.g., fragrance; skin soothing aids such as aloe, lavender, chamomile, green tea, calendula, etc.; skin moisturizers (humectants) such as glycerin, propylene glycol, betaine, and hydroxyethyl urea; or emollients other than those previously described; powders and the like.
  • skin soothing aids such as aloe, lavender, chamomile, green tea, calendula, etc.
  • skin moisturizers such as glycerin, propylene glycol, betaine, and hydroxyethyl urea
  • emollients other than those previously described
  • emulsions with lower levels of water and thus higher viscosities may be desired, especially when applied to the skin by means other than a wet wipe.
  • the emulsion may be formulated to be a lotion, gel or paste.
  • TABLE 1 shows seven highly aqueous, stable dimethicone emulsions with a viscosity less than 5,000 cps. They are denoted as base formulations F1-F7.
  • Parts A and B refer to ingredients in the oil and water phases respectively, and Part C is ingredients added to the formulation upon formation of the emulsion.
  • TABLE 4 Base Formulation Number Percent Clay in Formula Percent of Recovered Protease Percent Protease Bound F8 0.5 37.3 62.7 F8' 0.0 100.0 0.0 F9 0.5 11.1 88.9 F9' 0.0 100.0 0.0 F10 0.5 32.0 68.0 F10' 0.0 100.0 0.0 TABLE A 1 2 3 4 5 6 7 8 9 10 11 12
  • a score of 100 indicates that none of the fecal protease was bound by the formulation.
  • emulsions without magnesium aluminum silicate F8', F9' and F10' are not suitable for binding fecal protease.
  • a desirable level of gum blend is one that creates of emulsion stability, maintains a low viscosity and effectively binds clay to the fecal proteases responsible for skin irritation.
  • the amount of gum blend suitable for maintaining emulsion stability is dependent on the clay effectiveness in binding fecal proteases and the relative proportion of the gum blend components.
  • substrate means any material suitable for carrying the emulsion of the present disclosure. Suitable substrates include any material that does not hinder the clay's affinity for binding skin irritants or the deposition of emulsion components onto the skin, and that do not cause skin irritation. Substrates may be water dispersible.
  • suitable substrates include, but are not limited to, woven or non-woven webs, spunbond fabric, meltblown fabric, knit fabric, wet-laid fabric, scrims, needle-punched webs, synthetic fibers and natural fibers. It is to be understood that these suitable substrates are not mutually exclusive and can be used in a combination.
  • suitable fibrous materials may include, but are not limited to, synthetic fibers such as those derived from polyolefins, polyesters, polyamides, polyacrylics, polyethylene, polypropylene, polyvinyl, etc., alone or in combination with one another.
  • synthetic fibers such as those derived from polyolefins, polyesters, polyamides, polyacrylics, polyethylene, polypropylene, polyvinyl, etc., alone or in combination with one another.
  • natural fibers such as cotton, linen, hemp, jute, wool, wood pulp, etc.
  • regenerated cellulosic fibers such as viscose rayon and cuprammonium rayon or modified cellulosic fibers, such as cellulose acetate may likewise be used.
  • Blends of one or more of the above fibers may also be used if so desired.
  • nonwoven fabric refers to a fabric having a structure of individual fibers or filaments which are randomly and/or unidirectionally interlaid in a mat-like fashion.
  • Nonwoven fabrics can be made from a variety of processes including, but not limited to, air-laid processes, wet-laid processes, hydroentangling processes, staple fiber carding and bonding, and solution spinning.
  • Suitable nonwoven fabrics include, but are not limited to, spunbond fabrics, meltblown fabrics, wet-laid fabrics and combinations thereof.
  • spunbond fabric refers to a web of small diameter fibers and/or filaments which are formed by extruding a molten thermoplastic material, or coextruding more than one molten thermoplastic material, as filaments from a plurality of fine, usually circular, capillaries in a spinnerette with the diameter of the extruded filaments then being rapidly reduced, for example, by non-eductive or eductive fluid-drawing or other well-known spunbonding mechanisms.
  • the production of spunbond nonwoven webs is well-known and illustrated in patents such as Appel, et al., U.S. Pat. No. 4,340,563 ; Dorschner et al., U.S. Pat. No.
  • meltblown fabrics refers to a fabric comprising fibers formed by extruding a molten thermoplastic material through a plurality of fine, usually circular, die capillaries as molten threads or filaments into a high velocity gas (e.g. air) stream which attenuates the filaments of molten thermoplastic material to reduce their diameters, which may be to microfiber diameter. Thereafter, the meltblown fibers are carried by the high-velocity gas stream and are deposited on a collecting surface to form a web of randomly disbursed meltblown fibers.
  • a high velocity gas e.g. air
  • microfibers means small diameter fibers having an average diameter not greater than about 100 microns, for example, having a diameter of from about 0.5 microns to about 50 microns. More specifically microfibers may also have an average diameter of from about 1 micron to about 20 microns. Microfibers having an average diameter of about 3 microns or less are commonly referred to as ultra-fine microfibers.
  • wet-laid fabrics refers to fabrics formed by a process, such as a paper-making process, wherein fibers dispersed in a liquid medium are deposited onto a screen such that the liquid medium flows through the screen, leaving a fabric on the surface of the screen. Fiber bonding agents may be applied to the fibers in the liquid medium or after being deposited onto the screen. Wet-laid fabrics may contain natural and/or synthetic fibers.
  • spunlace fabrics refers to a web of material consisting of a blend of natural fibers and synthetic fibers, where the fibers are subjected to high-velocity water jets which entangle the fibers to achieve mechanical bonding.
  • the natural fibers are wood pulp fibers and the synthetic fibers are polyester fibers.
  • needle-punched and “needled” refer to a web of material consisting of one or more fibrous materials, wherein the fibers are subjected to needles which entangle the fibers to achieve mechanical interlocking without the need for adhesives or chemical additives.
  • woven fabric refers to a fabric containing a structure of fibers, filaments or yarns, which are orderly arranged in an interengaged fashion.
  • Woven fabrics typically contain interengaged fibers in a "warp” and "fill” direction. The warp direction corresponds to the length of the fabric while the fill direction corresponds to the width of the fabric.
  • Woven fabrics can be made on a variety of looms including, but not limited to, shuttle looms, Rapier looms, projectile looms, air jet looms and water jet looms.
  • composition of the present disclosure formulation may be incorporated into the basesheet in an add-on amount of from about 50% (by weight of the basesheet) to about 800% (by weight of the basesheet). More specifically, the formulations may be incorporated into the basesheet in an add-on amount of from about 200% (by weight of the basesheet) to about 600% (by weight of the basesheet) or from about 400% (by weight of the basesheet) to about 600% (by weight of the basesheet).
  • the formulation add-on amounts may vary depending on the composition of the basesheet.
  • the procedure used to make the emulsions used for testing includes the following steps:
  • the following method is used to measure the fecal binding property.
  • the purpose of this test is to demonstrate formulation stability upon exposure to possible freezing during shipping or storage.
  • the test is performed by freezing the composition at minus 20 degrees Celsius. Once frozen, the composition is allowed to completely thaw at room temperature. This freeze-thaw cycle is conducted for a total of three times. The test results are determined by visual inspection for phase separation.

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Claims (15)

  1. Emulsion zur Vorbeugung von Hautreizungen, wobei die Emulsion umfasst:
    ein nur in der Ölphase vorliegendes Geminitensid oder einen glucosidbasierten Emulgator;
    eine Kombination aus einem Gummi und Propylenglykolalginat, wobei die Kombination zwischen 0,01 Gew.-% und 0,5 Gew.-% der Emulsion ausmacht;
    einen polymeren Rheologiemodifikator, der ein Acryloyldimethyltaurat-Monomer umfasst;
    1 Gew.-% bis 10 Gew.-% Silikonöl;
    90 Gew.-% bis 98 Gew.-% Wasser; und
    0,1 Gew.-% bis 3 Gew.-% Ton; und
    wahlweise einen Konservierungsstoff.
  2. Emulsion nach Anspruch 1, wobei das Geminitensid Dinatriumethylendicocamid-PEG-15-disulfat ist.
  3. Emulsion nach Anspruch 1, wobei das Silikonöl aus Dimethicon besteht, oder wobei das Silikonöl aus der Gruppe bestehend aus Dimethicon, Dimethiconol, ethoxyliertem Dimethicon, Amodimethicon und Derivaten davon, alkylsubstituierten Derivaten einschließlich Stearyldimethicon und Behenyldimethicon, Phenyltrimethicon und Kombinationen davon ausgewählt wird.
  4. Emulsion nach Anspruch 1, wobei der Ton mit Wasser gewaschenen Smektitton umfasst und wobei der Ton vorzugsweise Magnesium-Aluminium-Silikat umfasst.
  5. Emulsion nach Anspruch 1, wobei der Ton in einer Menge von 0,5 Gew.-% bis 2 Gew.-% der Emulsion vorliegt.
  6. Emulsion nach Anspruch 1, die eine Viskosität von weniger als 5000 Centipoise aufweist.
  7. Emulsion nach Anspruch 1, wobei das Gummi aus Xanthangummi und Guargummi besteht oder wobei das Gummi aus der Gruppe bestehend aus Xanthangummi, Guargummi, Gellangummi, Gummi arabicum, Cellulosegummi, Dehydroxanthangummi, Sklerotiumgummi, Johannisbrotkernmehl und Kombinationen davon ausgewählt wird.
  8. Feuchttuch umfassend:
    ein Substrat, auf dem eine Emulsion abgelagert ist, wobei die Emulsion umfasst:
    ein nur in der Ölphase vorliegendes Geminitensid oder einen glucosidbasierten Emulgator;
    ein Gummigemisch, das ein Gummi und Propylenglykolalginat umfasst, wobei das Gummigemisch 0,5 Gew.-% oder weniger der Emulsion ausmacht;
    einen polymeren Rheologiemodifikator, der ein Acryloyldimethyltaurat-Monomer umfasst;
    1 Gew.-% bis 10 Gew.-% Silikonöl;
    90 Gew.-% bis 98 Gew.-% Wasser; und
    0,1 Gew.-% bis 3 Gew.-% Ton.
  9. Feuchttuch nach Anspruch 8, wobei das Gummi aus der Gruppe bestehend aus Xanthangummi, Guargummi, Gellangummi, Gummi arabicum, Cellulosegummi, Dehydroxanthangummi, Sklerotiumgummi, Johannisbrotkernmehl und Kombinationen davon ausgewählt wird.
  10. Feuchttuch nach Anspruch 8, wobei das Silikonöl aus der Gruppe bestehend aus Dimethicon, Dimethiconol, ethoxyliertem Dimethicon, Amodimethicon und Derivaten davon, alkylsubstituierten Derivaten einschließlich Stearyldimethicon und Behenyldimethicon, Phenyltrimethicon und Kombinationen davon ausgewählt wird.
  11. Feuchttuch nach Anspruch 8, wobei der Ton mit Wasser gewaschenen Smektitton umfasst.
  12. Feuchttuch nach Anspruch 8, das außerdem Behenylalkohol, Glycerylstearat und Glycerolstearatcitrat umfasst.
  13. Feuchttuch nach Anspruch 8, wobei die Gummis Xanthangummi und Guargummi sind und das Silikonöl Dimethicon ist.
  14. Feuchttuch nach Anspruch 13, wobei das Substrat ein Vliesstoff ist.
  15. Feuchttuch nach Anspruch 8, wobei das Substrat Gewebe, Spinnvlies, heißluftgezogenes Gewebe, Maschenware, nassgelegtes Gewebe, Gittergewebe oder Nadelgewebe umfasst.
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EP2866784A4 (de) 2016-04-06
CO7160065A2 (es) 2015-01-15
EP2866784A2 (de) 2015-05-06
AU2013282748B2 (en) 2017-05-11
AU2013282748A1 (en) 2014-12-04
KR20150027082A (ko) 2015-03-11
BR112014031523B1 (pt) 2019-07-02
IL235762A (en) 2017-04-30
US9393197B2 (en) 2016-07-19
BR112014031523A2 (pt) 2017-06-27
WO2014002037A3 (en) 2014-04-17
IL235762A0 (en) 2015-01-29
US20140004166A1 (en) 2014-01-02
WO2014002037A2 (en) 2014-01-03
MX2014015652A (es) 2015-03-20
KR101732239B1 (ko) 2017-05-02
AU2013282748A9 (en) 2017-10-05
MX343477B (es) 2016-11-04

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