EP2836302B8 - Verfahren und vorrichtung zur gezielten prozessführung in einem mikrofluidik-prozessor mit integrierten aktiven elementen - Google Patents

Verfahren und vorrichtung zur gezielten prozessführung in einem mikrofluidik-prozessor mit integrierten aktiven elementen Download PDF

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Publication number
EP2836302B8
EP2836302B8 EP13717014.8A EP13717014A EP2836302B8 EP 2836302 B8 EP2836302 B8 EP 2836302B8 EP 13717014 A EP13717014 A EP 13717014A EP 2836302 B8 EP2836302 B8 EP 2836302B8
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EP
European Patent Office
Prior art keywords
process control
active elements
integrated active
microfluidic processor
targeted process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP13717014.8A
Other languages
English (en)
French (fr)
Other versions
EP2836302A1 (de
EP2836302B1 (de
Inventor
Andreas Prof. Dr. RICHTER
Rinaldo Greiner
Merle ALLERDIßEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
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Technische Universitaet Dresden
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Publication of EP2836302A1 publication Critical patent/EP2836302A1/de
Application granted granted Critical
Publication of EP2836302B1 publication Critical patent/EP2836302B1/de
Publication of EP2836302B8 publication Critical patent/EP2836302B8/de
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Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0672—Swellable plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP13717014.8A 2012-04-13 2013-04-11 Verfahren und vorrichtung zur gezielten prozessführung in einem mikrofluidik-prozessor mit integrierten aktiven elementen Active EP2836302B8 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012206042A DE102012206042B4 (de) 2012-04-13 2012-04-13 Verfahren und Vorrichtung zur gezielten Prozessführung in einem Mikrofluidik-Prozessor mit integrierten aktiven Elementen
PCT/EP2013/057631 WO2013153181A1 (de) 2012-04-13 2013-04-11 Verfahren und vorrichtung zur gezielten prozessführung in einem mikrofluidik-prozessor mit integrierten aktiven elementen

Publications (3)

Publication Number Publication Date
EP2836302A1 EP2836302A1 (de) 2015-02-18
EP2836302B1 EP2836302B1 (de) 2021-12-08
EP2836302B8 true EP2836302B8 (de) 2022-01-12

Family

ID=48139927

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13717014.8A Active EP2836302B8 (de) 2012-04-13 2013-04-11 Verfahren und vorrichtung zur gezielten prozessführung in einem mikrofluidik-prozessor mit integrierten aktiven elementen

Country Status (4)

Country Link
US (1) US9272281B2 (de)
EP (1) EP2836302B8 (de)
DE (1) DE102012206042B4 (de)
WO (1) WO2013153181A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981166B2 (en) 2015-06-11 2021-04-20 Neofluidics Llc Manual or electronic pipette driven well plate for nano-liter droplet storage and methods of using same
DE102016124059B4 (de) 2016-07-25 2019-12-19 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Vorrichtung für die mikrofluidik
WO2018200896A1 (en) 2017-04-28 2018-11-01 Neofluidics, Llc Fluidic devices with reaction wells and uses thereof
CA3072328A1 (en) 2017-08-09 2019-02-14 Neofluidics, Llc Devices and methods for bioassay
US11305279B2 (en) 2017-11-10 2022-04-19 Neofluidics, Llc Integrated fluidic circuit and device for droplet manipulation and methods thereof
CA3158313A1 (en) 2018-10-26 2020-04-30 Unchained Labs Fluidic devices with reaction wells and constriction channels and uses thereof
DE102022125010A1 (de) 2022-09-28 2024-03-28 Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (IFW Dresden e.V.) Mikrofluidisches Bauteil
DE102023109715A1 (de) 2023-04-18 2024-10-24 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Mikrofluidische Vorrichtung und Verfahren zum Aktivieren dieser

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69011631T2 (de) 1989-06-14 1995-03-23 Westonbridge Int Ltd Mikropumpe.
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
ATE277450T1 (de) * 1994-11-10 2004-10-15 Orchid Biosciences Inc Flüssigkeitsverteilungssystem
US6030580A (en) * 1997-10-31 2000-02-29 Enerfab, Inc. Method of aseptically transporting bulk quantities of sterile products
US6283718B1 (en) 1999-01-28 2001-09-04 John Hopkins University Bubble based micropump
JP3548858B2 (ja) 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 流量の制御方法及びそれに用いるマイクロバルブ
DE10157317A1 (de) 2001-11-23 2003-06-05 Gesim Ges Fuer Silizium Mikros Grundelement eines Mikrofluidik-Prozessors
DE10202996A1 (de) 2002-01-26 2003-08-14 Eppendorf Ag Piezoelektrisch steuerbare Mikrofluidaktorik
JP4784508B2 (ja) * 2004-05-07 2011-10-05 コニカミノルタエムジー株式会社 検査用マイクロリアクタおよび検査装置ならびに検査方法
EP1824600B1 (de) * 2004-10-18 2016-12-28 Life Technologies Corporation Fluidbehandlungsvorrichtung mit grössenändernder barriere
KR20060088780A (ko) * 2005-02-02 2006-08-07 삼성전자주식회사 마이크로 벨브 장치 및 이를 응용한 장치
US20080069729A1 (en) 2005-02-16 2008-03-20 Mcneely Michael R Liquid Valving Using Reactive or Responsive Materials
US20100240022A1 (en) 2006-06-23 2010-09-23 Mcneely Michael R Reagent preparation and valving design for liquid testing
DE102006051535A1 (de) * 2006-10-27 2008-12-18 Andreas Dr. Richter Automatischer Mikrofluidik-Prozessor
CN102947655B (zh) * 2010-06-15 2015-11-25 嘉士伯酿酒有限公司 自冷容器及冷却装置

Also Published As

Publication number Publication date
DE102012206042B4 (de) 2013-11-07
WO2013153181A1 (de) 2013-10-17
US9272281B2 (en) 2016-03-01
EP2836302A1 (de) 2015-02-18
US20150044688A1 (en) 2015-02-12
DE102012206042A1 (de) 2013-10-31
EP2836302B1 (de) 2021-12-08

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