EP2836302B8 - Method and device for targeted process control in a microfluidic processor having integrated active elements - Google Patents

Method and device for targeted process control in a microfluidic processor having integrated active elements Download PDF

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Publication number
EP2836302B8
EP2836302B8 EP13717014.8A EP13717014A EP2836302B8 EP 2836302 B8 EP2836302 B8 EP 2836302B8 EP 13717014 A EP13717014 A EP 13717014A EP 2836302 B8 EP2836302 B8 EP 2836302B8
Authority
EP
European Patent Office
Prior art keywords
process control
active elements
integrated active
microfluidic processor
targeted process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP13717014.8A
Other languages
German (de)
French (fr)
Other versions
EP2836302B1 (en
EP2836302A1 (en
Inventor
Andreas Prof. Dr. RICHTER
Rinaldo Greiner
Merle ALLERDIßEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dresden
Original Assignee
Technische Universitaet Dresden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dresden filed Critical Technische Universitaet Dresden
Publication of EP2836302A1 publication Critical patent/EP2836302A1/en
Publication of EP2836302B1 publication Critical patent/EP2836302B1/en
Application granted granted Critical
Publication of EP2836302B8 publication Critical patent/EP2836302B8/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0672—Swellable plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP13717014.8A 2012-04-13 2013-04-11 Method and device for targeted process control in a microfluidic processor having integrated active elements Active EP2836302B8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012206042A DE102012206042B4 (en) 2012-04-13 2012-04-13 Method and device for targeted process control in a microfluidic processor with integrated active elements
PCT/EP2013/057631 WO2013153181A1 (en) 2012-04-13 2013-04-11 Method and device for targeted process control in a microfluidic processor having integrated active elements

Publications (3)

Publication Number Publication Date
EP2836302A1 EP2836302A1 (en) 2015-02-18
EP2836302B1 EP2836302B1 (en) 2021-12-08
EP2836302B8 true EP2836302B8 (en) 2022-01-12

Family

ID=48139927

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13717014.8A Active EP2836302B8 (en) 2012-04-13 2013-04-11 Method and device for targeted process control in a microfluidic processor having integrated active elements

Country Status (4)

Country Link
US (1) US9272281B2 (en)
EP (1) EP2836302B8 (en)
DE (1) DE102012206042B4 (en)
WO (1) WO2013153181A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016201430A1 (en) * 2015-06-11 2016-12-15 Neofluidics Llc Manual or electronic pipette driven well plate for nano-liter droplet storage and methods of using same
DE102016124059B4 (en) 2016-07-25 2019-12-19 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. DEVICE FOR MICROFLUIDICS
EP3615220A4 (en) 2017-04-28 2020-12-30 Neofluidics, LLC Fluidic devices with reaction wells and uses thereof
WO2019032690A1 (en) 2017-08-09 2019-02-14 Neofluidics, Llc Devices and methods for bioassay
JP7256198B2 (en) 2017-11-10 2023-04-11 ネオフルーイディクス，リミティド ライアビリティ カンパニー Integrated fluidic circuits and devices for droplet manipulation and methods thereof
US11998885B2 (en) 2018-10-26 2024-06-04 Unchained Labs Fluidic devices with reaction wells and constriction channels and uses thereof
DE102022125010A1 (en) 2022-09-28 2024-03-28 Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (IFW Dresden e.V.) Microfluidic component

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04501449A (en) 1989-06-14 1992-03-12 ウエストンブリッジ　インターナショナル　リミティド micro pump
US5798215A (en) * 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
JP3398749B2 (en) * 1994-11-10 2003-04-21 オーキッド バイオ サイエンシズ， インコーポレイテッド Liquid distribution system
US6030580A (en) * 1997-10-31 2000-02-29 Enerfab, Inc. Method of aseptically transporting bulk quantities of sterile products
US6283718B1 (en) 1999-01-28 2001-09-04 John Hopkins University Bubble based micropump
JP3548858B2 (en) 2001-01-22 2004-07-28 独立行政法人産業技術総合研究所 Flow control method and microvalve used therefor
DE10157317A1 (en) 2001-11-23 2003-06-05 Gesim Ges Fuer Silizium Mikros A base element used for a microfluid processor in cell biology, comprises an actuator based on a swellable polymer network having volume phase transition behavior and an interface arranged close to the actuator
DE10202996A1 (en) 2002-01-26 2003-08-14 Eppendorf Ag Piezoelectrically controllable microfluidic actuators
JP4784508B2 (en) * 2004-05-07 2011-10-05 コニカミノルタエムジー株式会社 Inspection microreactor, inspection apparatus, and inspection method
EP1824600B1 (en) * 2004-10-18 2016-12-28 Life Technologies Corporation Fluid processing device including size-changing barrier
KR20060088780A (en) * 2005-02-02 2006-08-07 삼성전자주식회사 Micro valve device and apparatus adopting the same
US20080069729A1 (en) * 2005-02-16 2008-03-20 Mcneely Michael R Liquid Valving Using Reactive or Responsive Materials
US20100240022A1 (en) * 2006-06-23 2010-09-23 Mcneely Michael R Reagent preparation and valving design for liquid testing
DE102006051535A1 (en) 2006-10-27 2008-12-18 Andreas Dr. Richter Automatic microfluidic processor
CN102947655B (en) * 2010-06-15 2015-11-25 嘉士伯酿酒有限公司 Self cooling container and cooling device

Also Published As

Publication number Publication date
EP2836302B1 (en) 2021-12-08
EP2836302A1 (en) 2015-02-18
DE102012206042B4 (en) 2013-11-07
US20150044688A1 (en) 2015-02-12
DE102012206042A1 (en) 2013-10-31
US9272281B2 (en) 2016-03-01
WO2013153181A1 (en) 2013-10-17

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