EP2788989B1 - Radionukliderzeuger mit ersten und zweiten atomen eines ersten elements - Google Patents

Radionukliderzeuger mit ersten und zweiten atomen eines ersten elements Download PDF

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Publication number
EP2788989B1
EP2788989B1 EP12824875.4A EP12824875A EP2788989B1 EP 2788989 B1 EP2788989 B1 EP 2788989B1 EP 12824875 A EP12824875 A EP 12824875A EP 2788989 B1 EP2788989 B1 EP 2788989B1
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Prior art keywords
atoms
present
daughter
life
tube
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Not-in-force
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EP12824875.4A
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French (fr)
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EP2788989A1 (de
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Peter Bode
Hubertus Theodoor WOLTERBEEK
Daniel Justin DE VRIES
Marcelis DE BRUIN
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Technische Universiteit Delft
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Technische Universiteit Delft
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0094—Other isotopes not provided for in the groups listed above

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (14)

  1. Verfahren zum Herstellen eines langlebigen Radioisotopengenerators, der in der Lage ist, hochspezifische und/oder trägerfreie Radioaktivität zu liefern, umfassend die folgenden Schritte:
    (a) Bereitstellen eines Ziels,
    (b) Aktivieren des Ziels, wodurch ein Radioisotopengenerator erhalten wird, wobei der Radioisotopengenerator Folgendes umfasst:
    (i) radioaktive erste Atome (Mutteratome) eines ersten Elements, die eine erste Halbwertszeit aufweisen, wobei sich die ersten Atome in einem metastabilen Zustand befinden,
    (ii) zweite Atome (Tochteratome) des ersten Elements, die radioaktiv sind, die eine zweite Halbwertszeit aufweisen, wobei sich die zweiten Atome in einem zweiten Zustand befinden, wie dem Grundzustand, wobei das zweite Atom ein Tochteratom des ersten Mutteratoms ist, wobei das Tochteratom durch die Emission eines hochveredelten Gammastrahlen-Übergangs gebildet wird, wie durch E2, E3, E4, E5, M2, M3, M4, M5, oder eine Kombination daraus, und das Abtrennen der ersten Atome (Mutteratome) von dem ersten Element unter Bildung zweiter Atome (Tochteratome) des ersten Elements.
  2. Verfahren nach Anspruch 1, umfassend den Schritt des
    (c) Einbindens des aktivierten Ziels, einschließlich erster Atome, zweiter Atome und inaktiver Zielatome, durch elektrochemische oder physikalische Abscheidung auf einer inerten Oberfläche, und/oder
    wobei die erste Halbwertszeit mindestens 2-mal so lang wie die zweite Halbwertszeit ist, bevorzugt mindestens 5-mal so lang, noch mehr bevorzugt mindestens 10-mal so lang, wie mindestens 25-mal so lang; und/oder
    wobei das Aktivieren durch eines oder mehrere der folgenden Verfahren durchgeführt wird: Neutronenreaktion, Protonenreaktion, photonukleare Reaktionen, wie Gamma- oder Röntgenstrahlung, Alphapartikel-Reaktion und Ionenstrahlreaktion.
  3. Verfahren nach den Ansprüchen 1 oder 2, wobei Zielatome, wie natürlich vorkommende oder isotopisch angereicherte Atome, ausgewählt sind aus der Gruppe umfassend 176Lu-Atome, 59Co-Atome, 187Re-Atome, 232Th-Atome, 45Sc-Atome, 44Ca-Atome, 79Br-Atome, 81Br-Atome, 80Se-Atome, 120Sn-Atome, 122Sn-Atome, 120Te-Atome, 122Te-Atome, 121Sb-Atome, 126Te-Atome, 128Te-Atome, 121I-Atome, 235U-Atome, 130Te-Atome, 132Xe-Atome, 136Ce-Atome, 138Ce-Atome, 138La-Atome, 139La-Atome, 177Hf-Atome, 185Re-Atome, 186W-Atome, 186Os-Atome, 191Ir-Atome, 193Ir-Atome, 192Os-Atome, 192Pt-Atome, 197Au-Atome, 198Pt-Atome, 241Am-Atome und 198Hg-Atome.
  4. Verfahren nach einem der vorstehenden Ansprüche, wobei erste Atome ausgewählt sind aus der Gruppe umfassend 44mSc-Atome, 58mCo-Atome, 80mBr-Atome, 121mSn-Atome, 121mTe-Atome, 127Sn-Atome, 127mTe-Atome, 129mTe-Atome, 137mCe-Atome, 177mLu-Atome, 186mRe-Atome, 192mIr-Atome, 198mAu-Atome, 229Ra-Atome, und 242mAm-Atome, bevorzugt 177mLu-, 44mSc-, 127mTe-, 129mTe-, 137mCe- und 186mRe-Atome.
  5. Verfahren nach einem der vorstehenden Ansprüche, wobei zweite Atome in Übereinstimmung mit ersten Atomen ausgewählt sind aus der Gruppe umfassend 44Sc-Atome, 58Co-Atome, 80Br-Atome, 121Sn-Atome, 121Te-Atome, 127Sn-Atome, 127Te-Atome, 129Te-Atome, 137Ce-Atome, 177Lu-Atome, 186Re-Atome, 192Ir-Atome, 198Au-Atome, 224Ra-Atome, 228Ra-Atome, und 242Am-Atome, bevorzugt 177Lu-Atome.
  6. Verfahren nach einem der vorstehenden Ansprüche, ferner umfassend den folgenden Schritt:
    Abscheiden der ersten Atome bei der Bildung der zweiten Atome durch chemische Abscheidung, bevorzugt wobei die zweiten Atome in ein flüssiges Medium abgeschieden werden, wie Gas, eine Flüssigkeit, eine überkritische Flüssigkeit, oder eine Kombination daraus.
  7. Verfahren nach Anspruch 6, wobei das flüssige Medium bevorzugt Wasser ist und ein oder mehrere gelöste Stoffe enthält, wie Salze, Säuren, Basen, Hilfsstoffe, Saccharide und Stabilisatoren.
  8. Langlebiger, hochspezifische Aktivität aufweisender und/oder trägerfreier Radioisotopengenerator, wobei der Radioisotopengenerator Zielatome umfasst, wobei Zielatome ausgewählt sind aus der Gruppe umfassend 44Ca-Atome, 45Sc-Atome, 59Co-Atome, 58mCo-Atome, 79Br-Atome, 80Se-Atome, 81Br-Atome, 120Sn-Atome, 120Te-Atome, 121Sb-Atome, 122Sn-Atome, 122Te-Atome, 126Te-Atome, 127I-At-ome, 12Sn-Atome, 128Te-Atome, 130Te-Atome, 132Xe-Atome, 136Ce-Atome, 138Ce-Atome, 138La-Atome, 139La-Atome, 176Lu-Atome, 177Hf-Atome, 185Re-Atome, 186W-Atome, 186Os-Atome, 187Re-Atome, 191Ir-Atome, 192Os-Atome, 192Pt-Atome, 193Ir-Atome, 197Au-Atome, 198Pt-Atome, 198Hg-Atome, 229Ra-Atome, 232Th-Atome, 235U-Atome und 241Am-Atome und
    (i) radioaktiven ersten Atomen (Mutteratomen) eines ersten Elements, das eine erste Halbwertszeit aufweist, wobei sich das erste Atom in einem metastabilen Zustand befindet,
    (ii) zweiten Atomen (Tochteratomen) des ersten Elements, die radioaktiv sind, die eine zweite Halbwertszeit aufweisen, wobei sich die zweiten Atome in einem zweiten Zustand befinden, wie dem Grundzustand;
    wobei das zweite Atom ein radioaktives Tochteratom des ersten Atoms (Mutteratom) ist und das radioaktive Tochteratom durch die Emission eines hochveredelten Gammastrahls gebildet wird, wie durch E2, E3, E4, E5, M2, M3, M4, M5, oder eine Kombination daraus, und durch ein Verfahren nach einem der Ansprüche 1-7 erhalten wird, wobei erste Atome bevorzugt ausgewählt sind aus der Gruppe bestehend aus 44mSc-Atomen, 80mBr-Atomen, 121mSn-Atomen, 121mTe-Atomen, 127mTe-Atomen, 129mTe-Atomen, 137mCe-Atomen, 177mLu-Atomen, 186mRe-Atomen, 192mIr-Atomen, 198mAu-Atomen, und 242mAm-Atomen.
  9. Produkt, umfassend den langlebigen, hochspezifische Aktivität aufweisenden und/oder trägerfreien Radioisotopengenerator nach Anspruch 8.
  10. Produkt nach Anspruch 9, wobei der Radioisotopengenerator:
    auf einer Oberfläche vorhanden ist, und/oder
    in einer Flüssigkeit vorhanden ist, und/oder
    in einer Matrix vorhanden ist, und/oder
    in einer chemischen Verbindung vorhanden ist, und/oder
    in einem Komplex vorhanden ist, und/oder Kombinationen davon.
  11. Produkt nach Anspruch 10, wobei der Radioisotopengenerator auf einer chemisch inerten Oberfläche vorhanden ist, wie einer Innenfläche einer rohrähnlichen Struktur, einer Oberfläche eines Partikels, aufgelöst in einer Flüssigkeit vorhanden ist, in einer 3D- und/oder 2D-Matrix vorhanden ist, wie einem Zeolithen, in einer chemischen Verbindung vorhanden ist wie einer metallorganischen Verbindung, in einem Komplex vorhanden ist, wie einem Komplex mit einem oder mehreren organischen Molekülen, in einem Komplex mit einem oder mehreren anorganischen Molekülen vorhanden ist und Kombinationen davon.
  12. Produkt nach Anspruch 11, umfassend
    ein Rohr (1), wobei das Rohr eine Innenfläche umfasst, die aus einem chemisch inerten Material gebildet ist, wie Glas, Teflon, einem geeigneten Polymer, Silikon, einem Metall wie Kupfer, Tantal, Titan, einer Metalllegierung oder einer Kombination daraus,
    einen Einlass (2) zum Bereitstellen einer Flüssigkeit in dem Rohr,
    einen Auslass (3) zum Freisetzen der Flüssigkeit aus dem Rohr,
    optional einen Schutz (6), der das Rohr umgibt, um zu verhindern, dass Radioaktivität auf die Umwelt einwirkt, wie einen Blei umfassenden Schutz, und
    einen langlebigen, hochspezifische Aktivität aufweisenden und/oder trägerfreien Radioisotopengenerator innerhalb des Rohrs.
  13. Kit, umfassend ein Produkt nach einem der Ansprüche 10-12.
  14. Produkt nach einem der Ansprüche 9-12 zur Herstellung eines Medikaments, beispielsweise für die Verwendung in der Strahlentherapie oder für bildgebende Systeme, wie eine Peptidrezeptor-Strahlentherapie, zum Zwecke der Diagnose oder Behandlung.
EP12824875.4A 2011-12-06 2012-12-06 Radionukliderzeuger mit ersten und zweiten atomen eines ersten elements Not-in-force EP2788989B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL12824875T PL2788989T3 (pl) 2011-12-06 2012-12-06 Generator radionuklidów mający pierwszy i drugi atom pierwszego pierwiastka

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2007925A NL2007925C2 (en) 2011-12-06 2011-12-06 Radionuclide generator.
PCT/NL2012/050856 WO2013085383A1 (en) 2011-12-06 2012-12-06 Radionuclide generator having first and second atoms of a first element

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EP2788989A1 EP2788989A1 (de) 2014-10-15
EP2788989B1 true EP2788989B1 (de) 2018-09-19

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EP (1) EP2788989B1 (de)
NL (1) NL2007925C2 (de)
PL (1) PL2788989T3 (de)
RU (1) RU2630475C2 (de)
WO (1) WO2013085383A1 (de)

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US10141079B2 (en) * 2014-12-29 2018-11-27 Terrapower, Llc Targetry coupled separations
US10867710B2 (en) 2015-09-30 2020-12-15 Terrapower, Llc Molten fuel nuclear reactor with neutron reflecting coolant
CN108352200B (zh) 2015-09-30 2021-11-09 泰拉能源公司 用于动态能谱迁移的中子反射体组件
US10665356B2 (en) 2015-09-30 2020-05-26 Terrapower, Llc Molten fuel nuclear reactor with neutron reflecting coolant
NL2017628B1 (en) * 2016-10-17 2018-04-24 Univ Delft Tech Isomeric Transition Radionuclide Generator, such as a 177mLu/177Lu Generator
US11363709B2 (en) 2017-02-24 2022-06-14 BWXT Isotope Technology Group, Inc. Irradiation targets for the production of radioisotopes
US20180244535A1 (en) 2017-02-24 2018-08-30 BWXT Isotope Technology Group, Inc. Titanium-molybdate and method for making the same
WO2021133797A1 (en) 2019-12-23 2021-07-01 Terrapower, Llc Molten fuel reactors and orifice ring plates for molten fuel reactors
US11728052B2 (en) 2020-08-17 2023-08-15 Terra Power, Llc Fast spectrum molten chloride test reactors

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US716353A (en) * 1902-07-29 1902-12-16 Constantine B Voynow Railway-track structure.
NL7902342A (nl) * 1979-03-26 1980-09-30 Byk Mallinckrodt Cil Bv Isotopengenerator.
CS255601B1 (en) * 1984-05-18 1988-03-15 Kristian Svoboda 99 mtc elution unit-built generator and method of its production
US6716353B1 (en) * 2002-10-30 2004-04-06 Ut-Battelle, Llc Method for preparing high specific activity 177Lu

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Publication number Publication date
PL2788989T3 (pl) 2019-03-29
WO2013085383A1 (en) 2013-06-13
RU2014127513A (ru) 2016-01-27
EP2788989A1 (de) 2014-10-15
NL2007925C2 (en) 2013-06-10
RU2630475C2 (ru) 2017-09-11

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