EP2788758A4 - Verwendung humanisierter mäuse zur bestimmung einer toxizität - Google Patents
Verwendung humanisierter mäuse zur bestimmung einer toxizitätInfo
- Publication number
- EP2788758A4 EP2788758A4 EP12854884.9A EP12854884A EP2788758A4 EP 2788758 A4 EP2788758 A4 EP 2788758A4 EP 12854884 A EP12854884 A EP 12854884A EP 2788758 A4 EP2788758 A4 EP 2788758A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- humanized mice
- determine toxicity
- toxicity
- humanized
- mice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000011577 humanized mouse model Methods 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161567466P | 2011-12-06 | 2011-12-06 | |
PCT/US2012/067983 WO2013086019A1 (en) | 2011-12-06 | 2012-12-05 | Use of humanized mice to determine toxicity |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2788758A1 EP2788758A1 (de) | 2014-10-15 |
EP2788758A4 true EP2788758A4 (de) | 2015-06-10 |
Family
ID=48574837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12854884.9A Withdrawn EP2788758A4 (de) | 2011-12-06 | 2012-12-05 | Verwendung humanisierter mäuse zur bestimmung einer toxizität |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150007357A1 (de) |
EP (1) | EP2788758A4 (de) |
CN (1) | CN104160272A (de) |
SG (1) | SG11201402112RA (de) |
WO (1) | WO2013086019A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016191286A1 (en) * | 2015-05-22 | 2016-12-01 | Champions Biotechnology, Inc. | Humanized mice and uses thereof |
KR20180013976A (ko) * | 2015-05-29 | 2018-02-07 | 고에끼 자이단 호우징 짓껭 도부쯔 쥬오 겡뀨쇼 | 평가 대상 약제의 혈액 독성 평가 방법 및 평가 대상 약제의 혈액 독성 평가용 모델 |
WO2017049002A1 (en) * | 2015-09-15 | 2017-03-23 | Massachusetts Institute Of Technology | A humanized mouse model of de novo human acute myeloid leukemia with a matching human immune system |
US9928025B2 (en) * | 2016-06-01 | 2018-03-27 | Ford Global Technologies, Llc | Dynamically equalizing receiver |
DK4080209T3 (en) * | 2017-04-17 | 2024-07-08 | Jackson Lab | Method of determining toxicity of an immunomodulatory drug for use in humans |
WO2019199799A1 (en) * | 2018-04-09 | 2019-10-17 | The Wistar Institute | Humanized mouse model |
WO2020041174A1 (en) * | 2018-08-20 | 2020-02-27 | The Jackson Laboratory | Method of determining toxicity of an immunomodulatory drug |
WO2020068615A1 (en) * | 2018-09-24 | 2020-04-02 | Albert Einstein College Of Medicine | Interleukin-8 for maintenance of human acute myeloid leukemia and myelodysplastic syndrome and uses thereof |
CN110940812A (zh) * | 2018-09-25 | 2020-03-31 | 上海恒润达生生物科技有限公司 | 一种评估cart细胞输注后免疫毒性检测方法 |
CA3158295A1 (en) * | 2019-11-15 | 2021-05-20 | Board Of Regents, The University Of Texas System | Humanized mouse model with human immune system |
CN112042597B (zh) * | 2020-07-22 | 2022-04-29 | 南京普恩瑞生物科技有限公司 | 一种双人源化肿瘤异种移植模型的构建方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL134723A0 (en) * | 1997-09-23 | 2001-04-30 | Zeneca Ltd | Amide derivatives for the treatment of diseases mediated by cytokines |
US6509514B1 (en) * | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
US20070036786A1 (en) * | 2005-07-11 | 2007-02-15 | Nadine Tuaillon | Method of treating autoimmune disease using humanized anti-CD16A antibodies |
EP1878342A1 (de) * | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immundefiziente Mäuse, die transgen für HLA Klassen I und II sind, und deren Verwendungen |
WO2009146029A1 (en) * | 2008-03-31 | 2009-12-03 | Gerold Feuer | An animal model and method of treatment for human t cell leukemia |
WO2009154995A2 (en) * | 2008-05-27 | 2009-12-23 | Kyowa Hakko Kirin Co., Ltd. | Interleukin 10 receptor (il-10r) antibodies and methods of use |
WO2011002727A1 (en) * | 2009-06-29 | 2011-01-06 | Qingfeng Chen | Methods of producing humanized non-human mammals |
PT3056082T (pt) * | 2009-10-06 | 2018-12-12 | Univ Yale | Ratinhos modificados geneticamente e enxerto |
-
2012
- 2012-12-05 US US14/362,774 patent/US20150007357A1/en not_active Abandoned
- 2012-12-05 WO PCT/US2012/067983 patent/WO2013086019A1/en active Application Filing
- 2012-12-05 SG SG11201402112RA patent/SG11201402112RA/en unknown
- 2012-12-05 CN CN201280068970.4A patent/CN104160272A/zh active Pending
- 2012-12-05 EP EP12854884.9A patent/EP2788758A4/de not_active Withdrawn
Non-Patent Citations (7)
Title |
---|
BUGELSKI P J ET AL: "Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies", HUMAN AND EXPERIMENTAL TOXICOLOGY, MCMILLAN, BASINGSTOKE, GB, vol. 19, no. 4, 1 April 2000 (2000-04-01), pages 230 - 243, XP008121941, ISSN: 0960-3271, DOI: 10.1191/096032700678815783 * |
BUGELSKI PETER J ET AL: "Monoclonal antibody-induced cytokine-release syndrome", EXPERT REVIEW OF CLINICAL IMMUNOLOGY, ENGLAND, vol. 5, no. 5, 1 September 2009 (2009-09-01), pages 499 - 521, XP009184062, ISSN: 1744-8409, DOI: 10.1586/ECI.09.31 * |
FRANK R. BRENNAN ET AL: "Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies", MABS, vol. 2, no. 3, 1 May 2010 (2010-05-01), pages 233 - 255, XP055072297, ISSN: 1942-0862, DOI: 10.4161/mabs.2.3.11782 * |
JACQUES DESCOTES: "Immunotoxicity of monoclonal antibodies", MABS, vol. 1, no. 2, 1 March 2009 (2009-03-01), pages 104 - 111, XP055186711, ISSN: 1942-0862, DOI: 10.4161/mabs.1.2.7909 * |
MINDI R WALKER ET AL: "Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 11, 2 June 2011 (2011-06-02), pages 1697 - 1705, XP028326747, ISSN: 1567-5769, [retrieved on 20110610], DOI: 10.1016/J.INTIMP.2011.06.001 * |
See also references of WO2013086019A1 * |
TIM WILLINGER ET AL: "Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement", TRENDS IN IMMUNOLOGY, vol. 32, no. 7, July 2011 (2011-07-01), pages 321 - 327, XP028238170, ISSN: 1471-4906, [retrieved on 20110421], DOI: 10.1016/J.IT.2011.04.005 * |
Also Published As
Publication number | Publication date |
---|---|
EP2788758A1 (de) | 2014-10-15 |
SG11201402112RA (en) | 2014-09-26 |
WO2013086019A1 (en) | 2013-06-13 |
US20150007357A1 (en) | 2015-01-01 |
CN104160272A (zh) | 2014-11-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20140619 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20150512 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A01K 67/027 20060101ALI20150506BHEP Ipc: G01N 33/53 20060101AFI20150506BHEP Ipc: A01K 67/00 20060101ALI20150506BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20151212 |