EP2739316A4 - Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate - Google Patents

Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate

Info

Publication number
EP2739316A4
EP2739316A4 EP12822647.9A EP12822647A EP2739316A4 EP 2739316 A4 EP2739316 A4 EP 2739316A4 EP 12822647 A EP12822647 A EP 12822647A EP 2739316 A4 EP2739316 A4 EP 2739316A4
Authority
EP
European Patent Office
Prior art keywords
prostate specific
specific membrane
membrane antigen
antigen inhibitors
radiolabeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP12822647.9A
Other languages
German (de)
English (en)
Other versions
EP2739316B1 (fr
EP2739316A1 (fr
Inventor
John W Babich
Craig Zimmerman
John L Joyal
Genliang Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Insight Pharmaceuticals Inc
Original Assignee
Molecular Insight Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Insight Pharmaceuticals Inc filed Critical Molecular Insight Pharmaceuticals Inc
Priority to EP19155531.7A priority Critical patent/EP3505192A1/fr
Priority to PL12822647T priority patent/PL2739316T3/pl
Publication of EP2739316A1 publication Critical patent/EP2739316A1/fr
Publication of EP2739316A4 publication Critical patent/EP2739316A4/fr
Application granted granted Critical
Publication of EP2739316B1 publication Critical patent/EP2739316B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP12822647.9A 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate Active EP2739316B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP19155531.7A EP3505192A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate
PL12822647T PL2739316T3 (pl) 2011-08-05 2012-08-03 Radioznakowane inhibitory antygenu błonowego specyficznego dla prostaty

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161515674P 2011-08-05 2011-08-05
PCT/US2012/049644 WO2013022797A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP19155531.7A Division EP3505192A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate
EP19155531.7A Division-Into EP3505192A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate

Publications (3)

Publication Number Publication Date
EP2739316A1 EP2739316A1 (fr) 2014-06-11
EP2739316A4 true EP2739316A4 (fr) 2015-03-11
EP2739316B1 EP2739316B1 (fr) 2019-04-10

Family

ID=47627059

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19155531.7A Pending EP3505192A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate
EP12822647.9A Active EP2739316B1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP19155531.7A Pending EP3505192A1 (fr) 2011-08-05 2012-08-03 Inhibiteurs radiomarqués d'antigène membranaire spécifique de la prostate

Country Status (10)

Country Link
US (2) US8926944B2 (fr)
EP (2) EP3505192A1 (fr)
JP (1) JP5843338B2 (fr)
AU (1) AU2012294639B2 (fr)
CA (1) CA2844151C (fr)
ES (1) ES2732060T3 (fr)
HU (1) HUE045028T2 (fr)
PL (1) PL2739316T3 (fr)
TR (1) TR201910084T4 (fr)
WO (1) WO2013022797A1 (fr)

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WO2017053268A1 (fr) * 2015-09-21 2017-03-30 Serrano-Ojeda Pedro Anastacio Composé de glutamine à élément à valeur de z élevée pour le traitement du cancer
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
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US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
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EP3011976A1 (fr) 2014-10-20 2016-04-27 Deutsches Krebsforschungszentrum Inhibiteurs marqués 18F de l'antigène membranaire spécifique de la prostate (PSMA), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate
US10736974B2 (en) 2014-10-22 2020-08-11 The Johns Hopkins University Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
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KR102156385B1 (ko) * 2018-03-30 2020-09-15 (주)퓨쳐켐 전립선암 진단 및 치료를 위한 psma-표적 방사성의약품
EP3590911A1 (fr) * 2018-07-01 2020-01-08 Studiengesellschaft Kohle MbH Réactif et procédé de désoxyfluoration spécifique au site de peptides
WO2020065045A1 (fr) 2018-09-28 2020-04-02 Universität Heidelberg Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation en tant qu'agents d'imagerie et agents pharmaceutiques pour le traitement de cancers exprimant le psma
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WO2020108753A1 (fr) 2018-11-28 2020-06-04 ITM Isotopen Technologien München AG Nouveaux agents de liaison à l'antigene tumoral et utilisations de ces agents
WO2020165409A1 (fr) 2019-02-14 2020-08-20 Deutsches Krebsforschungszentrum Ligands de l'antigène membranaire spécifique de la prostate (psma) comportant un lieur clivable par l'amylase
JP2022520799A (ja) 2019-02-14 2022-04-01 ルプレヒト－カールス－ウニベルジテート ハイデルベルク 改善された組織特異性を有する前立腺特異的膜抗原（ｐｓｍａ）リガンド
WO2020220023A1 (fr) * 2019-04-26 2020-10-29 Five Eleven Pharma Inc. Inhibiteurs de l'antigène membranaire spécifique de la prostate (psma) en tant qu'agents diagnostiques et agents thérapeutiques de type radionucléides
AR119479A1 (es) 2019-07-25 2021-12-22 Bayer As Radiofármacos dirigidos para diagnóstico y tratamiento de cáncer
CA3155519A1 (fr) * 2019-10-29 2021-05-06 Steve Shih-Lin Huang Agents d'imagerie ciblant le psma
WO2022096103A1 (fr) 2020-11-05 2022-05-12 ITM Isotopen Technologien München AG Association d'acide para-aminohippurique (pah) et de complexes radiomarqués destinée au traitement du cancer
EP4244216A1 (fr) 2020-11-12 2023-09-20 ABX Advanced Biochemical Compounds GmbH Ligands de l'antigène membranaire spécifique de la prostate (psma) contenant des blocs de construction de lieur hétéroaromatiques
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EP4355376A1 (fr) * 2021-06-17 2024-04-24 Mayo Foundation for Medical Education and Research Procédés et matériaux permettant de combiner des produits biologiques avec de multiples chélateurs
CN115745903A (zh) * 2021-09-03 2023-03-07 晶核生物医药科技(南京)有限公司 一种肽脲素衍生物、含其的药物组合物及其应用
WO2023086833A1 (fr) * 2021-11-09 2023-05-19 Case Western Reserve University Composés conjugués ciblés sur psma et leurs utilisations
WO2023208928A1 (fr) 2022-04-26 2023-11-02 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Dosage de ligands psma en vue de la détection de tissu cancéreux basée sur la fluorescence
WO2023222682A1 (fr) 2022-05-17 2023-11-23 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Ligands de l'antigène membranaire spécifique de la prostate (psma)
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Title
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Also Published As

Publication number Publication date
TR201910084T4 (tr) 2019-08-21
CA2844151A1 (fr) 2013-02-14
AU2012294639B2 (en) 2017-10-26
PL2739316T3 (pl) 2019-09-30
CA2844151C (fr) 2022-11-29
JP5843338B2 (ja) 2016-01-13
JP2014524419A (ja) 2014-09-22
AU2012294639A8 (en) 2014-03-06
US9388144B2 (en) 2016-07-12
EP3505192A1 (fr) 2019-07-03
HUE045028T2 (hu) 2019-12-30
AU2012294639A1 (en) 2014-02-27
EP2739316B1 (fr) 2019-04-10
WO2013022797A1 (fr) 2013-02-14
US8926944B2 (en) 2015-01-06
EP2739316A1 (fr) 2014-06-11
US20130034494A1 (en) 2013-02-07
US20150078998A1 (en) 2015-03-19
ES2732060T3 (es) 2019-11-20

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