EP2723315A2 - Utilisation d'élastomères de silicone dans des préparations cosmétiques - Google Patents
Utilisation d'élastomères de silicone dans des préparations cosmétiquesInfo
- Publication number
- EP2723315A2 EP2723315A2 EP12727668.1A EP12727668A EP2723315A2 EP 2723315 A2 EP2723315 A2 EP 2723315A2 EP 12727668 A EP12727668 A EP 12727668A EP 2723315 A2 EP2723315 A2 EP 2723315A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- oil
- acetate
- methyl
- alpha
- sio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Definitions
- the present invention relates to the use of silicone elastomers in cosmetic preparations.
- Preservatives are substances or substances which, when used in appropriate concentration, are intended to protect pharmaceutical and / or cosmetic preparations against, in particular, microbially caused adverse changes. Preservatives or mixtures of preservatives must act against bacteria, yeasts and fungi.
- a preservative is generally subject to the following requirements:
- Microorganisms may be present in cosmetic products primarily for production reasons or secondarily pass through the consumer into the cosmetic product.Therefore, the manufacturer of the cosmetic product must ensure that the finished product also on the entire period of use is safe (see Technical Rules for
- the preservatives generally need to be further dissolved in the preparation in order to be effective. Since most preservatives are better fat-soluble than water-soluble it happen that z. For example, in an emulsion whose aqueous phase is to be preserved, the preservative incorporated into the aqueous phase migrates in the course of storage in the fatty phase and thus the preservation of the aqueous phase is in question.
- preservatives in cosmetics is regulated by the Cosmetics Ordinance (KVO) and the EC Directive 76/768 in Germany and the European Union. Currently, 48 substances / mixtures are authorized as permanent and 4 temporary as preservatives in the EU.
- Formaldehyde releasers are preservatives which split off formaldehyde during the manufacture, storage or use of pharmaceutical or cosmetic agents and therefore have a preservative effect.
- formaldehyde Abspaltern the formaldehyde is in the form of ethereal compounds with alcohol, eg. B. as acetal or hemiacetal ago. Such compounds break down monomerically germicidal formaldehyde.
- Hemiacetals e.g. As the Semiformale of polyalcohols, such as ethylene glycol, 1, 2-propylene glycol, or butyl triglycol, are particularly suitable.
- the combination of such acetals with a number of methylol compounds leads to active substances, for example 2,4-dimethyl-6-acetoxy-m-dioxane and 2,4-dimethyl-6-propionoxy-m-dioxane.
- parabens methyl-, ethyl-, propyl-, butylparaben
- formaldehyde-releasing agents parabens (methyl-, ethyl-, propyl-, butylparaben) are regularly used in cosmetics as preserving agents. But these too
- (A) a S ⁇ - containing polysiloxane of the formula R 3 SiO (R ' 2 SiO) a (R "l-ISiO) b SiR 3 and, optionally, a Si-H containing polysiloxane of the formula HR 2 SiO (R'2SiO ) c SiR 2 H or the formula HR 2 SiO (R ' 2 SiO) a (R''l-ISiO) b SiR 2 H,
- R, R 'and R " alkyl groups having 1 to 6 C atoms
- Solvent selected from the group consisting of (i) organic components, (ii) components containing a silicon atom and any mixtures thereof,
- reaction is carried out until a gel is formed by cross-linking by the addition of ESi-H to the double bonds of the alpha, omega-diene
- R 2 hydrogen
- the object is achieved by the use of a Siloxanelastomergelgels,
- (A) a S ⁇ - containing polysiloxane of the formula R 3 SiO (R ' 2 SiO) a (R "l-ISiO) bSiR3 and, optionally containing a Si-H containing polysiloxane of the formula HR 2 SiO (R'2SiO) c SiR 2 H or the formula HR 2 SiO (R'2SiO) a (R "HSiO) b SiR 2 H,
- R, R 'and R " alkyl groups having 1 to 6 C atoms
- reaction is carried out until a gel is formed by cross-linking by the addition of ESi-H to the double bonds of the alpha, omega-diene
- R 2 hydrogen
- siloxane elastomers according to the invention are not preservatives within the meaning of the Cosmetics Ordinance, but are primarily incorporated into the preparations for other purposes.
- R 3 is selected from polyethers, pentylene, hexylene, heptylene, octylene, nonylene, decylene, dodecylene, tetradecylene and mixtures thereof.
- the siloxane elastomer II it is preferred in the case of the siloxane elastomer II) according to the invention if the compound contains 0.01 to 90 mol% cross-linker.
- the siloxane elastomer II) according to the invention can advantageously be prepared by the following process:
- each R 1 is independently a monovalent hydrocarbon group of 1 to 30 carbon atoms, a is 265 to 2,000 and d is 1 to 250
- an additional second ⁇ Si-containing polysiloxane is present, which is selected from HR 1 2 SiO (R 1 2 SiO) e SiR 1 2 H,
- (b) is selected from 1, 4-pentadiene, 1, 5-hexadiene, 1, 6-heptadiene, 1, 7-octadiene, 1, 8-nonadiene, 1, 9-decadiene, 1, 1 1 -dodecadiene, 1, 13-tetradecadiene and 1, 19-eicosadiene, 1, 3-butadiyne, 1, 5-hexadiyne (dipropargyl) and 1, hexene-5-yn.
- siloxane elastomer gels according to the invention can be obtained, for example, from Dow Corning under the trade name 9040 Silicone Elastomer Blend, 9041 Silicone
- Elastomer Blend or 9045 Silicone Elastomer Blend can be purchased.
- other elastomer gels such as, but not limited to, the Silsoft Silicone Gel from Momentive are also within the scope of the invention.
- the use according to the invention is advantageously characterized in that the preparation contains the siloxane elastomer gel in a concentration of 0.1 to 25
- the use according to the invention is preferably characterized in that the preparation contains the siloxane elastomer gel in a concentration of 5 to 20% by weight, based on the total weight of the preparation.
- Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation is in the form of an emulsion. That's it
- the preparation is in the form of an O / W emulsion.
- preparation according to the invention is in the form of an O / W emulsion, it is
- Glyceryl stearate citrate glyceryl stearate (self-emulsifying), stearic acid, stearate salts,
- preparations which contain no PEG (polyethylene glycols) or PEG derivatives are preferred.
- the use according to the invention is advantageously characterized in that the preparation is free of formaldehyde-releasing preservatives. These include, for example, dimethylol glycol, dimethylol urea, DMDM-hydantoin, quaternium-15 sodium hydroxymethylglycinate, tetramethylol glycoluril.
- the use according to the invention is advantageously characterized in that the preparation is free of parabens. These include, for example, methyl, ethyl, propyl and butylparaben.
- the oil or lipid phase according to the invention may contain all oils, fats, waxes and / or lipids customary in cosmetic preparations.
- the aqueous phase of the preparations according to the invention may advantageously comprise customary cosmetic auxiliaries, for example alcohols, in particular those of low C number, preferably ethanol and / or isopropanol or polyols of low C number and their ethers, preferably propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, foam stabilizers, electrolyte, self-tanning agents, etc.
- customary cosmetic auxiliaries for example alcohols, in particular those of low C number, preferably ethanol and / or isopropanol or polyols of low C number and their ethers, preferably propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol mono
- the composition according to the invention advantageously contains one or more humectants (moisturizers).
- Moisturizers are substances or mixtures of substances which give cosmetic preparations the property of reducing the moisture release of the horny layer (also called transepidermal water loss (TEWL) after application or spreading on the skin surface) and / or hydrating the horny layer positively influence.
- TEWL transepidermal water loss
- humectants in the context of the present invention are:
- glycerol for example, glycerol, lactic acid and / or lactates, especially sodium lactate,
- hyaluronic acid, chitosan and / or a fucose-rich polysaccharide which is deposited in the Chemical Abstracts under the registration number 178463-23-5 and, for example, are particularly advantageous.
- B. under the name Fucogel®1000 of the company SOLABIA SA is available.
- Moisturizers can also be used advantageously as anti-wrinkle active ingredients for protection against skin changes, as described, for example, in US Pat. B. occur during skin aging, can be used.
- the inventive preparation one or more humectants in a total concentration of 0, 1 to 20% by weight and preferably in a total concentration of 0.5 to 10% by weight, based in each case on the total weight of Preparation containing.
- the cosmetic preparations according to the invention may also advantageously, although not necessarily, contain fillers which are e.g. B. the sensory and cosmetic
- Starch and starch derivatives such as, for example, tapioca starch,
- Pigments which have neither primarily a UV filter effect nor a coloring effect (such as. For example, boron nitride etc.) and / or Aerosils ® (CAS no. 7631-86-9) and / or talc.
- the preparation as further ingredients one or more compounds selected from the group of compounds alpha-lipoic acid, folic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosylrutin, carnitine, carnosine, polydocanol, natural and / or synthetic isoflavonoids, flavonoids, creatine, creatinine, taurine, caffeine, menthol, ⁇ -alanine, tocopheryl acetate, urea; hyaluronic acid; dihydroxyacetone; 8-hexadecene-1, 16-dicarboxylic acid, glycyrrhetinic acid, glucosylglycerides and / or licochalcone A.
- UV filters selected from the group of compounds phenylene-1, 4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonklaresalze; 2-phenylbenzimidazole-5-sulfonic acid salts; 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and its salts; 4- (2-oxo-3-bomylidenemethyl) benzene sulfonic acid salts; 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid salts; 2,2'-methylene-bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol); 2- (2H-Benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [(trimethyl)
- Terephthalidendicamphersulfonklare 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester; 4- (dimethylamino) benzoic acid amyl ester; 4-Methoxybenzalmalon-klaredi (2-ethylhexyl) ester; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone;2,2'-dihydroxy-4-methoxybenzophenone; 2-ethylhexyl 2-hydroxybenzoate; 3- (4- (2,2-ethoxycarbonylvinyl) phenoxy) propenyl) methoxysiloxane / dimethylsiloxane copolymer; Dioctylbutylamidotriazone (INCI: diethylhexyl-butamidotriazone); 2,4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4
- preservative-free formulations were prepared and their microbiological stability was tested in the preservation stress test.
- the microbial stability was determined as follows: Evidence of the microbiological stability of a cosmetic product is usually demonstrated by testing for adequate preservation (preservation stress test). These are samples of a cosmetic product to be tested with test microbes
- the Absterbekinetiken be improved.
- less than 100 cfu / g were already detected after 7 days, whereas in Formula 1 this value is only obtained after 28 days.
- the Absterbekinetik has been improved by using a Siloxanelastomergelgel the Absterbekinetik / g with respect to the gram negative bacteria.
- the formulations with the siloxane elastomer gel according to the invention are more microbially stable. This is especially true for Candida albicans and the gram negative bacteria. Examples
- Glycerine 7.50 7.50 10.00 10.00 10.00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Silicon Polymers (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE201110078097 DE102011078097A1 (de) | 2011-06-27 | 2011-06-27 | Verwendung von Silikonelastomeren in kosmetischen Zubereitungen |
PCT/EP2012/061486 WO2013000742A2 (fr) | 2011-06-27 | 2012-06-15 | Utilisation d'élastomères de silicone dans des préparations cosmétiques |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2723315A2 true EP2723315A2 (fr) | 2014-04-30 |
Family
ID=46298423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12727668.1A Withdrawn EP2723315A2 (fr) | 2011-06-27 | 2012-06-15 | Utilisation d'élastomères de silicone dans des préparations cosmétiques |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2723315A2 (fr) |
DE (1) | DE102011078097A1 (fr) |
WO (1) | WO2013000742A2 (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2819417B2 (ja) * | 1989-04-17 | 1998-10-30 | 東レ・ダウコーニング・シリコーン株式会社 | 抗菌性シリコーンゴム粒状物の製造方法 |
JPH0762242A (ja) * | 1993-08-27 | 1995-03-07 | Shin Etsu Chem Co Ltd | 抗菌・抗かび性シリコーンゴム組成物 |
US5654362A (en) | 1996-03-20 | 1997-08-05 | Dow Corning Corporation | Silicone oils and solvents thickened by silicone elastomers |
US6770708B2 (en) * | 2002-08-27 | 2004-08-03 | Dow Corning Corporation | Silicone elastomers compositions |
DE102008053788A1 (de) * | 2008-10-22 | 2010-04-29 | Beiersdorf Ag | Kosmetische Formulierung mit Siloxanelastomeren zur Verbesserung der mikrobiologischen Stabilität |
-
2011
- 2011-06-27 DE DE201110078097 patent/DE102011078097A1/de not_active Withdrawn
-
2012
- 2012-06-15 EP EP12727668.1A patent/EP2723315A2/fr not_active Withdrawn
- 2012-06-15 WO PCT/EP2012/061486 patent/WO2013000742A2/fr active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO2013000742A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013000742A3 (fr) | 2013-12-05 |
WO2013000742A2 (fr) | 2013-01-03 |
DE102011078097A1 (de) | 2012-12-27 |
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