EP2720722A4 - MOLECULAR WITH SEVERAL VINYL SULPHONES - Google Patents

MOLECULAR WITH SEVERAL VINYL SULPHONES

Info

Publication number
EP2720722A4
EP2720722A4 EP12800682.2A EP12800682A EP2720722A4 EP 2720722 A4 EP2720722 A4 EP 2720722A4 EP 12800682 A EP12800682 A EP 12800682A EP 2720722 A4 EP2720722 A4 EP 2720722A4
Authority
EP
European Patent Office
Prior art keywords
containing molecule
vinylsulfone containing
vinylsulfone
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12800682.2A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2720722A1 (en
Inventor
Ying Chau
Yu Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hong Kong University of Science and Technology HKUST
Original Assignee
Hong Kong University of Science and Technology HKUST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hong Kong University of Science and Technology HKUST filed Critical Hong Kong University of Science and Technology HKUST
Publication of EP2720722A1 publication Critical patent/EP2720722A1/en
Publication of EP2720722A4 publication Critical patent/EP2720722A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/795—Polymers containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
EP12800682.2A 2011-06-16 2012-06-15 MOLECULAR WITH SEVERAL VINYL SULPHONES Withdrawn EP2720722A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161457836P 2011-06-16 2011-06-16
US201161457837P 2011-06-16 2011-06-16
PCT/CN2012/000827 WO2012171335A1 (en) 2011-06-16 2012-06-15 Multi-vinylsulfone containing molecule

Publications (2)

Publication Number Publication Date
EP2720722A1 EP2720722A1 (en) 2014-04-23
EP2720722A4 true EP2720722A4 (en) 2014-12-03

Family

ID=47356537

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12800682.2A Withdrawn EP2720722A4 (en) 2011-06-16 2012-06-15 MOLECULAR WITH SEVERAL VINYL SULPHONES

Country Status (4)

Country Link
US (1) US9592251B2 (zh)
EP (1) EP2720722A4 (zh)
CN (1) CN103687622A (zh)
WO (1) WO2012171335A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014160083A1 (en) * 2013-03-13 2014-10-02 Applied Cardiovascular Solutions, Llc. Methods, compositions, and devices for the occlusion of cavities and passageways
CN105209075B (zh) * 2013-04-18 2019-12-13 香港科技大学 生物相容性原位水凝胶
US9895394B2 (en) * 2014-03-10 2018-02-20 Kai-shun Christopher LEUNG Induction of chronic elevation of intraocular pressure with vinysulfonated hyaluronic acid (HA-VS) and thiolated hyaluronic acid (HA-SH)hydrogel
CA3055985A1 (en) 2017-03-22 2018-09-27 Genentech, Inc. Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
EP3675873A4 (en) 2017-09-01 2021-06-16 Pmidg, Llc FUNCTIONALIZED AND CROSS-LINKED POLYMERS
KR102435274B1 (ko) * 2019-10-24 2022-08-24 서울대학교병원 약물전달시스템으로서의 안구 주입형 마이크로젤 및 이를 포함하는 하이드로젤
US20230093832A1 (en) * 2020-01-16 2023-03-30 The Hong Kong University Of Science And Technology Compositions and methods for controlled release of target agent
US20240033283A1 (en) * 2020-12-03 2024-02-01 Pmidg, Llc Functionalized and crosslinked polymers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078285A1 (en) * 1999-06-18 2000-12-28 University Of Medicine And Dentistry Of New Jersey Controlled release of therapeutics by in-situ entrapment by matrix cross-linking
WO2010059883A1 (en) * 2008-11-19 2010-05-27 Rutgers, The State University Of New Jersey Degradable hydrogel compositions and methods
US7829118B1 (en) * 2009-07-30 2010-11-09 Carbylan Biosurgery, Inc. Modified hyaluronic acid polymer compositions and related methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
CA2359318C (en) 1999-02-01 2009-06-30 Donald Elbert Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
CN101065139A (zh) 2004-10-09 2007-10-31 扶瑞药业股份有限公司 眼用药剂递送系统
CN101338036B (zh) * 2007-07-06 2010-11-03 常州百瑞吉生物医药有限公司 生物相容快速凝胶化水凝胶及其喷雾剂的制备方法
US8821870B2 (en) 2008-07-18 2014-09-02 Allergan, Inc. Method for treating atrophic age related macular degeneration
US20100098772A1 (en) 2008-10-21 2010-04-22 Allergan, Inc. Drug delivery systems and methods for treating neovascularization
JP2012524793A (ja) * 2009-04-22 2012-10-18 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 免疫調節性生体分子を組み合わせて送達するためのヒドロゲル
CN102049067A (zh) * 2009-11-10 2011-05-11 清华大学 一种可原位交联的高分子水凝胶玻璃体替代材料
US9492383B2 (en) 2011-04-20 2016-11-15 Carbylan Therapeutics, Inc. Rapid in-situ gel forming compositions prepared via reaction of vinyl sulfone derivatized hyaluronic acid with thiol derivatized polyethylene glycol at alkaline pH

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078285A1 (en) * 1999-06-18 2000-12-28 University Of Medicine And Dentistry Of New Jersey Controlled release of therapeutics by in-situ entrapment by matrix cross-linking
WO2010059883A1 (en) * 2008-11-19 2010-05-27 Rutgers, The State University Of New Jersey Degradable hydrogel compositions and methods
US7829118B1 (en) * 2009-07-30 2010-11-09 Carbylan Biosurgery, Inc. Modified hyaluronic acid polymer compositions and related methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2012171335A1 *

Also Published As

Publication number Publication date
EP2720722A1 (en) 2014-04-23
US20140212373A1 (en) 2014-07-31
WO2012171335A1 (en) 2012-12-20
CN103687622A (zh) 2014-03-26
US9592251B2 (en) 2017-03-14

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20141105

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 9/00 20060101ALI20141030BHEP

Ipc: A61K 47/20 20060101AFI20141030BHEP

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Effective date: 20150602