EP2632902A2 - Verbessertes system zur oralen verabreichung eines arzneimittels - Google Patents
Verbessertes system zur oralen verabreichung eines arzneimittelsInfo
- Publication number
- EP2632902A2 EP2632902A2 EP11824692.5A EP11824692A EP2632902A2 EP 2632902 A2 EP2632902 A2 EP 2632902A2 EP 11824692 A EP11824692 A EP 11824692A EP 2632902 A2 EP2632902 A2 EP 2632902A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- drug
- drug delivery
- delivery system
- colon
- probiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Definitions
- the field of invention pertains to pharmaceutical formulations. More specifically, it pertains to an "Improved Oral Targetted Drug Delivery System (O-TDDS)".
- O-TDDS Oral Targetted Drug Delivery System
- the system is particularly suited for delivery of drugs having activity against the diseases located in the colon e.g. colon cancer, ulcerative colitis, protozoal infections etc.
- the present invention discloses an "Improved Oral Targetted Drug Delivery System".
- the system is particularly suited for delivery of drugs having activity against diseases located in the colon e.g. colon cancer, ulcerative colitis, protozoal infections etc.
- diseases located in the colon e.g. colon cancer, ulcerative colitis, protozoal infections etc.
- data pertaining to an anti-cancer agent, 5-Fluorouracil has been provided. However, the same is purely for illustrative purposes and is not restricting.
- the drug 5-Fluorouracil is one of the most commonly used anti-tumor agents. It was first synthesized in 1957 (Heidelberger, C, Chaudhuri, N. K., Danneberg, P., Mooren, D., Griesbach, L, 1957. Fluorinated pyrimidines, a new class of tumor-inhibitory compounds. Nature179, 663-666.). At that time it was the only agent with clinical activity against colorectal cancer. Due to its structural resemblance to natural pyrimidines, 5-FU interferes with nucleic acid synthesis, inhibits DNA synthesis, and eventually halts cell growth (Langenbach, R.J., Dancenberg, P.
- the drug not only kills tumor cells, but also the rapidly growing normal cells, including gastrointestinal (Gl) cells and bone marrow cells. This lack of target differentiation limits the use of the drug.
- Toxicity is expressed as vomiting, diarrhoea, structural alteration of mucosal cells, decreased nutrient absorption, white blood cell (WBC) depression, and decreased platelet cells.
- WBC white blood cell
- the most serious toxicities are gastrointestinal toxicity, bone marrow inhibition and immunotoxicity.
- Gastrointestinal toxicity and bone marrow inhibition are the dose limiting factors and hamper the use of higher and possibly more effective doses of 5-
- Gl damage The gastrointestinal damage includes stomatistis, diarrhoea, denudation of villi, destruction of the integrity of mucosa, an increase of the permeability of intestine, and decrease of activities of intestinal enzymes such as thymidine-kinase. It has been reported that due to the cytotoxic effects of 5-FU on the mucous membrane, it causes mucositis when given via parenteral and intra peritoneal route (Mahood, D.J., Dose, A.M., Loblui, C.L., 1991. Inhibition of 5-f uorouracil-induced mucositis by oral cryotherapy. J. Clin. Oncol. 9, 449-452. and Pico, J.L., Avila-Garavito, A., Naccache P., 1998. Mucositis: its occurrence, consequences, and treatment in the oncology setting. Oncologist 3, 446-451)
- Micro flora disturbance The ecological balance of normal micro flora is disturbed by the systemic administration of 5-FU. This leads to an alteration in the normal micro flora which, in turn, leads to a number of complications and multiple organ failure. This is accompanied by translocation of bacteria and diarrhoea. Moreover, there is a shift from gram (+) ve to gram (-) ve bacteria in the intestine, which increases the chances of secondary infections.
- the existing formulations of 5-FU available in the market comprise either injections (parenteral) or capsules (oral intake).
- both the existing formulations suffer from limitations as follows:
- the drug is also available for oral intake in form of capsules.
- the formulation has not become popular.
- a major limiting factor is the erratic drug release profile and also undesirable side effects such as diarrhea and Gl hemorrhage leading to bloody stools.
- the unpredictable release, wide variation in therapeutic effects and also undesirable side-effects has led to reliance of the clinicians on the parenteral formulation, despite its limitations and side-effects.
- the drug 5-fluorouracil is not released at all ih We's ' fomach or small intestine, since its 'protective coat' of natural polymers cannot be digested. However, when it reaches the colon, specific bacteria in the colon digest the natural polymeric coat, leading to 'targetted release' of the drug only in the colon.
- One more object of the invention is to disclose an Improved Oral Targetted Drug Delivery System comprising a unique combination of microspheres (drug + natural polymers) and probiotics in a single, pharmaceutically acceptable dosage form such as capsules.
- a further object of the invention is to disclose an Improved Oral Targetted Drug Delivery System for anti-cancer drugs such as 5-FU in which the undesirable side-effects caused by the drug viz: diarrhea, vomiting, weight loss, hair loss etc. are either drastically reduced or eliminated altogether.
- Yet another object is to disclose an oral drug delivery system in which the negative effects of the drug on the micro flora in the targeted region are overcome in an innovative manner by use of probiotics.
- a still further object is to disclose an improved oral drug delivery system in which the limitations and drawbacks of the prior art are overcome.
- the delivery system of the present invention comprises two elements packed in a single, pharmaceutically acceptable oral dosage form e.g. a capsule.
- the two elements are:
- Microspheres These comprise of the active drug 5-FU and natural polymers such as guar gum and xanthan gum.
- Probiotics These are in the form of spray dried, lyophilized powder of an appropriate probiotic e.g. Bifidobacterium species (Bifidobacterium bifidum, Bifidobacterium longum etc.)
- colonic drugs such as 5-FU do affect the colonic micro flora and thus functioning of natural polymer based, oral targeted drug delivery systems, how to solve the problem? How to ensure that functionality of delivery systems remained unaffected?
- the inventors adopted an innovative experimental approach using a 'living biological system' comprising rats. All the experimental procedures were approved by the Institutional Animal Ethics Committee vide Approval Number 954/ac/06/CPCSEA/1919. The experimental study was conducted on thirty Wister Albino rats.
- mice were divided into 6 groups of five each. Each animal in the group was given oral dose as indicated in Table 1 below:
- the dosages were freshly prepared every day by suspending in milk. They were administered by oral gavage needle for first and subsequent exposure for a duration of five days each, at an interval of 20 days.
- 5-FU considerably damages micro flora involved in release of drug from the 'natural gum based' delivery systems: Caecal contents of rats fed on 5-FU powder or 5-FU microspheres did not contain sufficiently active microbes. This is proven by the fact that when natural gum based drug delivery systems (compression coated tablets/microspheres) were exposed to the caecal contents of such rats, drug release was drastically reduced, ranging from 41%-54% compared to 83-92% in the control in which rats were not given any drug orally. This indicated that 'micro flora' in rats fed orally with 5-FU had been 'damaged' because it is these micro flora (bacteria) which are involved in digesting the natural gums in the 'targetted drug delivery systems'. Since release of drug was very less as compared to control, it indicated that the bacteria were being killed by the drug.
- microspheres comprising mixture of 5-FU and natural polymeric gums viz. guar gum and xanthan gum (details of microsphere preparation duly given in Table 4).
- the inventors used natural polymer based microspheres of 5-FU which has not been disclosed in the prior art.
- Use of microspheres was attempted because of two reasons- Firstly to enhance 'drug dispersal' in the colon so that undesirable side-effects at the site of release could be reduced. Experimental evidence proved that use of microspheres significantly reduced the side effects as compared to 5-FU powder.
- the 'microsphere based delivery system' of present invention does not require any specialized machinery and industrial scale batches can easily be manufactured.
- Damage to micro flora can be overcome: The damage to colonic micro flora can be overcome by co-administration of appropriate probiotics.
- test animals did not suffer from any weight loss and their weight was same as compared to the control animals
- the present invention thus marks a turning point related to:
- O-TDDS Improved Oral Targeted Drug Delivery System
- O-TDDS for delivery of colon specific drugs and anti-cancer agents such as 5-Fluorouracil, comprising a combination of microspheres (mixture of drug + natural polymers such as guar gum and xanthan gum) and probiotics in a single, pharmaceutically acceptable oral dosage form such as a capsule, has not been disclosed anywhere in the prior art to best of knowledge of the inventors. It is thus novel.
- the inventive step thus lies in the successful development by the inventors of an Improved Oral Targeted Drug Delivery System for delivery of colon specific drugs and anti-cancer agents such as 5-Fluorouracil, comprising a combination of microspheres (mixture of drug + natural polymers such as guar gum and xanthan gum) and probiotics in a single, pharmaceutically acceptable oral dosage form such as a capsule. It represents a significant technical advance over existing knowledge.
- the inventive step lies in the complete elimination of the negative side-effects of the drug (e.g. 5-FU) on the micro flora of the colon.
- the drug e.g. 5-FU
- the inventive step lies in the complete elimination of the negative side-effects of the drug (e.g. 5-FU) on the micro flora of the colon.
- the drug e.g. 5-FU
- the problem of affect of 5-FU on micro flora had not been addressed, such targeted drug delivery systems in which micro flora played a critical and functional role, were technically flawed with a strong possibility of failure. This was because once the micro flora was upset; the next dosage form would not work as the natural polymer coat would not open due to lack of colonic bacteria to digest the same. This problem has been solved in the present invention.
- the present invention discloses an improved oral targeted drug delivery system particularly suited for delivery of drugs having activity against the diseases located in the colon e.g. colon cancer, ulcerative colitis, protozoal infections etc.
- the concept disclosed in the present invention can well be extrapolated to other drugs. It can be used to reduce the side-effects in delivery systems where natural gums/polymers have been utilized to bring about 'targeted delivery'. Examples of such drugs targeted to colon using combination of natural gums such as guar gum and xanthan gum or guar gum alone are given in Table 5 and Table 6 respectively, below:
- present invention has successfully demonstrated a practical mechanism to maintain the integrity and intactness of the intestinal/colonic micro flora, in face of 'chemical attack' by colon specific drugs listed in Table 6 above. Since the approach used in the present invention primarily involves use of microspheres of the drug + probiotics 'packed' in a single, oral, pharmaceutically acceptable dosage form, the example of 5-FU given is not restrictive but may be regarded as an illustrative example to better explain the invention and promote understanding of the same.
- Delivery systems can utilize any suitable drug apart from drugs disclosed in present application.
- More than one probiotic can be used in a system.
- a combination of more than one drug and more than one probiotic can be used.
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- Microbiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2220DE2010 | 2010-09-17 | ||
PCT/IN2011/000642 WO2012035561A2 (en) | 2010-09-17 | 2011-09-19 | Improved oral targetted drug delivery system |
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EP2632902A2 true EP2632902A2 (de) | 2013-09-04 |
EP2632902A4 EP2632902A4 (de) | 2014-05-28 |
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EP11824692.5A Withdrawn EP2632902A4 (de) | 2010-09-17 | 2011-09-19 | Verbessertes system zur oralen verabreichung eines arzneimittels |
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EP (1) | EP2632902A4 (de) |
JP (1) | JP2013537221A (de) |
CN (1) | CN103347863A (de) |
WO (1) | WO2012035561A2 (de) |
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CN102871983B (zh) * | 2012-10-31 | 2015-12-09 | 中国人民解放军第四军医大学 | 藤黄酸结肠定位控释片及其制备方法 |
CN103142494B (zh) * | 2013-03-19 | 2018-06-26 | 河北凯盛医药科技有限公司 | 奥硝唑口服制剂及其制备方法 |
RU2554739C1 (ru) * | 2014-03-25 | 2015-06-27 | Александр Александрович Кролевец | Способ получения нанокапсул албендазола |
JP2017088540A (ja) * | 2015-11-10 | 2017-05-25 | ビオフェルミン製薬株式会社 | 5−フルオロウラシル誘発性腸疾患の予防及び/又は治療剤 |
CN105997937A (zh) * | 2016-07-04 | 2016-10-12 | 中北大学 | 5-氟尿嘧啶印迹凝胶微球制备方法 |
WO2018039087A1 (en) * | 2016-08-20 | 2018-03-01 | Gregg John Malcolm Hall | Antimicrobial drug methods of use & therapeutic compositions |
CN108653341B (zh) * | 2018-05-30 | 2021-04-30 | 华中科技大学 | 一种用于恶性肿瘤免疫治疗的药盒及其应用 |
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WO2004022031A2 (en) * | 2002-09-06 | 2004-03-18 | Canacure Corporation | Stable probiotic microsphere compositions and their methods of preparation |
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AUPQ132599A0 (en) * | 1999-07-01 | 1999-07-22 | Commonwealth Scientific And Industrial Research Organisation | Nasogastric enteral formulations |
CA2461708C (en) * | 2001-09-28 | 2012-08-07 | Nutraceutix, Inc. | Delivery system for biological component |
US20070098784A1 (en) * | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
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2011
- 2011-09-19 JP JP2013528836A patent/JP2013537221A/ja active Pending
- 2011-09-19 WO PCT/IN2011/000642 patent/WO2012035561A2/en active Application Filing
- 2011-09-19 EP EP11824692.5A patent/EP2632902A4/de not_active Withdrawn
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WO2004022031A2 (en) * | 2002-09-06 | 2004-03-18 | Canacure Corporation | Stable probiotic microsphere compositions and their methods of preparation |
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Also Published As
Publication number | Publication date |
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EP2632902A4 (de) | 2014-05-28 |
WO2012035561A2 (en) | 2012-03-22 |
CN103347863A (zh) | 2013-10-09 |
WO2012035561A3 (en) | 2012-07-19 |
WO2012035561A4 (en) | 2012-08-16 |
JP2013537221A (ja) | 2013-09-30 |
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