EP2610243A4 - Agent de marquage et séquence d'acides aminés l'utilisant, et procédé pour réaliser une analyse quantitative simultanée de multiples protéines - Google Patents
Agent de marquage et séquence d'acides aminés l'utilisant, et procédé pour réaliser une analyse quantitative simultanée de multiples protéinesInfo
- Publication number
- EP2610243A4 EP2610243A4 EP11820170.6A EP11820170A EP2610243A4 EP 2610243 A4 EP2610243 A4 EP 2610243A4 EP 11820170 A EP11820170 A EP 11820170A EP 2610243 A4 EP2610243 A4 EP 2610243A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- amino acid
- acid sequence
- same
- quantitative analysis
- labeling agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020100081659A KR101229704B1 (ko) | 2010-08-23 | 2010-08-23 | 동중체로 표지된 단백질 및 펩티드를 큰 질량의 y-타입 이온을 이용하여 정량분석하는 방법 |
KR1020100100538A KR101207742B1 (ko) | 2010-10-14 | 2010-10-14 | 라벨링제 및 이를 이용한 아미노산 서열 및 단백질 다중 정량 동시 분석방법 |
PCT/KR2011/006225 WO2012026743A2 (fr) | 2010-08-23 | 2011-08-23 | Agent de marquage et séquence d'acides aminés l'utilisant, et procédé pour réaliser une analyse quantitative simultanée de multiples protéines |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2610243A2 EP2610243A2 (fr) | 2013-07-03 |
EP2610243A4 true EP2610243A4 (fr) | 2014-04-02 |
Family
ID=45723924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11820170.6A Withdrawn EP2610243A4 (fr) | 2010-08-23 | 2011-08-23 | Agent de marquage et séquence d'acides aminés l'utilisant, et procédé pour réaliser une analyse quantitative simultanée de multiples protéines |
Country Status (5)
Country | Link |
---|---|
US (1) | US8809012B2 (fr) |
EP (1) | EP2610243A4 (fr) |
JP (1) | JP5683706B2 (fr) |
CN (1) | CN103228621B (fr) |
WO (1) | WO2012026743A2 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104136626B (zh) * | 2012-03-01 | 2017-05-03 | 诺沃—诺迪斯克有限公司 | N‑末端修饰的寡肽及其用途 |
US10145818B2 (en) * | 2012-10-22 | 2018-12-04 | President And Fellows Of Harvard College | Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry |
JP2016004032A (ja) * | 2014-06-19 | 2016-01-12 | 国立大学法人弘前大学 | ペプチドのアミノ酸配列の解析方法 |
US11085927B2 (en) | 2016-06-03 | 2021-08-10 | President And Fellows Of Harvard College | Techniques for high throughput targeted proteomic analysis and related systems and methods |
CN114436765B (zh) * | 2021-12-24 | 2023-03-31 | 中南大学 | 一种苄位氘代的α,α-二氘苄碘、二氘苄胺、二氘药物分子及其合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010008159A2 (fr) * | 2008-07-18 | 2010-01-21 | Postech Academy-Industry Foundation | Réactifs de marquage de masse variable ajustés en masse et en propriété et procédés analytiques pour le séquençage peptidique et la quantification de protéine multiplexée simultanés utilisant ceux-ci |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO178729C (no) | 1992-03-31 | 1996-05-22 | Daiichi Seiyaku Co | Terapeutisk aktive sukkerderivater |
IL111175A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
ATE191750T1 (de) | 1996-01-23 | 2000-04-15 | Rapigene Inc | Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen |
US8669116B2 (en) | 2002-03-11 | 2014-03-11 | President And Fellows Of Harvard College | Detection and quantification of modified proteins |
US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
US7307169B2 (en) | 2004-01-05 | 2007-12-11 | Applera Corporation | Isotopically enriched N-substituted piperazines and methods for the preparation thereof |
KR20080070272A (ko) | 2007-01-26 | 2008-07-30 | 유코미디어 주식회사 | 위치정보의 선택적 이용 기능이 구비된 무선단말과 이를위한 프로그램 기록매체 |
-
2011
- 2011-08-23 US US13/818,489 patent/US8809012B2/en not_active Expired - Fee Related
- 2011-08-23 WO PCT/KR2011/006225 patent/WO2012026743A2/fr active Application Filing
- 2011-08-23 CN CN201180048175.4A patent/CN103228621B/zh not_active Expired - Fee Related
- 2011-08-23 EP EP11820170.6A patent/EP2610243A4/fr not_active Withdrawn
- 2011-08-23 JP JP2013525824A patent/JP5683706B2/ja not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010008159A2 (fr) * | 2008-07-18 | 2010-01-21 | Postech Academy-Industry Foundation | Réactifs de marquage de masse variable ajustés en masse et en propriété et procédés analytiques pour le séquençage peptidique et la quantification de protéine multiplexée simultanés utilisant ceux-ci |
Non-Patent Citations (3)
Title |
---|
DONALD C DITTMER ET AL: "Tetramic acids and derivatives by telluride-triggered Dieckmann cyclizations 1", ISSUE IN HONOR OF PROF. FRANKLIN A. DAVIS ARKIVOC, 9 December 2009 (2009-12-09), pages 61 - 83, XP055093666, Retrieved from the Internet <URL:http://quod.lib.umich.edu/cache//5/5/5/5550190.0011.608/5550190.0011.608.pdf#page=1;zoom=75> [retrieved on 20131216], DOI: http://dx.doi.org/10.3998/ark.5550190.0011.608 * |
See also references of WO2012026743A2 * |
SEO J ET AL: "Mass-Balanced 1H/2H Isotope Dipeptide Tag for Simultaneous Protein Quantitation and Identification", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 80, no. 16, 15 August 2008 (2008-08-15), pages 6145 - 6153, XP008140244, ISSN: 0003-2700, [retrieved on 20080712], DOI: 10.1021/AC801007Y * |
Also Published As
Publication number | Publication date |
---|---|
JP2013536433A (ja) | 2013-09-19 |
JP5683706B2 (ja) | 2015-03-11 |
CN103228621B (zh) | 2016-06-15 |
EP2610243A2 (fr) | 2013-07-03 |
WO2012026743A2 (fr) | 2012-03-01 |
CN103228621A (zh) | 2013-07-31 |
US8809012B2 (en) | 2014-08-19 |
US20130183704A1 (en) | 2013-07-18 |
WO2012026743A3 (fr) | 2012-08-23 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20130322 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20140304 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/58 20060101ALI20140226BHEP Ipc: C07C 233/47 20060101AFI20140226BHEP Ipc: G01N 33/68 20060101ALI20140226BHEP |
|
17Q | First examination report despatched |
Effective date: 20170426 |
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GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: G01N 33/68 20060101ALI20180116BHEP Ipc: C07C 233/51 20060101ALI20180116BHEP Ipc: G01N 33/58 20060101ALI20180116BHEP Ipc: C07C 233/47 20060101AFI20180116BHEP |
|
INTG | Intention to grant announced |
Effective date: 20180208 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20180619 |