EP2575142B1 - Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System - Google Patents

Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System Download PDF

Info

Publication number
EP2575142B1
EP2575142B1 EP20110401600 EP11401600A EP2575142B1 EP 2575142 B1 EP2575142 B1 EP 2575142B1 EP 20110401600 EP20110401600 EP 20110401600 EP 11401600 A EP11401600 A EP 11401600A EP 2575142 B1 EP2575142 B1 EP 2575142B1
Authority
EP
European Patent Office
Prior art keywords
electromagnetic valve
flowing
enter
buffer tube
adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP20110401600
Other languages
English (en)
French (fr)
Other versions
EP2575142A1 (de
Inventor
Chia-Jung Chang
Mei-Hsiu Liao
Lie-Hang Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Nuclear Energy Research
Atomic Energy Council
Original Assignee
Institute of Nuclear Energy Research
Atomic Energy Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Nuclear Energy Research, Atomic Energy Council filed Critical Institute of Nuclear Energy Research
Priority to EP20110401600 priority Critical patent/EP2575142B1/de
Publication of EP2575142A1 publication Critical patent/EP2575142A1/de
Application granted granted Critical
Publication of EP2575142B1 publication Critical patent/EP2575142B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Definitions

  • the present invention relates to a radioactive medicine synthesis system; more particularly, relates to improving purity and yield of chemical product in an automatic radioactive medicine synthesis system.
  • Nuclear medicine uses affinitive column for adhesion of target medicine to obtain product after washing and eluting.
  • iodine isotope would process radioiodination in a buffer containing an oxidant.
  • yield of target and purity of radioactive chemical medicine are affected by the volume of solution; time for oxidation; and arrangement of adhesion, washing and eluting processes.
  • the yield and purity may become bad with high cost and the product obtained may become useless.
  • the source has to be increased. But, following the increase in source, its volume is increased too. As a result, the yield and purity are still not increased or even decreased.
  • a prior art separates the adhesion process and the washing process to reduce pollution of impurities.
  • the prior art is automated. The operators only have to take the column manually for washing at the final stage. However, the activity of the column may be still high, the pollution may happen to the operators or there may be a chance for operation mistake in the time before washing.
  • the easiest way for increasing the chemical production is to increase the volume of the reactants. But, in fact, it is not so simple. For example, the total volume for the reactions is critical.
  • reaction of radioiodination is processed in a liquid state and some reaction solutions can not be condensed, so that the yield may not be increased following the increase of the total reaction volume.
  • radioiodination may contains some incomplete reactions so that some unreacted iodine will be left over.
  • Purification has to be done to the product through processes of adhesion (of the product), washing and elution with an affinitive column, where the adhesion process includes processes of repeated back-and-forth flowing through the column to increase efficiency of adhesion.
  • the reaction solution filled in the column has a volume smaller than the total reaction volume, some problems may occur in the automatic system, even though an adhesion batch may be designed in theory. Because the column has a small diameter and the liquid has surface tension, incomplete adhesion may happen during the repeated flowing processes and some waste solution may be generated and discharged.
  • EP 1 772 157 A describes a synthesis method for manufacturing radiopharmaceuticals and nuclides in a module with a syringe pump unit.
  • the method comprises formation and/or introduction of a radioactive substance, processing the radioactive substance in at least one production facility, and ejection of the produced radiopharmaceuticals or nuclides
  • the method is carried out by means of pumping and suction operations of the syringe pump unit.
  • the main purpose of the present invention is to increase a number of target reaction containers from one into many for increasing reaction volume coordinated with increased reaction times and, by modifying an affinitive column of an automatic synthesis system, to increase production in a single batch conformed to quality check specifications.
  • the main purpose of the present invention is provide an automatic way to separate adhesion process and washing process by switching electromagnetic valves coordinated with different sizes of buffer tubes for increasing production and reducing cost
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, comprising steps of: (a) washing by: inputting a total solution of total solution by nitrogen gas to be flown through a second electromagnetic valve, a first electromagnetic valve and a fourth electromagnetic valve to enter into a first buffer tube; flowing said total solution through a sixth electromagnetic valve to enter an adhesion column to process adhesion; flowing said total solution through an eighth electromagnetic valve and a seventh electromagnetic valve to enter a second buffer tube; flowing a waste gas through a fifth electromagnetic valve and a third electromagnetic valve to be discharged; and staying said total solution in said second buffer tube; (b) backwashing by: flowing nitrogen gas through said second electromagnetic valve, said third electromagnetic valve and said fifth electromagnetic valve to push out said total solution in said second buffer tube; flowing said total solution through said seventh electromagnetic valve and said eighth electromagnetic valve to enter said adhesion column to process adhesion; flowing said total solution through said sixth electromagnetic valve to enter said first buffer tube; and flowing a waste gas through said fourth electromagnetic
  • FIG.1 is a structural view showing devices used in a preferred embodiment according to the present invention.
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, where an original chemical reaction are divided into multiple reactions with adhesions processed after the multiple reactions; and where the adhesions have a total solution flowing back and forth along an adhesion column 1 several times for enhancing adhesion efficiency. Since the total solution has a big volume, the adhesion column 1 is separately added with a buffer tube 21,22 at each end of the adhesion column 1 for guiding the flowing of the total solution coordinated with a plurality of three-way electromagnetic valves 31 ⁇ 39.
  • the column For removing unreacted radioactive iodine, the column must be cleaned.
  • the present invention added two more buffer tubes 23,24 for washing and backwashing to separate processes of adhesion and washing for improving washing effect with the coordination of the three-way electromagnetic valves 31 ⁇ 39.
  • FIG.2 to FIG.7 are views showing processes of washing with adhesion, backwashing with adhesion, discharging reaction solutions, backwashing, washing and eluting out product.
  • the present invention comprises the following steps:
  • the first to the ninth electromagnetic valves 31 ⁇ 39 are three-way electromagnetic valves; and, the first and the second buffer tubes 21,22 have diameters and volumes bigger than the third and the fourth buffer tubes 23,24.
  • the present invention increases a number of target reaction containers from one into many (e.g. three) for increasing reaction volume coordinated with increased reaction times.
  • An affinitive column of an automatic synthesis system is modified for increasing production in a single batch conformed to quality check specifications.
  • the present invention separates a chemical reaction into many reactions for repeatedly processing original reactions to avoid reducing yield on increasing reaction volume.
  • the present invention adds two plastic tubes at head and tail ends of the column to be used as buffer tubes for not only processing adhesion several times but also for solving the problem of incomplete adhesion for reaction solution owing to surface tension (i.e. waste solution).
  • the present invention adds two empty columns at head and tail ends of the column to be used as buffer tubes to separate adhesion process and washing process with coordination of electromagnetic valves for controlling to obtain products conformed to quality check specifications.
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, where, in an automatic way, adhesion process and washing process are separated by switching electromagnetic valves coordinated with different sizes of buffer tubes for increasing production and reducing cost.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Claims (3)

  1. Verfahren zur Verbesserung der Reinheit und Ausbeute eines chemischen Produktes in einem automatischen Synthese - System für radioaktive Arzneimittel, welches die nachfolgenden Schritte umfasst:
    (a) Waschen durch Einleiten einer Gesamtlösung der Reaktionslösungen mit Stickstoffgas, welche durch ein zweites Elektromagnetventil (32), ein erstes Elektromagnetventil (31) und ein viertes Elektromagnetventil (34) in ein erstes Pufferrohr (21) hineinströmen, wobei die besagte Gesamtlösung durch ein sechstes Elektromagnetventil (36) weiterfließt und in eine Adhäsionssäule (1) eintritt, wo eine Adhäsion erfolgt, wobei die besagte Gesamtlösung durch ein achtes Elektromagnetventil (38) und ein siebtes Elektromagnetventil (37) weiterfließt und in ein zweites Pufferrohr (22) eintritt, wobei ein Abgas durch ein fünftes Elektromagnetventil (35) und ein drittes Elektromagnetventil (33) strömt, um abgeführt zu werden, und wobei die besagte Gesamtlösung in dem besagten zweiten Pufferrohr (22) verbleibt,
    (b) Rückspülung durch Einleiten von Stickstoffgas durch das besagte zweite Elektromagnetventil (32), das besagte dritte Elektromagnetventil (33) und das besagte fünfte Elektromagnetventil (35), um die besagte Gesamtlösung aus dem besagten zweiten Pufferrohr (22) zu verdrängen, wobei die besagte Gesamtlösung durch das besagte siebte Elektromagnetventil (37) und das besagte achte Elektromagnetventil (38) strömt und in die besagte Adhäsionssäule (1) gelangt, wo Adhäsion erfolgt, wobei die besagte Gesamtlösung durch das besagte sechste Elektromagnetventil (36) strömt und in das besagte erste Pufferrohr (21) gelangt, wobei das Abgas durch das besagte vierte Elektromagnetventil (34) und das besagte erste Elektromagnetventil strömt, um abgeführt zu werden,
    (c) Entladen der Reaktionslösung durch Einleiten von Stickstoffgas durch das besagte zweite Elektromagnetventil (32), das besagte erste Elektromagnetventil (31) und das besagte vierte Elektromagnetventil (34), um die besagte Gesamtlösung, welche in dem besagten ersten Pufferrohr (21) verblieben ist, herauszudrücken, wobei die besagte Gesamtlösung durch das besagte sechste Elektromagnetventil (36), das besagte achte Elektromagnetventil (38) und ein neuntes Elektromagnetventil (39) strömt, um abgeführt zu werden,
    (d) Rückspülung durch Einleiten einer Reinigungsflüssigkeit durch das besagte zweite Elektromagnetventil (32), das besagte dritte Elektromagnetventil (33) und das besagte fünfte Elektromagnetventil (25), sodass diese in ein viertes Pufferrohr (24) eintritt, wobei die besagte Reinigungsflüssigkeit durch das besagte siebte Elektromagnetventil (37) und das besagte achte Elektromagnetventil (38) in die besagte Adhäsionssäule (1) einströmt, um Verunreinigungen auszuwaschen, wobei die besagte Reinigungsflüssigkeit durch das besagte sechste Elektromagnetventil (36) in ein drittes Pufferrohr (23) eingeleitet wird, und wobei die besagte Reinigungsflüssigkeit durch das besagte vierte Elektromagnetventil (34) und das besagte erste Elektromagnetventil (31) strömt, um abgeführt zu werden,
    (e) Waschen durch Einleiten einer Reinigungsflüssigkeit durch das besagte zweite Elektromagnetventil (32), das besagte erste Elektromagnetventil (31) und das besagte vierte Elektromagnetventil (34), sodass diese in das besagte dritte Pufferrohr (23) gelangt, wobei die besagte Reinigungsflüssigkeit durch das besagte sechste Elektromagnetventil (36) in die besagte Adhäsionssäule (1) einströmt, um Verunreinigungen auszuwaschen, und wobei die besagte Reinigungsflüssigkeit durch das besagte achte Elektromagnetventil (38) und das besagte neunte Elektromagnetventil (39) strömt, um abgeführt zu werden, und
    (f) Ausspülen des Produkts durch Einleiten einer eluierenden Flüssigkeit durch das besagte zweite Elektromagnetventil (32), das besagte erste Elektromagnetventil (31) und das besagte vierte Elektromagnetventil (34), sodass diese in das besagte dritte Pufferrohr (23) gelangt, wobei die besagte eluierende Flüssigkeit durch das besagte sechste Elektromagnetventil (36) in die besagte Adhäsionssäule (1) eingeleitet wird, um ein Produkt herauszulösen, und wobei das besagte Produkt durch das besagte achte Elektromagnetventil (38) und das besagte neunte Elektromagnetventil (39) strömt, um abgelassen zu werden.
  2. Verfahren nach Anspruch 1,
    wobei besagte erste bis neunte Elektromagnetventile (31-39) jeweils ein Drei - Wege - Elektromagnetventil sind.
  3. Verfahren nach Anspruch 1,
    wobei das besagte erste und das besagte zweite Pufferrohr (21, 22) jeweils einen Durchmesser und ein Volumen aufweisen, die größer sind als die des besagten dritten und des besagten vierten Pufferrohrs (23, 24).
EP20110401600 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System Not-in-force EP2575142B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20110401600 EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20110401600 EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Publications (2)

Publication Number Publication Date
EP2575142A1 EP2575142A1 (de) 2013-04-03
EP2575142B1 true EP2575142B1 (de) 2015-04-01

Family

ID=44992841

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20110401600 Not-in-force EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Country Status (1)

Country Link
EP (1) EP2575142B1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5368736A (en) * 1993-07-26 1994-11-29 The United States Of America As Represented By The United States Department Of Energy Process for the separation and purification of yttrium-90 for medical applications
ATE527038T1 (de) * 2001-06-22 2011-10-15 Pg Res Foundation Inc Automatisiertes system und verfahren zur trennung von radionukliden
EP1772157A1 (de) * 2005-10-06 2007-04-11 Karl-Heinz Jansen Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden
US7586102B2 (en) * 2006-08-14 2009-09-08 Board Of Regents The University Of Texas System Automated system for formulating radiopharmaceuticals

Also Published As

Publication number Publication date
EP2575142A1 (de) 2013-04-03

Similar Documents

Publication Publication Date Title
JP6530007B2 (ja) 担体無添加（１７７）Ｌｕ化合物を含有する放射性医薬品
EP3283218B1 (de) Regeneration von mischbettharzen
US8920573B2 (en) Method of improving purity and yield of chemical product in automatic radioactive medicine synthesis system
EP2575142A1 (de) Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System
JP5483958B2 (ja) 水酸化テトラアルキルアンモニウムの製造方法
CN109225355A (zh) 一种脱除无机盐的连续离子交换工艺及所采用的系统
TWI444183B (zh) 應用於放射性藥物自動化合成系統之改善放射化學純度及產量方法
CN209423642U (zh) 一种脱除无机盐的连续离子交换系统
CN204933436U (zh) 双釜式连续硝化反应装置
CN209829776U (zh) 一种工艺管道的清洗干燥装置
CN100546728C (zh) 冷却水管道清洗用装置
CN102998402A (zh) 一种环境中苯系物分析专用气相色谱柱
CN204066758U (zh) 一种处理乏燃料元件的溶解装置
EP1772157A1 (de) Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden
CN203625267U (zh) 一种氨肟化反应装置
CN201823338U (zh) 除虫菊循环萃取装置
WO2016105235A1 (ru) Реакторная установка для производства изотопной продукции
CN106190794A (zh) 一种发酵逸液的回收利用装置
CN221085646U (zh) 离交洗涤系统
CN103922515A (zh) 一种不锈钢酸洗废水的综合处理装置
CN105906488B (zh) 一种用于异丙醇生产中副产物二异丙醚的精制提纯装置
JP7286209B2 (ja) 石油化学製品中の金属成分の除去方法
JP5931353B2 (ja) 使用済核燃料の再処理方法および使用済核燃料の再処理施設
CN211635543U (zh) 一种一体化全连续流后处理清洗分离系统
CN211561932U (zh) 一种硝酸异辛酯静态连续分离设备

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110929

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: G21G 1/00 20060101AFI20140924BHEP

INTG Intention to grant announced

Effective date: 20141022

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 719499

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150515

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011015206

Country of ref document: DE

Effective date: 20150521

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20150401

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 719499

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150401

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150701

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150803

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20150922

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150702

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150801

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011015206

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: RO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150401

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

26N No opposition filed

Effective date: 20160105

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602011015206

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150927

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20160531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150927

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160401

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20160927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20110927

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401