EP2575142A1 - Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System - Google Patents

Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System Download PDF

Info

Publication number
EP2575142A1
EP2575142A1 EP11401600A EP11401600A EP2575142A1 EP 2575142 A1 EP2575142 A1 EP 2575142A1 EP 11401600 A EP11401600 A EP 11401600A EP 11401600 A EP11401600 A EP 11401600A EP 2575142 A1 EP2575142 A1 EP 2575142A1
Authority
EP
European Patent Office
Prior art keywords
electromagnetic valve
flowing
enter
total solution
buffer tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11401600A
Other languages
English (en)
French (fr)
Other versions
EP2575142B1 (de
Inventor
Chia-Jung Chang
Mei-Hsiu Liao
Lie-Hang Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Nuclear Energy Research
Atomic Energy Council
Original Assignee
Institute of Nuclear Energy Research
Atomic Energy Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Nuclear Energy Research, Atomic Energy Council filed Critical Institute of Nuclear Energy Research
Priority to EP20110401600 priority Critical patent/EP2575142B1/de
Publication of EP2575142A1 publication Critical patent/EP2575142A1/de
Application granted granted Critical
Publication of EP2575142B1 publication Critical patent/EP2575142B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Definitions

  • the present invention relates to a radioactive medicine synthesis system; more particularly, relates to improving purity and yield of chemical product in an automatic radioactive medicine synthesis system.
  • Nuclear medicine uses affinitive column for adhesion of target medicine to obtain product after washing and eluting.
  • iodine isotope would process radioiodination in a buffer containing an oxidant.
  • yield of target and purity of radioactive chemical medicine are affected by the volume of solution; time for oxidation; and arrangement of adhesion, washing and eluting processes.
  • the yield and purity may become bad with high cost and the product obtained may become useless.
  • the source has to be increased. But, following the increase in source, its volume is increased too. As a result, the yield and purity are still not increased or even decreased.
  • a prior art separates the adhesion process and the washing process to reduce pollution of impurities.
  • the prior art is automated. The operators only have to take the column manually for washing at the final stage. However, the activity of the column may be still high, the pollution may happen to the operators or there may be a chance for operation mistake in the time before washing.
  • the easiest way for increasing the chemical production is to increase the volume of the reactants. But, in fact, it is not so simple. For example, the total volume for the reactions is critical. The reaction of radioiodination is processed in a liquid state and some reaction solutions can not be condensed, so that the yield may not be increased following the increase of the total reaction volume. Besides, radioiodination may contains some incomplete reactions so that some unreacted iodine will be left over. Purification has to be done to the product through processes of adhesion (of the product), washing and elution with an affinitive column, where the adhesion process includes processes of repeated back-and-forth flowing through the column to increase efficiency of adhesion.
  • reaction solution filled in the column has a volume smaller than the total reaction volume, some problems may occur in the automatic system, even though an adhesion batch may be designed in theory. Because the column has a small diameter and the liquid has surface tension, incomplete adhesion may happen during the repeated flowing processes and some waste solution may be generated and discharged.
  • the main purpose of the present invention is to increase a number of target reaction containers from one into many for increasing reaction volume coordinated with increased reaction times and, by modifying an affinitive column of an automatic synthesis system, to increase production in a single batch conformed to quality check specifications.
  • the main purpose of the present invention is provide an automatic way to separate adhesion process and washing process by switching electromagnetic valves coordinated with different sizes of buffer tubes for increasing production and reducing cost
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, comprising steps of: (a) washing by: inputting a total solution of total solution by nitrogen gas to be flown through a second electromagnetic valve, a first electromagnetic valve and a fourth electromagnetic valve to enter into a first buffer tube; flowing said total solution through a sixth electromagnetic valve to enter an adhesion column to process adhesion; flowing said total solution through an eighth electromagnetic valve and a seventh electromagnetic valve to enter a second buffer tube; flowing a waste gas through a fifth electromagnetic valve and a third electromagnetic valve to be discharged; and staying said total solution in said second buffer tube; (b) backwashing by: flowing nitrogen gas through said second electromagnetic valve, said third electromagnetic valve and said fifth electromagnetic valve to push out said total solution in said second buffer tube; flowing said total solution through said seventh electromagnetic valve and said eighth electromagnetic valve to enter said adhesion column to process adhesion; flowing said total solution through said sixth electromagnetic valve to enter said first buffer tube; and flowing a waste gas through said fourth electromagnetic
  • FIG.1 is a structural view showing devices used in a preferred embodiment according to the present invention.
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, where an original chemical reaction are divided into multiple reactions with adhesions processed after the multiple reactions; and where the adhesions have a total solution flowing back and forth along an adhesion column 1 several times for enhancing adhesion efficiency. Since the total solution has a big volume, the adhesion column 1 is separately added with a buffer tube 21,22 at each end of the adhesion column 1 for guiding the flowing of the total solution coordinated with a plurality of three-way electromagnetic valves 31 ⁇ 39.
  • the column For removing unreacted radioactive iodine, the column must be cleaned.
  • the present invention added two more buffer tubes 23,24 for washing and backwashing to separate processes of adhesion and washing for improving washing effect with the coordination of the three-way electromagnetic valves 31 ⁇ 39.
  • FIG.2 to FIG.7 are views showing processes of washing with adhesion, backwashing with adhesion, discharging reaction solutions, backwashing, washing and eluting out product.
  • the present invention comprises the following steps:
  • the first to the ninth electromagnetic valves 31 ⁇ 39 are three-way electromagnetic valves; and, the first and the second buffer tubes 21,22 have diameters and volumes bigger than the third and the fourth buffer tubes 23,24.
  • the present invention increases a number of target reaction containers from one into many (e.g. three) for increasing reaction volume coordinated with increased reaction times.
  • An affinitive column of an automatic synthesis system is modified for increasing production in a single batch conformed to quality check specifications.
  • the present invention separates a chemical reaction into many reactions for repeatedly processing original reactions to avoid reducing yield on increasing reaction volume.
  • the present invention adds two plastic tubes at head and tail ends of the column to be used as buffer tubes for not only processing adhesion several times but also for solving the problem of incomplete adhesion for reaction solution owing to surface tension (i.e. waste solution).
  • the present invention adds two empty columns at head and tail ends of the column to be used as buffer tubes to separate adhesion process and washing process with coordination of electromagnetic valves for controlling to obtain products conformed to quality check specifications.
  • the present invention is a method of improving purity and yield of chemical product in an automatic radioactive medicine synthesis system, where, in an automatic way, adhesion process and washing process are separated by switching electromagnetic valves coordinated with different sizes of buffer tubes for increasing production and reducing cost.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP20110401600 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System Not-in-force EP2575142B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20110401600 EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20110401600 EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Publications (2)

Publication Number Publication Date
EP2575142A1 true EP2575142A1 (de) 2013-04-03
EP2575142B1 EP2575142B1 (de) 2015-04-01

Family

ID=44992841

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20110401600 Not-in-force EP2575142B1 (de) 2011-09-27 2011-09-27 Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System

Country Status (1)

Country Link
EP (1) EP2575142B1 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5368736A (en) * 1993-07-26 1994-11-29 The United States Of America As Represented By The United States Department Of Energy Process for the separation and purification of yttrium-90 for medical applications
WO2003000376A1 (en) * 2001-06-22 2003-01-03 Pg Research Foundation, Inc. Automated radionuclide separation system and method
EP1772157A1 (de) * 2005-10-06 2007-04-11 Karl-Heinz Jansen Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden
US20080035542A1 (en) * 2006-08-14 2008-02-14 Board Of Regents, The University Of Texas System Automated system for formulating radiopharmaceuticals

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5368736A (en) * 1993-07-26 1994-11-29 The United States Of America As Represented By The United States Department Of Energy Process for the separation and purification of yttrium-90 for medical applications
WO2003000376A1 (en) * 2001-06-22 2003-01-03 Pg Research Foundation, Inc. Automated radionuclide separation system and method
EP1772157A1 (de) * 2005-10-06 2007-04-11 Karl-Heinz Jansen Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden
US20080035542A1 (en) * 2006-08-14 2008-02-14 Board Of Regents, The University Of Texas System Automated system for formulating radiopharmaceuticals

Also Published As

Publication number Publication date
EP2575142B1 (de) 2015-04-01

Similar Documents

Publication Publication Date Title
Wellens et al. A continuous ionic liquid extraction process for the separation of cobalt from nickel
CN102432410B (zh) 管式连续硝化反应制取硝基化合物生产方法
US8920573B2 (en) Method of improving purity and yield of chemical product in automatic radioactive medicine synthesis system
EP2575142B1 (de) Methode zum Verbessern der Reinheit und der Ausbeute eines chemischen Produktes in einem automatischen radioaktiven Medizin-Synthese-System
CN102031369A (zh) 一种在酸碱度交替条件下离子交换固定塔提铀方法
WO2020112222A3 (en) Liquid-liquid mass transfer process and apparatus
JP5483958B2 (ja) 水酸化テトラアルキルアンモニウムの製造方法
CN109225355A (zh) 一种脱除无机盐的连续离子交换工艺及所采用的系统
TWI444183B (zh) 應用於放射性藥物自動化合成系統之改善放射化學純度及產量方法
CN205796077U (zh) 一种具有回收重氧水功能的18F‑NaF自动合成模块
CN204261377U (zh) 一种连续液-液萃取装置
CN103745758B (zh) 一种放射性料液的进料方法
CN204933436U (zh) 双釜式连续硝化反应装置
CN102998402A (zh) 一种环境中苯系物分析专用气相色谱柱
CN209829776U (zh) 一种工艺管道的清洗干燥装置
CN100546728C (zh) 冷却水管道清洗用装置
WO2005102993A1 (ja) 酸水溶液の精製方法
CN203426175U (zh) 铜杆冷却清洗装置
CN103922515A (zh) 一种不锈钢酸洗废水的综合处理装置
JP7286209B2 (ja) 石油化学製品中の金属成分の除去方法
WO2016105235A1 (ru) Реакторная установка для производства изотопной продукции
CN211561932U (zh) 一种硝酸异辛酯静态连续分离设备
CN204045227U (zh) 放射性屏蔽混合离子交换器
JP5931353B2 (ja) 使用済核燃料の再処理方法および使用済核燃料の再処理施設
CN103316503A (zh) 一种工业生产用层析装置

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20110929

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

RIC1 Information provided on ipc code assigned before grant

Ipc: G21G 1/00 20060101AFI20140924BHEP

INTG Intention to grant announced

Effective date: 20141022

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 719499

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150515

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602011015206

Country of ref document: DE

Effective date: 20150521

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20150401

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 719499

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150401

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150701

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150803

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20150922

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150702

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150801

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602011015206

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: RO

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150401

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

26N No opposition filed

Effective date: 20160105

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602011015206

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: LU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150927

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20160531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150927

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160401

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150930

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20160927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20110927

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150401