EP2529628B1 - Pestizidsystem mit gesteuerter Freisetzung für eine Zusammensetzung - Google Patents

Pestizidsystem mit gesteuerter Freisetzung für eine Zusammensetzung Download PDF

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Publication number
EP2529628B1
EP2529628B1 EP11168128.4A EP11168128A EP2529628B1 EP 2529628 B1 EP2529628 B1 EP 2529628B1 EP 11168128 A EP11168128 A EP 11168128A EP 2529628 B1 EP2529628 B1 EP 2529628B1
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EP
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Prior art keywords
deltamethrin
collar
propoxur
concentration
pyrethroid
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Not-in-force
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EP11168128.4A
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English (en)
French (fr)
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EP2529628A1 (de
Inventor
Elbio Humerto Taroni
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Konig do Brasil Ltda
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Konig do Brasil Ltda
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K27/00—Leads or collars, e.g. for dogs
    • A01K27/007—Leads or collars, e.g. for dogs with insecticide-dispensing means
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/22—O-Aryl or S-Aryl esters thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof

Definitions

  • the present invention relates to a controlled-release pesticide system.
  • This composition acts as an insecticide for controlling fleas and ticks, repelling and fighting phlebotominae vectors of leishmaniasis and mosquito vectors of dirofilariasis.
  • the active component parts were mixed with the polymer polyvinyl chloride and with this preparation collars were injected and molded to be used in animals as a controlled-release matrix.
  • This collar is intended to pest control of phlebotomine sandflies and canine leishmaniasis.
  • WO2004089083 is disclosed a PVC - based collar comprising deltamethrin (active) and isodiphenyl phosphate (IDDP) as carrier for said active, reducing the skin irritation caused by the active.
  • the purpose of the invention is to provide a controlled-release pesticide system avoiding the above mentioned drawbacks.
  • the present invention overcomes the aforementioned drawbacks of the mixtures (systems) of the prior art.
  • the inventors have surprisingly found that a mixture of triphenyl phosphate and cresyl diphenyl phosphate considerably favors the release of the active ingredients.
  • the application provides a controlled-release pesticide system of a mixture of active ingredients to fight against parasites based on a polymer matrix, being more effective in releasing the active ingredients than the aforementioned mixtures of the prior art. Furthermore, the pesticide systems of the present invention have a uniform rate of release of the active ingredient making the use of the active ingredient more efficient and effective.
  • a controlled-release pesticide system for a composition containing deltamethrin, propoxur and an insect repellant is for repelling or controlling fleas and ticks; and the phlebotominae vectors of leishmaniasis and mosquito vectors of dirofilariasis and acting as a pesticide system itself.
  • the system can be produced as a solid polymer system for the release of active ingredients, the system comprising a vinyl polymer, a synergistic mixture of plasticizers and a combination of active ingredients for controlling pests.
  • the improvement comprises not only the combination of new of drugs but also the complete release of the active ingredients.
  • the system based on a polymer matrix comprises as ingredients a vinyl polymer, a liquid plasticizer miscible with said polymer, the amounts of the plasticizer being as great as possible so that the plasticizer and polymer mixture always remains dry and fluid, and a mixture of triphenyl phosphate and cresyl diphenyl phosphate provided in an amount and optimal ratio such as to serve as a carrier for said active ingredients.
  • the susceptible etiological agents are fleas: Ctenocephalides felis, Ctenocephalides canis, Pulex irritans and Tunga penetrans.
  • Ticks Riphicephalus sanguineus, Amblyomma maculatum, Amblyoma fossum and Amblyoma neumanni.
  • Lice Trichodectes canis, Heterodoxus spiniger, Linognathus setosus and Felicola subrostratus.
  • Propoxur is a carbamate which binds to acetylcholinesterase, inactivating it. Said inactivation therefore causes an increase of acetylcholine at the level of muscarinic and nicotinic receptors of the autonomic nervous system. At appropriate doses, the mentioned effect takes place on the acetylcholinesterase of the insects, thus causing their death by paralysis.
  • the main conjugation pathway was established by means of glucuronidation followed by smaller amounts of sulfates and by an unidentified metabolite.
  • the percentage of propoxur metabolized in rabbit skin was not affected by the doses in the range of 25-200 micrograms/cm 2 .
  • the metabolism in human skin was virtually saturated at 100 micrograms/cm 2 .
  • ethyl butylacetylaminopropionate Another one of the active ingredients is ethyl butylacetylaminopropionate, being a very effective repellant in stinging and biting insects and arthropods.
  • Mosquitoes Anopheles gambiae and funestus, Aedes aegypti and albopictus, Culex pipiens and Culex quinquefasciatus).
  • Phlebotominae (Lutzomyia longipalpis and aragaoi, Lutzomyia cruzi, Lutzomyia intermedia, Lutzomyia migonei, Lutzomyia vvhitmani and shanonni, Lutzomyia tejadai, Lutzomyia vexator). Lice, horseflies, ticks, blackflies, stable flies, wasps, bees, house fly.
  • the system of the invention is formed with the following components:
  • the controlled-release system is in most cases a dog collar injected with deltamethrin, propoxur and ethyl butylacetylaminopropionate, with the following drugs and in the following proportions with the percentage values: Drug % PVC resin 40-50 Ethyl butylacetylaminopropionate 0.1-5 Pyrethroid 1-10 Propoxur 5-20 Isooctyl phthalate 5-15 Cresyl diphenyl phosphate 5-30 Triphenyl phosphate 5-30
  • the active ingredient pyrethroid can be chosen from the following compounds: deltamethrin, acrinathrin, tralomethrin, permethrin, cypermethrin, alphamethrin, cyhalothrin, the preferred pyrethroid being deltamethrin.
  • Deltamethrin is one of the most widely used components in insecticides worldwide, and it is a member of one of the safe insecticide families, the synthetic pyrethroids.
  • Deltamethrin is used both in agriculture and in veterinary medicine, and even in insect domestic control. Deltamethrin has been used to prevent the spread of diseases transmitted by mosquitoes and ticks in dogs, rodents and other digging animals. It is effective in eliminating a wide variety of pests from human homes, especially spiders, fleas, tics, cockroaches, bedbugs, ants and mosquitoes, among others.
  • Deltamethrin plays a very important role in the control of vectors of various diseases, such as malaria and leishmaniasis. It is used in the manufacture of mosquito nets with long-lasting insecticides. It is used in the control of different vectors, including: Mosquitoes (Anopheles Spp, anopheles gambiae and funestus, Aedes aegypti and albopictus, Culex pipiens and Culex quinquefasciatus).
  • Phlebotominae (Lutzomyia aragaoi, Lutzomyia cruzi, Lutzomyia intermedia, Lutzomyia longipalpis, Lutzomyia migonei, Lutzomyia vvhitmani and shanonni, Lutzomyia tejadai, Lutzomyia vexator).
  • the World Health Organization has detected an increase of leishmaniasis.
  • the WHO report recommends that dogs wear a collar impregnated with deltamethrin to avoid an infection and contact between phlebotominae and reservoir dogs, thereby reducing the risk of infection in humans and in canines.
  • the repellant system according to the invention is applicable particularly to the control of acaridae, for example, ticks, scabies mites, fly larvae, insects such as lice, bedbugs and different types of biting and stinging insects of the flebotominae type and which are involved in transmitting canine leishmaniasis that is caused by an insect bite and can be transmitted to humans, this disease is very common in countries in tropical and subtropical areas.
  • Another characteristic application of the invention is protection against insects, mosquitoes, ticks, lice and other infectioncarrying insects; in the best case scenario, these insects being a bother, and in a worst-case scenario, being the vectors of disease such as malaria and yellow fever.
  • arthropods are dangerous such as the Asian tiger mosquito (Aedes albopictus), which can be combated with the feature of the invention of ethyl butylacetylaminopropionate, with efficacy and a considerably safe toxicological profile.
  • the PVC is placed in the helical mixer and the mixer casing is heated up to 80°C.
  • the isooctyl phthalate is added, keeping the temperature at 80°C, then the cresyl diphenyl phosphate is added and mixed until perfectly homogenized.
  • the triphenyl phosphate is added and mixed until completely homogenized.
  • the deltamethrin is added to this mixture little by little, also at 80°C with stirring.
  • the propoxur is added at 80°C, and it is stirred until completely homogenized.
  • the repellant ethyl butylacetylaminopropionate is added and stirred.
  • the method used for the measurement was the following:
  • the assay consisted of measuring the active ingredient concentration on the surface of the collar.
  • the active ingredient concentration was always higher in the collar of the invention with respect to the competitor's collar.
  • the ratio of both favored the release so as to maintain a high concentration of deltamethrin and propoxur on the surface of the collar, carrying out its function of carrying the active ingredient to the surface.
  • Another preferred embodiment of the present invention is to add a dry mixture of resin, one or several highly miscible plasticizers, such as dioctyl adipate, to poly(vinyl chloride) or another vinyl polymer.
  • the amount of plasticizers used is the maximum amount which allows the mixture to remain dry and fluid.
  • the active ingredients are mixed separately with the carrying mixture formed by triphenyl phosphate and cresyl diphenyl phosphate, at a predetermined proportion, to form the carrier-Al mixture. This mixture is then melted and homogenized by means of careful kneading, and it is cooled to yield a solid that is ground into small particles.
  • the efficacy of two ectoparasitic collars was compared in the canine species. 30 animals of both sexes, mixed breeds, of different ages that were experimentally infested with 50 unfed adult fleas (Ctenocephalides felis) were used. The first ectoparasite count was conducted by means of the combing technique after 24 hours.
  • the canines were randomly divided into 3 groups of 10 animals each: group A was treated with a plastic matrix collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate; group B was treated with a plastic matrix collar injected with 4% deltamethrin and group C was given a plastic matrix collar without insecticide (control).
  • group A was treated with a plastic matrix collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate
  • group B was treated with a plastic matrix collar injected with 4% deltamethrin
  • group C was given a plastic matrix collar without insecticide (control).
  • the animals remained in individual cages, being given balanced feed and water ad libitum.
  • the treated and control groups had no physical contact with one another at no time during the study. The first observation was at 24 and 48 hours after applying the
  • Each of the animals was reinfested with 25 unfed adult fleas (Ctenocephalides felis) at 7, 14, 21, 35, 60, 90, 120, 150, 180 and 210 days. After each reinfestation, at 24 and 48 hours, the fleas were counted.
  • the efficacy observed during the first 48 hours after applying the treatments exceeded 95% in group A and did not reach 80% in group B.
  • group A the efficacy observed between days 8 and 152, both included, reached 100%.
  • group B the efficacy observed between days 15 and 121, both included, remained between 95% and 98%; being under the value considered as effective on day 152.
  • plastic matrix collar impregnated with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate controls infestations and reinfestations with fleas (Ctenocephalides felis), reaching higher efficacy percentages during a greater time period than the one containing 4 g% deltamethrin.
  • the comparative efficacy between two injected plastic matrix ectoparasitic collars was evaluated in canines experimentally infested with ticks (Rhipicephalus sanguineus ).
  • One of the products contained 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate (product A) and the other contained 4 g% deltamethrin (product B).
  • 30 animals of both sexes, mixed breeds, of different ages were used.
  • the dogs were mildly sedated in order to be experimentally infested with approximately 50 unfed adult ticks at a (1:1) male:female ratio.
  • the canines were randomly divided into 3 groups of 10 animals each and at 48 hours they were assigned the following treatments: group A: treated with a plastic matrix collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate; group B: treated with a plastic matrix collar injected with 4 % deltamethrin and group C: plastic matrix collar without insecticide (control).
  • group A treated with a plastic matrix collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate
  • group B treated with a plastic matrix collar injected with 4 % deltamethrin
  • group C plastic matrix collar without insecticide (control).
  • the animals remained in individual cages, being given balanced feed and water ad libitum.
  • the treated and control groups had no physical contact with one another at no time during the study.
  • the first evaluation was conducted at 48
  • Each of the animals was reinfested with 50 unfed adult ticks at a (1:1) male:female ratio at days: 7, 15, 30, 60, 90, 120, 150, 180, 195 and 210.
  • the acaricide effect measured through the efficacy percentage was calculated at 9, 17, 32, 62, 92, 122, 152, 182, 197 and 212 days.
  • the efficacy observed in the first 48 hours post-application exceeded 90% in group A and did not reach 65% in group B.
  • group A the efficacy observed between days 9 and 197 remained between 98 and 100%.
  • group B the efficacy observed between days 17 and 182 remained between 90% and 94%; on day 197 the efficacy was 86%.
  • the plastic matrix collar impregnated with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate controls infestations and reinfestations with ticks (Rhipicephalus sanguineus), reaching higher efficacy percentages during a greater time period than the one containing 4 g% deltamethrin.
  • the objective of the experimental assay was to evaluate the anti-biting/anti-feeding effect and the mortality of an insecticidal collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate against phlebotominae vectors of leishmaniasis in canines exposed in laboratory conditions for 36 weeks. 20 canines of both sexes, mixed breeds, of different ages were used.
  • An insecticidal collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate were applied to ten (10) dogs. A collar without active ingredients was put on the remaining animals.
  • the animals were exposed in individual nests measuring 1.8 meters high and of 1.2 square meters of surface area made of gauze and cotton, accessing through the base and one side.
  • the phlebotominae used corresponded to Lutzomya Longipalpis.
  • the observation frequency was: 24, 48, 72 and 96 hours, and at 4, 8, 12, 16, 20, 24, 30 and 36 weeks. 130-150 females and 30 males, 7 to 20 days of age, were placed in each nest thirty minutes before each observation.
  • One sedated canine was then introduced per each nest and it was kept for two hours. After that time, the dogs were taken out of the nest and were brushed for the purpose of identifying a dead insect on the blanket.
  • the dead insects found on the floor of the nest were swept up and placed in a suitable container identified with the number of the animal.
  • the living insects were collected by aspiration and were kept in a suitable container identified with the number of the animal.
  • the anti-feeding effect was obtained by comparing the results obtained between the control and treated dogs, dividing the difference between the average number of insects that fed on the control and treated animals by the average number of the insects that fed on the control animals. In the treated animals, for a period of 36 weeks only 3.0% of the female Lutzomya Longipalpis recovered from the nests had fed. The anti-feeding effect was 97%.
  • the mortality at 4 weeks reached 95% and at week 36 it reached 65%.
  • the objective of the experimental assay was to comparatively evaluate the anti-biting/anti-feeding effect and the mortality between an insecticidal collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate and another collar injected with 4 g% deltamethrin against phlebotominae vectors of leishmaniasis in canines exposed in laboratory conditions for 36 weeks.
  • the animals were exposed in individual nests measuring 1.8 meters high and of 1.2 square meters of surface area made of gauze and cotton, accessing through the base and one side.
  • the phlebotominae used corresponded to Lutzomya Longipalpis.
  • the observation frequency was: 24, 48, 72 and 96 hours, and at 4, 8, 12, 16, 20, 24, 30 and 36 weeks. 130-150 females and 30 males 7 to 20 days of age were placed in each nest thirty minutes before each observation. One sedated canine was then introduced per each nest and it was kept for two hours. After that time, the dogs were taken out of the nest and were brushed for the purpose of identifying a dead insect on the blanket. The dead insects found on the floor of the nest were swept up and placed in a suitable container identified with the number of the animal. The living insects were collected by aspiration and were kept in a suitable container identified with the number of the animal.
  • the objective of the experimental assay was to evaluate the anti-biting/anti-feeding effect and the mortality of two insecticidal collars against Culex pipiens pipiens mosquitoes transmitting canine dirofilariasis.
  • Treatment A consisted of an insecticidal collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate, the insecticidal collar corresponding to treatment B contained 4 g% deltamethrin and a plastic collar without repellant or insecticides was put on the animals that were part of treatment C.
  • the antibiting/anti-feeding effect and mortality were measured at 24 and 48 hours, at week 1 and at weeks 2, 4, 8, 12, 16, 20, 24, 28 and 32.
  • Each sedated dog was exposed for 90 minutes to 50 unfed female Culex pipiens pipiens obtained in a laboratory in a suitably made net. After that time, the animal was removed from the net and brushed for the purpose of identifying a dead insect on the blanket.
  • the dead insects found on the floor of the nest were picked up and were placed in a suitable container identified with the number of the animal.
  • the living insects were collected by aspiration and were kept in a suitable container identified with the number of the animal being fed with water/honey.
  • the anti-feeding effect and mortality were observed at 24 and 48 hours.
  • the anti-feeding effect was obtained by the calculation obtained from the ratio of the difference between the anti-feeding rate in the treated and control animals divided by the difference obtained between 1 and the anti-feeding rate in the control animals. Mortality was obtained by the calculation obtained from the ratio of the difference of the mortality rate in the treated dogs and the mortality rate in the control animals divided by the difference between 1 and the mortality rate in the control animals.
  • Anti-feeding effect Treatment A: 98 and 100% during the 32 weeks; treatment B: 92 and 97% during the first 28 weeks, 89% at week 32.
  • Mortality Treatment A: 85 and 96% up to week 28, 92% at week 32; treatment B: 63 and 85% up to week 28, 70% at week 32.
  • the values relating both to the anti-biting/anti-feeding effect and to mortality against Culex pipiens pipiens mosquitoes transmitting canine dirofilariasis obtained by using an insecticidal collar injected with 10 g% propoxur, 4 g% deltamethrin and 1 g% ethyl butylacetylaminopropionate exceeded those found when using an insecticidal collar injected with 4 g% deltamethrin during the 32 weeks in which the assay was conducted.

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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Claims (9)

  1. Pestizidzusammensetzung mit kontrollierter Freisetzung umfassend eine Polymermatrix aus Polyvinylchlorid, dadurch gekennzeichnet, dass es ein Pyrethroid in einer Konzentration von 1 bis 10%, Propoxur in einer Konzentration von 5 bis 20%, eine andere Insektenschutzmittel-Verbindung, welche nicht Pyrethroid ist, Triphenylphosphat in einer Konzentration von 5 bis 30%, und Cresyldiphenylphosphat in einer Konzentration von 5 bis 30% umfasst.
  2. Zusammensetzung nach Anspruch 1, wobei das Pyrethroid Deltamethrin ist.
  3. Zusammensetzung nach einem der Ansprüche 1 bis 2, wobei die Insektenschutzmittel-Verbindung, welche nicht Pyrethroid ist, in einer Konzentration von 0,1 bis 5 % vorhanden ist.
  4. Zusammensetzung nach Anspruch 3, wobei die Insektenschutzmittel-Verbindung, welche nicht Pyrethroid ist, Ethylbutylacetylaminopropionat ist.
  5. Zusammensetzung nach einem der Ansprüche 1 bis 4, wobei sie ferner Isooctylphtalat in einer Konzentration von 5 bis 15% umfasst.
  6. Pestizidsystem mit kontrollierter Freisetzung, dadurch gekennzeichnet, dass es eine Polymermatrix aus Polyvinylchlorid umfasst, welche spritzgegossen oder mit der Wirkstoffzusammensetzung nach einem der vorhergehenden Ansprüche gemischt ist.
  7. System nach Anspruch 6, wobei die Form eines Hundehalsbands oder ähnlicher Vorrichtungen aufweist.
  8. System nach Anspruch 7, wobei das Polyvinylchlorid in einer Konzentration von 40 bis 50 % vorhanden ist.
  9. Verwendung einer Zusammensetzung nach einem der Ansprüche 1 bis 6 als Insektizid zum Bekämpfen von Flöhen und Zecken, zum Abwehren und Bekämpfen von Phlebotominae, Vektoren der Leishmaniose, und Moskitos, Vektoren der Dirofilariose.
EP11168128.4A 2011-05-30 2011-05-30 Pestizidsystem mit gesteuerter Freisetzung für eine Zusammensetzung Not-in-force EP2529628B1 (de)

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US9258988B2 (en) 2013-07-16 2016-02-16 University Of Florida Research Foundation, Inc. Methods and devices for sustained release of substances
CN106689187A (zh) * 2016-12-06 2017-05-24 南通功成精细化工有限公司 一种含有残杀威的卫生杀虫组合物及其应用
WO2020051640A1 (en) * 2018-09-14 2020-03-19 Cocky Smart Pty Ltd Compositions and methods for enhancing wound healing

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US3318769A (en) 1963-05-31 1967-05-09 Shell Oil Co Resin compositions comprising organo-phosphorus pesticides
US3852416A (en) 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US4150109A (en) 1974-05-07 1979-04-17 Dick Pierre R G Devices for protecting animals from ectoparasites
DE2932920A1 (de) * 1979-08-14 1981-04-09 Bayer Ag, 5090 Leverkusen Ektoparasitizide mittel enthaltend substituierte phenoxybenzyloxy-carbonylderivate und carbaminsaeureester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von ektoparasiten
EP0885563A1 (de) 1997-06-18 1998-12-23 Hoechst Roussel Vet S.A. Vorrichtung zum Vertreiben von Schädlingen
US20040192650A1 (en) * 2003-03-31 2004-09-30 Redline, Inc. Pest control formulation and dispenser

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