EP2521525A1 - Procédé et dispositif pour générer un nanoaérosol - Google Patents

Procédé et dispositif pour générer un nanoaérosol

Info

Publication number
EP2521525A1
EP2521525A1 EP10725722A EP10725722A EP2521525A1 EP 2521525 A1 EP2521525 A1 EP 2521525A1 EP 10725722 A EP10725722 A EP 10725722A EP 10725722 A EP10725722 A EP 10725722A EP 2521525 A1 EP2521525 A1 EP 2521525A1
Authority
EP
European Patent Office
Prior art keywords
cartridge
fluid
atomized
nozzle
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10725722A
Other languages
German (de)
English (en)
Other versions
EP2521525B1 (fr
Inventor
Peter Brunner
Hans Peter Zarfl
Bernd Heiko Lindena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zarfl Hans Peter
MEDIC ACTIV VERTRIEBS GmbH
Original Assignee
Zarfl Hans Peter
MEDIC ACTIV VERTRIEBS GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zarfl Hans Peter, MEDIC ACTIV VERTRIEBS GmbH filed Critical Zarfl Hans Peter
Priority to EP10725722.2A priority Critical patent/EP2521525B1/fr
Publication of EP2521525A1 publication Critical patent/EP2521525A1/fr
Application granted granted Critical
Publication of EP2521525B1 publication Critical patent/EP2521525B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/06—Artificial hot-air or cold-air baths; Steam or gas baths or douches, e.g. sauna or Finnish baths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H35/00—Baths for specific parts of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/20—Non-portable devices, e.g. spraying booths
    • A61M35/25—Non-portable devices, e.g. spraying booths specially adapted for the application of sunscreen, tanning or self-tanning lotions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B05B1/262—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors
    • B05B1/265—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors the liquid or other fluent material being symmetrically deflected about the axis of the nozzle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B05B5/03—Discharge apparatus, e.g. electrostatic spray guns characterised by the use of gas, e.g. electrostatically assisted pneumatic spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
    • B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
    • B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle
    • B05B7/2435—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle the carried liquid and the main stream of atomising fluid being brought together by parallel conduits placed one inside the other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/06—Artificial hot-air or cold-air baths; Steam or gas baths or douches, e.g. sauna or Finnish baths
    • A61H2033/068—Steam baths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/14—Devices for gas baths with ozone, hydrogen, or the like
    • A61H2033/141—Devices for gas baths with ozone, hydrogen, or the like with ionised gas, e.g. ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/06—Artificial hot-air or cold-air baths; Steam or gas baths or douches, e.g. sauna or Finnish baths
    • A61H33/12—Steam baths for the face
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B14/00—Arrangements for collecting, re-using or eliminating excess spraying material

Definitions

  • the present invention relates to a method and an apparatus for producing a nano-aerosol by sputtering of fluids, in particular a method and an apparatus for producing a nano-aerosol, especially a nano-aerosol for therapeutic, diagnostic or disinfecting purposes.
  • liquid disinfectants can be sprayed as finely divided droplets to disinfect, for example, objects or contaminated with harmful aerosols room air.
  • the healing effect of vapors or aerosol mists which consist of finely divided water or oil droplets, has long been known.
  • conventional sauna or steam baths to water or an aqueous emulsion containing a small amount of essential oils, evaporated. The hot steam cools in
  • Mist generation by evaporation of water or an aqueous oil emulsion is due to the high temperature of the mist produced. While the stimulating effect of the hot mist can certainly be beneficial for certain applications, conventional sauna and steam baths are always associated with the disadvantage that the cycle of the bathing person is exposed to high loads and therefore sauna and steam baths for large populations
  • aqueous solutions or emulsions at lower temperatures, typically at temperatures of less than 35 or 40 ° C, preferably at temperatures in one
  • nebulizers are used.
  • a hollow-cylindrical compression chamber is provided with a closable opening, which is connected via a line to a high-pressure pump, from which the liquid to be atomized is conveyed.
  • the fluid to be atomized is arranged in a cartridge which has at least one outlet opening for atomizing the fluid and a movable piston which can be moved by a drive device.
  • a movable piston By means of the movable piston, such a pressure is exerted on the fluid in the cartridge that the fluid with the required
  • Flow rate of 50-300 m / s is discharged through the outlet opening in the form of a finely divided liquid mist.
  • a disadvantage of the known devices described above is, inter alia, that liquid particles having a relatively broad size distribution are produced.
  • the aerosol mist contains a mixture of particles with a diameter of a few nanometers to a few micrometers.
  • numerous aerosol applications are particularly advantageous and desirable particle sizes in the sub-micrometer range. Will in these cases too
  • the present invention is therefore based on the technical problem of providing a method and an apparatus for producing a nano-aerosol, wherein substantially fluid particles having a particle diameter of less than 1, 000 nanometers are produced.
  • the corresponding device should be simple and inexpensive to produce and operate and in particular allow a sterile atomization of active substance-containing fluids.
  • the invention therefore relates to a process for producing a nano-aerosol, wherein in a nozzle at least one fluid to be atomized by a
  • Nozzle orifice of the nozzle is atomized along an exit orifice in the form of fluid particles, which deflects atomized fluid particles from the original exit direction and at least partially separates larger fluid particles from smaller fluid particles, returns the separated larger fluid particles into the fluid being atomized, and delivers the smaller fluid particles to the environment.
  • the invention is based on the consideration that when sputtering a fluid by ejecting the fluid from a nozzle inevitably fluid particles with relatively wider
  • Size distribution arise. Instead of delivering the generated fluid particles directly to the environment, it is proposed to first divert the atomized fluid particles from the outlet direction, so that there is a separation of the larger Fluid particles from the smaller fluid particles can come. The finally discharged to the environment fluid particles contained in the inventive method a significantly reduced proportion of larger particles, preferably substantially only smaller fluid particles.
  • methods may produce smaller fluid particles in a desired size range while recirculating larger fluid particles into the fluid being atomized, thus avoiding loss of fluid to be atomized by delivery of fluid particles in an undesirable size range and substantially completely shaping the fluid to be atomized can be atomized by fluid particles of the desired size range.
  • Size range of the discharged small fluid particles can be adjusted and optimized in particular by modifying the Theological properties of the fluid to be atomized and by the operating parameters and the geometry of the sputtering device.
  • Cartridge in which the nozzle and the fluid to be atomized are arranged.
  • the cartridge which will be described in more detail below, may be a reusable cartridge, but more preferably is a disposable cartridge.
  • the fluid can be expelled from the nozzle in different ways.
  • a movable piston may be provided, the fluid for
  • Nozzle opening presses In contrast to the cartridge described, for example, in WO 2009/087053 A1, in such a case, the piston would not expel the entire fluid in a single stroke movement, since in the context of
  • the fluid is therefore discharged from the nozzle by means of the carrier gas and atomized into the fluid particles.
  • the carrier gas also serves to deliver the smaller fluid particles to the environment.
  • the nozzle is preferably designed so that the fluid to be atomized is aspirated and atomized by means of a negative pressure generated in the nozzle.
  • This negative pressure can be generated by the carrier gas flowing out of the nozzle in the sense of the known Venturi principle.
  • a hermetically sealed cartridge so that the method according to the invention is particularly suitable for dispensing sterile, fluid-containing fluids stored in the cartridge.
  • the method according to the invention is particularly suitable for dispensing sterile, fluid-containing fluids stored in the cartridge.
  • openings in the cartridge which allow the supply of the carrier gas and the delivery of the atomized smaller fluid particles to the environment.
  • closable or open cartridges can be used, for example, allow a replenishment during operation, which at high fluid consumption as
  • the larger fluid particles are returned under the action of gravity in the fluid to be atomized, while the smaller fluid particles in a direction different from the direction of gravity of gravity, for example, vertically upward, emits to the environment.
  • the smaller fluid particles in a direction different from the direction of gravity of gravity, for example, vertically upward, emits to the environment.
  • Can do this For example, be provided in the upper region of the cartridge outlet openings from which the carrier gas escapes and entrains the smaller fluid particles.
  • the fluid to be atomized preferably comprises at least one active substance.
  • the active ingredient may for example be selected from the group of active ingredients consisting of disinfectants, deodorizing agents, fragrances, cosmetic agents, diagnostic and / or therapeutic agents for
  • Typical agents include, for example
  • the fluid to be atomized may be an aqueous solution, an aqueous emulsion, in particular an oil-in-water emulsion, an oily solution, an oily emulsion, in particular a water-in-oil emulsion, an aqueous suspension or an oily suspension.
  • the aqueous solution is particularly preferably a salt solution.
  • an oily solution it is particularly preferable that it comprises a solution comprising essential oils.
  • the fluid to be atomized can also special
  • Drug formulations in the form of typically negatively charged lipid vesicles, wherein the drug is in the nucleus of a lipid envelope or in the lipid envelope itself.
  • the therapeutically effective agents for the treatment of living things for example, in the topical application of the generated nanoaerosol
  • Aerosol drugs for the treatment of respiratory diseases include. Also means for the treatment of general diseases and means for improving the general condition, for example, substances that are known in the wellness field can be used.
  • the atomized smaller particles that are released to the environment can be dispensed, for example, with a stationary or portable device onto the objects to be treated (for example, in the case of a disinfection process).
  • a treatment room can thereby serve any space that allows for the particular application, for example, the skin or the respiratory tract of a person to be treated or an animal to be treated with the atomized
  • the treatment room may also be an inhalation mask.
  • the treatment room may also be an inhalation mask.
  • the treatment room may also be an inhalation mask.
  • At least part of the smaller fluid particles to be dispensed are charged electrostatically.
  • the smaller fluid particles have a diameter of less than 1, 000 nanometers, preferably a diameter of 5-750 nm, in particular of 5-300 nm, and particularly preferably a diameter of 10-300 nm, in particular of 10-200 nm.
  • the average diameter of the discharged smaller fluid particles can be varied within certain limits. Since virtually no fluid particles with a diameter of more than one micrometer are contained in the emitted aerosol mist
  • Harmful pathogens present in suspended droplets can be controlled by collision with the fluid particles produced according to the invention which, for example, cause a lowering of the pH or oxidation in the droplets containing the pathogen.
  • the invention also relates to a cartridge for producing a nano-aerosol, comprising at least one reservoir for the fluid to be atomized
  • Demixing chamber having a deflector and at least one
  • a nozzle having at least one opening into the demixing chamber nozzle opening and at least one outgoing from the reservoir channel which opens into the nozzle.
  • the nozzle opening is preferably located on a longitudinal axis of the nozzle, in the extension of which the deflection device is arranged.
  • Severance chamber can get back into the reservoir.
  • the nozzle operates in a particularly preferred
  • Embodiment with a carrier gas Therefore, preferably at least one inlet opening into the nozzle for a carrier gas is provided.
  • Carrier gas is formed as a central bore, which opens at one end into the bottom of the cartridge and merges at the other end into the nozzle.
  • the bore opening into the bottom of the cartridge is closed by a pierceable wall.
  • the at least one outlet opening for the fluid to be atomized is provided by a pierceable or tearable wall locked.
  • one or more tear-open tabs can be arranged on the upper side of the cartridge, with the aid of which openings in the upper side can be produced.
  • the nozzle is designed as a Venturi nozzle.
  • the cartridge may also include means for connecting the reservoir to an electrical power source.
  • the cartridge consists of at least two components, which are connectable to each other after filling the fluid to be atomized.
  • the connection of the two components can be, for example, a plug connection, a screw connection or the like.
  • connection is designed so that after filling of the fluid to be atomized by the user no longer releasable connection of the two components is produced.
  • the two components can be glued or welded together.
  • the fluid to be atomized can be hermetically shot in the cartridge in this case, so that it can be ensured until use of the cartridge that no contamination from the outside penetrates and, for example, sterility of the fluid contained can be ensured.
  • the fluid to be atomized is then located in the cartridge closed in this way.
  • the invention also relates to an aerosol generator comprising a holder for receiving at least one cartridge of the type described above and means for ejecting the fluid contained in the cartridge in the form of a
  • Nanoaerosols includes.
  • the means for ejecting the fluid contained in the cartridge comprises a source of carrier gas, the holder having at least a first hollow mandrel communicating with the source of a carrier gas and capable of engaging in the supply line for the carrier gas of the cartridge, and at least a second one hollow thorn, which communicates with the environment and into the
  • Outlet opening for the fluid to be atomized cartridge can intervene includes.
  • the first hollow mandrel and the second hollow mandrel are mechanically, for example hydraulically or pneumatically driven into the hermetically sealed cartridge.
  • the cartridge itself may be provided with suitable tear-tabs, which are arranged so that they release one or more outlet openings when the cartridge is moved in the holder.
  • Cartridge be arranged so that they fold when moving in the cartridge in the holder and create one or more openings on the top of the cartridge, with the demixing chamber of the cartridge
  • the source of the carrier gas may comprise, for example, a compressor or a compressed gas cylinder, which preferably contains an inert gas.
  • the aerosol generator also comprises a voltage source which can be connected to the cartridge, for example in the form of an electrode which can be driven into the cartridge.
  • the invention also relates to a Nebelbadvorraum with a bath or treatment room for receiving at least one to be treated
  • Aerosol generator of the type described above comprises.
  • the mist-bath apparatus may be an aerosol cabin, as described in international patent applications WO 00/44331 A1 and WO 2009/087053 A1.
  • the Nebelbadvorraum also has means for this to
  • Electromagnetic field the attachment of the charged nanoparticles to the body or body parts of the living being can be increased.
  • Cartridge according to the invention for the therapeutic treatment of living beings, wherein the generated nano-aerosol is taken up via the lungs, the skin or in the form of a whole-body inhalation.
  • Aerosol mist is to be generated, from.
  • 1 to 25, preferably 1 to 20 ml of liquid are atomized to treat a person in a nebulizer device receiving the whole person, while in the treatment of larger animals, such as horses in appropriate stalls or chambers, up to a few 100 ml of fluid per treatment can be atomized.
  • larger animals such as horses in appropriate stalls or chambers
  • the cartridge of the invention is dimensioned.
  • the required amount of liquid can be provided by means of several cartridges, one after another or be used simultaneously, be atomized.
  • the cartridge according to the invention is not bound to a specific volume.
  • Substantial larger fluid volumes than those mentioned above are also conceivable. For example, in the air disinfection larger spaces over a longer period, such as an aircraft cabin during a
  • the cartridge according to the invention can be refilled or refilled.
  • the cartridge may have, for example, a refill opening or be connected via a refill line to a storage vessel for the fluid to be atomized.
  • FIG. 1 shows a fog bath device which is used to carry out the
  • inventive method is suitable
  • Fig. 2 is a schematic diagram of an embodiment of the invention
  • FIG. 3 shows a preferred embodiment of the cartridge according to the invention in a side view
  • Fig. 4 is a bottom view of the cartridge of Fig. 3;
  • Fig. 5 is a plan view of the cartridge of Fig. 3;
  • Fig. 6 is an axial longitudinal section through the cartridge of FIG. 3 along the
  • Fig. 7 is an enlarged detail of the cross section of Fig. 6;
  • Fig. 8 is an axial longitudinal section of the cartridge of Fig. 3 along the line
  • FIG. 9 is an enlarged detail view of the cross section of FIG. 8; FIG.
  • FIG. 10 shows a variant of the upper part of the cartridge of FIG. 3;
  • Fig. 1 1 is a plan view of the variant of the upper part of Fig. 10;
  • FIG. 12 shows a first variant of the tear tab of FIG. 10
  • FIG. 13 shows a second variant of the tear-open tab of FIG. 10;
  • FIG. and 14 shows a variant of the drive of the cartridge receptacle of FIG. 2.
  • Fig. 1 shows a generally designated by the reference numeral 10
  • the Nebelbadvorraum 10 is of a bottom plate 1 1, a ceiling plate 12, side windows 13 made of acrylic glass and two along the arrows A, B movable front discs 14, 15, the access to the treatment chamber 10th
  • Nebelbadvortechnische 10 extends between the bottom plate 1 1 and the ceiling plate 12, a pipe 16.
  • a waterproof seat 17 is disposed on an upper side of the bottom plate 1 1.
  • the aerosol generated can via a arranged in the tube 16 grid 18 in the
  • the seat 17 can be earthed or charged opposite polarity.
  • the aerosol particles in the treatment room 19 are attracted to the person to be treated. Accordingly, for example, the
  • Side walls 13 of the Nebelbadvoriques 10 consist of a conductive material which is charged after completion of the treatment opposite to the aerosol particles. The remaining aerosol particles in the treatment room are then attracted to the side walls and can then be easily wiped off.
  • a suction fan may be provided, which residual aerosol particles after the
  • Treatment from the treatment room 19 sucks. That way is
  • an aerosol generator according to the invention generally designated by the reference numeral 20 is shown schematically, as it can be used in the Nebelbadvorraum 10 of FIG. 1.
  • the aerosol generator 20 has a holder 21 for a replaceable cartridge, in which the fluid to be atomized is located.
  • the holder 21 has a fixed upper part 22 and a movable lower part 23, which is connected to a pneumatic drive 24.
  • the holder 21 and the pneumatic drive 24 may, for example, be arranged in the tube 16 of the fog bath device 10 of FIG. 1.
  • the pneumatic drive 24 is connected to a compressor 25, which can be arranged for example under the seat 17 of the Nebelbadvorhchtung 10.
  • Two alternating pressurized lines 26, 27 lead from the compressor to the pneumatic drive to move a piston 28 up and down.
  • the piston 28 is connected via a piston shaft 29 with the movable lower part 23 of the holder 21.
  • a central, hollow mandrel 30 is arranged, which is also connected via a line 31 to the compressor 25 and can be acted upon with compressed air.
  • a metal tip 32 is arranged in the movable lower part 23 of the holder 21, which is connected via an electrical line 33 to a pole 34 of a low-current source 35.
  • the other pole 36 of the low-current source 35 may, for example, with a in the seat 17 of the
  • Nebelbadvorhchtung 10 of FIG. 1 recessed metal plate 37 are connected.
  • the fixed upper part 22 of the holder 21 has in the illustrated
  • Embodiment a central guide pin 38 and circular to the
  • a first hermetically sealed cartridge 40 is used, which will be described in more detail below in connection with Figs. 3-13.
  • the cartridge 40 is the fluid 41 to be atomized.
  • the cartridge 40 is compressed between upper part 22 and lower part 23 of the holder 21 so that the hollow mandrel 30 and the metal tip 32 can penetrate into the lower side 42 of the cartridge 40, while the spikes 39 pierce the upper side 43 of the cartridge.
  • the guide pin 38 engages in this case in a provided in the top of the cartridge 40
  • Recess 44 a To generate the nano-aerosol, compressed air is injected via the hollow mandrel 30 into the cartridge 40. The compressed air and smaller aerosol particles in the sub-micrometer range leave the cartridge 40 then over the hollow mandrels 39 and pass from the top 45 of the upper part 22 of the holder 21 in the
  • the upper part 22 can be connected via a line 46 to the same pole 34 of the voltage source 35, to which also serves as the electrode metal tip 32 is connected, so that the upper part 22 and the generated aerosol particles are charged the same name.
  • FIG. 3 shows a first variant of the cartridge 40 according to the invention in a schematic side view.
  • the outer housing of the cartridge 40 consists of two injection molded parts 47, 48, which are inextricably connected after filling the fluid to be atomized for the user, for example by
  • the lower part 48 of the cartridge 40 has a
  • the cartridge has a height of about 55 mm and a diameter of about 30 mm.
  • a few milliliters of a fluid may be dispensed in the mist bath apparatus of FIG.
  • Fig. 4 the bottom 42 of the cartridge 40 of FIG. 3 is shown.
  • the bottom 42 has a central opening into which a plug 50 is inserted.
  • the hollow mandrel 41 can engage in the plug and pierce its bottom 51 and thus penetrate into the interior of the cartridge 40.
  • a plurality of rings 52 are formed, the bottoms 53 are also closed.
  • one of the bottoms 53 of the rings 52 may be pierced by the mandrel 32 serving as the electrode.
  • the upper side 43 of the upper part 47 of the cartridge 40 is formed as a ring, which delimits the recess 44, in which the guide pin 38 of the holder 21 of the aerosol generator 20th can intervene.
  • the hollow mandrels 39 of the holder 21 are preferably arranged so that when penetrating the mandrels in the top 43 evenly distributed on the ring 43 openings in the top of the cartridge 40 are introduced.
  • FIG. 6 shows a longitudinal section of the cartridge 40 of FIG. 3 along the plane defined by the line VI-VI in FIG.
  • the cartridge has a central bore 54, which extends from the bottom 51 of the central ring 50 and opens into a nozzle tip 55.
  • Fig. 7 the limited in Fig. 6 with the circle VII nozzle tip 55 is shown enlarged.
  • the bore 54 serves as a supply line for the carrier gas, which is blown into the nozzle 55.
  • the nozzle tip 55 is formed as a Venturi nozzle, so that the nozzle gas flowing through the carrier gas to be atomized fluid from a
  • the nozzle 55 consists of an outer jacket 57, which is formed in the present case together with the lower part 48 as a one-piece injection-molded part.
  • an inner shell 58 is inserted through the bottom 42 of the cartridge in the outer shell in the production of the cartridge so that between the inner shell and outer shell an annular channel 59 recessed, which communicates with the reservoir 56 and via which the fluid to be atomized 41 in the nozzle tip 55 can be sucked.
  • a plurality of ribs 60 may be provided as spacers on the upper side of the inner jacket 58 or on the underside of the outer jacket 57 (cf., in particular, FIG.
  • the carrier gas flowing out of the opening 61 of the inner jacket 58 through the opening 62 of the outer jacket 57 provides a negative pressure in the annular gap 59 which sucks the fluid to be atomized from the reservoir 56 to the opening 62.
  • the opening 62 of the outer shell 57 has an opening angle of about 32 ° in the example shown.
  • the diameter of the opening 61 is in the example of Fig. 3 to 9 about 0.6 mm and the diameter of the opening 62 at the narrowest point 0.9 mm. If the supply line 54 with a pressure of the
  • Carrier gas of about 2 bar applied so arise when leaving the
  • Nozzle tip 55 fluid particles in the sub-micron range and fluid particles with
  • a demixing chamber 63 is provided in the cartridge in the transition region of upper part 47 and lower part 48.
  • the demixing chamber 43 comprises a deflector 64, which comprises a punch 65, which in the
  • Gravity can flow back into the fluid reservoir 56 while smaller submicron fluid particles are discharged through openings 66 that are inserted through the spikes 39 of the retainer 21 into the top 43 of the cartridge 40.
  • the cartridge according to the invention can therefore be used to ensure that the fluid 41 in the cartridge remains in the cartridge
  • the bottom 67 of the fluid reservoir 56 has a footing 68 of the channel 59 weighted slope.
  • FIG. 8 shows a longitudinal section of the cartridge 40 of FIG. 3 along the plane defined by the line VIII-VIII. In this plane are inwardly directed reinforcing ribs of the cartridge.
  • Outer sleeve formed channel 59 shown in more detail. 10 shows a variant 47 'of the upper part 47 of the cartridge 40 of FIG. 3.
  • the upper part 47' has on its surface 43 'tear tabs 69', which are formed with the upper part 47 'as an integral component.
  • the upper part 22 of the holder 21 of FIG. 2 does not have any thorns 39, but instead may have, for example, a slightly conical inner surface which presses the tear tabs inwards when the pneumatic drive 24 moves over the movable lower part 23 of the holder 21, the cartridge is pressed into the upper part 22.
  • the upper part 22 of the attitude can be cleaned particularly easily.
  • FIG. 1 shows a top view of the top 47 'of FIG. 10.
  • FIG. 12 shows a variant 69 "of the tear tabs 69' of FIG. 10.
  • the tear tabs 69" of the triangular tabs 69 'of FIG 10 but have a recess 71 "on one side
  • the tear tabs 69 "are not bent inwardly, but are pushed downwardly in the plane of Fig. 12. The tear tabs 69" then substantially tilt about a corner 72. *** " so that the tear tab configuration shown in phantom in FIG. 12 is formed where an opening 70 "in the surface 43" is released.
  • FIG. 13 shows a further variant 69 "'of the tear tab 69' of FIG. 13
  • Tear tab 69 "'of FIG. 13 is substantially rectangular in shape and has a rounded upper edge 74"' is.
  • the upper part 22 of the holder 21 (FIG. 2) can be designed as a hollow cylinder, which further facilitates its cleaning.
  • a cheaper variant 24 'of the cartridge drive 24 of the aerosol generator of FIG. 2 is shown schematically.
  • the aerosol generator essentially corresponds to the aerosol generator 20 of FIG. 2 and is the For clarity, no longer with all its components shown.
  • the aerosol generator in turn has a holder 21 for a replaceable
  • Cartridge 40 in which there is the fluid to be atomized.
  • a pneumatic drive reference numeral 24 in FIG. 2
  • a purely mechanical drive 24 ' is provided.
  • the cartridge 40 is set on an upper carriage 81 movably mounted in the holder 21.
  • On a movable lower carriage 82 is the central, hollow mandrel 30, as it is already known from Fig. 2.
  • the lower carriage 82 may be one by hand
  • operable toggle lever 83 are moved upward to one hand to pierce the mandrel 30 in the bottom of the cartridge 40 and on the other hand to press the upper carriage 81 with the cartridge 40 against the (not shown in Fig. 14) upper part 22 of the holder.
  • the knee lever 83 on a user-operable operating arm 84.
  • Cartridge thorns (comparable to the spines 38 in Fig. 2) or only a suitable mating ring for buckling tear tabs of the cartridge 40 on.
  • the (not shown in Fig. 14) compressor 25 is then no longer responsible for the drive, but only for the generation of compressed air, which is blown through the hollow mandrel 30 into the cartridge 40.
  • an electrode (not shown here) (analogous to the electrode 32 of FIG. 2) can be inserted into the cartridge in order to charge the fluid electrostatically.

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un procédé et un dispositif pour générer un nanoaérosol, avec lesquels on pulvérise dans une buse au moins un fluide à pulvériser par une ouverture de buse le long d'une direction de sortie sous forme de particules de fluide, on dévie les particules de fluide pulvérisées de la direction de sortie et on sépare au moins partiellement des particules de fluide plus grandes des particules de fluide plus petites, on recycle les particules de fluide plus grandes séparées dans le fluide à pulvériser, et on envoie les particules de fluide plus petites dans l'environnement. A cet effet, on utilise une cartouche dans laquelle la buse et le fluide à pulvériser sont disposés. Selon l'invention, on génère dans la buse un flux d'un gaz porteur et on met le au moins un fluide à pulvériser dans la buse en contact avec le gaz porteur.
EP10725722.2A 2010-01-10 2010-06-17 Procédé et dispositif pour générer un nanoaérosol Active EP2521525B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10725722.2A EP2521525B1 (fr) 2010-01-10 2010-06-17 Procédé et dispositif pour générer un nanoaérosol

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10150393 2010-01-10
EP10725722.2A EP2521525B1 (fr) 2010-01-10 2010-06-17 Procédé et dispositif pour générer un nanoaérosol
PCT/EP2010/058586 WO2011082838A1 (fr) 2010-01-10 2010-06-17 Procédé et dispositif pour générer un nanoaérosol

Publications (2)

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EP2521525A1 true EP2521525A1 (fr) 2012-11-14
EP2521525B1 EP2521525B1 (fr) 2015-08-05

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US (1) US9566211B2 (fr)
EP (1) EP2521525B1 (fr)
WO (1) WO2011082838A1 (fr)

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ES2593622T3 (es) 2011-08-31 2016-12-12 Medic Activ Vertriebs Gmbh Cartucho de fluido y dispositivo de dispensación
DK3024521T3 (en) * 2013-07-24 2019-02-04 Medic Activ Vertriebs Gmbh Replacement cartridge
DE102014207053A1 (de) * 2014-04-11 2015-10-15 Hyve Ag Vorrichtung zum Erzeugen von Aerosolen
GB201419455D0 (en) * 2014-10-28 2014-12-17 Linde Ag A gas fed atomiser
US10086182B2 (en) 2016-06-09 2018-10-02 Basil C. Ogbu Steam therapy equipment for good health and wellness
USD856140S1 (en) * 2018-03-09 2019-08-13 Hans Peter Zarfl Aerosol dispenser
EP3593907B1 (fr) * 2018-07-13 2021-05-19 Elysion Family Office GmbH Buse pour nano-aérosol
IT201800009586A1 (it) * 2018-10-18 2020-04-18 Tazio Zerbini Capsula monouso per la generazione di un aerosol
FR3093655A1 (fr) * 2019-03-14 2020-09-18 Jean-Paul JANIN Dispositif de diffusion de produits liquides et boitier apte à recevoir un tel dispositif
WO2020223661A1 (fr) * 2019-05-02 2020-11-05 Tomi Environmental Solutions, Inc. Procédé et système permettant d'améliorer l'efficacité de la réduction de populations microbiennes à l'aide de peroxyde d'hydrogène ionisé/en aérosol, procédé d'utilisation associé
IT202000009088A1 (it) * 2020-04-27 2021-10-27 3A Health Care S R L Dispositivo e kit di erogazione di una sostanza nebulizzata
DE102020113812A1 (de) 2020-05-22 2021-11-25 Medic Activ Vertriebs Gmbh Transportgesicherte permanent offene Wechselkartusche zur Aerosolerzeugung
CN116492581B (zh) * 2023-06-29 2023-09-15 云南艾柯生物科技有限公司 一种用于治疗鼻炎的喷雾装置

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US5235969A (en) * 1990-08-20 1993-08-17 Intersurgical (Guernsey) Limited Nebulizer having combined structure for removing particles over two microns
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US5823179A (en) * 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
DE19903377C1 (de) 1999-01-28 2000-04-27 Manfred Buesselmann Ganzkörper-Nebelbadvorrichtung und Verfahren zum Verabreichen eines Ganzkörper-Nebelbades
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Also Published As

Publication number Publication date
EP2521525B1 (fr) 2015-08-05
US20130067656A1 (en) 2013-03-21
WO2011082838A1 (fr) 2011-07-14
US9566211B2 (en) 2017-02-14

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