EP2454269A4 - Verbessertes screening von biopolymeren - Google Patents

Verbessertes screening von biopolymeren

Info

Publication number
EP2454269A4
EP2454269A4 EP10800125A EP10800125A EP2454269A4 EP 2454269 A4 EP2454269 A4 EP 2454269A4 EP 10800125 A EP10800125 A EP 10800125A EP 10800125 A EP10800125 A EP 10800125A EP 2454269 A4 EP2454269 A4 EP 2454269A4
Authority
EP
European Patent Office
Prior art keywords
biopolymers
improved screening
screening
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10800125A
Other languages
English (en)
French (fr)
Other versions
EP2454269A1 (de
Inventor
James R Heath
Su Seong Lee
Jaehong Lim
Junhoe Cha
Sylvia Tan
Shi Yun Yeo
Yi Li Ang
Yiran Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science Technology and Research Singapore
Original Assignee
Agency for Science Technology and Research Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SG2009/000258 external-priority patent/WO2011010964A1/en
Application filed by Agency for Science Technology and Research Singapore filed Critical Agency for Science Technology and Research Singapore
Publication of EP2454269A1 publication Critical patent/EP2454269A1/de
Publication of EP2454269A4 publication Critical patent/EP2454269A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP10800125A 2009-07-15 2010-07-15 Verbessertes screening von biopolymeren Withdrawn EP2454269A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22588109P 2009-07-15 2009-07-15
PCT/SG2009/000258 WO2011010964A1 (en) 2009-07-22 2009-07-22 Differentiation of isobaric amino acids and other species
PCT/SG2010/000266 WO2011008173A1 (en) 2009-07-15 2010-07-15 Improved screening of biopolymers

Publications (2)

Publication Number Publication Date
EP2454269A1 EP2454269A1 (de) 2012-05-23
EP2454269A4 true EP2454269A4 (de) 2013-03-06

Family

ID=43449602

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10800125A Withdrawn EP2454269A4 (de) 2009-07-15 2010-07-15 Verbessertes screening von biopolymeren

Country Status (4)

Country Link
EP (1) EP2454269A4 (de)
KR (1) KR20120093151A (de)
CN (1) CN102498123A (de)
WO (1) WO2011008173A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9863956B2 (en) 2009-07-22 2018-01-09 Agency For Science, Technology And Research Differentiation of isobaric amino acids and other species
CN111748089B (zh) * 2019-03-28 2023-07-18 成都先导药物开发股份有限公司 一种生物素标记化合物以及确定化合物结合靶标蛋白的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134697A1 (en) * 2004-10-28 2006-06-22 The Regents Of The University Of California Method of preparing coded compound libraries
WO2011010964A1 (en) * 2009-07-22 2011-01-27 Agency For Science, Technology And Research Differentiation of isobaric amino acids and other species

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84939A (en) * 1987-01-06 1991-05-12 Baylor College Medicine Chemically inert wafer for synthesizing biopolymers
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US6998467B1 (en) * 1995-04-28 2006-02-14 The Hospital For Sick Children Antibody specific for presenilin 1 and method of use thereof
US5922840A (en) * 1996-07-23 1999-07-13 Kansas State University Research Foundation Methods for purifying synthetic peptides
US6060246A (en) * 1996-11-15 2000-05-09 Avi Biopharma, Inc. Reagent and method for isolation and detection of selected nucleic acid sequences
AU766502B2 (en) * 1998-11-02 2003-10-16 Lynx Therapeutics, Inc. Method for making complementary oligonucleotide tag sets
US6852493B2 (en) * 1999-05-14 2005-02-08 Iris Biotechnologies, Inc. Magnetic field enhanced hybridization of target molecules to immobilized probes
US20020197653A1 (en) * 2001-03-05 2002-12-26 Matthew Shair System for detecting reporter gene expression
WO2005116643A2 (en) * 2004-05-25 2005-12-08 Carlsberg A/S Identification of compounds modifying a cellular response
KR101088579B1 (ko) * 2004-10-04 2011-12-05 재단법인서울대학교산학협력재단 젤 타입의 코어-쉘 수지
WO2007009457A2 (en) * 2005-07-18 2007-01-25 2Curex Aps Identification of protein ligands modifying a cellular response
US7291471B2 (en) * 2005-11-21 2007-11-06 Agilent Technologies, Inc. Cleavable oligonucleotide arrays
GB0601031D0 (en) * 2006-01-18 2006-03-01 Novartis Ag Organic compounds
US20080113875A1 (en) * 2006-09-08 2008-05-15 Pierre Chaurand Molecular detection by matrix free desorption ionization mass spectrometry

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060134697A1 (en) * 2004-10-28 2006-06-22 The Regents Of The University Of California Method of preparing coded compound libraries
WO2011010964A1 (en) * 2009-07-22 2011-01-27 Agency For Science, Technology And Research Differentiation of isobaric amino acids and other species

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DAVIES M ET AL: "Inverted Peptides - Single Bead Analysis by Methionine Scanning and Mass Spectrometry", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 38, no. 49, 8 December 1997 (1997-12-08), pages 8565 - 8568, XP004096000, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(97)10285-4 *
LEBL M ET AL: "MULTIPLE RELEASE OF EQUIMOLAR AMOUNTS OF PEPTIDES FROM A POLYMERIC CARRIER USING ORTHOGONAL LINKAGE-CLEAVAGE CHEMISTRY", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, MUNKSGAARD, COPENHAGEN, DK, vol. 41, no. 2, 1 February 1993 (1993-02-01), pages 201 - 203, XP000336695, ISSN: 0367-8377 *
LEE S S ET AL: "Accurate MALDI-TOF/TOF sequenceing of one-bead-one-compound peptide libraries with application to identification of multiligand pretein affinity agents using in situ click chemistry screening", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 82, no. 2, 15 January 2010 (2010-01-15), pages 672 - 679, XP002683927, ISSN: 0003-2700 *
LEE SU SEONG ET AL: "Rapid microwave-assisted CNBr cleavage of bead-bound peptides.", JOURNAL OF COMBINATORIAL CHEMISTRY 2008 NOV-DEC, vol. 10, no. 6, November 2008 (2008-11-01), pages 807 - 809, XP009166176, ISSN: 1520-4774 *
ROBINS L I ET AL: "On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 14, no. 23, 1 December 2006 (2006-12-01), pages 7728 - 7735, XP027992204, ISSN: 0968-0896, [retrieved on 20061201] *
SALMON S E ET AL: "DISCOVERY OF BIOLOGICALLY ACTIVE PEPTIDES IN RANDOM LIBRARIES: SOLUTION-PHASE TESTING AFTER STAGED ORTHOGONAL RELEASE FROM RESIN BEADS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 90, 1 December 1993 (1993-12-01), pages 11708 - 11712, XP000652261, ISSN: 0027-8424, DOI: 10.1073/PNAS.90.24.11708 *
See also references of WO2011008173A1 *
ZHIGUANG YU ET AL: "Combinatorial epitope search: pitfalls of library design", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 7, no. 1, 7 January 1997 (1997-01-07), pages 95 - 98, XP004135973, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(96)00585-9 *

Also Published As

Publication number Publication date
WO2011008173A1 (en) 2011-01-20
EP2454269A1 (de) 2012-05-23
KR20120093151A (ko) 2012-08-22
CN102498123A (zh) 2012-06-13

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