EP2454170B1 - Reservoir de fluide - Google Patents

Reservoir de fluide Download PDF

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Publication number
EP2454170B1
EP2454170B1 EP10737469.6A EP10737469A EP2454170B1 EP 2454170 B1 EP2454170 B1 EP 2454170B1 EP 10737469 A EP10737469 A EP 10737469A EP 2454170 B1 EP2454170 B1 EP 2454170B1
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EP
European Patent Office
Prior art keywords
fluid reservoir
liquid
fluid
filling body
reservoir
Prior art date
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Active
Application number
EP10737469.6A
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German (de)
English (en)
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EP2454170A1 (fr
Inventor
Lutz Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thinxxs Microtechnology GmbH
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Thinxxs Microtechnology GmbH
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Publication of EP2454170A1 publication Critical patent/EP2454170A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/268—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being enclosed in a small pack, e.g. bag, included in the package
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber

Definitions

  • the invention relates to a fluid reservoir, in particular a fluid reservoir for integration into a miniaturized flow cell, having a storage space which is enclosed by two bodies in fluid-tight contact with one another.
  • the invention further relates to a method for producing such a fluid reservoir.
  • Fluid accumulators of this type are known, e.g. as emptied by deformation blister memory.
  • the dome-like storage space such Blister Grande always contains a certain amount of residual air, which affects the exact dosage dispensed volume of liquid.
  • the compressible residual air quantity initially ensures a delay of the liquid delivery.
  • a manual or mechanical pressing pressure on the Brister decreases, as a result of the relaxation of the residual air quantity, an uncontrolled subsequent fluid spillage occurs.
  • Attempts to avoid the inclusion of residual air by completely filling the storage space with the liquid in the production of the memory this leads to an undesired displacement of liquid in a gap between the adjacent bodies due to the curved meniscus fluid '.
  • the WO 98/01360 A1 describes a spraying device which has a liquid storage in addition to gas storage, which is emptied together with the gas storage while transporting gas and liquid to a spray nozzle.
  • the spray nozzle is preceded by a receiving space for a body formed by fibers.
  • the Güs Grande, the liquid storage and the receiving space are formed by fluid-tight abutting body.
  • the invention has for its object to provide a new fluid accumulator of the type mentioned above, which allows a more accurate dosage dispensed amounts of liquid.
  • the fluid reservoir according to the invention which achieves this object is characterized in that a solid filling body filling the remaining storage space is arranged in the storage space in addition to a stored liquid.
  • a depression is formed in the first body, the liquid to be stored is filled into the depression and the depression is fluid-tightly covered by a second body to form the storage space, wherein according to the invention the depression is only partially filled with the liquid and into the depression Furthermore, a solid packing is used, which completely fills the storage space together with the filled liquid.
  • liquid and filling body can form no residual air cushion in the storage space, which could delay or uncontrollably prolong the delivery of liquid.
  • a filled by the stored liquid part of the storage space is completely or predominantly limited by one of the two bodies and the solid packing. That is, in the manufacture of the memory, the surface of the liquid facing the first body is completely or partially covered by the filling body, against which the second body is then applied when closing the storage space. The second body is so no or only a small fluid meniscus opposite. Alternatively, a liquid meniscus facing the first body could be smoothed out by the filling body immersed in the liquid.
  • the two enclosing the storage space body are not only fluid-tight, possibly under pressure, to each other, but are also connected to each other, in particular welded together and / or glued.
  • the two bodies abut each other with flat surfaces and the filling body has a flush surface with these flat surfaces.
  • the filling body has a flush surface with these flat surfaces.
  • At least one of the two bodies can be formed by a film which is deformable for emptying the memory and, for example, covers a depression forming the storage space in a thicker plate.
  • the film itself has a bulge forming the storage space, so that a memory in the form of a blister is formed.
  • two films form the memory, of which at least one is deformed.
  • the films consist e.g. made of plastic, aluminum or plastic coated aluminum and are glued together fluid-tight or welded.
  • the filling body is connected to one of the two bodies, in particular integrally connected, wherein the filling body protrudes from the one body into a recess forming the storage space and formed by the other body.
  • the protruding filling body enters the depression and displaces all air therefrom.
  • the volume of the part of the storage space filled by the liquid can be small compared to the total volume of the storage space, i.e., by varying the size of the filling body, the fillable amounts of liquid can be varied for a given total volume of the storage space.
  • the filler may have a surface adapted to a die for deforming said bulge. A stamp compressing the blister bulge is thus centered and prevents unwanted wrinkling of the blister film.
  • the filler can form a tool for producing an outlet opening, which can be actuated by deformation of the film.
  • the packing may e.g. comprise a mandrel or a slide, which pierces a film or / and brings a predetermined breaking point to bursting.
  • the filler may be a body melting at room temperature.
  • a piece of ice forming the packing may then provide for the dilution of a stored aqueous fluid.
  • the filler may also be provided for interaction with the stored liquid, wherein in addition to chemical reactions, for example, the inclusion of unwanted portions of the liquid, such as particles, oxygen or ions, would be possible.
  • the filler has a hydrophilic surface, which advantageously allows easy wetting by the stored liquid.
  • the filler can be designed to receive gas, where it advantageously removes small amounts of residual air from the storage space.
  • the liquid could be at least partially degassed prior to storage so that it can hold residual air.
  • the filling body fills up a step-shaped projection of the bulge.
  • the e.g. dome-shaped bulge then transmits no forces on the lower edge of the foot or bulge when deformed.
  • the formation of an outlet opening by breaking a predetermined breaking point at the foot edge is not hindered.
  • the filler has gaps, openings and / or channels of certain dimensions, which are wetted by the liquid to be stored while displacing the air during insertion of the filling body into the storage.
  • the liquid to be stored by means of these contours to the fluidic output of the memory, such. a blister channel known in the art, passed in a controlled manner.
  • the flow cell connected to the reservoir may be connected to an injection needle, and the fluid to be stored may be a drug, the emptying of the reservoir being suitable for administering a drug comparable to a syringe.
  • the storage space is preferably elongated to form.
  • FIG. 1 An in Fig. 1 and the following figures in each case fragmentary illustrated flow cell has a plastic plate 1 with cavities, which are covered by a film 2 connected to the plastic sheet 1.
  • a film 2 connected to the plastic sheet 1.
  • FIGS. 1 to 5 as well as the Fig. 7 are known as cavities a chamber 3 and a transport channel 4, in Fig. 6 only one transport channel 27.
  • a fluid reservoir is arranged on the plastic plate 1, which comprises two films 6 and 7 connected to one another in a flat manner.
  • the film 6 is in turn connected on its side facing away from the film 7 with the plastic plate 1.
  • the foils 6, 7 can be welded together and the foil 6 can be welded or glued to the plate 1 and / or connected by double-sided adhesive film (not shown).
  • the film 7 has a dome-shaped bulge 8, through which a storage space for receiving a liquid 9 is formed between the films 6, 7. At 10 can be broken by pressure on the bulge 8 leading to the transport channel 4 opening channel.
  • a residual air cushion 11 is formed in the storage space.
  • the residual air is compressed, which after bursting of the opening channel 10 forming the predetermined breaking point leads to an uncontrolled discharge of liquid from the storage space.
  • a plate-shaped solid packing 12 is arranged, which completely fills the storage space together with a liquid contained in the storage space 9a. Only in a narrow gap between the plate edge surface of the filling body 12 and the wall of the storage space liquid 9a can pass. The shape of the edge of the packing determines the position and size of the gap. A plate surface 13 of the filling body 12 facing the film 6 therefore terminates flush with the contact surface 14 formed between the films 6, 7. In contrast to the memory 5, no or hardly any residual air is present in the storage space of the storage 5a.
  • the memory space contains an in Fig. 3 shown memory 5b no residual air.
  • the memory 5b differs from the memory 5a in that a filling body 15 is significantly thicker than the plate-shaped filling body 12. Accordingly, a smaller volume of liquid 9b is included in the reservoir 5b.
  • Fig. 3 clarified. Can (for a given size of the bulge) by varying the plate thickness and geometry different sized storage spaces for liquids are formed, with very small storage spaces can be produced with exactly measured volume.
  • Fig. 4 shows a memory 5c with a bulge 8c, which has a step approach 16.
  • a formed by the step approach 16 part of the storage space is filled by a plate-shaped packing 17 whose thickness is between the thickness of the packing 12 and the filling body 15. Due to the stepped approach, a foot point 18 of the bulge 8c is laterally replaced by the base 19 of a dome part of the bulge 8c, so that a pressing force exerted on the dome part is transmitted to the base point 18 only in a weakened manner. Bursting in a predetermined breaking point present at 18 is not hindered by the pressure exerted on the bulge 8c.
  • FIG. 5 shown fluid reservoir 5d has a filler 20, which is articulated at 21.
  • a compressive force By exerting a compressive force on the bulge 8d in accordance with arrow 22, there is therefore a displacement of a part of the filling body 22 according to arrow 23, wherein the filling body at 24 forms a predetermined breaking point to form an outlet opening.
  • Fig. 6 goes out a memory 5e with a filler 25.
  • the filling body 25 comprises a mandrel 26, which upon application of a compressive force to the bulge 8e according to arrow 22 (FIG. Fig. 5 ) can be pushed through the film 6 to form an outlet opening, so that the memory 5e is in communication with the above-mentioned transport channel 27.
  • An in Fig. 7 shown memory 5f has a filling body 28 which is formed on its side facing away from the film 6 corresponding to a plunger 29 for exerting a compressive force on the bulge 8f.
  • the bulge 8f is formed in a first step in the film 7, in the case of a plastic film, for example by hot-drawing, in the case of an aluminum foil typically used for blisters by cold-drawing.
  • Liquid to be stored 9f is filled in the vessel space formed by the bulge 8f.
  • the dotted line 30 in Fig. 8b indicates the resulting liquid level.
  • the filler 28 is inserted into the bulge 8f, wherein the surface of the filling body 28f facing away from the liquid 9f is flush with the surface 14f of the film 7 or projects slightly beyond it.
  • the film 7 is connected to the film 6 to form a closed storage space, wherein the storage space is filled by the liquid 9f and the filling body 28 without residual air.
  • FIGS. 9 and 10 show the memory of Fig. 4 similar memories with a step approach 16g or 16h.
  • a packing 17g arranged in the stepped shoulder 16g has an indentation 35 at the edge. When the reservoir is emptied, fluid is supplied through this slot 35 to an exit port of the reservoir at 24g.
  • a packing 17h of the memory of Fig. 10 has a central passage and a radial channel 37 which leads to a storage outlet opening 24h.

Claims (15)

  1. Réservoir de fluides, en particulier destiné à être intégré dans une cellule d'écoulement miniaturisée, présentant une chambre de réservoir, entourée par des corps (6,7) placés l'un contre l'autre de manière étanche aux fluides, caractérisé en ce qu'un corps de remplissage (12;15;17;20;25;28) solide remplissant le reste de la chambre de réservoir est disposé dans la chambre de réservoir, en plus d'un liquide accumulé (9).
  2. Réservoir de fluides selon la revendication 1, caractérisé en ce qu'une partie de la chambre de réservoir remplie par le liquide accumulé (9) est délimitée principalement par un des deux corps (7) et le corps de remplissage solide (12;15;17;20;25;28).
  3. Réservoir de fluides selon la revendication 1 ou 2, caractérisé en ce que les deux corps (6,7) placés l'un contre l'autre de manière étanche aux fluides sont assemblés l'un à l'autre, en particulier soudés et/ou collés l'un à l'autre.
  4. Réservoir de fluides selon l'une quelconque des revendications 1 à 3, caractérisé en ce que les deux corps (6,7) se placent l'un contre l'autre de manière étanche aux fluides avec des surface planes (14) et le corps de remplissage (12;15;17;20;25;28) présente une surface (13) affleurante par rapport aux surfaces planes (14).
  5. Réservoir de fluides selon l'une quelconque des revendications 1 à 4, caractérisé en ce qu'au moins un des deux corps (6,7) est formé par une feuille.
  6. Réservoir de fluides selon la revendication 5, caractérisé en ce que la feuille présente un renflement (8) déformable pour la formation de la chambre de réservoir.
  7. Réservoir de fluides selon l'une quelconque des revendications 1 à 6, caractérisé en ce que le corps de remplissage est assemblé, en particulier d'un seul tenant, avec un des deux corps et s'avance à partir dudit un corps dans un creux formant la chambre de réservoir, formé par l'autre corps.
  8. Réservoir de fluides selon l'une quelconque des revendications 1 à 7, caractérisé en ce que le volume de la partie remplie par le liquide (9b) de la chambre de réservoir est petit par rapport au volume total de la chambre de réservoir.
  9. Réservoir de fluides selon l'une quelconque des revendications 6 à 8, caractérisé en ce que le corps de remplissage (28) présente une surface adaptée à un piston (29) destiné à déformer le renflement (8f) pour expulser le liquide accumulé.
  10. Réservoir de fluides selon l'une quelconque des revendications 6 à 9, caractérisé en ce que le corps de remplissage (20,25) forme un outil pour réaliser une ouverture de sortie (24) qui peut être actionné avec la déformation du renflement (8d,8e).
  11. Réservoir de fluides selon la revendication 10, caractérisé en ce que le corps de remplissage (20,25) comprend un mandrin (26) et/ou forme un curseur.
  12. Réservoir de fluides selon l'une quelconque des revendications 6 à 11, caractérisé en ce que la chambre de réservoir forme un épaulement (16) à paliers qui est rempli par le corps de remplissage (17) jusqu'à une zone de bord.
  13. Réservoir de fluides selon l'une quelconque des revendications 1 à 12, caractérisé en ce que le corps de remplissage (17g,17h) présente une ouverture, un canal et/ou une entaille pour guider le liquide jusqu'à une sortie (24g,24h) du réservoir.
  14. Procédé pour la fabrication d'un réservoir de fluides, en particulier d'un réservoir de fluides destiné à être intégré dans une cellule d'écoulement miniaturisée, un creux (8f) étant formé dans un premier corps (7), un liquide (9) accumulé étant introduit dans le creux (8f) et le creux (8f) était recouvert de manière étanche aux fluides par un deuxième corps (6) en formant une chambre de réservoir, caractérisé en ce que le creux (f) n'est rempli que partiellement par le liquide (9f) et un corps de remplissage (28) solide est placé dans le creux (8f), remplissant, ensemble avec le liquide (9f), complètement la chambre de réservoir.
  15. Procédé selon la revendication 14, caractérisé en ce que la surface du liquide (9f) tournée vers le deuxième corps (6) est recouverte totalement ou pour la majeure partie par le corps de remplissage (28).
EP10737469.6A 2009-07-11 2010-06-07 Reservoir de fluide Active EP2454170B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009032744A DE102009032744A1 (de) 2009-07-11 2009-07-11 Fluidspeicher
PCT/DE2010/000646 WO2011006460A1 (fr) 2009-07-11 2010-06-07 Réservoir de fluide

Publications (2)

Publication Number Publication Date
EP2454170A1 EP2454170A1 (fr) 2012-05-23
EP2454170B1 true EP2454170B1 (fr) 2014-08-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP10737469.6A Active EP2454170B1 (fr) 2009-07-11 2010-06-07 Reservoir de fluide

Country Status (4)

Country Link
US (1) US8783488B2 (fr)
EP (1) EP2454170B1 (fr)
DE (1) DE102009032744A1 (fr)
WO (1) WO2011006460A1 (fr)

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US9662650B2 (en) 2013-07-29 2017-05-30 Atlas Genetics Limited Fluidic cartridge and method for processing a liquid sample
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US9908114B2 (en) 2013-07-29 2018-03-06 Atlas Genetics Limited Cartridge, cartridge reader and method for preventing reuse of the cartridge
US9993818B2 (en) 2013-07-29 2018-06-12 Atlas Genetics Limited Valve which depressurises, and a valve system
US9999883B2 (en) 2013-07-29 2018-06-19 Atlas Genetics Limited System and method for processing fluid in a fluidic cartridge

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EP3427830B1 (fr) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Analyse de cibles multiplexes intégrées
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
EP2932268A4 (fr) 2012-12-17 2016-10-19 Leukodx Ltd Systèmes et méthodes de détection d'un état biologique
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US9222623B2 (en) 2013-03-15 2015-12-29 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
EP2851121B1 (fr) * 2013-09-20 2022-11-02 thinXXS Microtechnology GmbH Dispositifs et procédés permettant de former des microcanaux ou réservoirs de microfluide
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
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DE102009032744A1 (de) 2011-01-13
EP2454170A1 (fr) 2012-05-23
US8783488B2 (en) 2014-07-22
US20120187117A1 (en) 2012-07-26
WO2011006460A1 (fr) 2011-01-20

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