EP2442641A4 - METHOD FOR REDUCING SIDE EFFECTS OF THE TRANSFUSION OF AGED RED BLOOD CELLS - Google Patents

METHOD FOR REDUCING SIDE EFFECTS OF THE TRANSFUSION OF AGED RED BLOOD CELLS

Info

Publication number
EP2442641A4
EP2442641A4 EP10789844.7A EP10789844A EP2442641A4 EP 2442641 A4 EP2442641 A4 EP 2442641A4 EP 10789844 A EP10789844 A EP 10789844A EP 2442641 A4 EP2442641 A4 EP 2442641A4
Authority
EP
European Patent Office
Prior art keywords
transfusion
methods
blood cells
red blood
adverse effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10789844.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2442641A1 (en
Inventor
Steven L Spitalnik
Eldad A Hod
Gary M Brittenham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University in the City of New York
Original Assignee
Columbia University in the City of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University in the City of New York filed Critical Columbia University in the City of New York
Publication of EP2442641A1 publication Critical patent/EP2442641A1/en
Publication of EP2442641A4 publication Critical patent/EP2442641A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Mechanical Engineering (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP10789844.7A 2009-06-16 2010-06-01 METHOD FOR REDUCING SIDE EFFECTS OF THE TRANSFUSION OF AGED RED BLOOD CELLS Withdrawn EP2442641A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18760009P 2009-06-16 2009-06-16
US27557909P 2009-08-31 2009-08-31
PCT/US2010/001610 WO2010147621A1 (en) 2009-06-16 2010-06-01 Methods for ameliorating adverse effects associated with transfusion of aged red blood cells

Publications (2)

Publication Number Publication Date
EP2442641A1 EP2442641A1 (en) 2012-04-25
EP2442641A4 true EP2442641A4 (en) 2016-03-09

Family

ID=43356660

Family Applications (1)

Application Number Title Priority Date Filing Date
EP10789844.7A Withdrawn EP2442641A4 (en) 2009-06-16 2010-06-01 METHOD FOR REDUCING SIDE EFFECTS OF THE TRANSFUSION OF AGED RED BLOOD CELLS

Country Status (4)

Country Link
US (1) US20120294826A1 (ja)
EP (1) EP2442641A4 (ja)
JP (1) JP2012530133A (ja)
WO (1) WO2010147621A1 (ja)

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US20130143817A1 (en) * 2009-12-08 2013-06-06 New York Blood Center, Inc. Use of transferrin in treatment of beta-thalassemias
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US10475527B2 (en) 2012-03-22 2019-11-12 Biomerieux, Inc. Method and system for detection of microbial growth in a specimen container
WO2013169361A1 (en) * 2012-05-09 2013-11-14 Howard University Iron chelators as hiv-1 inhibitors
EP2890982B1 (en) * 2012-08-28 2020-12-16 Puget Sound Blood Center Biochemical markers of red blood cell storage and toxicity
ES2726820T3 (es) 2013-01-31 2019-10-09 Emd Millipore Corp Dispositivo de captura directa desechable
LT3492593T (lt) * 2013-11-13 2021-11-25 Children's Medical Center Corporation Nukleazės sąlygojama genų raiškos reguliacija
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
GB2532960A (en) * 2014-12-02 2016-06-08 Imp Innovations Ltd Blood filter
JP6824994B2 (ja) 2015-10-07 2021-02-03 サングイ バイオ ピーティーワイ． エルティーディー 血液の調製及びプロファイリング
US11564948B2 (en) 2015-12-22 2023-01-31 Sangui Bio Pty Ltd Therapeutic methods using erythrocytes
CN109414542B (zh) * 2016-06-23 2022-09-09 希玛奈克斯特股份有限公司 管理需要输血的患者群体中的不良事件的方法
EP3559253A4 (en) 2016-12-20 2020-08-26 Sangui Bio Pty. Ltd BLOOD PROFILING WITH PROTEASE INHIBITORS
CN113545337B (zh) * 2021-07-21 2022-08-26 益诺思生物技术南通有限公司 哺乳动物心脏瓣膜的定型方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0304183A1 (en) * 1987-08-20 1989-02-22 Biomedical Frontiers, Inc. Stabilization of deferoxamine to chelate free ions in physiological fluid
WO1991015215A1 (en) * 1990-03-30 1991-10-17 Biomedical Frontiers, Inc. Fluid resuscitation
US5632897A (en) * 1992-09-11 1997-05-27 Fresenius Ag Method for removing aluminum ions from blood
EP1016460A2 (en) * 1998-11-10 2000-07-05 Becton Dickinson and Company Method for coating a blood collection device

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US4613616A (en) * 1984-07-20 1986-09-23 Research Corporation Polymeric iron chelators
US8029795B2 (en) * 1999-12-30 2011-10-04 Gwathmey, Inc. Targeted iron chelator delivery system
WO2001066171A1 (fr) * 2000-03-10 2001-09-13 Asahi Medical Co., Ltd. Nouveau filtre pour leucopherese
AU2001269690A1 (en) * 2000-05-10 2001-11-20 David A. Sirbasku Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth
US6573258B2 (en) * 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
US7160855B2 (en) * 2002-03-14 2007-01-09 Children's Hospital & Research Center At Oakland Enhancement of iron chelation therapy
US20080138433A1 (en) * 2002-07-05 2008-06-12 Celonova Biosciences, Inc. Vasodilator eluting blood storage and administration devices with a specific polyphosphazene coating and methods for their manufacture and use
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
JP4757024B2 (ja) * 2002-11-07 2011-08-24 テクニオン リサーチ アンド ディベラップメント ファウンデイション リミテッド 神経保護鉄キレート剤及びそれを含む医薬組成物
JP2006516979A (ja) * 2003-02-05 2006-07-13 ニューサウス イノベーションズ ピーティーワイ リミテッド 金属イオンキレート化剤およびその治療的使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304183A1 (en) * 1987-08-20 1989-02-22 Biomedical Frontiers, Inc. Stabilization of deferoxamine to chelate free ions in physiological fluid
WO1991015215A1 (en) * 1990-03-30 1991-10-17 Biomedical Frontiers, Inc. Fluid resuscitation
US5632897A (en) * 1992-09-11 1997-05-27 Fresenius Ag Method for removing aluminum ions from blood
EP1016460A2 (en) * 1998-11-10 2000-07-05 Becton Dickinson and Company Method for coating a blood collection device

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J. A. KNIGHT ET AL.: "The Effect of Metal Chelators on Lipid Peroxidation in Stored Erythrocytes*f", ANNALS OF CLINICAL AND LABORATORY SCIENCE, vol. 22, no. 4, 1 January 1992 (1992-01-01), pages 207 - 213, XP055244449, Retrieved from the Internet <URL:http://www.annclinlabsci.org/content/22/4/207.full.pdf> *
LENI BONSDORFF ET AL: "Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY., vol. 37, no. 1, 1 June 2003 (2003-06-01), NL, pages 45 - 51, XP055230703, ISSN: 0928-8244, DOI: 10.1016/S0928-8244(03)00109-3 *
S. S. MARWAH ET AL.: "Increased non-transferrin bound iron in plasma-depleted SAG-M red blood cell units", VOX SANGUINIS, vol. 82, 1 January 2002 (2002-01-01), pages 122 - 126, XP055244342, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/doi/10.1046/j.1423-0410.2002.00153.x/epdf> *
TIMOTHY B. CHASTON ET AL: "Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity", AMERICAN JOURNAL OF HEMATOLOGY, vol. 73, no. 3, 20 June 2003 (2003-06-20), pages 200 - 210, XP055119380, ISSN: 0361-8609, DOI: 10.1002/ajh.10348 *

Also Published As

Publication number Publication date
WO2010147621A1 (en) 2010-12-23
JP2012530133A (ja) 2012-11-29
US20120294826A1 (en) 2012-11-22
EP2442641A1 (en) 2012-04-25

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