EP2425837A4 - Verwendung von zellautophagen (typ-ii-zellapoptose)-hemmern - Google Patents
Verwendung von zellautophagen (typ-ii-zellapoptose)-hemmernInfo
- Publication number
- EP2425837A4 EP2425837A4 EP10769307A EP10769307A EP2425837A4 EP 2425837 A4 EP2425837 A4 EP 2425837A4 EP 10769307 A EP10769307 A EP 10769307A EP 10769307 A EP10769307 A EP 10769307A EP 2425837 A4 EP2425837 A4 EP 2425837A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cell
- inhibitors
- type
- autophagy
- apoptosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000006907 apoptotic process Effects 0.000 title 1
- 230000004900 autophagic degradation Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910082966A CN101869568A (zh) | 2009-04-27 | 2009-04-27 | 细胞自噬(ⅱ型细胞凋亡)作用抑制剂的用途 |
PCT/CN2010/072231 WO2010124618A1 (zh) | 2009-04-27 | 2010-04-27 | 细胞自噬(ii型细胞凋亡)作用抑制剂的用途 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2425837A1 EP2425837A1 (de) | 2012-03-07 |
EP2425837A4 true EP2425837A4 (de) | 2013-01-23 |
EP2425837B1 EP2425837B1 (de) | 2015-03-04 |
Family
ID=42994775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10769307.9A Active EP2425837B1 (de) | 2009-04-27 | 2010-04-27 | Verwendung von zellautophagen (typ-ii-zellapoptose)-hemmern |
Country Status (6)
Country | Link |
---|---|
US (1) | US20120238566A1 (de) |
EP (1) | EP2425837B1 (de) |
JP (1) | JP5658741B2 (de) |
CN (1) | CN101869568A (de) |
DK (1) | DK2425837T3 (de) |
WO (1) | WO2010124618A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2667874A4 (de) * | 2011-01-27 | 2014-07-30 | Univ Princeton | Mtor-kinase-hemmer als antivirusmittel |
CN104511017A (zh) * | 2013-09-29 | 2015-04-15 | 复旦大学 | 一种降低纳米递药材料体内外毒性药物复合物及其制备方法 |
WO2017083971A1 (en) * | 2015-11-16 | 2017-05-26 | University Of Manitoba | Compositions and methods for treatment of influenza |
GB201611712D0 (en) | 2016-07-02 | 2016-08-17 | Hvivo Services Ltd | Methods and compounds for the treatment or prevention of severe or persistent influenza |
KR102078137B1 (ko) * | 2017-03-07 | 2020-02-17 | 가톨릭대학교 산학협력단 | 쇼그렌 증후군 진단을 위한 조성물 |
CN109745320B (zh) * | 2019-03-08 | 2021-04-20 | 中国农业科学院兰州兽医研究所 | 一种sb203580在制备预防口蹄疫病毒感染的药物中的应用 |
CN110398405A (zh) * | 2019-08-26 | 2019-11-01 | 贵州大学 | 高效制作山羊子宫组织石蜡包埋的方法 |
CN113134004A (zh) * | 2021-03-29 | 2021-07-20 | 中国医学科学院医学生物学研究所 | 一种3-甲基腺嘌呤在制备预防铜绿假单胞菌诱导的急性肺炎药物中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060276438A1 (en) * | 2004-10-04 | 2006-12-07 | Natarajan Sethuraman | Prevention and treatment of influenza with glutamine antagonist agents |
WO2007139150A1 (ja) * | 2006-05-30 | 2007-12-06 | The University Of Tokushima | TNFα阻害物質を含有してなる抗インフルエンザウイルス剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006078774A2 (en) * | 2005-01-19 | 2006-07-27 | The Trustees Of The University Of Pennsylvania | Regulation of autophagy and cell survival |
CN101267779A (zh) * | 2005-07-27 | 2008-09-17 | 福罗里达大学研究基金会有限公司 | 使用热休克治疗眼睛疾病 |
CN101820757A (zh) * | 2007-06-01 | 2010-09-01 | 普林斯顿大学托管委员会 | 通过调节宿主细胞代谢途径治疗病毒感染 |
-
2009
- 2009-04-27 CN CN200910082966A patent/CN101869568A/zh active Pending
-
2010
- 2010-04-27 DK DK10769307.9T patent/DK2425837T3/en active
- 2010-04-27 WO PCT/CN2010/072231 patent/WO2010124618A1/zh active Application Filing
- 2010-04-27 JP JP2012507592A patent/JP5658741B2/ja active Active
- 2010-04-27 EP EP10769307.9A patent/EP2425837B1/de active Active
- 2010-04-27 US US13/265,692 patent/US20120238566A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060276438A1 (en) * | 2004-10-04 | 2006-12-07 | Natarajan Sethuraman | Prevention and treatment of influenza with glutamine antagonist agents |
WO2007139150A1 (ja) * | 2006-05-30 | 2007-12-06 | The University Of Tokushima | TNFα阻害物質を含有してなる抗インフルエンザウイルス剤 |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Week 200849, Derwent World Patents Index; AN 2008-H74031, XP002682031 * |
LEVINE B ET AL: "Autophagy in cell death: an innocent convict?", THE JOURNAL OF CLINICAL INVESTIGATION,, vol. 115, no. 10, 1 October 2005 (2005-10-01), pages 2679 - 2688, XP008116133, DOI: 10.1172/JCI26390 * |
Also Published As
Publication number | Publication date |
---|---|
EP2425837A1 (de) | 2012-03-07 |
JP2012530685A (ja) | 2012-12-06 |
EP2425837B1 (de) | 2015-03-04 |
CN101869568A (zh) | 2010-10-27 |
WO2010124618A1 (zh) | 2010-11-04 |
DK2425837T3 (en) | 2015-05-26 |
US20120238566A1 (en) | 2012-09-20 |
JP5658741B2 (ja) | 2015-01-28 |
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Ipc: A61P 31/16 20060101ALI20121218BHEP Ipc: A61K 31/366 20060101ALI20121218BHEP Ipc: A61K 31/5377 20060101ALI20121218BHEP Ipc: A61K 31/52 20060101AFI20121218BHEP Ipc: A61K 31/4439 20060101ALI20121218BHEP Ipc: A61P 11/00 20060101ALI20121218BHEP |
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