EP2404864A1 - Brise-ampoule - Google Patents

Brise-ampoule Download PDF

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Publication number
EP2404864A1
EP2404864A1 EP11004745A EP11004745A EP2404864A1 EP 2404864 A1 EP2404864 A1 EP 2404864A1 EP 11004745 A EP11004745 A EP 11004745A EP 11004745 A EP11004745 A EP 11004745A EP 2404864 A1 EP2404864 A1 EP 2404864A1
Authority
EP
European Patent Office
Prior art keywords
ampoule
outer container
head
cavity
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP11004745A
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German (de)
English (en)
Other versions
EP2404864B1 (fr
Inventor
Sebastian Vogt
Hubert Büchner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heraeus Medical GmbH
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Heraeus Medical GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Medical GmbH filed Critical Heraeus Medical GmbH
Publication of EP2404864A1 publication Critical patent/EP2404864A1/fr
Application granted granted Critical
Publication of EP2404864B1 publication Critical patent/EP2404864B1/fr
Active legal-status Critical Current
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
    • B67B7/00—Hand- or power-operated devices for opening closed containers
    • B67B7/92—Hand- or power-operated devices for opening closed containers by breaking, e.g. for ampoules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T225/00—Severing by tearing or breaking
    • Y10T225/30—Breaking or tearing apparatus
    • Y10T225/371—Movable breaking tool

Definitions

  • the invention relates to a device for opening ampoules comprising an outer container, in which a closed ampoule is arranged with an ampoule body and an ampoule head, and comprising a cavity in the region of the ampoule head, wherein the cavity comprises at least one opening and a connection to the ampoule.
  • the invention provides a robust apparatus for storing and opening monomer vials of vacuum cementing systems for polymethyl methacrylate bone cements pre-filled with cement powder and monomer liquid and provided to the medical user as full-pre-pack vacuum cementing systems.
  • PMMA bone cements have been known for decades and are based on the fundamental work of Sir Charnley ( Charnley, J .: Anchorage of the femoral head prosthesis of the shaft of the femur. J. Bone Joint Surg. 42 (1960) 28-30 .).
  • the basic structure of the PMMA bone cements has remained basically the same since then.
  • PMMA bone cements consist of a liquid monomer component and a powder component.
  • the monomer component generally contains the monomer methyl methacrylate and an activator (N, N-dimethyl-p-toluidine) dissolved therein.
  • the powder component consists of one or more polymers prepared on the basis of methyl methacrylate and comonomers such as styrene, methyl acrylate or similar monomers by polymerization, preferably suspension polymerization, an X-ray opaque and the initiator dibenzoyl peroxide.
  • a plastically deformable dough is formed by swelling the polymers of the powder component in the methyl methacrylate.
  • the activator reacts N, N-dimethyl-p-toluidine with dibenzoyl peroxide to form radicals.
  • the radicals formed initiate the radical polymerization of the methyl methacrylate.
  • the viscosity of the cement paste increases until it solidifies.
  • Polymethyl methacrylate bone cements may be mixed in suitable mixing cups by means of spatulas by mixing the cement powder with the monomer liquid.
  • a disadvantage of this approach that air pockets may be present in the formed cement dough, which may later cause a destabilization of the bone cement.
  • the mixing of bone cement powder with the monomer liquid in vacuum mixing systems is preferred because air entrainment from the cement paste is largely removed by mixing in a vacuum and thus optimum cement quality is achieved ( Breusch SJ et al .: The state of cementing technology in Germany. Z Orthop. 1999, 137: 101-07 ). Vacuum mixed bone cements have significantly reduced porosity and therefore exhibit improved mechanical properties.
  • the Optipac TM (Biomet Switzerland) full-prep mixing system currently on the market in Europe uses simple tubes placed laterally in the lower part of the cartridge, which pierce the cartridge wall, to apply the monomer liquid approximately in the middle of the cement powder sucked from the vacuum of aluminum composite bags in the cement powder.
  • Aluminum composite bags have only been known for the packaging and storage of monomer liquid for a few years. Very good experiences with respect to the storability of monomer liquid are available with glass ampoules. Glass ampoules have been used successfully for decades for conventional polymethyl methacrylate bone cements. Glass ampoules have in addition to the perfect tightness also the advantage that they in large numbers too low prices can be made. Therefore, it makes sense to use glass ampoules for packaging and storage of monomer liquid in pre-pack vacuum cementing systems.
  • WO 2010/012114 A1 a device for opening ampoules is described. This is analogous to DE 195 32 015 A1 a rotating mechanism for shearing the ampoule head. The only difference to DE 195 32 015 A1 is that a rotary sleeve is moved against the vial holder and not as in the DE 195 32 015 A1 the ampoule holder against the rotary sleeve.
  • a generic opening device in which a glass ampoule is mounted in a pressure-resistant outer container and the head of the glass ampoule can be sheared by the movement of a safety valve engaging in the outer container.
  • the safety valve comprises an elastic sealing sleeve and a pot-like lower part, which engages in the head of the ampoule, in order to be able to shear off these reliably.
  • the safety valve at its outlet channel handles, such as a coil spring, for actuating the safety valve.
  • the opening of the ampoule is very simple by this structure, the complex structure of the safety valve with the large number of individual components is disadvantageous. On the one hand, this leads to increased costs in the production of such an opening device, on the other hand, the ampoule can be opened accidentally in the manufacture of the opening device.
  • the object of the invention is the development of a robust, as simple as possible device for storage and opening of monomer vials of Vakuumztementiersystemen for polymethylmethacrylate bone cements, which are already prefilled with cement powder and monomer liquid and can be made available to the medical user as Prepac Vakuumzementiersysteme.
  • the device should consist of a minimum number of parts and be inexpensive to manufacture. The production should also be possible reliably without the risk of destroying the ampoules. From the user without special knowledge, the device must be used quickly and safely for the opening of monomer vials. It must be possible in the device no jamming during the opening of the ampoule.
  • the ampoule head is at least partially disposed in the connection of the cavity to the ampoule and the walls of the outer container comprise at least one deformable region or consist entirely of a deformable material, whereby a tilting of the ampoule against the compound is enabled, and the diameter of the connection is adapted to the dimensions of the ampoule head such that the ampoule head is breakable when the ampoule is tilted against the connection or can be broken off from the ampoule body.
  • the deformable region encloses the entire circumference of the outer container.
  • the inner diameter of the connection is the same size or larger, preferably 0.5-1.5 mm larger and in particular 1 mm larger than the outer diameter of the ampoule head.
  • a further advantageous embodiment of the invention results when the height 'and the cross section of the cavity are at least as large as the height of the ampoule head to the breaking edge of the ampoule.
  • the device is not visually recognizable deformable by applying vacuum to 90 mbar vacuum.
  • a particularly advantageous embodiment of the invention provides that the outer container is attached to a hollow body in which the cavity is formed, wherein the hollow body comprises the opening and consists of a solid non-hand deformable material.
  • the particular cylindrical hollow body is limited on the upper side by an ampoule pad in which the compound is arranged.
  • the outer container is positively and / or positively, in particular with a thread and / or a snap, attached to the hollow body.
  • the ampoule has a predetermined breaking point at the connection of the ampoule body to the ampoule head.
  • the outer container is formed of rubber-elastic plastic and / or that the outer container is formed bellows-like at least in one area.
  • the outer container, the ampoule and / or the connection are rotationally symmetrical, in particular cylindrical.
  • the outer container is a cylinder jacket open on both sides, in particular a heat-shrinkable tube, which connects the ampoule and the hollow body to one another in a gastight manner.
  • the invention also proposes a cartridge system comprising a device according to one of the preceding claims and a cement cartridge which is connected to the opening via a conduit.
  • the device and the cement cartridge are arranged on a foot part and the device is mounted on the foot part such that liquid due to gravity and / or due to a differential pressure from the open ampoule through the cavity and the opening in the line flowing in the foot part.
  • the invention is therefore based on the surprising finding that a movable outer container can be used to open an ampoule stored therein when the ampoule head is fixed against the movement of the outer container. This achieves in the simplest way that the ampoule body can be moved against the ampoule head, whereby the ampoule head breaks or breaks off from the ampoule body.
  • an ampoule with the ampoule head is loosely placed in a holder with a cylindrical bore below which there is a larger cavity with a hole.
  • a flexible outer container is placed over the ampoule and the holder and fixed gas-tight at least on the holder.
  • the tight fixation on the bracket is sufficient if the flexible outer container is a hollow cylinder closed on one side. If the outer container is a cylinder open on both sides, such as a heat-shrinkable tube, a tight fixing of the outer container to the ampoule must also be provided.
  • the structure is thereby particularly simple and inexpensive to implement. At the same time, the operation is simple and safe. Even in difficult circumstances, such as surgical operations, the application is easy and even by unskilled assistants readily possible.
  • a rigid sleeve is arranged over the flexible region of the outer shell.
  • This sleeve prevents tilting of the ampoule and must be withdrawn before use.
  • the fixation of the ampoule head can be firmly connected to a cartridge system, so that a user of the cartridge system, which holds this in one hand, the ampoule easily with the other hand by tilting the outer container, or the ampoule can open. This will make the entire cartridge system ready for use.
  • a cavity in the context of the present invention a simple line is to be understood, which need not necessarily be large enough to accommodate the broken ampoule head.
  • the transition from the cavity to the opening can then no longer be distinguished.
  • the transition from the connection to the cavity can also be stepless. It only needs to be taken to ensure that the broken ampoule head does not completely prevent the leakage of the contents of the ampoule.
  • a cavity sufficiently sized to receive the ampoule head, or even capable of allowing rotation of the broken ampoule head in the cavity is particularly advantageous because then the liquid contents of the broken ampoule head can flow out and so forth Use is usable.
  • the compound is mainly used to fix the ampoule head against a tilting movement of the ampoule.
  • a negative pressure in the cavity and in the interior of the outer container can also be generated via the opening.
  • the contents of the ampoule can also be sucked through the opening, or more precisely pressed through the higher pressure in the ampoule or from the outside.
  • gravity can also be used to allow the contents of the ampoule to flow through the connection, the cavity and the opening.
  • FIG. 1 shows a schematically illustrated cross-sectional view of a device according to the invention with a compound (1) in which an ampoule head (2) is arranged, wherein the compound (1) connects a cavity (3) with a region in which an ampoule (4) is arranged ,
  • the ampoule (4) may for example consist of glass, ceramic or another material.
  • On the opposite side of the connection (1) of the cavity (3) has an opening (5) is provided.
  • the connection (1) is for example a cylindrical bore in an ampoule pad (6).
  • the ampoule pad (6) is part of a cylindrical hollow body, in the bottom surface of which the opening (5) is located.
  • Around the ampoule (4) and the cylindrical hollow body around an outer container (7) is arranged.
  • the outer container (7) is connected via a thread (8) with the cylindrical hollow body, or with the ampoule pad (6).
  • an external thread (8) is provided on the cylindrical hollow body and an internal thread is provided on the outer container (7).
  • the outer container (7) is designed as a closed cylindrical hollow body on one side, which consists of a flexible material, such as rubber.
  • the cylindrical hollow body with the ampoule pad (6) consists of a stiff, solid material, such as plastic.
  • the ampoule (4) is placed upside down in the device, so that a liquid content of the ampoule (4) runs out of this when the ampoule head (2) is broken off.
  • the user of such a device can open the ampoule (4) by tilting or bending the upper portion of the outer container (7) against the ampoule support (6). Since the ampoule head (2) can not be tilted out of the connection (1), it remains in the connection (1) stuck and eventually breaks off or breaks completely.
  • a predetermined breaking point can be provided at the connection from the ampoule head (2) to the ampoule body, in which, for example, the material from which the ampoule (4) is made is particularly thin or scratched.
  • the broken ampoule head (2) falls into the cavity (3).
  • the vial head (2) is shaped and weighted to rotate as it descends so that the contents of the vial head (2) can run out of it.
  • the contents of the ampoule (4) pours into the cavity (3), since the cavity (3) is arranged below the ampoule (4). Subsequently, the liquid from the cavity (3) passes through the opening (5) and is available to the user.
  • the device serves for the liquid contained in the ampoule (4) to be subsequently miscible with a cement in a cement cartridge (not shown).
  • the device can be firmly connected to a cartridge system (not shown).
  • FIG. 2 shows an alternative embodiment of a device according to the invention in a schematic representation.
  • a portion (19) of an outer container (17) is flexible, while the rest of the outer container (17) is inflexible.
  • An ampoule (14) is in the upper part of the outer container (17).
  • the device shown has already been deformed by a force acting in the figure from the left at the upper end of the outer container (17).
  • an ampoule head (12) of the ampoule (14) is broken off.
  • the ampoule head (12) could not follow the movement of the ampoule (14) because it is in a compound (11) from a cavity (13) to the upper part of the outer container (17) inserted.
  • connection (11) is a recess in an ampoule pad (16), which in turn is part of a hollow body, which is arranged below the ampoule (40).
  • the hollow body has a further opening (15).
  • the outer container (17) is connected to the hollow body via a snap (18).
  • a rigid sleeve (not shown) may be provided, which is arranged around the outer container (17). This sleeve must then be removed before opening the ampoule (14).
  • the flexible region (19) may be made of a different material than the rest of the outer container (17).
  • both the flexible region (19) and the outer container (17) consist of the same material, wherein the thickness of the material in the flexible region (19) is less than in the walls of the outer container (17) and thereby better deformability in the flexible region (19) is given.
  • FIG. 3 shows a schematic representation of the device according to FIG. 2 after the ampoule head (12) has fallen down into the cavity (13).
  • the ampoule head (12) When falling, the ampoule head (12) has rotated due to its shape and nature, so that the contents of the ampoule head (12) run out of this into the cavity (13) and finally through the opening (15) expires from the device.
  • the contents of the ampoule (14) runs from this into the cavity (13), as indicated by the upper arrow.
  • the liquid from the opened ampoule (14) also passes out of the cavity (13) through the opening (15), as indicated by the lower arrow.
  • the upper part of the device (outer container (17) with ampoule body) is still in an inclined position.
  • the flexible region (19) has thus plastically deformed.
  • the upper part but also back to its original position (as in the embodiment according to FIG. 1 and the contents of the ampule (14) would still leak out. So that the ampoule head (12) does not get stuck in the connection (11) in the ampoule support (16), the inner diameter of the connection can be somewhat larger than the outer diameter of the ampoule head (12).
  • a suitable form of connection may assist in turning the broken ampule head (12) in the cavity (13) so that the contents of the ampule head (12) will drain.
  • the void (13) must be sufficiently large relative to the vial head (12) to allow the vial head (12) to rotate in the void (13).
  • the ampoule head (12) may be pointed and elongated, unlike the vial heads shown in the figures. Likewise it can be provided that the ampoule head (12) breaks not only at one, but at several points, so that the contents of the shards of the ampoule head (12) pours into the cavity (13).
  • a sieve or a filter (not shown) can be arranged above the opening (15) in the cavity (13).
  • FIG. 4 shows a schematic representation of a device according to the invention with an unopened ampoule (24), which is arranged in a cartridge system according to the invention.
  • the closed ampoule (24) is mounted in the upper part of an outer container (27), which is connected via a thread (28) with a hollow body which is fixedly arranged on a foot part (50) of the cartridge system.
  • the foot part (50) and the hollow body of the device can also be constructed as a common molding, for example made of plastic.
  • a cavity (23) is arranged in the hollow body.
  • the connection (21) extends through an ampoule support (26) which limits the cavity (23) up to the ampoule (24).
  • a filter (60) is placed over an opening (25) intended to separate solid parts, such as shards, from the liquid contents of the ampoule (24).
  • the outer container (27) has a circumferentially comprehensive flexible area (29) on which the outer container (27) is deformable. This makes it possible to cancel the ampoule head (22) by the upper portion of the outer container (27) with the body of the ampoule (24) tilted, or is rotated perpendicular to the axis of symmetry of the ampoule (24).
  • the opening (25) is connected to a conduit (53) in the foot part (50), which connects the device according to the invention with a cement cartridge (51).
  • the liquid from the ampoule (24) can be conveyed by means of a negative pressure through the conduit (53) in the cement cartridge (51). There, the liquid mixes with the cement powder and the mixture can be expelled with the aid of a delivery piston (52) from the cement cartridge (51) and the cement can be applied.
  • the movement of the delivery piston can also be forced by applying compressed air.
  • the flexible area (29) can also be realized by a bellows.
  • the outer container (7, 17, 27) is elastically deformable in the longitudinal direction by mechanical force. This means that the ampoule pad (6, 16, 26) facing away from the closed end of the outer container (7, 17, 27) by a simple movement perpendicular to its axis by a few degrees is movable.
  • the in the outer container (7, 17, 27) located ampoule (4, 14, 24) is thus forcibly moved with.
  • the ampoule head (2, 12, 22) is located in the hollow cylindrical connection (1, 11, 21) of the ampoule pad (6, 16, 26).
  • the ampoule pad (6, 16, 26) is not rubbery. This means that the ampoule body is sheared by movement of the outer container (7, 17, 27) against the non-moving ampoule head (2, 12, 22).
  • the inner diameter of the hollow-cylindrical ampoule pad (6, 16, 26) is larger than the ampoule head (2, 12, 22).
  • the sheared-off vial head (2, 12, 22) falls through the vial support (6, 16, 26) into the cavity (3, 13, 23) and gives the connection (1, 11, 21) to the vial support (6, 16, 26 ) free for the inflowing monomer liquid.
  • This cavity (3, 13, 23) has a height greater than the entire length of the separated ampoule head (2, 12, 22).
  • the cross section of the cavity (3, 13, 23) is so large that the sheared ampoule head (2, 12, 22) can lie horizontally at the bottom of the cavity (3, 13, 23).
  • the height of the cavity (3, 13, 23) is important so that the separated ampoule head (2, 12, 22) in its fall through the connection (1, 11, 21) in the ampoule pad (6, 16, 26) so can rotate so that it can lie horizontally on the bottom of the cavity (3, 13, 23).
  • the volume of monomer liquid present in the ampoule head (2, 12, 22) can run out.
  • the cross-section of the break point between the ampoule head (2, 12, 22) and the ampoule body is dimensioned so that a trouble leakage of the ampoule (4, 14, 24) at Gravity is ensured on the monomer liquid.
  • the geometry of the ampoule (4, 14, 24) must be adapted to the surface tension of the monomer liquid.
  • the outflow of the monomer is made possible by the opening (5, 15, 25) arranged in the bottom of the cavity (3, 13, 23).
  • the breaking of the ampoule (4, 14, 24) can be easily followed by the bursting sound, but is also noticeable by the sudden overcoming of the resistance. It is not essential in which direction the outer container (7, 17, 27) is moved perpendicular to the cylinder axis. It is only essential that a relative movement of the upper end of the outer container (7, 17, 27) takes place perpendicular to the ampoule axis.
  • the outer container (7, 17, 27) may have a ribbing on the inside parallel to the cylinder axis. As a result, an additional shock absorption of the ampoule (4, 14, 24) during transport is possible.
  • the ampoule pad (6, 16, 26) is not elastically deformable.
  • the outer container (7, 17, 27) is non-positively and / or positively connected to the ampoule pad (6, 16, 26).
  • the outer container (7, 17, 27) can be connected by a simple thread (8, 28) with the ampoule pad (6, 16, 26). It is also possible to form a snapping (18) on the outer container (7, 17, 27), which can be snapped with a circumferential ridge on the vial support (6, 16, 26). It is also possible to put the outer container (7, 17, 27) on the ampoule support (6, 16, 26), so that a fixation by the restoring force of the rubber-elastic outer container (7, 17, 27) is effected.
  • the outer container (7, 17, 27) is preferably formed of rubber-elastic plastic.
  • the outer container (7, 17, 27) may optionally be formed bellows.
  • the outer container (7, 17, 27) may be formed of rubber-elastic material so that only in the height of the break point of the ampoule (4, 14, 24) such a thin wall (19, 29) is present that this is elastomeric and that the rest of the outer container (7, 17, 27) has a thicker wall, which is no longer elastically deformable.
  • the deformable regions (19, 29) are then thinner than the walls of the outer container (7, 17, 27).
  • the invention also provides a method for opening ampoules, which is characterized in that the outer container (7, 17, 27) with the closed ampoule (4, 14, 24) from its cylinder axis by movement of the ampoule pad (6, 16, 26 ) is moved opposite the end of the outer container (7, 17, 27) so that the ampoule body is moved against the inside of the ampoule support (6, 16, 26) fixed ampoule head (2, 12, 22), whereby the ampoule head (2 , 12, 22) is broken by the ampoule body.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Devices For Opening Bottles Or Cans (AREA)
EP11004745.3A 2010-07-07 2011-06-10 Brise-ampoule Active EP2404864B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201010026496 DE102010026496B4 (de) 2010-07-07 2010-07-07 Ampullenbrecher

Publications (2)

Publication Number Publication Date
EP2404864A1 true EP2404864A1 (fr) 2012-01-11
EP2404864B1 EP2404864B1 (fr) 2017-04-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP11004745.3A Active EP2404864B1 (fr) 2010-07-07 2011-06-10 Brise-ampoule

Country Status (7)

Country Link
US (1) US9334147B2 (fr)
EP (1) EP2404864B1 (fr)
JP (1) JP5698083B2 (fr)
CN (1) CN102311079B (fr)
AU (1) AU2011203038B2 (fr)
CA (1) CA2745126C (fr)
DE (1) DE102010026496B4 (fr)

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CN103466525A (zh) * 2013-10-08 2013-12-25 张建娟 一种医用开瓶装置
EP2893888A1 (fr) * 2014-01-10 2015-07-15 Heraeus Medical GmbH Système d'ampoule contenant un liquide médical et capuchon doté d'un dispositif de filtre
EP4282518A1 (fr) 2022-05-23 2023-11-29 Heraeus Medical GmbH Dispositif et procédé de préparation de la pâte de ciment osseux
EP4299169A1 (fr) 2022-06-30 2024-01-03 Heraeus Medical GmbH Dispositif et procédé de fourniture de la pâte de ciment osseux

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CN102066236B (zh) * 2008-07-29 2012-05-30 药物混合系统股份公司 一种用于打开封闭的流体容器的装置
AU2013243887A1 (en) * 2012-04-03 2014-11-13 Synthes Gmbh Device and method for opening an ampoule
DE102014109905B4 (de) 2014-07-15 2017-02-09 Heraeus Medical Gmbh Vakuummischsystem und Verfahren zum Mischen von Polymethylmethacrylat-Knochenzement
DE102015106899B3 (de) 2015-05-04 2016-07-14 Heraeus Medical Gmbh Vorrichtung zum Mischen und Lagern von Polymethylmethacrylat-Knochenzement
DE102015108783B3 (de) 2015-06-03 2016-07-14 Heraeus Medical Gmbh Vorrichtung zum Mischen und Lagern von Polymethylmethacrylat-Knochenzement
DE102015111320B4 (de) * 2015-07-13 2018-10-18 Heraeus Medical Gmbh Vakuummischsystem und Verfahren zum Mischen von Polymethylmethacrylat-Knochenzement
DE102015116245B4 (de) 2015-09-25 2019-01-31 Heraeus Medical Gmbh Vorrichtung und Verfahren zum Öffnen von Glasampullen sowie Zementiervorrichtung
DE102016106261B4 (de) * 2016-04-06 2018-03-15 Heraeus Medical Gmbh Vorrichtung zum Mischen und Lagern von Polymethylmethacrylat-Knochenzement mit Druckpumpe und Ampullenbrecher
GB2561542B (en) * 2017-03-17 2019-03-20 Rabmed As Ampoule closure
CN106946203A (zh) * 2017-05-12 2017-07-14 郇晶晶 一种医用安瓿瓶无菌开启方法及装置
CN108163792A (zh) * 2018-03-21 2018-06-15 中国人民解放军总医院 封闭式安瓿折断装置
CN109734032B (zh) * 2019-03-20 2024-02-27 上海市东方医院（同济大学附属东方医院） 安剖瓶开瓶器
CN110054134A (zh) * 2019-05-15 2019-07-26 四川大学华西医院 一种一次性安瓿消毒开启器
EP4049965A1 (fr) * 2021-02-25 2022-08-31 Lutz Packaging GmbH Récipient à ampoules avec dispositif d'ouvertures d'ampoules intégré
CN114890360B (zh) * 2022-05-12 2023-07-25 中南大学湘雅医院 一种安培瓶开瓶器

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CN103466525A (zh) * 2013-10-08 2013-12-25 张建娟 一种医用开瓶装置
EP2893888A1 (fr) * 2014-01-10 2015-07-15 Heraeus Medical GmbH Système d'ampoule contenant un liquide médical et capuchon doté d'un dispositif de filtre
EP4282518A1 (fr) 2022-05-23 2023-11-29 Heraeus Medical GmbH Dispositif et procédé de préparation de la pâte de ciment osseux
EP4299169A1 (fr) 2022-06-30 2024-01-03 Heraeus Medical GmbH Dispositif et procédé de fourniture de la pâte de ciment osseux

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CN102311079B (zh) 2015-08-05
AU2011203038B2 (en) 2014-01-16
DE102010026496B4 (de) 2014-05-22
JP2012017147A (ja) 2012-01-26
CN102311079A (zh) 2012-01-11
JP5698083B2 (ja) 2015-04-08
CA2745126A1 (fr) 2012-01-07
US20120006874A1 (en) 2012-01-12
AU2011203038A1 (en) 2012-02-02
EP2404864B1 (fr) 2017-04-12
DE102010026496A1 (de) 2012-01-12
US9334147B2 (en) 2016-05-10

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