EP2393597B1 - Dispositif d'echantillonnage pour des liquides biologique - Google Patents

Dispositif d'echantillonnage pour des liquides biologique Download PDF

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Publication number
EP2393597B1
EP2393597B1 EP10707441.1A EP10707441A EP2393597B1 EP 2393597 B1 EP2393597 B1 EP 2393597B1 EP 10707441 A EP10707441 A EP 10707441A EP 2393597 B1 EP2393597 B1 EP 2393597B1
Authority
EP
European Patent Office
Prior art keywords
test device
housing
cutting part
indication
cutting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP10707441.1A
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German (de)
English (en)
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EP2393597A1 (fr
Inventor
Walter Franz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gaudlitz GmbH
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Gaudlitz GmbH
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Publication date
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Publication of EP2393597A1 publication Critical patent/EP2393597A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se

Definitions

  • the invention relates to a test device for liquids of the human or animal body according to the preamble of claim 1.
  • the body fluid to be tested is blood, but the invention is not limited thereto, but the test device according to the invention is also applicable to other body fluids of the human or animal body, which is expressly covered by the invention should be included.
  • test device in which a predetermined amount of the blood to be examined is applied to a carrier and introduced with this into a reagent with which the blood reacts chemically. Either the user perceives a visually perceptible change with this chemical reaction or, after reacting with the reagent, the blood is applied to an indicator, for example a so-called test strip, which, depending on its nature, causes a color change. Based on the color change, the user can read whether and, if necessary to what extent the examined blood has a deviation from the desired state.
  • the known test device consists of several assemblies or components that the user must apply one after the other. This procedure is complicated and entails the risk that the user does not observe the sequence of the modules and thereby makes the test falsified or unusable. In addition, there is a risk that individual components fall in use on the floor and thereby pollute, whereby the test device is also unusable.
  • test device in the WO 2005/071388 A1 is shown.
  • three functional areas are arranged one behind the other in series.
  • a liquid to be tested can be supplied in a feed region, wherein the feed region is followed by a reaction region which is separated from the feed region by a dividing wall.
  • a further chamber is formed, in which the liquid can be viewed after the reaction with the reagent.
  • the user To perform the test, the user must pierce the partitions axially. In this way, the test procedure depends on the skill of the user and it is not guaranteed a well-defined sequence of the test.
  • the invention has for its object to provide a test device of the type mentioned, which is applicable to the user in a simple manner and which ensures a precisely defined procedure of the test.
  • the invention is based on the basic idea of carrying out all the phases of the test in a single, preferably tubular housing in which different functional areas are formed.
  • the body fluid to be examined or the blood can be supplied in a predetermined amount or introduced into the housing.
  • the blood then passes through a reaction area within the housing and at the end reaches an indication area with an indication element, at which the user can read the result of the test.
  • the blood From the supply area, the blood enters the reaction area, which is connected downstream of the feed area and separated therefrom by at least one closed partition wall.
  • the reaction area In the reaction area there is at least one reagent with which the blood reacts chemically.
  • the feed region In the initial state of the test device, the feed region is completely separated from the reaction region by the closed partition wall.
  • a user-operable cutting device is provided, by means of which the dividing wall is destructible, so that the blood flows into the reaction area where it is mixed with the reagent and reacts chemically.
  • the reaction area is followed by the indication area, which is separated from the reaction area by a separating element with a defined passage opening.
  • the indication element for example a test strip, is arranged, to which the blood after the Reaction with the reagent through the passage opening in a defined form is supplied.
  • the arrangement of said functional areas within a single tubular housing ensures that the blood can only reach the indication area after it has passed through the reaction area and has reacted there with the reagent. An unintentional change in the order of the individual test phases is excluded.
  • the blood can be supplied in any way to the feed region of the tubular housing.
  • the feed region has a capillary tube in which the blood to be tested can be received as a result of capillary forces.
  • the test person whose blood is to be examined, is removed in the usual way, at least one drop of blood, for example, by the skin is pierced at the fingertip.
  • the needle or tip used for this purpose can be integrated into the test device at a suitable location, but it is also possible to puncture the skin by means of a separate tip.
  • the blood In order to allow the amount of blood taken up by the capillary tube to flow through the individual regions of the housing of the test device, the blood must counteract the force the capillary forces flow out of the capillary tube again.
  • This can be achieved, for example, by acting on one end of the capillary tube an overpressure.
  • this can be achieved in that a cap can be placed on the capillary tube, by means of which the amount of blood in the capillary tube is forced out of this.
  • the cap has an inner blind bore into which the capillary tube can be inserted without play.
  • the space located between the bottom of the blind bore and the inserted end of the capillary tube is reduced resulting in a pressure increase that causes the blood to exit the capillary tube at the opposite end is pushed out.
  • the cutting device may comprise a cutting part which is rotatably mounted in the housing and / or axially displaceable and has a cutting blade. Due to the axial displaceability of the cutting part of the user can bring the cutting blade with the opening partition into abutment and pierce them. The rotatability of the cutting part and the cutting blade can support this opening process.
  • the cutting part with the cutting blade should have a well-defined relative to the housing of the test device Execute movement that is not at the discretion of the user, but is determined by a corresponding guide device.
  • the movement of the cutting part is controlled via a gate, which is formed in the housing.
  • the cutting part has a guide pin, which passes through the gate, which is preferably formed by a guide slot or a guide, in close fit.
  • a secure guide is ensured when two corresponding slotted guides are formed on diametrically opposite sides of the housing.
  • the Cutting part with the cap is in fluid form engagement. The user then twists and / or shifts the cap, which is easily accessible to him, and thus also the cutting part according to the course of the slide, so that a defined movement is achieved.
  • a thread may be provided which defines the movement between the cutting part and the housing.
  • the blood flows from the feed zone into the reaction zone and reacts with the reagent located there.
  • the reagent is not freely movably received in the reaction area, but is contained in a cartridge which is inserted into the housing and has at least one sealing film, which is destructible by means of the cutting device. In this way it is possible to prefabricate the cartridge with the desired reagent and to insert it into the housing in a filled and closed state during the manufacture of the test device. Thus, the possibility is given to use different reagents in similar housing depending on the application by only the corresponding prefabricated cartridge must be used.
  • the cartridge comprises a tubular housing part, which is inserted under close fit in the housing of the test device and at its two ends pointing in the axial direction of the housing in each case by means of a Closing foil is closed, which may be sealed, for example.
  • a Closing foil is closed, which may be sealed, for example.
  • the individual cartridges are arranged directly following one another in the axial direction of the tubular housing of the test device and are preferably tensioned against one another by means of a tensioning element. In this way, the individual cartridges occupy a defined position within the housing.
  • the backdrop that controls the movement of the cutting part a stepped course, ie have a polygonal course.
  • the cutting part is displaced axially until the cutting blade located thereon opens the first cartridge, so that the blood is mixed with the reagent located in the first cartridge and reacts with it.
  • the axially behind other cartridges are initially undamaged. Then, when the cutting part is rotated relative to the housing, a second axial movement of the cutting part along the gate is possible, whereby the cutting blade opens the next cartridge and the blood can also react with the reagent of this second cartridge.
  • the blood flows onto the separator which separates the reaction zone from the subsequent indication zone, but has a defined through-hole of very small dimensions, i. having a diameter of less than 1mm.
  • the blood impinging on the separating element can flow through the passage opening and then impinges on the indication element, for example a test strip suitable for the respective application, which can discolor depending on the test result.
  • the separating element is cup-shaped and fits snugly into the housing.
  • the passage opening may preferably be formed in the bottom of the separating element. The cup-shaped design of the separating element ensures that the blood collects in this and then run off through the passage opening formed in the bottom and can enter the indication element.
  • the through opening is surrounded by spacer elements which on the one hand, does not hinder the flow of blood into the passage opening, but on the other hand substantially reduces the risk of closure of the passage opening by means of cut-out pieces of film, since the pieces of film are retained by the spacer elements before they can lay directly on the passage opening.
  • the indication element is preferably formed by an indicator strip or test strip, which is aligned in the longitudinal direction of the tubular housing of the test device and from the outside of the housing, which is either transparent or at least in the region of the indicator element has a transparent window, by a user after performing the Tests can be considered.
  • a receptacle for the indication element is formed on the side of the separating element facing the indication element.
  • it may be a tubular approach, in which the indication element is preferably inserted and clamped with little elastic deformation. In this way, the indication element is arranged directly at the mouth of the passage opening, so that it is ensured that the entire blood mixed with the reagents, which flows through the passage opening, enters the indication element.
  • the strip-shaped indication element is also held at the opposite, the separator facing away from the end in a holder, so that a secure Positioning of the indication element is ensured relative to the housing.
  • a test device 10 shown in the figures has an elongate, tubular housing 11, which in accordance with FIG. 1 and 2 bottom end is closed by a cap 12.
  • a holder 13 is integrated on the side facing the inside of the housing 11, in which a strip-shaped indication element 45 is inserted and held.
  • the strip-shaped indication element 45 extends in the axial direction of the housing 11 and is seated at its opposite upper end in a tubular socket 44 of a cup-shaped separating element 41.
  • Das Strip-shaped indication element 45 is safely and immovably positioned in an indication region 40 of the housing 11 by the lower holder 13 and the upper receptacle 44.
  • the separating element 41 which separates the lower indication region 40 from an overlying reaction region 30, has a cup-shaped, upwardly opening cross-section and sits in close fitting in a sealed manner in the housing 11.
  • an axially extending through hole 42nd formed, which opens directly on the front side of the strip-shaped indication element 45.
  • the through hole 42 of spacers 43 (s. Figure 4 ), which protrude from the ground by a small amount upwards.
  • each cartridge 31, 34, 37 has a tubular housing part 31a, 34a, 37a, whose outer dimensions correspond to the inner dimensions of the housing 11, and is at the top and at the bottom by a respective sealing film 32, 33 and 35, 36 and 38, 39 closed.
  • a reagent or other chemical substance is necessary, which is necessary for the examination of the body fluid or the blood.
  • the cartridges 31, 34 and 37 are prefabricated and are inserted in the filled and sealed state with close fit in the housing 11, so that they in the axial direction with their tubular housing parts 31 a, 34a, 37a lie on top of each other, as in particular in FIG. 4 is shown.
  • the lower, the indication element 45 facing cartridge 37 is located with its lower end on the upper edge of the cup-shaped separating element 41.
  • a clamping element 15 is arranged in the form of a clamping sleeve which is stretched under elastic deformation against the inner wall of the housing 11 and the three cartridges 31, 34 and 37 clamped in the axial direction against each other and securely positioned.
  • the upper film 32 of the upper cartridge 31 forms a dividing wall between a reaction area 30 of the test apparatus 10 comprising the cartridges 31, 34 and 37 and an overlying feed area 20, in which the test apparatus 10 is supplied with a predetermined amount of the blood to be examined.
  • a cutting device 19 is arranged within the housing, which includes a cutting part 22.
  • the cutting part 22 consists of an upper, in the housing 11 substantially free of play inserted holding body 21 to which on its underside a tubular extension 21b is formed, at its lower, the cartridges 31, 34, 37 end facing a cutting blade 23 in shape wearing a cutting teeth made cutting ring.
  • an annular or cylindrical sealing element 16 is arranged, which rests on the inside of the housing 11 and the outer side of the tubular projection 21b and is supported in the axial direction on the upper side of the clamping sleeve 15.
  • an axial center hole 21 a is formed, in which a capillary tube 24 is inserted, which protrudes upward.
  • a tubular cap 25 has an inner blind bore 26, with which it can be placed without play on the upwardly projecting portion of the capillary tube 24.
  • the cap 25 has a handle portion 28 on which a user can grasp the cap 25 and, in particular, rotate and axially displace it.
  • a guide body 27 is formed, which has an axial projection 27 a (s. Figure 5 ), with which it can engage with a receptacle 22 a of the holding body 21 of the cutting part 22 so that a force exerted on the handle 25 on the cap 25 rotational movement is transmitted to the cutting part 22.
  • the holding body 21 of the cutting member 22 has a radially outwardly extending guide pin 17 which is formed in a housing 11 in the form of a cam-shaped cam in the form of a slot-shaped gate 14 (s. Fig.1 ) intervenes.
  • the gate 14 has an upper, extending in the circumferential direction of the housing 11 1.Ab4.000 14a, an adjoining, extending in the longitudinal direction of the housing 11 second section 14b, an adjoining in the circumferential direction of the housing 11 extending third section 14c and a subsequent, extending in the longitudinal direction of the housing 11 4th section 14d.
  • diametrically opposite side of the housing 11 is provided, in which a corresponding further guide pin 17 engages.
  • the body fluid to be examined or the blood is introduced into the upper supply area 20 of the test apparatus 10.
  • the cap 25 is removed from the capillary tube 24 and the upper free end of the capillary tube 24 is brought into contact with a drop of blood, for example on the finger tip of a subject. Due to the capillary action of the capillary tube 24, the blood enters and fills the capillary tube 24. In this way, a predetermined amount of blood is thereby received the volume of the capillary tube 24.
  • the cap 25 is placed with its blind bore 26 on the capillary tube 24 and completely pushed.
  • the projection 27 a of the guide body 27 of the cap 25 engages with the receptacle 22 a of the cutting part 22, so that a transmission of a rotational movement of the cap 25 to the cutting part 22 is possible.
  • the user rotates the cap 25, whereby the cutting part 22 is rotated as far as the guide pin 17 attached to it can move in the first section 14 a of the link 14. Subsequently, the user presses on top of the cap 25, whereby the cutting member 22 is moved in the axial direction of the housing 11 down and the guide pin 17, the second section 14 b of the gate 14 along.
  • This running in the axial direction of the housing 11 movement of the cutting member 22 is limited by the length of the second portion 14 b of the gate 14.
  • the cutting blade 23 formed at its lower end comes into contact with the upper sealing foil 32 of the upper cartridge 31 and destroys it.
  • the blood located in the interior 29 of the tubular extension 21b can thus mix with the reagent contained in the cartridge 31 and react with it.
  • the other cartridges 34 and 37 are still closed.
  • the user again turns the cap 25, whereby the guide pin 17 runs along the third section 14c of the link 14 and passes into the fourth section 14d of the link 14 extending in the longitudinal direction of the housing 11. In this position is It is possible for the user to further push the cap 25 into the housing 11, whereby the cutting part 23 is displaced inside the housing 11 and both the lower sealing foil 33 of the first cartridge, the immediately following upper sealing foil 35 of the second cartridge 34 , pierces and destroys the lower sealing foil 36 of the second cartridge 34, the immediately following upper sealing foil 38 of the third cartridge 37 and also the lower sealing foil 39 of the lower third cartridge 37.
  • the blood also comes into contact with the reagents or antibodies or other reactants contained in the second cartridge 34 and the third cartridge 37 and reacts with them.
  • the blood then enters the bowl-shaped separator 41 from above and flows through the through-bore 42 into the immediately underlying strip-shaped indicator 45, where it may cause a color change which the user may make from the outside of the cabinet through a window 18 (see FIG , Fig.1 ).

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (15)

  1. Dispositif d'échantillonnage (10) pour des liquides du corps humain ou animal, avec un boîtier en forme de tube (11) dans lequel sont réalisées :
    - une zone d'amenée (20) servant à amener une quantité prédéterminée de liquide corporel à tester,
    - une zone de réaction (30) placée en aval de la zone d'amenée (20) et séparée de celle-ci par une paroi de séparation (32) fermée et dans laquelle le liquide corporel peut être amené en réaction chimique avec au moins un réactif ; et
    - une zone d'indication (40) placée en aval de la zone de réaction (30), séparée de celle-ci par un élément de séparation (41) doté d'une ouverture traversante (42) définie et dans laquelle un élément d'indication (45) est disposé et à laquelle le liquide corporel peut être amené à travers l'ouverture traversante (42) après la réaction avec le réactif ;
    caractérisé en ce qu'un dispositif de coupe (19) pourvu d'une partie tranchante (22) permet de détruire la paroi de séparation (32), le mouvement de la partie tranchante (22) étant commandé via une coulisse (14) réalisée dans le boîtier (11) et la partie tranchante (22) possédant une tige de guidage (17) traversant la coulisse (14) selon un ajustement serré.
  2. Dispositif d'échantillonnage selon la revendication 1, caractérisé en ce que la zone d'amenée (20) comporte un tube capillaire (24) dans lequel le liquide corporel à tester peut être reçu par application de forces capillaires.
  3. Dispositif d'échantillonnage selon la revendication 2, caractérisé en ce qu'un bouchon (25) servant à sortir le liquide corporel se trouvant dans le tube capillaire (24) hors de ce dernier peut être placé sur le tube capillaire (24).
  4. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 3, caractérisé en ce que la partie tranchante (22) est disposée de façon à pouvoir pivoter dans le boîtier (11) et/ou à pouvoir être déplacée dans le plan axial et possède une lame tranchante (23).
  5. Dispositif d'échantillonnage selon la revendication 3 ou 4, caractérisé en ce que la partie tranchante (22) peut être amenée en prise fluide par forme avec le bouchon (25) et être déplacée à l'aide de celui-ci.
  6. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 5, caractérisé en ce que le réactif est disposé dans une cartouche (31, 34, 37) insérée dans le boîtier (11) et comportant au moins un opercule de fermeture (32, 33, 35, 36, 38, 39) pouvant être détruit à l'aide du dispositif de coupe (19).
  7. Dispositif d'échantillonnage selon la revendication 6, caractérisé en ce que la cartouche (31, 34, 37) comporte une partie de boîtier en forme de tube (31 a, 34a, 37a) insérée sous un ajustement étroit réalisé dans le boîtier (11) et respectivement fermée au niveau de ses extrémités orientées dans la direction axiale du boîtier (11) au moyen d'un opercule de fermeture (32, 33, 35, 36, 38, 39).
  8. Dispositif d'échantillonnage selon la revendication 6 ou 7, caractérisé en ce que plusieurs cartouches (31, 34, 37) sont disposées les unes derrière les autres dans la direction axiale du boîtier (11).
  9. Dispositif d'échantillonnage selon la revendication 8, caractérisé en ce que les cartouches (31, 34, 37) sont serrées les unes contre les autres à l'aide d'un élément de serrage (15).
  10. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 9, caractérisé en ce que l'élément de séparation (41) prend une forme d'écuelle et repose en ajustement serré dans le boîtier (11).
  11. Dispositif d'échantillonnage selon la revendication 10, caractérisé en ce que l'ouverture traversante (42) est réalisée dans le fond de l'élément de séparation (41).
  12. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 11, caractérisé en ce que l'ouverture traversante (42) est ceinte d'éléments d'écartement (43).
  13. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 12, caractérisé en ce qu'un logement (44) prévu pour l'élément d'indication (45) est réalisé sur le côté de l'élément de séparation (42) orienté vers la zone d'indication (40).
  14. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 13, caractérisé en ce que l'élément d'indication (45) est directement disposé contre l'embouchure de l'ouverture traversante (42).
  15. Dispositif d'échantillonnage selon l'une quelconque des revendications 1 à 14, caractérisé en ce que l'élément d'indication (42) repose dans un support (13) au niveau de son extrémité opposée à l'élément de séparation (41).
EP10707441.1A 2009-02-05 2010-02-03 Dispositif d'echantillonnage pour des liquides biologique Active EP2393597B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102009007616A DE102009007616A1 (de) 2009-02-05 2009-02-05 Testvorrichtung für Flüssigkeiten des menschlichen oder tierischen Körpers
PCT/EP2010/000663 WO2010089102A1 (fr) 2009-02-05 2010-02-03 Dispositif d'essai pour l'analyse de liquides du corps humain ou animal

Publications (2)

Publication Number Publication Date
EP2393597A1 EP2393597A1 (fr) 2011-12-14
EP2393597B1 true EP2393597B1 (fr) 2014-05-07

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EP10707441.1A Active EP2393597B1 (fr) 2009-02-05 2010-02-03 Dispositif d'echantillonnage pour des liquides biologique

Country Status (8)

Country Link
US (1) US20110294201A1 (fr)
EP (1) EP2393597B1 (fr)
JP (1) JP2012517006A (fr)
CA (1) CA2751407A1 (fr)
DE (1) DE102009007616A1 (fr)
ES (1) ES2487541T3 (fr)
PT (1) PT2393597E (fr)
WO (1) WO2010089102A1 (fr)

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CN103890163B (zh) 2011-06-19 2016-09-14 阿博根公司 用于样品采集的装置、溶液和方法
ES2635596T3 (es) * 2012-06-20 2017-10-04 Fabpulous B.v Dispositivo y método de prueba rápida
JP6344794B2 (ja) * 2014-08-20 2018-06-20 株式会社佐藤アンプル製作所 検体検査用具

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CA2751407A1 (fr) 2010-08-12
JP2012517006A (ja) 2012-07-26
ES2487541T3 (es) 2014-08-21
PT2393597E (pt) 2014-12-26
US20110294201A1 (en) 2011-12-01
EP2393597A1 (fr) 2011-12-14
DE102009007616A1 (de) 2010-08-12
WO2010089102A1 (fr) 2010-08-12

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