EP2371343A2 - Device for storing and metering a solution - Google Patents

Abstract

The device (100) has a container (104) comprising an inner area filled with a fixed amount of solvent, and a mounting device (103) for mounting the container at a laboratory vessel (101) that has an inner area, where the solvent is dosed into the inner area of the vessel from the container. An opening unit (107) opens the container, such that a continuous connection for the solvent is established from the inner area of the container to the inner area of the vessel. Another opening unit opens a locking device of the vessel, where the mounting device has an elastic stopper (111).

Description

The present invention relates to a device for storing and / or dosing a solvent for dissolving a substance to be used in liquid form.

One area where it must be ensured that substances that need to be stored for a long period of time do not lose their activity or effectiveness is in vitro diagnostics. In this field, liquid reagents are used which are suitable for the detection of an analyte with a biological sample, for. B. be brought into contact with blood plasma. The reagents often contain biologically or chemically active substances, such as antibodies, enzymes, etc., which are essential for carrying out the detection method. The problem is that many substances lose their effectiveness if they are stored in liquid form over a longer period of time. Therefore, in order to render these compositions durable and to ensure sufficient biological activity over an acceptable period of time, they are usually provided as dry powders, for example by methods such as spray drying, bulk crystallization, vacuum drying, foam drying or lyophilization. Shortly before using the reagent, the user prepares the liquid reagent by mixing the dried substance with a suitable liquid reconstitution agent.

Other areas where separate provision and storage of dry powder and associated solvent common are pharmaceutical or cosmetic compositions and foods which would also have poor stability in the liquid state.

The conventional method of reconstitution is laborious and time consuming for the user. In addition, there is a risk that the user will use a wrong reconstitution agent, that a wrong volume of reconstitution agent will be used, or that contamination will be caused. Such errors can lead to increased variance in efficacy and, in the worst case, uselessness of the reconstituted liquid composition. Other sources of error in the reconstitution of lyophilized products, which can lead to the aforementioned disadvantages, are the various types of aids, such as filling aids, measuring cups, pipettes and pipette tips, which are used by the user during reconstitution.

Therefore, various devices and methods have been developed to ensure the separate storage of lyophilisates and liquid reconstitution media.

The DE 10011502 A1 describes a closure element for a reaction vessel. This closure element has a reservoir with a solid mixture, which is needed in a reaction. By placing the closure element on the reaction vessel and inverting the device, the solid mixture is mixed with the liquid sample contained in the reaction vessel. However, this device has the disadvantage that during mixing of the two components always a part of the solid mixture can remain in the reservoir, resulting in Differences in the concentration of the solid mixture in the sample can lead.

Moreover, from the WO 02102295 A2 a spike known, with the help of which liquid under pressure, in an ampoule containing a substance, can be introduced, without causing foaming. This spike is particularly intended for reconstitution of a lyophilized drug and thus designed so that only a minimum of reconstituted drug remains in the vial. However, the thorn has the disadvantage that the device in which he is in the WO 02102295 A2 Use is very complex and difficult to use.

In addition, in the WO 2007020239 A1 the structure of a container with two chambers for storage and combination of a solid lyophilisate and a reconstitution agent explained. The container includes a plug which separates the two chambers in the initial state. If the reconstitution is to take place, the plug is maneuvered into a recess in the container wall, creating a connection between the two chambers, which allows the reconstitution of the lyophilisate. Nevertheless, the plug is always in the way during the reconstitution reaction, so that the reaction can be comparatively tedious. In addition, there is no guarantee that the content of the two chambers will be completely mixed.

Therefore, a device would be of great advantage, allowing the mixing of a substance, preferably a dry powder, with a liquid medium to proceed rapidly, completely and without the use of additional aids, so that the substance subsequently has a defined concentration in the liquid medium is present. Furthermore, a less elaborate device would be advantageous, which can be produced more cost-effectively than known from the prior art devices.

In addition, a device would be useful that ensures easy and error-free handling.

An object of the present invention is to provide a device for storing and / or dosing a solvent which avoids the above-mentioned disadvantages.

In particular, it is an object of the present invention to provide a device for storing and / or dosing a solvent in which it is ensured that a substance is present after reconstitution with a solvent in a predetermined, reproducible concentration.

These objects are achieved with the features of the present set of claims.

1. a) einen Behälter, mit einem ersten Innenraum, der mit einer festgelegten Menge des Lösungsmittels befüllbar ist, sowie
2. b) eine Anbringeinrichtung zum Anbringen des Behälters an ein Gefäß mit einem zweiten Innenraum, in welchen das Lösungsmittel aus dem Behälter dosiert werden soll, sowie
3. c) ein Mittel zum Öffnen des Behälters, wodurch eine für das Lösungsmittel durchgängige Verbindung des ersten Innenraums des Behälters mit dem zweiten Innenraum des Gefäßes herstellbar ist,

aufweist.The present invention relates to a device for storing and / or dosing a solvent, which

1. a) a container having a first internal space which can be filled with a predetermined amount of the solvent, and
2. b) an attachment device for attaching the container to a vessel having a second interior, in which the solvent is to be dispensed from the container, and
3. c) a means for opening the container, whereby a solvent-continuous connection of the first interior of the container with the second interior of the vessel can be produced,

having.

The term "solvent" is intended below to denote a liquid for dissolving, dispersing or mixing a substance. In particular, it may be meant a reconstitution agent for a lyophilizate, such as. As distilled water, deionized water, buffer solutions, salt solutions or other suitable liquids.

The term "substance" is intended below to designate a substance in a storable state, for example, as a liquid, as a gel or as a solid, for. As a powder, as crystals or as a lyophilisate, is present, but still brought for its intended purpose in contact with a solvent, so it must be reconstituted. The term "reconstitution" is to be understood broadly within the meaning of the present invention and comprises contacting a solvent with a solid, gelatinous or liquid substance.

The term "container" is intended below to designate a device with an interior, which is suitable for receiving and storing a solvent. In the state of use, the interior of the container is filled with the solvent and hermetically sealed. In a preferred embodiment, in the interior of the container further comprises a gas bubble, which causes an overpressure relative to the pressure in the vessel in which the solvent is to be metered. This has the advantage that the solvent is sucked to a certain extent from the container after opening the container, whereby a maximum emptying of the container is ensured. In this embodiment, the interior of the container preferably has no angular, but rounded corners or edges in order to avoid adherence of solvent residues.

In one embodiment of the container, the inner surface of the container forms the boundary of the interior. The container is preferably made of a plastic material, for. B. of polyethylene terephthalate (PET). Preferably, the container is made of a transparent material so that the user can control the filling and emptying of the container. In another embodiment, the container comprises a first outer container as a housing and a second inner container, for. B. a thin-walled plastic bag, wherein the inner surface of the inner container forms the boundary of the interior.

Preferably, the inner surface of the interior of the container has liquid-repellent, preferably hydrophobic properties. This causes the solvent to bead when emptying the container, leaving no residual solvent in the container. This in turn ensures a precise dosage of the solvent and the production of a defined concentration of the substance in the solvent.

In one possible embodiment, the container for the solvent is a threaded bottle made of plastic or glass.

The term "vessel" is intended below to designate a device with an interior for receiving and storage a substance, eg. As a lyophilisate, is suitable and in which the solvent for dissolving, dispersing or mixing, that is dosed to reconstitute the substance from the container. The term "vessel" includes in particular for chemical purposes suitable laboratory vessels, such. B. test tubes, reagent bottles, z. As glass, plastic, metal or porcelain, laboratory vessels with standard grinding etc.

The term "set amount" is intended to mean a defined amount in the following. It is important that the container of a device according to the invention is filled with a defined amount of a solvent and / or releases only a fixed amount, so that the substance is present in a desired concentration after reconstitution with the solvent.

The term "attachment device" is intended below to designate a device which allows the attachment of the container to a vessel. The term "attaching the container to a vessel" is to be understood broadly and includes, for. As well as the placement of the container "completely outside" or "completely inside" or "partially within" the vessel. Any type of arrangement is conceivable, as long as it is ensured that between the interior of the container with the solvent and the interior of the vessel with the storable substance a sealed against the environment compound is produced, so that the stored solvent in the container doses lossless in the vessel can be in order to come into contact with the substance stored therein. For this purpose, the attachment device of the device according to the invention comprises a first region for attachment to the container and a second region for attachment to the vessel.

In one embodiment, the attachment means consists of a single component, for example a resilient plug having an opening which is forced into the mouth of the vessel (see eg. Fig. 3 ). The lateral surfaces of the plug cause attachment to the vessel via the generated pressing pressure. The upper surface of the plug is shaped according to the type of the container with the solvent, so that the container can be positively connected to the plug.

In another embodiment, the portion of the attachment provided for attachment to the vessel comprises a profiled notch, e.g. As a thread, whereby a connection with high holding force with a vessel having a matching complementary notch, z. B. a mating thread, can be produced.

In another embodiment, the region of the attachment device, which is intended for attachment to the vessel, comprises a plug-in element of a plug connection, for. B. a pin, which also has a connection with high holding force with a vessel having a matching complementary plug-in element, for. B. a blind hole for the pin can be made.

In a further embodiment, the region of the attachment device, which is provided for attachment to the container, is formed so that a positive connection with a suitably shaped container can be produced. For example, a region of the attachment device can be sleeve-shaped or cuff-shaped, so that a precisely fitting container can be used.

Furthermore, the region of the attachment device, which is intended for attachment to the container, a profiled notch, for. As a thread, whereby a connection with high holding force with a container having a matching complementary notch, z. B. a mating thread, can be produced.

Furthermore, the region of the attachment device, which is provided for attachment to the container, a plug-in element of a connector, for. As a pin, which also has a connection with high holding force with a container having a matching complementary plug-in element, for. B. a blind hole for the pin can be made.

The attachment device may be formed in one piece. It may, for example, consist of a plastic which is shaped accordingly by means of an injection molding process. A one-piece attachment means in the form of a plug is preferably made of an elastic material, such. As cork, natural rubber or rubber. Further, the attachment means may be integrally molded but made of different materials. For example, the area of the attachment device, which serves to attach to the vessel, in the form of a plug, for. As rubber, be designed, and the area of the attachment device, which serves to attach to the container, in the form of a cuff, z. B. be made of plastic, so that a perfect fit container can be used. The various components may, for. B. be permanently connected by means of a welding process.

In one embodiment, the attachment device comprises further components, for example a seal. If the device according to the invention is such that the solvent has to pass out of the container through an opening in the attachment device in order to get into the vessel with the substance to be dissolved (see, for example, US Pat. Fig. 1 ), prevents a seal, z. B. in the form of a rubber ring, which rotates the opening in the applicator, the unwanted escape of solvent during dosing. When using a device according to the invention with a closed vessel, in which a negative pressure prevails, the seal further prevents that when opening the closure device of the vessel, the negative pressure in the vessel is compensated by the atmospheric pressure. This is advantageous because the solvent is sucked to a certain extent in the vessel after opening the container, whereby a maximum emptying of the container is ensured.

Another component of the attachment means may be a plug having an opening which is inserted into the opening of the vessel containing the substance to be dissolved. Such a plug as part of the attachment means may comprise a device for opening the container (see eg. Fig. 1 )

The term "means for opening the container" is to be understood broadly and is intended below to denote a means which is able to effect an opening of the container. The means for opening the container is such that it causes the opening of the container only when it is actuated, so that it is ensured that a continuous connection for the solvent of the interior of the container with the interior of the vessel only at the time in which a Solution or mixing of the substance with the solvent should really take place, is produced.

The means for opening the container may be a device which is arranged on the attachment device and / or on the container. Preferably, this is a device which is able to effect a perforation of the container, for example a mandrel, a hook or a piston. Preferably, this type of perforating device is actuated by a rotating, pushing or sliding mechanism. In a preferred embodiment, the opening device consists of a first part which is arranged on the container, for. B. a spur with a survey, and a second part which is arranged on the attachment device, for. B. a second survey, which represents a mechanical resistance for the first part (see eg. Fig. 4 ). Such an opening device can be actuated by rotation, or displacement, whereby the first part is partially separated from the container by the resistance of the second part at a predetermined breaking point and opens the container by perforation.

Alternatively, the means for opening the container consists of design features of the container (see eg. Fig. 6 ). For this purpose, the container is deformable by compressive force and also has a predetermined breaking point for the escape of the solvent. By exerting a compressive force on the container, for. B. by finger pressure, the internal pressure of the container is increased, so that the predetermined breaking point is damaged. As a result, a continuous connection of the interior of the container with the interior of the vessel is produced for the solvent.

In a preferred embodiment, the means for opening the container further comprises constructive features of the attachment device (see eg. Fig. 6 ). For this purpose, the attachment device is such that it optimally influences the deformation of the container, for. B. characterized in that the region of the attachment device, which serves to attach to the container, particularly flexible or particularly rigid portions.

In one embodiment of the device according to the invention for storing and / or dosing a solvent, the device further comprises a vessel having an interior in which the solvent from the container can be metered. In the interior of the vessel is a substance to be brought into contact with the solvent, for. B. a lyophilisate.

The device according to the invention is suitable for dosing a solvent in many types of vessels.

Particularly desirable is the use of the device according to the invention for dosing a solvent in vessels that are initially closed and the z. B. contain a lyophilisate. Such vessels are usually hermetic with a closure device, usually with a rubber stopper, d. H. hermetically sealed. Often there is a negative pressure in these vessels.

In one embodiment of the device according to the invention for storing and / or dosing a solvent, the device therefore also has a means for opening the closure device of the vessel. This allows the dosage of a solvent in a vessel with a substance, without the vessel previously in a separate Work step must be opened. This has the advantage that a contact of the vessel opening with the fingers or other manipulation aids is avoided, whereby a potentially problematic handling of the vessel during opening is eliminated and thus the risk of contamination is reduced.

The means for opening the closure device of the vessel is such that it causes the opening of the closure device of the vessel only when it is actuated, so that it is ensured that a continuous connection for the solvent of the interior of the container with the interior of the vessel to the first Time, in which a solution or mixing of the substance with the solvent should really take place, is produced.

The means for opening the closure device of the vessel may be a device which is arranged on the attachment device. Preferably, this is a device that is able to effect a perforation of the closure device of the vessel, for example a mandrel, a hook or a piston. Another means for opening the closure device of the vessel consists of an adaptation of the container in the region of the container, which faces the closure device of the vessel and can be brought into contact therewith. The mouth region of the container can be configured as a perforation device, for example, by the fact that the mouth region is pointed or edged and has sufficient strength, for. Example by reinforcement with a shock-resistant material (see, eg. Fig. 7C ). Preferably, such perforating devices are actuated by a rotating, pushing or sliding mechanism. In a preferred Embodiment, the opening device for opening the closure device of the vessel forms a unit with the opening device for opening the container and is operated synchronously and by means of the same rotating, pushing or sliding mechanism as the opening device for opening the container (see, for example, US Pat. Fig. 8 ). This has the advantage that both the solvent in the container and the substance in the vessel are stored in different, hermetically sealed interiors until the time of reconstitution. Alternatively, the means for opening the closure device of the vessel acts independently of the means for opening the container. For example, independent operation may be achieved by opening the device to a vessel and opening the closure device of the vessel by means of a perforating device provided on the attachment device by rotating or pushing the device, while opening the container at a later time when the device is in operation Reconstitution is carried out, for example, by exerting a compressive force on the container, so that the predetermined breaking point of the container is damaged.

In a preferred embodiment, the device according to the invention comprises a container with a solvent, an attachment device for attaching the container to the vessel and means for opening the container, and further comprising means for opening the closure device of the vessel and a seal on a vessel contains a lyophilized substance and which is hermetically sealed with a closure device, preferably a rubber stopper. Only when the substance is to be brought into contact with the solvent, by operating the opening means a continuous connection of the interior of the container made with the interior of the vessel. After a possible incubation period, the substance is ready for use and can be removed from the vessel. If not all of the ready-to-use substance is to be used immediately, the container may be resealed and stored after removal of a portion of the ready-to-use substance, preferably with the device of the invention.

Preferably, a vessel containing a substance may be provided together with a device of the invention containing a suitable solvent for the substance in a test kit for use in an analytical procedure. Another object of the present invention is therefore a test kit containing a device according to the invention for storing and / or dosing a solvent and a vessel into which the solvent is metered and which contains a substance to be dissolved. The vessel and the device can either already be arranged in one unit in the test kit or can be present separately.

The device according to the invention has the advantage that the user does not need pipetting tools and does not have to dose the solvent himself. The use of the device allows the user to quickly and safely provide a ready-to-use substance of defined concentration. The concentration deviations between different reconstitution processes of arrangements comprising a device according to the invention and a laboratory vessel of the same type are preferably ≦ 1%. Thus, application errors due to inaccurate solvent dosing or incorrect solvent selection are excluded.

figure description

• FIG. 1
  Fig. 1 shows a schematic representation of a cross section of an embodiment of the device 100 according to the invention, which is applied to a laboratory vessel 101 containing a substance 102. In this example, the device according to the invention comprises a container 104 having an interior space and a thin-walled location 108 which is filled with a fixed amount of a solvent 105 and has a gas bubble 106. The device according to the invention further comprises an attachment device 103 for attaching the container 104 to the vessel 101, which has a first region 109 for attachment to the container and a second region 110 for attachment to the vessel. Furthermore, the attachment device 103 comprises a plug 111 with an opening 112 and a seal 113. An opening device 107 for the container 104 is provided on the plug 111, here a hook. This figure shows the device according to the invention during storage of the solvent z. B. as part of a test kit.
• FIG. 2
  Fig. 2 shows a schematic representation of a cross section of the preferred embodiment of the device 100 according to the invention Fig. 1 (here 200) after operation of the opening means 207 and during the dissolving or mixing operation between the solvent 205 and the substance 202. The thin-walled portion 208 of the container has been pierced by the opening means 207, here the hook. The opening of the container is preferably effected by the attachment means 203 forming a unit with the container 204 which is movable with respect to the plug 211 with the opening means 207.
  Preferably, the vessel 201 is a threaded bottle, and the portion 210 of the attachment means 203 for attachment to the vessel has a corresponding mating thread. By rotation of the unit of attachment 203 and container 204 relative to the immovable plug 211 with the opening device 207, there is a break through the thin-walled portion 208 of the container 204, whereby a solvent-continuous connection of the interior of the container 204 with the interior of the vessel 201, and the solvent 205 may flow into the vessel 201.
  In an alternative embodiment, the attachment device 203 and the laboratory vessel 201 are firmly connected to each other. If this is the case, the container 204 is replaced by z. B. a rotational, sliding, or pushing movement relative to the attachment device 203 and the laboratory vessel 201 is moved so that the opening device 207 is triggered.
• FIG. 3
  Fig. 3 shows a schematic representation of a cross section of an alternative embodiment of the device 300 according to the invention, which is applied to a laboratory vessel 301 containing a substance 302. In this example, the attachment means 303 consists of a plug 311 having an opening 312 which is pressed into the opening of the vessel. The lateral surfaces of the stopper 311 cause the attachment to the vessel 301 via the generated pressing pressure. The upper surface of the stopper 311 is shaped in accordance with the type of the container 304 with the solvent, so that the container is positively connected to the stopper. At the plug 311 is an opening means 307 for the Container, here a hook, attached. In this embodiment, the attachment device 303 and the laboratory vessel 301 are firmly connected to each other. To initiate the dosing of the container 304 by z. B. a rotary, sliding, or pushing movement relative to the attachment device 303 and the laboratory vessel 301 is moved so that the opening device 307 is triggered. The thin-walled portion 308 of the container 304 is pierced, whereby a continuous connection for the solvent 305 of the interior of the container 304 is made with the interior of the vessel 301.
• FIG. 4
  Fig. 4 shows a schematic representation of a preferred embodiment of a means for opening 440 of a container, which is arranged on the attachment device 443 and the container 444. In this example, the opening device 440 consists of a first part, here a spur 441 with a protrusion 442, which is arranged in the vicinity of the thin-walled portion 445 on the container 444 and a second part 446, here a survey, which is arranged on the attachment device 443 and is a mechanical resistance for the first part, the spur 441 with the survey 442 represents. The attachment device 443 sits on the laboratory vessel (not shown) and comprises an opening 447. If the container 444 is rotated counterclockwise (see arrow direction) by a quarter turn, the survey 442 abuts against the survey 446 and breaks away towards the center. In this case, the thin-walled region 445 is pierced by the spur 441 and the solvent can pass from the container through the opening 447 into the laboratory vessel.
• FIG. 5
  Fig. 5 shows a schematic representation of a cross section of a further alternative embodiment of the device 500 according to the invention. The device 500 is applied to a laboratory vessel 501 containing a substance 502. In this example, the apparatus 500 has an opening device 507 with a breaker 514 and an opening mechanism 515. The device 500 forms the lid of the laboratory vessel 501. In addition, the device 500 comprises a container 504 comprising a thin-walled body 508, a solvent 505 and a gas bubble 506.
  In this example, the container is arranged by the attachment device in the laboratory vessel, so that in this example, the attachment device is disposed at least during the dosing of the container.
  In this embodiment, the container 504 is preferably placed on the laboratory vessel 501 under negative pressure relative to the gas bubble 506 together with the attachment device 503. The opening mechanism 515, in this example, acts on the opener 514 by pressure or rotary motion so as to break through the thin-walled location 508.
• FIG. 6
  Fig. 6 shows a schematic representation of a cross section of another alternative embodiment of the device 600 according to the invention. The device 600 is applied to a laboratory vessel 601 containing a substance 602. In this example, the attachment means 603 comprises a plug 611 having a flexible location 614, an opening, and a sealing lip 617. In addition, the device 600 comprises a container 604, comprising an inner container 618, here a thin-walled plastic bag, a predetermined breaking point 616, a solvent 605 and a pressure point 615.
  Fig. 6A shows the state before operating the opening mechanism while Fig. 6B shows the state during or after the reconstitution of the substance 602 by the solvent 605.
  By pressing on the pressure point 615 on the container 604 a deformation in the region of the flexible portion 614 of the plug 611 is effected, and the upper part of the container 604 inverts down ( Fig. 6B ). Due to the increased internal pressure, the inner container 618 breaks in the region of the predetermined breaking point 616, and the solvent 605 is metered into the laboratory vessel 601. If a vacuum prevails in the laboratory vessel 601 relative to the ambient pressure, this step can take place in the closed state. In this embodiment, the pressure point 615, the flexible location 614 and the predetermined breaking point 616 form the means for opening the container.
  The sealing lip 617 causes the substance 602 during storage or later in the ready-to-use state to come into contact only with the material of the plug 611 and not with the container 604, the inner container 618 or the predetermined breaking point 616.
• FIG. 7
  Fig. 7 shows schematic representations of cross sections of further alternative embodiment of parts of the device according to the invention.
  Figs. 7A and B show schematic representations of cross sections of a stoppered with a plug 719 vessel 701, here a threaded bottle for the Lyophilization, with a lyophilized substance 702. Such prior art lyophilization containers are suitable for use with a device according to the invention.
  Fig. 7A shows the state before or during lyophilization. At this time, the threaded bottle 701 is only partially closed with the plug 719. Since the stopper 719 is pressed only about halfway into the vessel opening, the groove-shaped recesses 720 in the stopper 719 allow the gas exchange between the vessel interior and the environment during the lyophilization.
  Fig. 7B shows the state after freeze-drying. After completion of the lyophilization, the plug 719 is pressed completely onto the threaded bottle 701 under vacuum, whereby the groove-shaped recesses 720 are closed and the lyophilized substance 702 remains airtight under vacuum.
  Fig. 7C shows a schematic representation of a cross section of another alternative embodiment of the device 700 according to the invention. In this embodiment, the device comprises an attachment device 703, here a screw cap with a central opening, a container 704, comprising an inner container 718, here a thin-walled plastic bag. The inner container 718 contains a solvent 705 and optionally a gas bubble and has a predetermined breaking point 716, a pressure point 715 and a perforation device 721, in this case the pointed, impact-resistant mouth region of the container 704. The perforation device 721 is the means for opening the closure device of the vessel, here the plug 719.
  In this embodiment, the pressure point 715, the flexible location 714 and the predetermined breaking point 716 form the means for opening the container.
  Figs. 7D and 7E show schematic representations of cross sections of the embodiment of the device 700 according to the invention, which in Fig. 7C is described.
  The device 700 is screwed onto a vessel 701 containing a substance 702.
  Fig. 7D shows the state before operating the opening mechanism while Fig. 7E shows the state during or after the reconstitution of the substance 702 by the solvent 705.
  In this example, the device 700 according to the invention can be applied by initially incomplete screwing onto the vessel 701 and stored therewith ( Fig. 7D ). At the time that the reconstitution is to take place, the device is screwed completely onto the vessel, whereby the perforation device 721, in this case the pointed, impact-resistant mouth region of the container 704, pierces the closure device of the vessel 701, here the stopper 719.
  The means for opening the container is actuated independently of the device for opening the vessel. By pressing on the pressure point 715 on the container 704 a deformation in the region of the flexible location 714 of the attachment device 703 is effected, and the upper part of the container 704 inverts downwards ( Fig. 7E ). Due to the increased internal pressure, the inner container 718 breaks in the region of the predetermined breaking point 716, and the solvent 705 is metered into the vessel 701. prevails In the laboratory vessel 701 a negative pressure, this step can take place in the closed state. In this embodiment, the pressure point 715, the flexible location 714 and the predetermined breaking point 716 form the means for opening the container.
  The device 700 may be unscrewed after reconstitution. The substance 702 is now ready to use in the threaded bottle 701 before. To get to the ready-to-use substance, pipette through the opening of the stopper 719. Thus, the ready-to-use substance is largely protected against evaporation even if the attachment device 703 has been removed. Unless the ready-to-use substance is consumed at once, the device 700 is suitable for resealing the threaded bottle 701.
• FIG. 8
  Fig. 8 2 shows schematic representations of cross sections of a further, alternative embodiment of the device 800 according to the invention (FIG. Fig. 8A ).
  Fig. 8A shows a device 800 according to the invention, comprising an attachment device 803, the region 810, which is provided for attachment to the vessel, preferably has a thread. The portion 809 of the attachment 803 provided for attachment to the container is suitably configured for a container 804. The container 804 comprises an inner container 818, here a thin-walled plastic bag containing the solvent 805. The container 804 further comprises here a displacement unit 822, which is displaceable within the container and with which a uniform pressure on the inner container 818 can be exercised. The attachment device 803 further comprises an opening device 807, here a double-ended spur a holding element, for opening the container and for opening the closure device of a vessel. Deformable spacers 823, for example elastic elements made of rubber, are provided on the side of the opening device, which project beyond the double-end spur and prevent the opening mechanism from being prematurely released.
  Fig. 8B and 8C show schematic representations of cross sections of the embodiment of the device 800 according to the invention, which in Fig. 8A is described. The device 800 is preferably screw-capped onto a vessel 801 containing a substance 802. The vessel 801 is further closed with a closure device, here a stopper 819.
  Fig. 8B shows the state before operating the opening mechanism while Fig. 8C shows the state during or after the reconstitution of the substance 802 by the solvent 805.
  In this example, the device 800 according to the invention can be screwed onto the vessel 801 and stored with it ( Fig. 8B ), z. B. as part of a test kit. By the time the reconstitution is to take place, e.g. B. by vertical finger pressure on the displacement unit 822, the spacers 823 pushed together and the two-end spur opening means 807 pierces the inner container 818 and the closure device of the vessel, here the plug 819. Through this continuous connection between the inner container 818 and the interior of the vessel 801, the solvent 805 enter the vessel 801 and mix with the substance 802.

Preferably, there is a negative pressure in the interior of the hermetically sealed vessel 801. This favors the complete emptying of the inner container 818.

LIST OF REFERENCE NUMBERS

contraption

100, 200, 300, 500, 600, 700, 800

vessel

101, 201, 301, 501, 601, 701, 801

substance

102, 202, 302, 502, 602, 702, 802

attachment

103, 203, 303, 443, 503, 603, 703, 803

container

104, 204, 304, 444, 504, 604, 704, 804

solvent

105, 205, 305, 505, 605, 705, 805

gas bubble

106, 206, 306, 506

opening device

107, 207, 307, 507, 807

Thin-walled site

108, 208, 308, 508

Area of the attachment device for attachment to the container

109, 209, 809

Area of the attachment device for attachment to the vessel

110, 210, 810

Plug as part of the attachment

111, 211, 311, 611

Opening (in the stopper)

112, 212, 312

poetry

113, 213

Means for opening a container

440

spur

441

survey

442, 446

Thin-walled area

445

opening

447

opener

514

opening mechanism

515

Flexible job

614, 714

bruise

615, 715

Breaking point

616, 716

sealing lip

617

inner container

618, 718, 818

Plug (as vascular closure device)

719, 819

Grooved recess

720, 820

perforation

721

displacement unit

822

spacer

823

Claims (15)

Device (700, 800) for storing and / or dosing a solvent, comprising said device a) a container (704, 804), with a first interior, filled with a fixed amount of the solvent (705, 805), as well as b) an attachment device (703, 803) for attaching the container to a vessel (701, 801), which has a second interior, in which the solvent can be metered from the container, as well as c) means for opening the container, whereby a continuous connection for the solvent of the first interior of the container with the second interior of the vessel can be produced, and d) a means for opening a closure device of the vessel. Apparatus according to claim 1, characterized in that the container (704) contains a fixed amount of the solvent (705) and a gas bubble. Apparatus according to claim 1, characterized in that the container (704, 804) comprises a first outer container as a housing and a second inner container (718, 818), wherein the inner surface of the second inner container forms the boundary of the interior of the container, which can be filled with the solvent (705, 805). Device according to one of claims 1-3, characterized in that the region (809) of the attachment device, which is intended for attachment to the container (804), and / or the region (810) of the attachment device, which is suitable for fastening the vessel (801) is provided, having a profiled notch or a plug-in element of a plug connection. Device according to one of claims 1-4, characterized in that the attachment device additionally comprises a seal. Device according to one of claims 1-5, characterized in that the means (807) for opening the container to the attachment means and / or the container is arranged. Device according to one of claims 1-6, characterized in that the means (807) for opening the container is a device for perforating the container. Device according to one of claims 1-5, characterized in that the means for opening the container is formed of a compressible force deformable container (704) having a predetermined breaking point (716) for the escape of the solvent. Apparatus according to claim 8, characterized in that the means for opening the closure device of the vessel is a device (721, 807) for perforating the closure device. Device according to claim 9, characterized in that the device (721) for perforating the closure device is arranged on the container (704). Apparatus according to claim 9, characterized in that the device (807) for perforating the closure device forms a unit with the device for perforating the container. Apparatus (100, 200, 300, 500, 600, 700, 800) for storing and / or dosing a solvent, comprising said apparatus a) a container (104, 204, 304, 504, 604, 704, 804), having a first interior, fillable with a fixed amount of the solvent (105, 205, 305, 505, 605, 705, 805), as well as b) an attachment means (103, 203, 303, 503, 603, 703, 803) for attaching the container to a vessel (101, 201, 301, 501, 601, 701, 801) having a second interior, in which the solvent is metered from the container, as well c) means for opening the container, whereby a continuous connection for the solvent of the first interior of the container with the second interior of the vessel can be produced. Apparatus according to claim 12, characterized in that the attachment means (303) consists of a resilient plug (311) having an opening (312). Apparatus according to claim 12, characterized in that the region (110, 210) of the attachment means, which is intended for attachment to the vessel, a plug (111, 211, 611). Kit for a diagnostic test method comprising a device according to one of the preceding claims, which contains a defined amount of a solvent, and a vessel with a substance to be dissolved.

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