EP2361106A1 - Injecteur à unité cylindre-piston, et jupe de piston active, stérile en permanence - Google Patents

Injecteur à unité cylindre-piston, et jupe de piston active, stérile en permanence

Info

Publication number
EP2361106A1
EP2361106A1 EP09774630A EP09774630A EP2361106A1 EP 2361106 A1 EP2361106 A1 EP 2361106A1 EP 09774630 A EP09774630 A EP 09774630A EP 09774630 A EP09774630 A EP 09774630A EP 2361106 A1 EP2361106 A1 EP 2361106A1
Authority
EP
European Patent Office
Prior art keywords
piston
cylinder
sealing
injector
disposable injector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09774630A
Other languages
German (de)
English (en)
Inventor
Rudolf Matusch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of EP2361106A1 publication Critical patent/EP2361106A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion

Definitions

  • the invention relates to a disposable injector having at least one cylinder-piston unit whose piston is movable relative to the cylinder between two Hubendlagen, wherein the cylinder-piston unit comprises at least one compensating clearance against the environment sealing sealing system.
  • Such a disposable injector is known. When pumping, germs originating from the air could enter the cylinder interior.
  • the present invention is therefore based on the problem to develop a disposable injector, in which the above-mentioned disadvantage can not occur.
  • the sealing system for sterile sealing comprises a first and a second fixing area.
  • the cylinder or the piston carries both to each other at least about the piston stroke spaced fixing regions or the cylinder carries the first fixing region and the piston carries the second, relative to the first displaceable at least by the piston stroke Fixing and the piston has a waisted area.
  • FIG. 1 disposable injector with two-chamber system
  • FIG. 7 Detail of the cylinder-piston unit with empty cylinder
  • FIG. 8 disposable injector with a sealing bellows with the piston extended
  • FIG. 10 disposable injector with rolling bellows
  • FIG. 11 disposable injector with on the inside of the
  • FIG. 12 disposable injector with on the outside of the
  • FIGS. 1-5 show a disposable injector (4) and a two-chamber system (99) adapted to it.
  • FIG. 1 shows, for example, the delivery state to the user in which the disposable injector (4) is preloaded, the first chamber (105) is partially filled with solvent (1) and the second chamber (255) is partially filled with lyophilisate (2), for example both chambers (105, 255) are separated from each other.
  • the two chambers (105, 255) are connected together and prepared the injection solution.
  • FIG. 3 shows the disposable injector (4) and the two-chamber system (99) after production and pumping of the injection solution, and
  • FIG. 4 shows this injector (4) with the injector-side chamber (105) before triggering.
  • the needleless disposable injector (4) is triggered and the injection solution (3) is sprayed out.
  • the disposable injector (4) shown in FIGS. 1-5 comprises a housing (10), a piston-actuating punch (60) and a helical compression spring (50) as a spring-energy accumulator.
  • a trip unit (80) with a trigger element (82) and a Sich ceremoniesselernent (90) are arranged on the housing (10).
  • the housing (10) is a one-piece, cup-shaped, open-bottom hollow body with overhead floor (39). It is e.g. made of a glass fiber reinforced polyamide by injection molding.
  • the housing (10) has a substantially tubular shape and is divided into two functional areas, which are on the one hand, the upper cladding region (31) and on the other hand, the lower fixing region (41).
  • the housing (10) has, for example, two window-like openings (33) lying opposite one another.
  • a pressure rod (21) is formed as an elastic bending beam.
  • the molding Place for the printing bars (21) is just above the fixing area (41).
  • To form the respective pressure rod (21) is in the lower region of the jacket portion (31) has a narrow, at least approximately U-shaped gap surrounding the individual pressure rod (21) laterally and above.
  • the pressure rod (21) has, for example, 80% of its length, the wall thickness and the curvature of the wall of the housing (10). Among other things, this area also has the function of a spring-elastic bending beam (28). He has a crescent-shaped cross-section.
  • this bending beam (28) may also be provided with a rectangular cross section in order to reduce bending stresses occurring in use in the bending beam edge area.
  • the upper free end of the individual pressure rod (21) is formed by the radially outwardly projecting cam (22).
  • the latter has at least one support surface (23) oriented in the direction of the center line (5) and a contact surface (24) facing away from the center line (5).
  • the lower half of the housing (10) is surrounded by the sleeve-like trigger element (82).
  • This is, for example, substantially cylindrical and made, for example, of acrylonitrile-butadiene-styrene copolymer (ABS).
  • the trigger element (82) is mounted longitudinally displaceably on the radial outer surface (13) of the housing (10). It ends at the rear with a sharp edge (85), which is part of a front-side return edge (84) of the trigger element (82). Below the edge (85), according to FIG. 1, the cams (22) formed on the pressure rods (21) touch with their outer contact surfaces. Chen (24) securing the inner wall (59) of the trigger element (82).
  • a trigger cap (81) is fixed, which completely surrounds the rear end of the housing (10).
  • the trigger cap (81) comprises a circumferential widening (83), in which the cams (22) are received when the injector is triggered, cf. FIG. 5.
  • this widening (83) partial widenings or uncovered openings may also be present per push rod (21) in the case of a non-rotationally symmetrical triggering element (82).
  • the trigger cap (81) slidably abuts the outer wall (13) of the housing (10).
  • the in the housing (10) arranged piston actuating ram (60) is divided into two areas.
  • the lower area is the spool (76). Its diameter is slightly smaller than the inner diameter of the rear portion of the cylinder (101) of a cylinder-piston unit (100).
  • the lower end face (77) of the piston slide (76) acts directly on the piston (111) of this cylinder-piston unit (100).
  • the end face (77) and the piston back facing it are e.g. formed complementary and have at least approximately the same Kegeiwmkel.
  • the spool (76) and the piston (111) for example, a distance of 2 - 4 millimeters.
  • the upper region of the piston actuating punch (60), the stamping plate (73), is a flat, at least partially cylindrical disc whose outer diameter is a few tenths of a millimeter smaller than the inner diameter of the housing (10) in the jacket region (31).
  • the lower end face has a collar surface arranged around the piston slide (76). (75). It has the shape of a truncated cone whose tip angle is about 100 to 140 degrees. In the illustrated embodiment, the collar surface (75) has a point angle of 140 degrees.
  • the imaginary tip of the truncated cone sleeve lies on the center line (5) in the area of the piston slide (76).
  • the collar surface (75) may also be spherically curved.
  • piston slide (76) can also be designed as a separate component, separate from the stamping plate (73). For this purpose, it is then guided on the inner wall of the housing (10).
  • the helical compression spring (50) is prestressed.
  • the helical compression spring (50) is supported on the bottom (39) of the housing (10) via a spacer sleeve (19).
  • the spring force of the helical compression spring (50) is transmitted via the stamp plate (73) on the pressure rods (21). Due to the inclination of the collar surface (75), the pressure rods (21) are urged radially outward in the manner of a wedge gear.
  • the release sleeve (82) supports this radial force permanently.
  • the piston actuating ram (60) has a guide pin (62) above the stamping plate (73). The latter leads the
  • the fixing region (41) for receiving the installable cylinder-piston unit (100), which comprises the first chamber (105).
  • the fixing region (41) comprises, for example, eight spring hooks (42) aligned parallel to the center line (5).
  • the spring hooks (42) each have an at least two-sided rear handle (43) for play-free recording of the cylinder-piston unit (100).
  • the opposite flanks of the rear handle (43) include an angle of eg 90 degrees.
  • the length and the spring rate of the spring hooks (42) are dimensioned so that the cylinder-piston unit (100) without plastic deformation of the spring hook (42) can be installed.
  • the cylinder-piston unit (100) comprises a transparent cylinder (101) which can be filled with water for injection purposes (1) or an injection solution (3).
  • the water for injections (1) may already contain active substances.
  • the cylinder (101) is e.g. a clear, thick-walled pot whose possibly cylindrical outer wall carries a, for example, circumferential locking ring (102) which rests rigid against the edges of the rear grip (43) of the spring hook (42).
  • the cylinder (101) is made, for example, from the amorphous thermoplastic cycloolefin copolymer (COC). This material is almost impermeable to water vapor, which enables a permanent storage of the injection solution.
  • the rodless piston (111) sits in the cylindrical or conical bore of the cylinder (101), for example. This is produced, for example, from the Teflon® derivative tetrafluoroethylene / hexafluoroethylene copolymer (FEP).
  • FEP Teflon® derivative tetrafluoroethylene / hexafluoroethylene copolymer
  • the cylinder inner wall (109) has in the illustrations of Figures 1-5 two mutually longitudinally offset annular grooves (116, 117) in which a sterile closing sealing system (121) with two fixing regions (122, 123) superimposed.
  • the distance between the two annular grooves (116, 117) to each other in the embodiment is greater than the piston stroke.
  • the two fixation Regions (122, 123) in this embodiment are each part of a sterile closing sealing element (124, 125), for example of sealing rings, which rest against the piston (111).
  • the sealing elements (124, 125) can also be quad-rings, lip seals or other equivalent sealing elements.
  • the sealing elements (124, 125) of this two-part sealing system (121) may be glued to the cylinder.
  • the fixing portions (122, 123) may be held in the piston (111).
  • first fixing region (122) on the cylinder (101) and a second fixing region (123) on the piston (111).
  • the two fixing regions (122, 123) can then be displaced relative to one another by the piston stroke, without the active piston skirt being able to transport germs from the environment (9) into the cylinder interior (110).
  • FIG. 6 shows a detail of the disposable injector (4) shown in FIG.
  • the piston (111) sits the piston (111) in the extended stroke end position. Both sealing elements (124, 125) abut the piston (111) and close the cylinder interior (110) and the sealed section (118) sterile against the environment (9).
  • the cylinder (101) is widened between the two annular grooves (116, 117) so that even an unguided piston (111) can not touch the cylinder (101) in this area.
  • the piston is in the representation of Figure 6 in the sterile sealed portion (118) fitted.
  • the circumferentially waisted area (108) has a length which is approximately 25% of the piston area. velvet length corresponds.
  • the waisted region (108) has a diameter which is 16 to 20% smaller than the maximum inner diameter of the cylinder in the area of the solution-receiving cylinder interior (110).
  • the front transition which lies between the waisted area (108) and the front, ie here below lying, piston area, for example, has a cone angle of 35 to 40 degrees.
  • the other, rear transition has a cone angle between 35 and 90 degrees.
  • the upper end of the piston (111) in this illustration is, for example, conical above the sealing element (125).
  • the piston (111) has at its front, at least approximately conically shaped end face an axial annular groove (112) for receiving a sealing ring (114) or a permanently elastic sealant.
  • This sealing ring (114) separates a displacement chamber (134) from a compensation chamber (135) in the cylinder interior space (110).
  • the piston (111) has a e.g. central, truncated cone-shaped recess (115), in which a pump rod (140) by means of a tapered thread (141) is screwed.
  • the pump rod (140) can be released with little effort from the piston (111). Possibly.
  • a e.g. be embedded cylindrical metal plate in the rear end face of the piston (111).
  • the pump rod (140) has for coupling to the piston (111) at its lower end, for example, a conical pointed thread (141), a trapezoidal thread, etc.
  • the cone angle of the pointed thread (141) is eg six degrees.
  • the thread of the pointed thread (141) presses when screwing the pump rod (140) into the piston recess (115), the required mating thread.
  • the screwing-in process is ended, for example, when the front end of the pumping rod (140) contacts the bottom of the recess (115).
  • the described special threads (141) used for coupling purposes require only a small amount of screwing in and out. forces. Of course, other releasable couplings can be used, such as a key / keyhole system or a simple latching system.
  • the pumping rod (140) has over most of its length, e.g. a consistent cross-section and a smooth surface. Their largest diameter is about two millimeters in the embodiment. It is e.g. made of a glass fiber reinforced polyamide. At its rear end, which protrudes from the bore (87) of the trigger cap (81), it has e.g. two differently divided scales (148) and (149).
  • the scale (148) fits e.g. to a cylinder-piston unit (100), whose cylinder (101) has a mean inner diameter of seven millimeters, while the other scale (149) belongs to a cylinder (101) with six millimeters inner diameter.
  • the differently sized cylinders (101) can optionally be plugged into the injector (4).
  • FIGS. 2 and 7 show the piston (111) in the retracted position.
  • the rear end of the piston (111) has left the upper sealing element (125).
  • the upper widening (119) of the piston (111) now lies in the region of the lower sealing element (124).
  • the sealing system (121) still seals the cylinder interior (110) sterile.
  • the cylinder bottom of the contour of the front piston end face is at least approximately adjusted, there is a short cylindrical, nozzle-like bore (106). Its diameter is about 0.1 to 0.5 millimeters. This bore (106) is one to five times as long as its diameter. It ends in a cylindrical recess (107) of the bottom, outer end face (103) of the cylinder (101). This end face (103) can increase the application security are additionally provided with an adhesive ring (104).
  • the spring energy store (50) is a helical compression spring, which is arranged on the piston-actuating punch (60) with the stamping plate (73). By means of the stamping plate (73), the spring-loaded piston actuation plunger (60) is supported on the pressure rods (21) of the housing (10).
  • the piston actuating punch (60) is e.g. arranged so that it does not touch the piston, but with its lower end, e.g. is guided laterally in the upper region of the cylinder (101).
  • the piston actuating punch (60) has a e.g. central bore (63), which is crossed by the pump rod (140) with great play.
  • the upper half of the through hole (63) is largely cylindrical, while the lower half conically narrows downwards. In the area of the lower end face (77), the bore is only one to two tenths of a millimeter larger than the outer diameter of the pump rod (140).
  • a container adapter (200) in which the container (250) closed with a stopper (257) and partly filled with a lyophilisate (2) is arranged.
  • the container (250) is secured to the container adapter (200) via a cap (230) and a tear-off band (260).
  • a pierced double adapter (240) Between the container (250) and the cylinder (101) sits a pierced double adapter (240).
  • the first cylinder-piston unit (100) in the disposable injector (4) is inserted and locked.
  • the container adapter (200) is also inserted into the disposable injector (4).
  • the second cylinder (250) is inserted into the container area (221) and locked in the latching hook (223) facing away from the intermediate floor (211).
  • the plug (257) is closed. After that, the tamper-evident closures (90, 260) are attached.
  • the liquid (1) is to be pumped into the container (250).
  • the tear-off lug (261) is removed from the cap (230) by severing the perforation (262) and the cap (230) is pulled off the rear part of the container (250).
  • an elastic sealing ring which closes the gap between the container (250) and the inner wall of the container portion (221) sterile.
  • the container (250) is pushed into the container adapter (200).
  • the container (250) on the inner wall of the container adapter (200) slides forward until it rests with the flange edge (258) on the stops (225).
  • the container (250) has pushed the snap-action hooks (223) sideways and the opening (253) of the container (250) has been sealingly pushed over a circumferential land onto the container portion (245) of the dual adapter (240).
  • the container stopper (257) has been pushed inwards out of the opening (253), so that now the cylinder interior (110) and the container interior space (255) communicate via the through-channel (241).
  • the pump rod (140) is held to sensitive usually between the index finger and the thumb of the serving hand.
  • the piston (111) is pushed in, the sealed sterile section (118) of the piston (111) is moved into the cylinder interior (110). If, for example, germs have accumulated on the piston (111) of the cylinder-piston unit (100) during storage, this contamination is present after insertion of the piston (111), cf. FIG. 7, outside the sealing element (124) and thus outside the sealed cylinder interior (110).
  • the lyophilisate (2) dissolves in the liquid (1).
  • the dissolution process can be optically controlled because the container (250) protruding from the container adapter (200) is transparent.
  • the newly formed solution (3) is pumped back into the cylinder interior (110).
  • the injector is held so that the opening (253) of the container (250) points in the direction of gravity.
  • the piston (111) is pulled over the pump rod (140) in a rear position. Bubble-free filling is checked via the windows (206).
  • the tear-off banderole (94) is separated from the main part (92) and the adapter part (93) by means of the tear-off tab (95).
  • the grooves (57) of the trigger element (82) are visible.
  • the container adapter (200) is now pulled down from the cylinder (101), cf. FIG. 4.
  • the injector is placed on the injection site and the sleeve-like trigger element (82) down - pushed - in the direction of the injection site.
  • the pressure rods (21) bend elastically outward into their actual starting position. In this case, the cams (22) slip over the edge (85) outwards into the widening (83).
  • the now no longer deformed pressure rods (21) release the piston actuation plunger (60), so that the piston (111) under the action of the spring element (50) moves abruptly downwards for emptying the cylinder (101), cf. FIG. 5.
  • the piston friction decreases in the meantime since the sealing elements (124, 125) do not rest in a braking manner when passing through the waisted piston region (108).
  • Figures 8 and 9 show a disposable injector (4)
  • the sealing system (121) has two by means of a bellows (126), for example a bellows connected fixing regions (122, 123). Both fixing regions (122, 123) are each part of elastically deformable rings (127, 128).
  • the lower ring (127) located here in an annular groove (116) of the cylinder (101) and in this embodiment is applied to the piston (111).
  • the upper ring (128) is seated in an annular groove (113) of the piston (111).
  • the sealing system (121) covers the movement joint between the cylinder (101) and the piston (111) and thus hermetically seals the cylinder interior (110).
  • FIG. 8 shows the sealing system (121) when the piston (111) is extended and in FIG. 9 when the piston (111) is retracted.
  • the Ausretes syndromem (135) and thus the cylinder interior (110) is sterile against the environment (9) sealed and protected from any contamination.
  • FIGS. 8 and 9 The actuation of the disposable injector (4) shown in FIGS. 8 and 9 takes place as described in connection with the embodiment illustrated in FIGS. 1-7.
  • the bellows (126) can also be designed as a rolling bellows, cf. FIG. 10.
  • the cylinder-side fixing region (122) of the sealing system (121) can be held in an annular groove (139) on the outside of the cylinder (101).
  • the piston-side fixing region (123) of the sealing system (121) can, for example, dip into the cylinder (101). In the exemplary embodiment, this fixing region (123) is not in contact with the cylinder (101).
  • FIG. 11 shows a sealing system (121) with a bellows-type sealing element (129), which surrounds the end face of the piston (111) like a finger cot.
  • the cylinder-side fixing region (122) is part of an elastically deformable ring (127) which is in an annular groove (116) of the cylinder inner wall (109). sitting.
  • the sealing element (129) is not tensioned.
  • the upper piston end here has two circumferential grooves (131, 132) with, for example, identical cross-section.
  • the locking adapter (143) has on its inner surface e.g. on two levels segmented or circumferentially arranged elevations (145, 146).
  • the lower elevations (145) are in this case e.g. shallower than the upper, to facilitate a complete sliding of the locking adapter (143) on the piston (111) during assembly.
  • the piston (111) only one groove (131; 132) and the locking adapter (143) only one level of elevations (145; 146) have.
  • the pumping of the liquids takes place as described above.
  • the e.g. firmly connected to the locking adapter (143) connected pump rod (140) remains after pumping in the housing (10).
  • the pump rod (140) and the locking adapter (143) connected to a coupling the pump rod (140) can be removed after pumping.
  • the piston-actuating ram (60) strikes the ratchet adapter (143) with, for example, the flat end face (77) of the piston slide (76). Slide the piston (111) for pushing out the injection solution (3) forward of its end face (144).
  • the disposable injector (4) shown in FIG. 12 has the same structure as the exemplary embodiment according to FIG. 11.
  • the cylinder-side fixing region (123) of the one-piece sealing system (121) is fastened to the outside of the cylinder (101) in an annular groove (139) ,
  • the sealing system (121) by means of the locking adapter (143) is fixed.
  • the pumping rod (140) is constructed as described in connection with FIG. The pumping and triggering takes place as in the previously described embodiment. After release, the piston (111) strikes into its retracted stroke end position, whereby the piston movement only experiences a very low frictional resistance.
  • the disposable injector (4) can also be designed without a pump rod (140).
  • the second container (250) is designed as a second cylinder-piston unit.
  • the sterility of the cylinder interior (110) is ensured even with a multiple pumping over.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un injecteur unidirectionnel comprenant au moins une unité cylindre-piston (160), dont le piston est déplaçable par rapport au cylindre entre deux positions de fin de course, l'unité cylindre-piston comprenant au moins un système d'étanchéité (121) rendant étanche une chambre de compensation (135) vis-à-vis de l'environnement. En outre, le système d'étanchéité comprend, en vue d'obtenir une étanchéité stérile, une première zone de fixation (121) et une seconde zone de fixation (122). Le cylindre (101) ou le piston (111) porte deux zones de fixation distantes entre elles d'au moins la course du piston, ou bien le cylindre porte la première zone de fixation, et le piston porte la seconde de fixation, déplaçable de la première, d'au moins la course du piston.
EP09774630A 2008-12-17 2009-12-03 Injecteur à unité cylindre-piston, et jupe de piston active, stérile en permanence Withdrawn EP2361106A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008062405A DE102008062405A1 (de) 2008-12-17 2008-12-17 Injektor mit Zylinder-Kolben-Einheit und dauerhaft sterilem aktiven Kolbenhemd
PCT/EP2009/008611 WO2010075929A1 (fr) 2008-12-17 2009-12-03 Injecteur à unité cylindre-piston, et jupe de piston active, stérile en permanence

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EP2361106A1 true EP2361106A1 (fr) 2011-08-31

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US (1) US8394069B2 (fr)
EP (1) EP2361106A1 (fr)
JP (1) JP5726749B2 (fr)
DE (1) DE102008062405A1 (fr)
WO (1) WO2010075929A1 (fr)

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Publication number Publication date
JP5726749B2 (ja) 2015-06-03
WO2010075929A1 (fr) 2010-07-08
US20110238015A1 (en) 2011-09-29
US8394069B2 (en) 2013-03-12
JP2012511975A (ja) 2012-05-31
DE102008062405A1 (de) 2010-11-18

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