EP2323482A4 - Substituierte dihydroisochinolinon- und isochinolindionderivate als calciumkanalblocker - Google Patents

Substituierte dihydroisochinolinon- und isochinolindionderivate als calciumkanalblocker

Info

Publication number
EP2323482A4
EP2323482A4 EP09805358A EP09805358A EP2323482A4 EP 2323482 A4 EP2323482 A4 EP 2323482A4 EP 09805358 A EP09805358 A EP 09805358A EP 09805358 A EP09805358 A EP 09805358A EP 2323482 A4 EP2323482 A4 EP 2323482A4
Authority
EP
European Patent Office
Prior art keywords
isoquinolinedione
derivatives
calcium channel
channel blockers
dihydroisoquinolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09805358A
Other languages
English (en)
French (fr)
Other versions
EP2323482A1 (de
Inventor
Joseph L Duffy
Scott B Hoyt
Clare London
Christian P Stevenson
Andrew M Ullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP2323482A1 publication Critical patent/EP2323482A1/de
Publication of EP2323482A4 publication Critical patent/EP2323482A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
EP09805358A 2008-08-06 2009-07-27 Substituierte dihydroisochinolinon- und isochinolindionderivate als calciumkanalblocker Withdrawn EP2323482A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18812808P 2008-08-06 2008-08-06
PCT/US2009/051787 WO2010017048A1 (en) 2008-08-06 2009-07-27 Substituted dihydroisoquinolinone and isoquinolinedione derivatives as calcium channel blockers

Publications (2)

Publication Number Publication Date
EP2323482A1 EP2323482A1 (de) 2011-05-25
EP2323482A4 true EP2323482A4 (de) 2011-08-17

Family

ID=41663936

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09805358A Withdrawn EP2323482A4 (de) 2008-08-06 2009-07-27 Substituierte dihydroisochinolinon- und isochinolindionderivate als calciumkanalblocker

Country Status (6)

Country Link
US (1) US20110136842A1 (de)
EP (1) EP2323482A4 (de)
JP (1) JP2011530512A (de)
AU (1) AU2009279937A1 (de)
CA (1) CA2732757A1 (de)
WO (1) WO2010017048A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173395B2 (en) 2011-07-04 2015-11-03 Bayer Intellectual Property Gmbh Use of substituted isoquinolinones, isoquinolindiones, isoquinolintriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants
CA2886097C (en) * 2012-09-27 2020-07-14 Quincy Bioscience, Llc Methods for alleviating symptoms of multiple sclerosis based on apoaequorin-containing compositions
CN107074856A (zh) 2014-09-05 2017-08-18 阿略斯泰罗斯医疗公司 CaMKII抑制剂及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133459A1 (en) * 2005-06-09 2006-12-14 Vertex Pharmaceuticals Incorporated Indane derivatives as modulators of ion channels
US20070203130A1 (en) * 2005-09-09 2007-08-30 Timothy Neubert Bicyclic derivatives as modulators of voltage gated ion channels
WO2009045381A1 (en) * 2007-10-04 2009-04-09 Merck & Co., Inc. N-substituted oxindoline derivatives as calcium channel blockers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107165A (en) * 1970-01-06 1978-08-15 Endo Laboratories Tris[tetrahydroisoquinoline] compounds
HU167263B (de) * 1973-02-12 1975-09-27
DE3614000A1 (de) * 1986-04-25 1987-10-29 Boehringer Mannheim Gmbh Neue isochinolindione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU202842B (en) * 1988-01-27 1991-04-29 May & Baker Ltd Process for producing new isoquinolinone derivatives and pharmaceutical compositions containing them
AU2003250466A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3-isoquinolinone derivatives as matrix metalloproteinase inhiitors
EA019833B1 (ru) * 2007-01-22 2014-06-30 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006133459A1 (en) * 2005-06-09 2006-12-14 Vertex Pharmaceuticals Incorporated Indane derivatives as modulators of ion channels
US20070203130A1 (en) * 2005-09-09 2007-08-30 Timothy Neubert Bicyclic derivatives as modulators of voltage gated ion channels
WO2009045381A1 (en) * 2007-10-04 2009-04-09 Merck & Co., Inc. N-substituted oxindoline derivatives as calcium channel blockers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2010017048A1 *

Also Published As

Publication number Publication date
CA2732757A1 (en) 2010-02-11
AU2009279937A1 (en) 2010-02-11
US20110136842A1 (en) 2011-06-09
JP2011530512A (ja) 2011-12-22
WO2010017048A1 (en) 2010-02-11
EP2323482A1 (de) 2011-05-25

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Legal Events

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