EP2307837A2 - Method for producing a multilayer compound on a cip-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities - Google Patents
Method for producing a multilayer compound on a cip-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavitiesInfo
- Publication number
- EP2307837A2 EP2307837A2 EP09777292A EP09777292A EP2307837A2 EP 2307837 A2 EP2307837 A2 EP 2307837A2 EP 09777292 A EP09777292 A EP 09777292A EP 09777292 A EP09777292 A EP 09777292A EP 2307837 A2 EP2307837 A2 EP 2307837A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- drying oven
- designed
- drying
- multilayer compound
- carrier material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 38
- 238000000576 coating method Methods 0.000 title claims abstract description 20
- 239000011248 coating agent Substances 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 238000009434 installation Methods 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000001035 drying Methods 0.000 claims abstract description 71
- 238000004140 cleaning Methods 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 239000012876 carrier material Substances 0.000 claims abstract description 13
- 239000002131 composite material Substances 0.000 claims description 28
- 239000000463 material Substances 0.000 claims description 9
- 239000007921 spray Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 235000012431 wafers Nutrition 0.000 claims description 4
- 229940100640 transdermal system Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000000356 contaminant Substances 0.000 claims description 2
- 230000008021 deposition Effects 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000001727 glucose Nutrition 0.000 claims description 2
- 229930195712 glutamate Natural products 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000004745 nonwoven fabric Substances 0.000 claims description 2
- 239000002985 plastic film Substances 0.000 claims description 2
- 229920006255 plastic film Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 150000003397 sorbic acid derivatives Chemical class 0.000 claims description 2
- 229920002994 synthetic fiber Polymers 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 239000002759 woven fabric Substances 0.000 claims description 2
- 239000012991 xanthate Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000005507 spraying Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B13/00—Machines and apparatus for drying fabrics, fibres, yarns, or other materials in long lengths, with progressive movement
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B13/00—Machines and apparatus for drying fabrics, fibres, yarns, or other materials in long lengths, with progressive movement
- F26B13/10—Arrangements for feeding, heating or supporting materials; Controlling movement, tension or position of materials
- F26B13/14—Rollers, drums, cylinders; Arrangement of drives, supports, bearings, cleaning
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/02—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/02—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure
- F26B21/022—Circulating air or gases in closed cycles, e.g. wholly within the drying enclosure with provisions for changing the drying gas flow pattern, e.g. by reversing gas flow, by moving the materials or objects through subsequent compartments, at least two of which have a different direction of gas flow
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
Definitions
- the present invention relates to a production method for a multi-layer composite, in which first one or more layers are applied to a carrier material by coating with a liquid component, after which the coated multilayer composite is dried and then the dried multilayer composite is rolled up.
- the last step in the process is the cleaning of the plant, which is carried out according to the invention by means of a CIP system, d. H. a system integrated in the system that enables a "cleaning-in-place".
- the invention also relates to the use of the multilayer composite produced by the process according to the invention as a transdermal system for the application of pharmaceutical agents and the application of z.
- cosmetic agents cosmetic agents, pharmaceutical agents, dietary supplements or medical devices in body cavities.
- Transdermal systems and wafers are made from sheet-like materials, and the manufacture of the sheet-like materials involves several sequential steps such as coating, drying and reeling on rolls. They are described, for example, in WO 03/61635.
- the actual process of production is usually followed by the cleaning of the plant during operation. The plant should namely be ready for use as quickly as possible to produce another, new recipe to avoid uneconomic downtime. Furthermore, the cleaning process should be validatable safely.
- the coating step one or more liquid components are applied to a substrate by means of a coater.
- the subsequently coated multi-layer composite still contains a relatively high proportion to liquid that is normally removed by heat in the next step.
- the finished coated multi-layer composite is therefore fed to dry a drying oven, which is preferably operated in a continuous mode.
- the drying oven may comprise one or more drying zones.
- the individual drying zones differ in their different temperatures and air volumes.
- each drying zone should have its own air control, which usually also incorporates filter and heating elements.
- the effect of the heat in the drying oven on the coated multi-layer composite the moisture from the coated multi-layer composite enters the air flow.
- dry fresh air In order to keep the humidity in the air circulation stable, dry fresh air must be supplied, with which the used moist air is replaced. Fluctuations in the humidity in the fresh air supply have an immediate effect on the efficiency of the drying and indirectly on the quality characteristics of the finished product, which should not be too moist, but also not too dry.
- the dried multilayer composite emerging from the drying oven is immediately wound on rolls.
- the drying of the coated multi-layer composite should be optimally adjusted to the requirements of transdermal application systems or wafers, including the fact that the drying oven has several drying zones with controllable air flow, whereby a precise and individual regulation of the air humidity must be ensured at all times in the individual drying zones.
- This object is achieved by a method of the type mentioned, the characteristics of which are to be seen in that during the drying of the coated multilayer composite in the drying oven, the air circulation is completely adjusted to fresh air supply and that the interior of the drying oven is controlled cleanable.
- a carrier material for the multilayer composite are web-like materials such as paper webs or textile webs in the form of woven or nonwoven fabrics of natural or artificial fibers, but it can also be used plastic films, which may optionally be provided with holes.
- Suitable liquid components for the coating of the support material for the process according to the invention are essentially organic raw materials mixed with water and / or organic solvents. Even mixtures of organic raw materials that are water-soluble or suspendable in water, are ideal. Examples of such organic raw materials are polymers such as polyvinyl alcohol, polyvinylpyrrolidone, cellulose derivatives, polyvinyl acetate, polyethylene glycol, alginates, xanthates, gelatin and other more or less water-soluble polymers known to the person skilled in the art. If desired, the liquid components may contain other fillers such as mannitol, lactose, calcium phosphates, glucose or sorbic acid derivatives. Also suitable are additives of active Substances such as medicines, flavors, menthol, glutamate and other additives, sometimes volatile.
- the coating of the carrier material with one or more liquid components is carried out according to the invention by conventional application techniques.
- the liquid components can be applied to the substrate z. B. poured, with the help of rollers or with other, the expert known in the art processes are applied.
- the drying oven used for the process according to the invention preferably has at least two, more preferably up to fourteen, drying zones in which the air circuit is completely set to fresh air supply.
- the supply air nozzles are designed so that they lent in each drying zone a uniform ventilation of the entire surface of the present in the respective drying zone coated multi-layer composite with the conditioned fresh air flow.
- Each individual drying zone in the drying oven has a conditioning of the supplied fresh air flow which can be regulated independently of all other drying zones. This ensures that the optimum drying conditions can be precisely set in each drying zone via the air volume, the air temperature and the humidity.
- the drying oven used for the process according to the invention is preferably designed so that its entire interior can be cleaned in a controlled manner and easily accessible. This means in particular that all components of the drying oven, which can come into contact with the product produced therein, need not be removed for the purpose of cleaning, but can be cleaned with the help of integrated in the drying oven system in CIP technology.
- the outer housing of the drying oven is designed so that the upper part of the drying oven can be lifted upwards, so as to ensure easy accessibility for the upper and lower part of the drying oven. This serves to control the cleaning success of the CIP technique. All built-in parts inside the drying oven are designed in such a way that disassembly for cleaning purposes is not necessary.
- the interior of the drying oven is executed dead space free. This means that any corners and niches that might be considered for the deposition of possible impurities do not occur through appropriate technical design or, if so, are then shielded against ingress of contaminants by suitable cover elements.
- All transport rollers with which the coated multi-layer composite is moved through the drying oven and the various drying zones are preferably designed as hollow shafts and equipped with spray nozzles. When connected to a high-pressure pump, this enables very fast cleaning of these transport rollers from the inside as well as the cleaning of their immediate environment inside the drying oven, without the need to dismantle these parts of the drying oven.
- the spray nozzles are arranged according to the invention so that all areas of the interior of the drying oven are achieved by means of the CIP technique and are controlled so cleanable.
- the transport rollers preferably rotate slowly during the cleaning process, which optimizes the cleaning effect in the entire interior of the drying oven.
- the cleaning fluid needed for the cleaning collects in the downwardly conical bottom of the drying oven and can either be fed back to the high pressure pump or simply drained or removed by means of a pump.
- a purification process can be uniquely characterized and validated.
- the multilayer composite produced by the process according to the invention is particularly suitable for use as a transdermal system for the application of medicaments or cosmetics or for application in body cavities.
- FIG. 1 shows schematically how a multi-layer composite is produced according to the invention in a multi-stage process.
- FIG. 2 shows, in a schematic representation, a vertical section through a segment of a drying oven suitable for the method according to the invention in a lateral view.
- the unwinding 1 of the carrier material 2 is shown in FIG. 1 with the aid of reference symbols.
- the unwound substrate 2 is coated in the downstream coating station 3 with one or more liquid components.
- the coated carrier material 4 is fed to the drying oven 5, which in the embodiment according to FIG. 1 comprises a plurality of drying zones T1, T2, T3, Tx-1 and Tx.
- the air supply 6 is shown, while the exhaust air 7 is collected in the lower part of the drying oven 5 and discharged laterally.
- the dried multi-layer composite 8 leaving the drying oven 5 at the drying station Tx is fed via a deflection roller 9 to the reeling station 10 and rolled up there.
- FIG 2 the same reference numerals have the same meaning as in Figure 1.
- Shown is a single furnace segment Tn suitable for the process according to the invention drying oven 5.
- the furnace segment Tn has an upper housing part 11 which is movable in the direction of arrow up and down, and a lower housing part 12 which is tapered downwards and has a drain 15. Exactly between the upper housing part 11 and the lower housing part 12 moves to be dried in the furnace segment Tn multilayer composite 14 in the arrow direction from left to right.
- the air supply 6 can be seen, while the exhaust air 7 exits laterally downwards.
- the air entering through the air supply 6 is applied via a combined heating nozzle system 16 to be dried multi-layer composite 14, which by means of guide rollers 17 which are equipped with spray nozzles, not shown, through the dry segment Tn in the arrow direction from left to right is moved.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008034453A DE102008034453A1 (en) | 2008-07-24 | 2008-07-24 | Method for producing a multi-layer composite on a CIP-capable coating system and use of the multilayer composite produced therewith for transdermal application or application in body cavities |
PCT/EP2009/005239 WO2010009848A2 (en) | 2008-07-24 | 2009-07-20 | Method for producing a multilayer compound on a cip-capable coating installation and use of the multilayer compound produced by said method for transdermal application or the application in body cavities |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2307837A2 true EP2307837A2 (en) | 2011-04-13 |
EP2307837B1 EP2307837B1 (en) | 2018-09-05 |
Family
ID=41501028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09777292.5A Active EP2307837B1 (en) | 2008-07-24 | 2009-07-20 | Method for producing a multilayer compound on a cip-capable coating installation |
Country Status (17)
Country | Link |
---|---|
US (1) | US8864047B2 (en) |
EP (1) | EP2307837B1 (en) |
JP (2) | JP2011528613A (en) |
KR (1) | KR101629527B1 (en) |
CN (1) | CN102099650B (en) |
AU (1) | AU2009273514B2 (en) |
BR (1) | BRPI0916291B1 (en) |
CA (1) | CA2731600C (en) |
DE (1) | DE102008034453A1 (en) |
ES (1) | ES2700654T3 (en) |
HK (1) | HK1158302A1 (en) |
IL (1) | IL210727A (en) |
MX (1) | MX2011000827A (en) |
NZ (1) | NZ590407A (en) |
RU (1) | RU2530120C2 (en) |
WO (1) | WO2010009848A2 (en) |
ZA (1) | ZA201100131B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102490461B (en) * | 2011-11-27 | 2015-09-23 | 西安新达机械有限公司 | A kind of method for designing of drying equipment of full-automatic high-speed medicinal aluminum foil printing coating machine |
CN110131983A (en) * | 2018-02-02 | 2019-08-16 | 丹东金丸集团有限公司 | A kind of capsule full automatic drying process and the drying unit for implementing this method |
CN108469174B (en) * | 2018-03-09 | 2020-07-24 | 河北陶菊农业科技有限公司 | Automatic medicinal daisy stoving frame paves |
CN108554867A (en) * | 2018-03-24 | 2018-09-21 | 浙江海宁普赛自动化科技有限公司 | A kind of cleaning device of technical machinery special for automatic |
CN108940983A (en) * | 2018-06-25 | 2018-12-07 | 安徽名扬刷业有限公司 | A kind of roller-brush type cleaning device of aluminium sheet |
CN109163516A (en) * | 2018-09-20 | 2019-01-08 | 东阳市新意工业产品设计有限公司 | A kind of chemical production equipment and its working method |
CN109865699A (en) * | 2019-03-22 | 2019-06-11 | 广西电网有限责任公司贵港供电局 | A kind of Portable mutual inductor rapid decontamination tool |
CN111774369A (en) * | 2020-06-23 | 2020-10-16 | 武汉工程大学 | Cosmetic raw materials washs drying device |
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SU683808A1 (en) * | 1977-05-06 | 1979-09-05 | Всесоюзный Государственный Научно-Исследовательский И Проектный Институт Химико-Фотографической Промышленности | Plant for applying multilayer coatings onto substrate |
SU1362507A1 (en) * | 1986-03-06 | 1987-12-30 | Завод Тяжелых Бумагоделательных Машин | Irrigating assembly |
JPS6333597A (en) * | 1986-07-29 | 1988-02-13 | Kansai Paint Co Ltd | Drying furnace provided with device for cleaning dust |
JPH08192125A (en) * | 1995-01-12 | 1996-07-30 | Hitachi Ltd | Tank cleaning system |
US5849099A (en) * | 1995-01-18 | 1998-12-15 | Mcguire; Dennis | Method for removing coatings from the hulls of vessels using ultra-high pressure water |
DE19543412A1 (en) | 1995-11-21 | 1997-05-22 | Waldner Gmbh & Co Hermann | Dryers, in particular for the chemical or pharmaceutical industry |
JPH09248537A (en) * | 1996-03-18 | 1997-09-22 | Hitachi Ltd | Tank washing system |
US6018886A (en) * | 1996-06-25 | 2000-02-01 | Eastman Kodak Company | Effect of air baffle design on mottle in solvent coatings |
US5934178A (en) * | 1997-01-04 | 1999-08-10 | Heat & Control, Inc. | Air impingement oven |
JPH11188302A (en) * | 1997-12-26 | 1999-07-13 | Trinity Ind Corp | Drying oven |
US7220427B2 (en) * | 1998-07-08 | 2007-05-22 | Oryxe | Mixture for transdermal delivery of low and high molecular weight compounds |
DE19918105C1 (en) * | 1999-04-22 | 2000-09-21 | Lohmann Therapie Syst Lts | Transdermal patch for administering neuroleptic agent i.e. fluphenazine, flupentixol or triflupromazine, includes matrix layer containing penetration enhancer and hydrocarbon polymer |
JP2002045740A (en) * | 2000-05-25 | 2002-02-12 | Nippon Paint Co Ltd | Method and apparatus for removing resinous deposit occurring from coating material |
JP4406179B2 (en) * | 2000-09-18 | 2010-01-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | Apparatus and process for uniformly drying products in web form produced by coating |
DE10058253C2 (en) * | 2000-09-18 | 2002-10-31 | Lohmann Therapie Syst Lts | Device and method for uniform drying of web-shaped products produced by coating |
AU2003208326A1 (en) | 2002-01-25 | 2003-09-02 | Lts Lohmann Therapie-Systeme Ag | Method and device for producing products in web form |
DE10218007A1 (en) * | 2002-04-23 | 2003-11-06 | Bayer Ag | Freeze dryer |
US20040009180A1 (en) * | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
JP5548329B2 (en) * | 2003-08-04 | 2014-07-16 | 杏林製薬株式会社 | Transdermal preparation |
DE202004020631U1 (en) | 2004-04-30 | 2005-09-15 | Optimags Dr Zimmermann Gmbh | Device for coating a carrier foil with a pharmaceutical active ingredient used in the manufacture of transdermal acting plasters comprises an application module arranged next to drying modules |
FI120316B (en) * | 2004-12-31 | 2009-09-15 | Metso Paper Inc | A method for improving the runnability of the drying section of a paper machine |
JP5178520B2 (en) * | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | Solid polymer delivery compositions and methods of use thereof |
WO2007129340A1 (en) * | 2006-05-10 | 2007-11-15 | Comber S.R.L. | Conical-base drier |
DE202007016425U1 (en) | 2007-11-22 | 2008-01-31 | Herbert Olbrich Gmbh & Co. Kg | Apparatus for treating a substrate web |
DE202007017655U1 (en) | 2007-12-18 | 2008-03-06 | Herbert Olbrich Gmbh & Co. Kg | Apparatus for treating a substrate web |
-
2008
- 2008-07-24 DE DE102008034453A patent/DE102008034453A1/en not_active Ceased
-
2009
- 2009-07-20 MX MX2011000827A patent/MX2011000827A/en active IP Right Grant
- 2009-07-20 CA CA2731600A patent/CA2731600C/en not_active Expired - Fee Related
- 2009-07-20 EP EP09777292.5A patent/EP2307837B1/en active Active
- 2009-07-20 BR BRPI0916291A patent/BRPI0916291B1/en not_active IP Right Cessation
- 2009-07-20 CN CN200980128292.4A patent/CN102099650B/en not_active Expired - Fee Related
- 2009-07-20 US US13/054,153 patent/US8864047B2/en active Active
- 2009-07-20 RU RU2011102258/05A patent/RU2530120C2/en active
- 2009-07-20 WO PCT/EP2009/005239 patent/WO2010009848A2/en active Application Filing
- 2009-07-20 NZ NZ590407A patent/NZ590407A/en not_active IP Right Cessation
- 2009-07-20 KR KR1020117001623A patent/KR101629527B1/en active IP Right Grant
- 2009-07-20 ES ES09777292T patent/ES2700654T3/en active Active
- 2009-07-20 AU AU2009273514A patent/AU2009273514B2/en not_active Ceased
- 2009-07-20 JP JP2011519071A patent/JP2011528613A/en not_active Withdrawn
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2011
- 2011-01-05 ZA ZA2011/00131A patent/ZA201100131B/en unknown
- 2011-01-18 IL IL210727A patent/IL210727A/en active IP Right Grant
- 2011-11-18 HK HK11112499.8A patent/HK1158302A1/en not_active IP Right Cessation
-
2017
- 2017-04-10 JP JP2017077307A patent/JP6498717B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO2010009848A2 * |
Also Published As
Publication number | Publication date |
---|---|
MX2011000827A (en) | 2011-02-25 |
IL210727A0 (en) | 2011-03-31 |
JP2011528613A (en) | 2011-11-24 |
KR20110049776A (en) | 2011-05-12 |
CN102099650A (en) | 2011-06-15 |
AU2009273514A1 (en) | 2010-01-28 |
JP6498717B2 (en) | 2019-04-10 |
WO2010009848A3 (en) | 2010-10-28 |
CN102099650B (en) | 2016-03-16 |
RU2011102258A (en) | 2012-07-27 |
HK1158302A1 (en) | 2012-07-13 |
AU2009273514B2 (en) | 2016-04-21 |
KR101629527B1 (en) | 2016-06-10 |
ZA201100131B (en) | 2011-09-28 |
WO2010009848A2 (en) | 2010-01-28 |
JP2017159299A (en) | 2017-09-14 |
NZ590407A (en) | 2013-05-31 |
US20110117177A1 (en) | 2011-05-19 |
CA2731600C (en) | 2017-01-03 |
US8864047B2 (en) | 2014-10-21 |
ES2700654T3 (en) | 2019-02-18 |
DE102008034453A1 (en) | 2010-02-11 |
EP2307837B1 (en) | 2018-09-05 |
BRPI0916291B1 (en) | 2020-04-28 |
CA2731600A1 (en) | 2010-01-28 |
IL210727A (en) | 2015-07-30 |
RU2530120C2 (en) | 2014-10-10 |
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