EP2262464B1 - Zwischenstück für zu perforierende Flaschen zur Herstellung von Infusionsflüssigkeiten - Google Patents

Zwischenstück für zu perforierende Flaschen zur Herstellung von Infusionsflüssigkeiten Download PDF

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Publication number
EP2262464B1
EP2262464B1 EP20090719854 EP09719854A EP2262464B1 EP 2262464 B1 EP2262464 B1 EP 2262464B1 EP 20090719854 EP20090719854 EP 20090719854 EP 09719854 A EP09719854 A EP 09719854A EP 2262464 B1 EP2262464 B1 EP 2262464B1
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EP
European Patent Office
Prior art keywords
interface device
connection base
syringe
bottle
needle
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Active
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EP20090719854
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English (en)
French (fr)
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EP2262464A1 (de
Inventor
Jean-Luc Carrez
Jean-Louis Coussegal
Laurent Barre
Pierrick Guyomarc'h
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Vygon SA
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Vygon SA
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Publication of EP2262464A1 publication Critical patent/EP2262464A1/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration

Definitions

  • the invention relates to an interfacing device for connecting a syringe and a puncture bottle containing a medicament for the purpose of preparing liquids for infusion into a patient.
  • An example of such a device is described in the document FR 2717086 .
  • the drug to be administered is in powder form in a vacuum vial (called Vial). This bottle is closed by an elastomeric membrane stopper.
  • the nursing staff responsible for the preparation pushes with the syringe liquid to infuse into the bottle, which again, again, air with possible drug particles not yet diluted.
  • the vial is then shaken and the mixture is sucked through the elastomeric membrane cap using the syringe.
  • the liquid infusion mixture plus diluted drug is injected and sucked several times in and out of the vial with the syringe, in order to thoroughly mix the drug with the liquid.
  • outlets and air inlets in the bottle which involves risks of pollution for the health care staff responsible for the preparation, on the one hand, and, on the other hand, for mixing prepare.
  • the needle is out of the bottle. It must then be disconnected from the syringe without stinging and avoid direct contact of the mixture thus made with the care staff responsible for the preparation.
  • the filled syringe is then connected near the patient to an infusion bag connected thereto or connected directly to the patient himself.
  • An object of the invention as defined in the claims is to provide an interfacing device located between the vial to be perforated containing the pure drug in powder form and the syringe containing the liquid to be infused, which is secure while remaining simple of use in preparing the mixture between the liquid to be infused and the pure drug in the flask to be perforated.
  • an interface device for connecting a syringe and a bottle to be perforated containing a medicament, comprising a base for connection to the flask to be perforated, the connection base comprising air circulation means, intended to allow inflow and outflow of the vial to be perforated, comprising air filtration means.
  • air circulation means equipped with means for filtering this air impose a flow of air between the bottle and the outside, passing through the filtering means which will then retain, on the one hand during the air outlet of the bottle, the pure drug particles not yet diluted and, secondly, when air enters the bottle, impurities contained in the ambient air entering the bottle. This helps to secure the handling and preparation of the mixture.
  • the interfacing device (1) is intended to be mounted on a perforating vial (2), also called Vial, at a distal end of the interfacing device (1) and on a syringe (not shown) at the a level of a proximal end of said interfacing device (1).
  • the interfacing device (1) comprises, from the distal end towards the proximal end, a clipping cap (10) intended to place and hold said interfacing device on a flask to be perforated (2), a first connection base (100), called “distal”, in which slides a hollow perforation needle (30) at the proximal end of which is mounted a second connection base (50), called “proximal”, on which are installed filtration means (60).
  • the filtration means (60) can be connected directly to a syringe containing a liquid for infusion to be mixed with a pure drug contained in the flask to be perforated (2).
  • a membrane connector (3) is positioned between the syringe and the filter means.
  • the interfacing device (1) according to the invention further comprises a deformable membrane (40) surrounding the hollow perforation needle (30) and fixed at a distal end to the distal connection base (100) and at a distal end (40). proximal end to the proximal connection base (50).
  • the interfacing device (1) according to the invention has a storage and handling device (20) which keeps the two connection bases (100) and (50) away from one another.
  • the storage and handling device (20) includes an extension for maintaining in a predetermined position the clipping cap (10) mounted on the distal connection base (100).
  • the distal connection base (100) comprises a body (104), here integrally molded.
  • the body (104) of the base of distal connection (100) comprises a tubular longitudinal chamber (105) extending between a proximal end (114) and a distal end (107) where the longitudinal chamber terminates, in its extension, by a conduit (103).
  • the longitudinal chamber (105) is here of frustoconical shape of revolution.
  • the body (104) has an orifice (108) substantially perpendicular to a main axis of the longitudinal chamber (105).
  • the orifice (108) opens on one side into the longitudinal chamber (105) and on the other side out of the body (104) forming the distal connection base (100).
  • the longitudinal chamber (105) has a circumferential groove (106) for receiving a seal (120) which is traversed so that sliding by the hollow perforation needle (30) of the interfacing device (1).
  • the distal connection base (100) has a cannula (102) which is inserted into this duct (103) and is sealingly attached thereto, and so as to extend slightly into the duct (103).
  • the hollow perforation needle (30) is substantially coaxially received in the cannula (102) so as to slide with a functional clearance (101) along a major axis of the cannula (102).
  • the orifice (108) opening into the longitudinal chamber (105) is closed by filtration means (109).
  • the filtration means (109) comprise, here, a particulate filter allowing to retain any particles suspended in the air when the air crosses, in whatever sense, the filtration means (109).
  • the particulate filter has a porosity of about 0.2 ⁇ m, that is, the filter retains any particles larger than 0.2 ⁇ m in size.
  • the body (104) of the distal connection base (100) has, on an outer circumference, a groove (110) adjacent the orifice (108) and located above this orifice in a proximal direction.
  • This groove (110) is intended to cooperate with the storage and handling device (20) to be described later.
  • the distal connection base (100) Located between this groove (110) and the proximal end (114) of the body (104), the distal connection base (100) has a series of corrugations (113) on an outer periphery of said body (104). As illustrated in figure 2 , this series of corrugations (113) is intended to receive an end of the deformable membrane (40) of the interfacing device (1) according to the invention.
  • a tightening sleeve (34) surrounds the end of the membrane opposite the series of corrugations (113) of the body (104) of the connection base.
  • distal (100) At the distal end (107), the distal connection hub (100) includes a groove (115) proximally surmounting a tapered end of revolution (116). This frustoconical end of revolution (116) and this groove (115) are intended to receive and form a ball joint with a clipping cap (10) which will be described below.
  • the clipping cap (10) is of generally cylindrical general shape of revolution.
  • the clipping cap (10) has a substantially plane bottom (17) and substantially perpendicular to an axis of revolution of the clipping cap (10).
  • the bottom (17) has at its center a through opening (11) having a frustoconical shape (18) inlet and a countersink (19).
  • the through orifice (11) is intended to cooperate with the groove (115) and the frustoconical end (116) of the distal end (107) of the distal connection base (100), the counterbore (19) being then received in the throat (115).
  • the clipping cap (10) comprises a series of tongues (12) uniformly distributed over a circumference and extending in projections, substantially parallel to the axis of revolution of the clipping cap (10), a radially outer periphery of the bottom (17) of said clipping cap (10).
  • Each of the tongues (12) comprises a first portion (15) substantially parallel to the axis of revolution of the clipper stopper (10) followed by a corrugation (14) oriented centripetally with respect to the axis of revolution of the clipper cap (10) then a portion flaring frustoconically (13).
  • Each of the tongues (12) is further elastically deformable to allow the introduction of the clipping cap (10) on a neck of the flask to be perforated (2). Once placed on the perforating vial (2), the clipper cap (10) holds the neck of the vial to be perforated (2) trapped at the portion (15) of the tongues (12), the corrugations (14). now the neck in place while the end of the parts (13) comes into contact with an outer wall of the flask to be perforated (2), as illustrated in the Figures 1, 2 , 12 to 14 .
  • the proximal connection base (50) is generally cylindrical in shape. Like the distal connection base (100), the proximal connection base (50) is, here, integrally molded.
  • the proximal connection base (50) has a distal end (51) in which is arranged a conduit (57) opening into a tubular chamber (56) substantially cylindrical in shape of revolution.
  • a central portion of the proximal connection base (50) includes a series of corrugations (53) whose role is similar to the series of corrugations (113) of the distal connection base (100) that has just to be described.
  • the series of corrugations (53) makes it possible to hold in place, in cooperation with a clamping sleeve (35) similar to the clamping sleeve (34) previously described, the other end of the deformable membrane (40) of the interfacing device ( 1) according to the invention.
  • connection base (50) comprises, on the one hand, a female connector (54) extending the chamber (56) and made according to the Luer or Luer-Lock standard, and on the other hand, a cup formed of two petals (55) extending around the female connector (54).
  • Each of the petals (55) is substantially semicircular in shape of the main axis of the proximal connection base (50). Since the female connector (54) meets the Luer or Luer-Lock standards, the latter is able to directly receive a syringe having a male end to the standard Luer or Luer-Lock, The petals (55) then receiving the base of the barrel of the syringe.
  • the female connector (54) receives a filtration device (60) which will now be described with reference to FIG. figure 2 .
  • the filtration device (60) comprises a downstream element (62) which itself comprises a male connector (66) corresponding to the Luer or Luer-Lock standard and comprising a conduit (64).
  • the filter device (60) includes an upstream member (61) having a female connector (65) complying with the Luer or Luer-Lock standard.
  • the two elements upstream (61) and downstream (62) are placed one on the other, head to tail, and thus delimit a chamber (63) adapted to receive a particulate filter that will help retain the particles in suspension in the liquid to be infused which will pass through the filtration device (60).
  • the particulate filter will not let the particles in suspension in the liquid to be infused whose size is greater than a value between about 2 microns and about 5 microns.
  • the Luer or Luer-Lock female connector (65) is intended to directly receive the male Luer or Luer-Lock tip of the syringe or a membrane connector (3), as illustrated in FIG. figure 2 for example.
  • the second (so-called “proximal") connection base (50) is mounted on a proximal end (33) of the hollow perforation needle (30) so that the hollow perforation needle (30) extends slightly in the chamber (56) of the proximal connection base (50). Mounting of the proximal connection base (50) on the needle (30) is sealed at the conduit (57).
  • the hollow perforation needle (30) comprises at a distal end (31) a bevel surmounted by retaining means (32) whose dimensions are slightly greater than an internal diameter of the cannula (102) in which is slidably mounting the hollow perforation needle (30). This prevents the needle from coming out of the cannula completely.
  • the retaining means (32) comprise a slight deformation produced by crushing the hollow perforation needle (30).
  • the storage and handling device (20) comprises a substantially cylindrical body (24) of revolution, hollow and open on one side.
  • the body (24) has manipulating tabs (21) projecting from opposite sides of the opening, facing one another, and tangentially to the body (24).
  • Each of the ends of the body (24) has a clamp (23, 22) intended to cooperate respectively with the groove (52) of the proximal connection base (50) and the groove (110) of the distal connection base ( 100).
  • the storage and handling device (20) comprises an outgrowth projecting from the end comprising the clamp (22) substantially parallel to an axis of revolution of the body (24). This protrusion is intended to come into contact with the clipper cap (10) in order to neutralize the existing ball joint connection between the clipping cap (10) and the distal connection base (100).
  • the interfacing device (1) In storage, the interfacing device (1) is equipped with the storage and handling device (20), as illustrated in FIG. Figures 1 and 2 . The The caregiver prepares the interfacing device (1) by the tabs (21) of the storage and handling device (20).
  • the health care staff in charge of the preparation connects a syringe filled with liquid to infuse (saline, for example) on the membrane connector (3), if it is present, or directly on the female Luer or Luer-Lock connector (65) of the filter device (60).
  • the liquid to be infused is then injected into the vial to be perforated (2), which pushes the air contained in said vial to the outside, which air can only exit through the filtration means (109) of the through orifice. (108) of the distal connection base (100). If this air contains particles, they are then blocked by the seal (120), on the one hand, and on the other hand, the filtration means (109).
  • the health care staff responsible for the preparation then shake the bottle in order to best dilute the drug contained in the bottle (2) with infused liquid that has been injected. Thereafter, the caregiver removes the storage and handling device (20) by pressing the two tabs (21) towards each other to open the clip ends (23) and (22) so that the latter can be removed from the grooves (52) of the proximal connection base (50) and (110) of the distal connection base (100). Once the storage and handling device (20) removed, the caregiver can then lower the hollow perforation needle to the bottom of the bottle by sliding the needle (30) in the connection base (100) by pressing by example on the connection base (50).
  • the nursing staff can draw the mixture thus generated with the syringe and inject it back into the vial. several times in order to better homogenize it.
  • the liquid to be perfused when it is sucked back into the syringe is filtered by the filtering device (60) avoiding that the pure drug particles not yet diluted are found in the syringe.
  • the nursing staff can incline the perforating bottle (2) and swivel the interfacing device (1) according to the invention at the level of the connecting the clipping cap (10) and the distal end of the distal connection base (100) to reach with the bevel (31) of the hollow perforation needle (30) the lower and inner edge of said vial to be perforated (2) as illustrated in figure 14 .
  • the empty perforating bottle (2) / interface device according to the invention (1) is discarded as it is, without disconnecting the bottle from the interfacing device. (1).
  • the hollow perforation needle (30) can not exit the vial due to the presence of the retaining means (32) at the distal end (31) of the hollow perforation needle (30). Thus, the health care worker in charge of the preparation is protected from any accidental sting with this hollow perforation needle (30).
  • the diaphragm connector membrane (3) is easy to clean before any connection of the syringe.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (13)

  1. Zwischenstück (1), welches dazu bestimmt ist, eine Spritze und eine zu perforierende, ein Medikament enthaltende Flasche (2) zu verbinden, umfassende eine Perforationshohlnadel (30) und ein Anschlussstück (100) an die zu perforierende Flasche, wobei das Anschlussstück Mittel zur Luftzirkulation (101, 105, 108, 109) aufweist, die dazu bestimmt sind, das Eintreten und das Austreten von Luft in die und aus der zu perforierenden Flasche zu ermöglichen, umfassend Mittel zur Luftfiltration (109) und eine Kanüle (102), die dazu bestimmt ist, sich in die zu perforierende Flasche an einem distalen Ende der Kanüle zu erstrecken, dadurch gekennzeichnet, dass die Perforationshohlnadel gleitend mit einem Funktionsspiel (101) in der Kanüle befestigt ist.
  2. Zwischenstück gemäß Anspruch 1, dadurch gekennzeichnet, dass die Perforationshohlnadel durch eine Dichtung (120) gleitend in dem Anschlussstück (100) in einem proximalen Teil (114) des Anschlussstücks befestigt ist.
  3. Zwischenstück gemäß einem der Ansprüche 1 und 2, dadurch gekennzeichnet, dass die Luftzirkulationsmittel eine Mündungsöffnung (108) auf der Außenseite aufweisen.
  4. Zwischenstück gemäß Anspruch 3, dadurch gekennzeichnet, dass die Mündungsöffnung durch Filtrationsmittel (109) verschlossen wird.
  5. Zwischenstück gemäß Anspruch 4, dadurch gekennzeichnet, dass die Filtrationsmittel einen Partikelfilter in der Größenordnung zwischen etwa 2 µm und etwa 5 µm aufweisen.
  6. Zwischenstück gemäß einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass das Anschlussstück in einem distalen Teil (107) einen Klammerdeckel (10) aufweist, der dazu bestimmt ist, eine Befestigung des Zwischenstücks auf der zu perforierenden Flasche durch Klammerung zu ermöglichen.
  7. Zwischenstück gemäß Anspruch 6, dadurch gekennzeichnet, dass der Klammerdeckel auf dem Anschlussstück mittels einer Kugelkopfverbindung befestigt ist.
  8. Zwischenstück gemäß Anspruch 1, dadurch gekennzeichnet, dass die Perforationshohlnadel an einem distalen Ende (31) Mittel (32) zum Halten der Nadel in der Kanüle aufweist.
  9. Zwischenstück gemäß Anspruch 8, dadurch gekennzeichnet, dass die Haltemittel eine Verformung aufweisen, die durch das Eindrücken der Perforationshohlnadel bewirkt wird.
  10. Zwischenstück gemäß einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass es außerdem ein zweites Anschlussstück (50) an die Spritze aufweist.
  11. Zwischenstück gemäß Anspruch 10, dadurch gekennzeichnet, dass das zweite Anschlussstück Mittel (60) zur Filtration einer Flüssigkeit, die durch die Spritze angesaugt wird, wenn die Flasche perforiert ist, aufweist.
  12. Zwischenstück gemäß einem der Ansprüche 10 bis 11, dadurch gekennzeichnet, dass das zweite Anschlussstück in einem proximalen Teil ein Membranverbindungsstück (3) aufweist, welches den direkten und gesicherten Anschluss der Spritze ermöglicht.
  13. Zwischenstück gemäß einem der Ansprüche 10 bis 12, dadurch gekennzeichnet, dass das zweite Anschlussstück (50) abdichtend in einem distalen Teil (51) auf einem proximalen Ende (33) der Perforationshohlnadel befestigt ist.
EP20090719854 2008-03-12 2009-03-11 Zwischenstück für zu perforierende Flaschen zur Herstellung von Infusionsflüssigkeiten Active EP2262464B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0851620A FR2928539B1 (fr) 2008-03-12 2008-03-12 Dispositif d'interfacage pour flacons a perforer a fins de preparations de liquides perfuses
PCT/EP2009/052882 WO2009112535A1 (fr) 2008-03-12 2009-03-11 Dispositif d'interfacage pour flacons a perforer a fins de preparations de liquides perfuses

Publications (2)

Publication Number Publication Date
EP2262464A1 EP2262464A1 (de) 2010-12-22
EP2262464B1 true EP2262464B1 (de) 2012-10-10

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EP20090719854 Active EP2262464B1 (de) 2008-03-12 2009-03-11 Zwischenstück für zu perforierende Flaschen zur Herstellung von Infusionsflüssigkeiten

Country Status (10)

Country Link
US (1) US20110004183A1 (de)
EP (1) EP2262464B1 (de)
JP (1) JP2011513013A (de)
KR (1) KR20100129317A (de)
CA (1) CA2717508A1 (de)
DK (1) DK2262464T3 (de)
ES (1) ES2395486T3 (de)
FR (1) FR2928539B1 (de)
PT (1) PT2262464E (de)
WO (1) WO2009112535A1 (de)

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US20110004183A1 (en) 2011-01-06
FR2928539A1 (fr) 2009-09-18
JP2011513013A (ja) 2011-04-28
WO2009112535A1 (fr) 2009-09-17
ES2395486T3 (es) 2013-02-13
EP2262464A1 (de) 2010-12-22
FR2928539B1 (fr) 2012-02-24
DK2262464T3 (da) 2013-01-21
PT2262464E (pt) 2012-12-20
KR20100129317A (ko) 2010-12-08
CA2717508A1 (fr) 2009-09-17

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