EP2240470A4 - Verbessertes und neues verfahren zur herstellung von bosentan - Google Patents

Verbessertes und neues verfahren zur herstellung von bosentan

Info

Publication number
EP2240470A4
EP2240470A4 EP09705099A EP09705099A EP2240470A4 EP 2240470 A4 EP2240470 A4 EP 2240470A4 EP 09705099 A EP09705099 A EP 09705099A EP 09705099 A EP09705099 A EP 09705099A EP 2240470 A4 EP2240470 A4 EP 2240470A4
Authority
EP
European Patent Office
Prior art keywords
bosentan
preparation
improved
novel process
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09705099A
Other languages
English (en)
French (fr)
Other versions
EP2240470A2 (de
Inventor
Reddy Manne Satyanarayana
Sajja Eswaraiah
Reddy Ghojala Venkat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSN Laboratories Pvt Ltd
Original Assignee
MSN Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSN Laboratories Pvt Ltd filed Critical MSN Laboratories Pvt Ltd
Publication of EP2240470A2 publication Critical patent/EP2240470A2/de
Publication of EP2240470A4 publication Critical patent/EP2240470A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP09705099A 2008-01-10 2009-01-09 Verbessertes und neues verfahren zur herstellung von bosentan Withdrawn EP2240470A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN103CH2008 2008-01-10
IN2334CH2008 2008-09-24
PCT/IN2009/000032 WO2009095933A2 (en) 2008-01-10 2009-01-09 Improved and novel process for the preparation of bosentan

Publications (2)

Publication Number Publication Date
EP2240470A2 EP2240470A2 (de) 2010-10-20
EP2240470A4 true EP2240470A4 (de) 2012-05-23

Family

ID=40913375

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09705099A Withdrawn EP2240470A4 (de) 2008-01-10 2009-01-09 Verbessertes und neues verfahren zur herstellung von bosentan

Country Status (2)

Country Link
EP (1) EP2240470A4 (de)
WO (1) WO2009095933A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008315757A1 (en) 2007-10-24 2009-04-30 Generics [Uk] Limited Novel crystalline forms
EP2240469A2 (de) * 2008-01-24 2010-10-20 Actavis Group PTC EHF Substantiell reine und stabile kristalline form von bosentan
CA2712860C (en) 2008-02-08 2014-11-18 Abhay Gaitonde Process for preparing bosentan
WO2010015623A1 (en) * 2008-08-05 2010-02-11 Farmaprojects, S. A. Process for the preparation of endothelin receptor antagonists
US20110263623A1 (en) * 2008-08-12 2011-10-27 Cadila Healthcare Limited Process for preparation of bosentan
CN102272108A (zh) * 2008-11-03 2011-12-07 基因里克斯(英国)有限公司 用于分析波生坦及相关物质的hplc方法以及这些物质作为参比标准和标记的用途
IT1393136B1 (it) * 2009-03-11 2012-04-11 Sifa Vitor S R L Procedimento per la preparazione del bosentan
JP2012523444A (ja) 2009-04-13 2012-10-04 サンド・アクチエンゲゼルシヤフト 内皮受容体アンタゴニスト（ボセンタン）を調製するための方法
WO2011021216A2 (en) * 2009-08-10 2011-02-24 Msn Laboratories Limited Improved process for the preparation of 4-(1,1-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide
WO2011024056A2 (en) 2009-08-27 2011-03-03 Aurobindo Pharma Limited An improved process for the preparation of bosentan
AU2010317410B9 (en) * 2009-11-12 2014-10-23 Sun Pharmaceutical Industries Limited Crystalline forms of bosentan salts and processes for their preparation
WO2012020421A1 (en) 2010-08-11 2012-02-16 Megafine Pharma (P) Ltd. A novel process for preparation of bosentan
CN103153964B (zh) * 2010-10-01 2016-10-05 Zach系统股份公司 制备波生坦一水合物及其中间体的方法
US20130245259A1 (en) 2012-03-16 2013-09-19 Natco Pharma Limited Process for the preparation of bosentan monohydrate
WO2013186706A1 (en) * 2012-06-12 2013-12-19 Cadila Pharmaceuticals Ltd Process for the preparation of bosentan
TR202018841A2 (tr) * 2020-11-23 2021-01-21 Yilmaz Usta Duygu Uzun zi̇nci̇rli̇ mono ve di̇gli̇seri̇t karişimlari i̇le hazirlanan bosentan monohi̇drat yüklü kendi̇li̇ği̇nden nanoemülsi̇fi̇ye i̇laç taşiyici si̇stemleri̇n (snedds) formülasyonu

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292740A (en) * 1991-06-13 1994-03-08 Hoffmann-La Roche Inc. Sulfonamides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW287160B (de) * 1992-12-10 1996-10-01 Hoffmann La Roche
AU2001263850A1 (en) * 2000-04-20 2001-11-07 Actelion Pharmaceuticals Ltd Pyrimidine-sulfonamides having endothelin-antagonist activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292740A (en) * 1991-06-13 1994-03-08 Hoffmann-La Roche Inc. Sulfonamides

Also Published As

Publication number Publication date
EP2240470A2 (de) 2010-10-20
WO2009095933A3 (en) 2011-06-30
WO2009095933A2 (en) 2009-08-06

Similar Documents

Publication Publication Date Title
EP2240470A4 (de) Verbessertes und neues verfahren zur herstellung von bosentan
HK1141013A1 (en) Process for the preparation of certain substituted sulfilimines
ZA201202504B (en) Process for the preparation of calcobutrol
SI2151428T1 (sl) Postopek za pripravo agomelatina
PL2387566T3 (pl) Sposób przygotowania rosuwastatyny
ZA200907191B (en) Process for the preparation of gefitiib
IL208792A0 (en) Process for the preparation of amides
HK1169396A1 (en) Improved process for the preparation of ambrisentan and novel intermediates thereof
PL390042A1 (pl) Sposób wytwarzania kwasu chlebowego
SI2189442T1 (sl) Postopek in intermediati za pripravo aliskirena
EP2300467A4 (de) Neuartige und verbesserte verfahren zur herstellung von paliperidon
SI2151429T1 (sl) Postopek za pripravo agomelatina
PL388931A1 (pl) Sposób otrzymywania fluorokarbofunkcyjnych silseskwioksanów
IL243809A0 (en) Process for the production of γ-ketosulfide compound and γ-ketosulfide compounds
EG26332A (en) Process for the preparation of benzonoprons
HU0700818D0 (en) Process for the preparation of polyirocyanates of the diphenylmethone series
IL208868A0 (en) Processes for the preparation of amides
IL211382A0 (en) Process for the preparation of ethanedinitrile
IL217460A0 (en) Novel process for the preparation of 4-aminobut-2-enolides
PL2462154T3 (pl) Nowa krystaliczna postać CDB-4124 i sposób jej wytwarzania
IL213110A0 (en) Process for the preparation of tetrazine derivatives
GB0812613D0 (en) Process for the preparation of 1-deoxyidonojirimycin
EG27000A (en) Process for the preparation of ibodutant (MEN15596) and related intermediates
IL220160A (en) A process for the preparation of defrasirox
PL388933A1 (pl) Sposób otrzymywania fluorosilikonów

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100810

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 401/04 20060101AFI20110706BHEP

TPAC Observations filed by third parties

Free format text: ORIGINAL CODE: EPIDOSNTIPA

A4 Supplementary search report drawn up and despatched

Effective date: 20120420

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 239/52 20060101ALI20120416BHEP

Ipc: C07D 239/47 20060101AFI20120416BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20121120