EP2184492B1 - Procédé destiné à la commande de pompe péristaltique - Google Patents

Procédé destiné à la commande de pompe péristaltique Download PDF

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Publication number
EP2184492B1
EP2184492B1 EP08450172A EP08450172A EP2184492B1 EP 2184492 B1 EP2184492 B1 EP 2184492B1 EP 08450172 A EP08450172 A EP 08450172A EP 08450172 A EP08450172 A EP 08450172A EP 2184492 B1 EP2184492 B1 EP 2184492B1
Authority
EP
European Patent Office
Prior art keywords
medium
squeezing elements
flow rate
squeezing
rotor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP08450172A
Other languages
German (de)
English (en)
Other versions
EP2184492A1 (fr
Inventor
Simon Ickinger
Arnold Bartel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP08450172A priority Critical patent/EP2184492B1/fr
Priority to AT08450172T priority patent/ATE538312T1/de
Priority to US12/611,293 priority patent/US20100135824A1/en
Publication of EP2184492A1 publication Critical patent/EP2184492A1/fr
Application granted granted Critical
Publication of EP2184492B1 publication Critical patent/EP2184492B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0081—Special features systems, control, safety measures
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
    • F04B49/06—Control using electricity
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B2203/00—Motor parameters
    • F04B2203/02—Motor parameters of rotating electric motors
    • F04B2203/0209—Rotational speed
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B2205/00—Fluid parameters
    • F04B2205/05—Pressure after the pump outlet
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B2205/00—Fluid parameters
    • F04B2205/09—Flow through the pump
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B2205/00—Fluid parameters
    • F04B2205/13—Pressure pulsations after the pump

Definitions

  • Peristaltic pumps are displacement pumps in which the medium to be delivered is passed through a tube which is usually U-shaped, but can also be arranged linearly or along a substantially arbitrary path.
  • This hose is supported in the housing of the pump and is successively clamped by squeezing, such as rollers or shoes, which are moved by an actuator.
  • this actuator is stirred as a rotor.
  • the rotor rotation moves the Abklstellenstelle created by the squeezing along the tube and thus drives a front of the Abklemmstelle lying volume of the medium to be delivered in the hose ahead.
  • an intake vacuum is generated at the hose inlet.
  • the actuators are designed as linear drives, or are - arranged in the manner of a piano keyboard - a plurality of squeezing behind the other along the hose, which are each pressed by a separate actuator in sequence against the hose, so that a kind of progressive movement sets.
  • the main advantages of peristaltic pumps are a gentle conveyance of sensitive material, a completely closed system, the absence of valves, the possibility of conveying media with solid particles and the precise metering of the flow rates. Because of these properties, peristaltic pumps are often used in laboratory equipment, for example, in blood analyzers that use peristaltic pumps for blood sample transport in the device or the washing process, etc.
  • a disadvantage of peristaltic pumps is that due to varying hose properties and wear of the hose variable delivery rates occur.
  • a ripple in the flow rate of the medium in the hose is produced, as in the diagram of FIG Fig. 2 to see.
  • the ripple thus represents a deviation from the average flow rate and causes depending on the position of the engaging roles briefly higher or lower flow.
  • the diagram of Fig. 2 represents the time course of the flow rates v of the medium to be delivered in .mu.l / min for a peristaltic pump with two different percolating tubes of the same type, but different ages or different lot number.
  • peristaltic pump is equipped with a roller position determination.
  • This can be, for example, an inductive or optical pulse generator on a roller. As soon as the roller equipped with the pulse generator passes a measuring point, a signal is output.
  • a stepper motor drives the rotor of the pump, a position determination may be made by the internal control of the stepper motor.
  • a motor controller controlling the motor driving the rotor may control the angular velocity of the rotor as a function of pulley position by counteracting a flow rate ripple this ripple is smoothed, ie reduced, becomes.
  • the motor control must be adjusted so that it compensates for a minimum ripple (that would be eg in Fig. 2 the flow rate curve M2 with the smaller amplitude).
  • the disadvantage is that residual ripple remains for all pump constellations except those with the minimum ripple.
  • the document EP 1 835 179 A1 discloses a method for controlling a peristaltic pump according to the preamble of claim 1.
  • the present invention has for its object to provide a solution to the problems of the prior art explained.
  • the present invention is intended to reduce the waviness of the delivery rate of peristaltic pumps, as well as to provide a peristaltic pump control which permits continuous calibration of a peristaltic pump during operation with respect to flow rate and ripple. It is of utmost importance that in particular the waviness of peristaltic pumps is reduced, which do not form a closed unit, but in which the tube is a replacement part or consumable, which is replaced at relatively short intervals.
  • the necessary sample volume of the sample medium transported by peristaltic pumps in laboratory devices, in particular blood analysis devices should be able to be reduced by the present invention.
  • the invention solves this problem by a method for controlling a peristaltic pump with the characterizing features of claim 1.
  • Advantageous embodiments of the invention will become apparent from the dependent claims and the description.
  • the method according to the invention for controlling a peristaltic pump explained at the outset comprises measuring over the time a fluidic parameter representative of the flow rate of the medium through the tube, determining the relative ripple of the flow rate of the medium from the measured time course of the fluidic parameter, and smoothing the waviness by adjusting the speed of travel of the crimping elements based on the detected waviness of the flow rate.
  • the flow rate of the medium is measured by detecting the period of time that media packets or front and end of media or media packets require to pass through a constant-velocity measurement path in the flow path of the peristaltic pump.
  • the positions of the pinch elements are detected and assigned to the durations, resulting in a curve of the relative ripple of the flow rate.
  • the media packages are generated by introducing air bubbles into the media stream, the media stream being from either a sample medium or a calibration fluid, such as a calibration fluid, a quality control fluid or a wash fluid from a blood analyzer. To avoid measuring artifacts, it is intended to introduce the air bubbles into the medium flow at irregular intervals.
  • the solution according to the invention is based on the principle that, by adjusting the speed of travel of the pinch elements of the peristaltic pump as a function of the instantaneous position of the pinching elements, it is possible to compensate for or at least reduce the waviness of the flow rate.
  • the invention additionally takes into account that the waviness of the flow rate can change when replacing the peristaltic hose of the peristaltic pump and / or due to the aging of the hose.
  • the invention provides for adapting the variation of the speed of movement of the squeezing elements of the peristaltic pump necessary for smoothing the waviness of the flow rate by recurrent calibration during operation and corresponding adjustment of the control of the rotational speed of the rotor to the current hose properties.
  • the invention is thus ideally suited for use in peristaltic pumps, which do not form an inseparable unit, but in which the corrugated hose as a consumable material has to be exchanged again and again.
  • the invention is suitable both for use in classic, simple peristaltic pumps with factory preset constant speed of the squeezing and peristaltic pumps, which are factory calibrated to certain tube properties by a dependent on the position of the squeezing elements periodic variation of the speed of travel is preset.
  • the ripple is smoothed by adjusting the preset periodic variation of the speed of travel of the squeezing elements based on the determined relative ripple of the flow rate.
  • adjusting the periodic variation of the speed of travel of the squeezing elements comprises calculating a calibration factor from the determined ripple of the flow rate of the medium and adjusting the periodic variation of the speed of travel of the squeezing elements by the calibration factor.
  • the calibration factor (or the determined ripple of the flow rate as one contiguous size) during operation to check whether it is within predefined limits, and to carry out a recalculation of the calibration factor when these limits are exceeded, which leads to an adaptation of the periodic variation of the speed of movement of the squeezing elements.
  • the invention is suitable for use in all types of peristaltic pumps, for example in the types mentioned above, in which the corrugated hose is arranged linearly or along any predetermined path.
  • the squeeze elements may for example be arranged individually by actuators movable in the form of a "piano keyboard" along the Walk hose, or be moved together by an actuator, such as a linear drive, or a belt driven by a conveyor belt.
  • the actuator is a motor driven rotor from which the squeezing elements are moved in a circular motion along the tube, wherein the position of the squeezing elements is detected during the rotor rotation and the speed of movement of the squeezing elements by controlling the angular velocity of the rotor is adjusted.
  • the measurement volume of the measurement path and the size of the medium packets are selected so that the period of the ripple of the Flow rate, which corresponds to the distance between adjacent squeezing and the speed of movement of the squeezing, in particular the rotor angular velocity, is a multiple of the time required for the medium packages to flow through the measuring section.
  • An accurate and rapid measurement of the time duration for the passage of the medium packets through the measurement path is preferably achieved by using optical sensors.
  • the peristaltic pump 1 comprises a rotor 3 driven by a motor 2 for rotation in the direction of the arrow r.
  • the rotor 3 has at its circumference equidistant from one another crimping elements 4, which in this embodiment are in the form of rollers.
  • the squeezing elements 4 could be designed as sliding elements.
  • the rotor 3 is looped about at an angle of 180 ° by a whipping hose 5, which is supported on its outside on a housing structure 6.
  • the squeezing 4 pass successively in and out of squeezing engagement with the tube 5, whereby at the inlet 5a of the tube 5, a negative pressure is generated, which is to be conveyed by the peristaltic pump medium 7, such as a blood sample or rinsing liquid in the Hose 5 sucks and conveyed through the tube 5 to the pump outlet 5b.
  • the peristaltic pump medium 7 such as a blood sample or rinsing liquid in the Hose 5 sucks and conveyed through the tube 5 to the pump outlet 5b.
  • the period p of the ripple w in turn results from the angular velocity r of the rotor 3 and the distance between adjacent squeezing 4.
  • a new period p which begins until the intervention of the next squeezing element 4 takes in the tube 5.
  • a position sensor 8 can be provided.
  • the motor 2 is designed as a stepping motor, it is also possible to detect the position of the pinching elements 4 from the step sequence of the motor.
  • the peristaltic pump 1 is known from the prior art. Without the inventive control and calibration to be described below but even with the known variation of the angular velocity r of the rotor, it would show a reasonably smooth conveying behavior only for a whipping hose 5 with precisely defined properties. But since each Walk hose 5 changes its properties in the course of its life due to the stress and environmental influences and in the case of replacement of the Walk hose 5 hardly a replacement by a Walk hose with identical properties is possible, the conveying behavior would in practice the known ripples the flow rate of the Show media. Due to the measures according to the invention, however, the waviness of the flow rate of medium conveyed through the tube 5 can be permanently reduced to a minimum.
  • Fig. 3 shows a block diagram of an arrangement of the peristaltic pump 1 of Fig. 1 with a pump controller 12 according to the invention and measuring means 10 for detecting the fluidic parameter according to the present invention.
  • the peristaltic pump 1 is equipped with a position sensor 8 for detecting the precise position of the pinching members 4 of the rotor 3.
  • the pump controller 12 is designed to vary the angular velocity of the rotor 3 periodically as a function of the position of the squeezing elements 4 in accordance with a predetermined course, so that a base reduction of the ripple of the flow rate v of medium conveyed through the tube 5 is achieved.
  • the predetermined course of the periodic variation of the angular velocity of the rotor 3 can be stored, for example, in a table in a memory of the pump control 12.
  • the preparation of this table for example, when assembling the pump 1 by detecting the course of the flow rate of the medium through the tube 5 with uniform rotation of the rotor 3 and calculating a compensation curve, which counteracts the ripple of the flow rate and in the form of said table in the memory of the controller 12th is filed.
  • the invention provides calibration means 11, which are designed for example as a microprocessor, and recalibrate the pump control 12 at certain time intervals.
  • the time intervals of the calibration can either be event-controlled, for example, each time the tube 5 is exchanged, or timed based on predetermined intervals.
  • the calibration means 11 detect a fluidic parameter FP representative of the flow rate v of the medium, which is measured by means of the measuring means 10. From the measured fluidic parameter FP then determine the calibration means 11 the ripple of the flow rate of the medium (see diagram of Fig.
  • this change to the pump controller 12 maintains the principal course of varying the angular velocity of the rotor, but adjusts the absolute values and amplitude, respectively.
  • the peristaltic pump 1 can be preceded by a fluid switch 13 which supplies the sample medium 17 as medium 7 to be transported during normal operation of the pump and supplies a calibration liquid 14 for the calibration. which is, for example, flushing fluid.
  • a valve 16 is provided in the path of the calibration liquid 14, with which air 15 can be introduced so as to generate individual medium packages 14 from the flow of the calibration liquid 14, as will be explained in more detail below.
  • a receiver 18 for the medium 7 is provided downstream of the fluidic fluid detection means 10.
  • the fluidic parameter is the flow rate of the medium.
  • the measuring section MS is located in the fluidic path of the peristaltic pump, for example in the tube 5 or a downstream therefrom line.
  • the measuring path MS has a constant, but due to component tolerances may not be known volume.
  • This measuring path MS is limited by two optical sensors S1, S2, which can detect medium packets 14a or their beginning and end during operation.
  • These medium packages are generated by the fluid switch 13 (see Fig. 3 ) is switched to the supply of calibration fluid 14, and is introduced through the valve 16 in a temporal sequence of air 15 in the calibration liquid 14.
  • the medium packages 14a have different volumes and / or different distances from one another.
  • the residence time of the medium packages 14 in the measuring section is measured and plotted as a function of the squeezing element position in a table or a diagram.
  • the process is repeated with several media packages 14a, resulting in a table or curve of the relative waviness as a function of the squeeze element position.
  • the length of the measuring path MS is to be chosen such that the time required for each medium packet 14a to pass through the measuring path MS is only a fraction, for example less than one fifth of the period p of the waviness w of the peristaltic pump 1.
  • the control of the fluid switch 13 and the valve 16 is performed by the calibration means 11, which the Duration of the passage of the medium packets 14a is fed through the measuring path MS and get the exact positions of the squeezing elements 4 supplied from the position sensor 8 at the same time and thus can create the said table or curve of the relative ripple.
  • a calibration factor KF is calculated from the table and supplied to the pump controller 12, which changes the absolute values or amplitude of the periodically varying angular velocity of the rotor on the basis of the determined calibration factor KF.
  • the controller 12 of the peristaltic pump 1 can be calibrated at each tube change or for each operating state or at regular intervals. After calibration, the fluid switch 13 is switched to the position in which the sample medium 17 is supplied to the peristaltic pump 1.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Reciprocating Pumps (AREA)

Claims (7)

  1. Procédé pour la commande d'une pompe péristaltique (1) qui comprend des éléments pinceurs (4) déplacés par au moins un actionneur, lesquels agissent sur un tuyau souple (5) dans lequel est convoyé un fluide (7), dans lequel les éléments pinceurs (4) parviennent successivement en engagement de pincement avec le tuyau souple (5) et hors d'un tel engagement, comprenant les opérations consistant à
    mesurer au cours du temps un paramètre fluidique (FP) représentatif pour la vitesse de traversée (v) du fluide (7) à travers le tuyau souple (5),
    déterminer les ondulations (w) de la vitesse de traversée (v) du fluide (7) à partir de l'évolution temporelle mesurée du paramètre fluidique (FP), et
    lisser les ondulations (w) par réglage de la vitesse de déplacement des éléments pinceurs (4) en se basant sur les ondulations déterminées (w) de la vitesse de traversée (v), dans lequel
    le paramètre fluidique est la vitesse de traversée (v) du fluide (7), caractérisé par la détection de la durée nécessaire pour que des paquets de fluide (14a) ou respectivement le front et la fin du fluide (7) ou des paquets de fluides (14a) traversent un trajet de mesure (MS) situé dans le trajet d'écoulement de la pompe péristaltique avec volume de mesure constant, par la détection simultanée des positions des éléments pinceurs (4) et association des positions des éléments pinceurs (4) aux durées temporelles, dont résulte une courbe des ondulations de la vitesse de traversée, et
    en ce que les paquets de fluide (14a) sont générés par introduction d'air (15) dans un courant de fluide, et en particulier en ce que l'air (15) est introduit dans le courant de fluide à intervalles irréguliers.
  2. Procédé selon la revendication 1, caractérisé en ce que pour des pompes péristaltiques qui présentent une variation périodique préétablie, en particulier en usine, de la vitesse de progression des éléments pinceurs (4) en fonction d'une position momentanée des éléments pinceurs (4), on procède au lissage des ondulations (w) par réglage de la variation périodique préétablie de la vitesse de progression des éléments pinceurs (4) en se basant sur les ondulations déterminées (w) de la vitesse de traversée.
  3. Procédé selon la revendication 1 ou 2, caractérisé en ce que le réglage de la variation périodique de la vitesse de progression des éléments pinceurs (4) comprend le calcul d'un facteur de calibrage (KF) à partir des ondulations déterminées (w) de la vitesse de traversée (v) du fluide (7) et le réajustement de la variation périodique de la vitesse de progression des éléments pinceurs (4) à raison du facteur de calibrage (KF).
  4. Procédé selon la revendication 3, caractérisé en ce que le facteur de calibrage (KF) est vérifié en cours de fonctionnement pour savoir s'il tombe à l'intérieur de limites prédéterminées et, en cas de dépassement de ces limites, on procède à un nouveau calcul du facteur de calibrage (KF).
  5. Procédé selon l'une des revendications précédentes, caractérisé en ce que l'actionneur est un rotor (3) entraîné par un moteur (2), rotor par lequel les éléments pinceurs (4) sont déplacés en un mouvement circulaire le long du tuyau (5), dans lequel la position des éléments pinceurs est détectée pendant la rotation du rotor et la vitesse de progression des éléments pinceurs (4) est réglée par commande de la vitesse angulaire (r) du rotor (3).
  6. Procédé selon la revendication 1, caractérisé en ce que le volume de mesure du trajet de mesure et les volumes des paquets de fluides (14a) sont ainsi choisis que la période (p) des ondulations de la vitesse de traversée, qui correspond à la distance des éléments pinceurs voisins et à la vitesse de progression des éléments pinceurs (4), en particulier à la vitesse angulaire du rotor (r), s'élève à un multiple de la période dont les paquets de fluides ont besoin pour traverser le trajet de mesure (MS).
  7. Procédé selon la revendication 1, caractérisé en ce que la traversée des paquets de fluides (14a) à travers le trajet de mesure (MS) est détectée au moyen de capteurs optiques (S1, S2).
EP08450172A 2008-11-05 2008-11-05 Procédé destiné à la commande de pompe péristaltique Not-in-force EP2184492B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08450172A EP2184492B1 (fr) 2008-11-05 2008-11-05 Procédé destiné à la commande de pompe péristaltique
AT08450172T ATE538312T1 (de) 2008-11-05 2008-11-05 Verfahren zur peristaltikpumpensteuerung
US12/611,293 US20100135824A1 (en) 2008-11-05 2009-11-03 Process for Peristaltic Pump Control

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08450172A EP2184492B1 (fr) 2008-11-05 2008-11-05 Procédé destiné à la commande de pompe péristaltique

Publications (2)

Publication Number Publication Date
EP2184492A1 EP2184492A1 (fr) 2010-05-12
EP2184492B1 true EP2184492B1 (fr) 2011-12-21

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EP08450172A Not-in-force EP2184492B1 (fr) 2008-11-05 2008-11-05 Procédé destiné à la commande de pompe péristaltique

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US (1) US20100135824A1 (fr)
EP (1) EP2184492B1 (fr)
AT (1) ATE538312T1 (fr)

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CN105708580B (zh) * 2016-04-12 2017-10-31 浙江大学 一种温控型智能辅助供液系统
CN207454227U (zh) * 2017-10-31 2018-06-05 四川南格尔生物科技有限公司 一种高精度蠕动泵流速控制系统
CN108457845A (zh) * 2018-04-02 2018-08-28 汉仲坤（上海）控制系统有限公司 智能软管泵
US11846279B2 (en) * 2021-01-29 2023-12-19 Masterflex, Llc Accurate volume dispensing using pump and flow sensor
CN114962229A (zh) * 2021-08-20 2022-08-30 保定雷弗流体科技有限公司 一种蠕动泵的流量控制方法及装置
CN114002986B (zh) * 2021-11-02 2023-04-21 保定创锐泵业有限公司 一种防爆型蠕动泵智能控制系统

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Publication number Publication date
ATE538312T1 (de) 2012-01-15
EP2184492A1 (fr) 2010-05-12
US20100135824A1 (en) 2010-06-03

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