EP2174884A1 - Fermeture à appliquer et à encliqueter sur un récipient - Google Patents

Fermeture à appliquer et à encliqueter sur un récipient Download PDF

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Publication number
EP2174884A1
EP2174884A1 EP09012723A EP09012723A EP2174884A1 EP 2174884 A1 EP2174884 A1 EP 2174884A1 EP 09012723 A EP09012723 A EP 09012723A EP 09012723 A EP09012723 A EP 09012723A EP 2174884 A1 EP2174884 A1 EP 2174884A1
Authority
EP
European Patent Office
Prior art keywords
cap
container
plug
closure
closure according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09012723A
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German (de)
English (en)
Other versions
EP2174884B1 (fr
Inventor
Peter Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Friedrich Sanner GmbH and Co KG
Original Assignee
Friedrich Sanner GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Sanner GmbH and Co KG filed Critical Friedrich Sanner GmbH and Co KG
Publication of EP2174884A1 publication Critical patent/EP2174884A1/fr
Application granted granted Critical
Publication of EP2174884B1 publication Critical patent/EP2174884B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means

Definitions

  • the invention relates to a closure for a container, comprising a cap, wherein the cap forms an interior, in which a plug for sealing the container can be inserted in the axial direction, and wherein the cap holding pieces for holding the plug, which in the Protrude interior.
  • Closures of the type mentioned are used to seal containers made of glass or plastic, which contain substances that z. B. are freeze-dried or sterilized.
  • the containers are in particular small bottles or ampoules made of glass or plastic, from which sterilized or freeze-dried substances are removed with a hypodermic needle.
  • the containers are sealed against the atmosphere by a rubber stopper, with the stopper permanently held in the container by a cap.
  • a rubber stopper in an ampoule Introduce glass and firmly connect the stopper with the ampoule through a metallic cap.
  • the material to be picked up is placed in the container and the closure with the stopper is first placed on the container such that a passage connects the container interior to the atmosphere. In this drying position, it is possible to dry the fabric inside the container.
  • the plug is first inserted in the axial direction in the cap and held by holding pieces in this. The thus prefabricated closure can now be transported and placed on the container.
  • a disadvantage here is that the plug can not be sufficiently cleaned or sterilized when the closure is seated on the container. Since the flat surface abuts a mating surface of the cap, the vapor can not reach this flat surface sufficiently. Furthermore, it is disadvantageous that the plug can fall out of the cap when transporting the closure, if the clamping action of the cap is not sufficient.
  • the invention is therefore based on the object, a closure of the type mentioned in such a way and further, that a recorded in the cap stopper is held captive in the cap and easily together with the Container which can be sterilized or cleaned in this substance and the cap.
  • a closure for a container of the type mentioned above is characterized in that the holding pieces lock the plug such that it is fixed in a predetermined position in the axial direction.
  • a latching of the plug by the holding pieces connects the plug to the cap in a captive manner.
  • a sterilizing agent can flow around the plug so that it is sufficiently cleaned. It is possible to sterilize the cap and stopper together.
  • the fixation of the plug in a predetermined position prevents individual surfaces or regions of the plug from abutting the cap in such a way that the sterilizing agent can not reach these surfaces or areas.
  • the cap can be transported together with the plug, which is inserted into its interior, to a container. The closure can then be placed on the container and placed in a drying position.
  • the container is largely protected against the ingress of contaminants when the closure is in the drying position.
  • the drying position In the drying position, the drying of the previously introduced into the container substance can take place. It is conceivable to dry the substance by means of freeze-drying under the application of reduced pressure and temperatures below freezing point.
  • a closure is indicated which captures the plug sealing the container captive and can be sterilized or dried together with the container and the substance in this recorded substance. Consequently, the object mentioned above is achieved.
  • the holding pieces could be designed as tabs, which are articulated elastically on the inside of the cap.
  • the cap could have at least one spacer which projects into the interior and cooperates with the holding pieces in axially fixing the plug.
  • the spacer ensures that the plug is fixed in a predetermined position that allows the plug to flow around. It is prevented that the plug rests with a larger surface on a mating surface of the cap.
  • the spacers could be formed knob-shaped against this background and protrude in the axial direction from the inside of the cap into the interior. Due to this specific embodiment, a flat surface of the plug can be punctured against the inside of the Cap are supported.
  • a sterilizing agent e.g. As steam, or a cleaning agent can wash around the knob-shaped spacers and the plug together. The selective placement of the flat surface of the plug on the spacers minimizes the area not reached by sterilizing agents or cleaning agents.
  • the cap could be latched with a plug having a sealing portion and an upper portion that is flared over the sealing portion.
  • a plug is particularly suitable for insertion into a narrowed container neck of the container.
  • the sealing portion may sealingly abut in the container neck of the container, wherein the upper portion may come to rest on an enlarged container edge of the container sealing.
  • a stopper can be locked captively with the holding pieces when it is transported to the container and held thereon in a drying position.
  • the plug made of rubber or thermoplastic elastomer.
  • the plug should withstand temperatures of minus 50 ° to 121 °. The extremely low temperatures occur during the freeze-drying of a substance in the container. Sterilization by steam can reach temperatures of 121 ° C and more.
  • the upper portion of the plug could lie between the holding pieces and the spacers, wherein the holding pieces engage behind the upper portion and wherein the sealing portion protrudes axially.
  • the closure can be transported to the container, wherein the plug in the cap is taken captive.
  • the axially projecting sealing portion can be inserted into the container neck of the container.
  • the plug could have a sealing portion, in whose lateral surface a slot-shaped recess for forming a passage is formed.
  • the slot-shaped recess ensures that there is a flow connection between the container interior and the atmosphere when the closure is placed in a drying position on the container.
  • the slot-shaped recess forms a passage when the sealing portion of the plug protrudes into the container when the closure is placed on the container.
  • Such a slot-shaped recess is not necessary if the sealing portion of the plug is so short that it does not protrude into the container neck when the closure is placed on the container. In this case, there is a passage between the container rim and the lower end of the plug, which does not protrude into the container neck.
  • the cap could have on the inside of clamping pieces for latching behind a container edge.
  • the closure can be pressed onto the container and permanently connected to the container.
  • the clamping pieces are designed as tabs, which are articulated elastically on the inside of the cap.
  • the container neck can be introduced together with the container edge in the axial direction in the cap and press the tabs in the radial direction to the outside. After the edge of the container has passed the tabs, these can spring back due to their elastic articulation to its original position and engage behind the edge of the container.
  • At the periphery of the inside of the cap could be arranged equidistantly as clamping pieces at least two tabs.
  • Four tabs have proven to be particularly advantageous to permanently connect the closure firmly to the container.
  • the equidistant arrangement of the tabs ensures a circumferentially uniform contact pressure of the closure to the container.
  • the clamping pieces can also serve as a stop when the closure is in the drying position on the container.
  • the cap could have on the inside clamping elements which are formed as axially extending, projecting into the interior webs.
  • the formation of clamping elements allows a guide or centering of the closure when pressed onto the container. Furthermore, the clamping elements create a clamping action by which the cap is pressed in the drying position against the container edge.
  • the cap could have a tamper-evident closure, which is hinged to the cap to release a puncture site for a hypodermic needle.
  • a tamper-evident closure Through the tamper-evident closure, the consumer can be given the information that the container is in intact condition. Only after tearing off the tamper-evident closure is the puncture site accessible for an injection needle. The puncture site can be protected from contamination by the tamper-evident closure.
  • the cap could be a support member for biasing a handle portion of the tamper-evident closure.
  • a handle portion of the tamper-evident closure By this specific embodiment, it is possible to easily grasp the handle portion, for example, with a thumbnail and deduct the tamper-evident closure.
  • the cap has first cap openings which break through the lateral surface of the cap.
  • the first cap openings allow demolding of the injection-molded cap.
  • a first cap opening may serve to receive the handle portion of the tamper-evident closure.
  • the handle portion which opens into the first cap opening, are particularly easily taken by a consumer.
  • the cap could have second cap openings which break through the lid of the cap. These cap openings serve to facilitate removal from the injection-molded cap.
  • first and second cap apertures serve not only to facilitate demoulding of the cap after injection molding, but also to allow passage of steam or sterilant during sterilization of the cap and / or escape of gaseous constituents from the container when the cap is in place Drying position is located on the container.
  • the cap is made of a plastic.
  • a plastic can be used to make the cap in one piece by injection molding.
  • the cap is made of polypropylene or HDPE. These materials have proven to be particularly temperature stable. The high temperature stability is necessary to withstand sterilization by heat or steam. Further, the use of a plastic allows the replacement of the aluminum caps known in the art. In normal sterilization, the plastic used must be at a temperature of at least 20 minutes Withstand 121 ° Celsius. Furthermore, the plastic used must withstand a very low temperature of -50 ° C for at least 24 hours. The same requirements apply to the material from which the plug is made.
  • a container could comprise a closure according to any one of the preceding claims. Such a container can be made particularly cost-effective while maintaining all sterility requirements.
  • Fig. 1 shows an exploded view of the closure with plug and cap and the container according to a first embodiment.
  • Fig. 1 shows a container 1, which may for example be bottle-shaped and may consist of glass or plastic.
  • the container 1 has a narrowed container neck 2, to which an extended container edge 3 is connected.
  • the container 1 has a container opening 4 which is surrounded by the container edge 3.
  • Above the container rim 3, a plug 10 for insertion into the container opening 4 is shown.
  • the plug 10 is made of rubber, for example.
  • the plug 10 has a sealing portion 11 and an upper portion 12, which is extended relative to the sealing portion 11.
  • the plug 10 and its sealing portion 11 is designed substantially cylindrical.
  • the sealing portion 11 of the plug 10 may have a circumferential sealing bead for engagement with the container 1.
  • the cap 20 has holding pieces 22 which protrude into the interior 29 of the cap 20.
  • the cap 20 also has first cap openings 26, which break through the lateral surface of the cap 20.
  • the cap 20 further includes second
  • the cap 20 has a tamper-evident closure 24, which protrudes with a handle portion 24 a in a first cap opening 26.
  • Fig. 2 shows the plug 10 inserted in the cap 20 and the container Fig. 1 ,
  • the cap 20 can be transported to the container 1 with the plug 10 inserted.
  • Fig. 3 shows the container 1 and the cap 20 Fig. 2 in the drying position, in which the cap 20 is partially placed on the container 1.
  • the closure is placed on the container 1, that a passage described in more detail below connects the container interior with the atmosphere. Nevertheless, the container 1 is largely protected against the ingress of contaminants.
  • the drying position the drying of the previously introduced into the container 1 substances can be done.
  • the fabrics may be dried by freeze drying using low pressure and temperatures below freezing.
  • the invention is particularly suitable for medicaments, for example injectables, which can be introduced into the container 1.
  • Fig. 4 shows the attached to the container 1 cap 20 Fig. 3 in the closed position.
  • the closure can be brought into the closed position in which the stopper 10 closes the container 1.
  • the cap 20 of the closure has a tearable tamper-evident closure 24 which releases a puncture site.
  • an injection needle can be inserted through the stopper 10 and the contents, optionally after prior addition of a solvent, such as water, are removed.
  • Fig. 5a shows the container 1 and shutter Fig. 1 in cross-section along a first cut.
  • Fig. 5b shows the container 1 and the shutter Fig. 1 in cross section along a second cut.
  • the closure for the container 1 comprises the cap 20, wherein the cap 20 forms an inner space 29, in which the plug 10 for sealing the container 1 in the axial direction can be inserted.
  • the cap 20 has holding pieces 22 for holding the plug 10, which protrude into the inner space 29.
  • the Holding pieces 22 can lock the plug 10 in such a way that it is fixed in a predetermined position in the axial direction.
  • the holding pieces 22 are formed as tabs, which are articulated elastically on the inner side 29 a of the cap 20.
  • the tabs protrude radially inward.
  • On the circumference of the inner side 29a of the cap 20 are arranged as holding pieces 22 four tabs equidistant.
  • the cap 20 has spacers 23, which protrude into the inner space 29, and cooperate with the holding pieces 22 during the axial fixing of the plug 10.
  • the spacers 23 are knob-shaped and protrude in the axial direction from the inner side 29 a of the cap 20 into the inner space 29.
  • the cap 20 can be latched with the stopper 10, which has a sealing portion 11 and an upper portion 12, which is widened in relation to the sealing portion 11.
  • the upper portion 12 can be applied between the holding pieces 22 and the spacers 23, wherein the holding pieces 22 engage behind the upper portion 12 and wherein the sealing portion 11 protrudes axially.
  • the cap 20 has on the inner side 29 a clamping pieces 21 for latching behind the container rim 3.
  • the clamping pieces 21 are formed as tabs, which are hinged to the inner side 29 a of the cap 20 elastically.
  • On the circumference of the inner side 29 a of the cap 20 21 tabs are arranged equidistantly as clamping pieces 21.
  • the cap 20 has on the inner side 29a clamping elements 28 which are formed as axially extending, projecting into the interior 29 webs.
  • the cap 20 has a tamper-evident closure 24 which is hinged to the cap 20 to release a puncture site 25 for an injection needle.
  • the cap 20 has a support member 30 for biasing the handle portion 24a of the tamper-evident closure 24.
  • the cap 20 has first cap openings 26, which break through the lateral surface of the cap 20.
  • the grip portion 24a of the tamper-evident closure 24 protrudes into a first cap opening 26.
  • the cap 20 has second cap openings 27 which break through the lid of the cap 20.
  • the first cap openings 26 and second cap openings 27 allow the cap 20 to flow through during sterilization or freeze-drying.
  • the cap 20 is made of a plastic. In particular, it may have a wall thickness W between 0.2 and 5 mm, preferably between 0.5 and 2 mm.
  • Fig. 6a shows the container 1 and the shutter Fig. 2 in cross-section along a first cut.
  • Fig. 6b shows the container 1 and the shutter Fig. 2 in cross section along a second cut.
  • the cap 20 is latched to the plug 10, which has a sealing portion 11 and an upper portion 12 which is widened relative to the sealing portion 11.
  • the upper portion 12 is located between the holding pieces and the spacers 23, wherein the holding pieces 22 engage behind the upper portion 12 and wherein the sealing portion 11 protrudes in the axial direction of the container 1.
  • the plug 10 is formed substantially cylindrical and has a concave cavity, which allows the sealing portion 11 when inserted into the container neck 2 of the container 1 to press slightly radially together.
  • the plug 10 is locked with the cap 20, they can be sterilized together become. Through the first cap openings 26 and the second cap openings 27, steam or sterilizing agent can flow out of the interior of the container through the cap 20 past the stopper 10. The plug 10 can be lapped by the sterilizing agent.
  • holding position lock the holding pieces 22 the plug 10 such that it is fixed in a predetermined position in the axial direction.
  • the plug 10 is indeed rotatable in the cap 20, but apart from a small game no longer stayednverschietik.
  • the spacers 23 prevent displacement of the plug 10 upwards, the holding pieces 22 prevent displacement of the plug 10 down.
  • Fig. 7a shows the container 1 and the shutter Fig. 3 in cross section along a first cut with an opened passage 13 in the drying position.
  • Fig. 7b shows the container and the closure Fig. 3 in cross-section along a second cut with the opened passage 13 in the drying position.
  • the closure is placed on the container 1 so that a passage 13 connects the container interior with the atmosphere.
  • the passage 13 is annular and is formed by a gap formed between the plug 10 and the container 1.
  • the container 1 is largely protected against the ingress of contaminants.
  • the holding pieces 22 lock the plug 10 so that it is fixed in a predetermined position in the axial direction.
  • the clamping pieces 21 form a stop for engagement with the container and thus facilitate the positioning of the plug 10th
  • Fig. 8a shows the container 1 and the shutter Fig. 4 in cross-section along a first cut in the closed position.
  • Fig. 8b shows the container 1 and the shutter Fig. 4 in cross-section along a second cut in the closed position.
  • the plug 10 closes the container 1.
  • the container edge 3 presses in the closed position, the holding pieces 22 radially outward, so that they release the stopper 10.
  • the plug 10 is now sealingly on the container edge 3 with its upper portion 12.
  • the sealing portion 11 is inserted into the container 1 and seals it from abutting against the container 1.
  • the cap 20 has on the inner side 29 a clamping pieces 21 for latching behind the container rim 3.
  • the clamping pieces 21 are formed as tabs, which are hinged to the inner side 29 a of the cap 20 elastically.
  • On the circumference of the inner side 29a of the cap 20 are arranged as clamping pieces 21 four tabs equidistant, which engage behind the container edge 3 latching.
  • the cap 20 of the closure has a tearable tamper-evident closure 24 which releases a puncture site 25.
  • an injection needle can be inserted through the stopper 10 and the contents, optionally after prior addition of a solvent, such as water, are removed.
  • Fig. 9a shows a view of the cap 20 from below. Visible are the knob-shaped spacers 23 which are circumferentially arranged on a circle. It can further be seen that the holding pieces 22 and the clamping pieces 21 are arranged one above the other and offset relative to one another on the inside 29a of the cap 20.
  • Both the holding pieces 22 and the clamping pieces 21 are formed as radially inwardly projecting tabs, which are articulated elastically on the inner side 29 a of the cap 20.
  • Fig. 9a further shows the tamper-evident closure 24 equipped with a grip portion 24a.
  • Fig. 9b shows a side view of the cap 20 Fig. 9a.
  • Fig. 9b shows that the cap 20 has a support member 30 for biasing the handle portion 24a of the tamper-evident closure 24.
  • the grip portion 24a of the tamper-evident closure 24 protrudes into a first cap opening 26.
  • the support member 30 is in the mounted state on the plug 10 so that it pushes the handle portion 24 slightly in the axial direction upwards. Therefore, the consumer can grasp the grip portion 24a better.
  • Fig. 9c shows a view of the cap 20 from Fig. 9a from above. This view, the second cap openings 27 are removed, which are arranged circumferentially. Furthermore, the first cap openings 26 can be seen in the lateral surface of the cap 20. Finally shows Fig. 9c the tamper-evident closure 24 with its grip portion 24a.
  • the tamper-evident closure 24 is designed omega-shaped in plan view.
  • Fig. 10 shows an exploded view of a second embodiment with a plug 10 ', which has a longer sealing portion 11' and a recess 14 formed therein.
  • the plug 10 ' has a sealing portion 11', in whose lateral surface a slot-shaped recess 14 for forming a in Fig. 13 formed passage is formed.
  • Fig. 11 shows a cross section of the closure and the container Fig. 10
  • the cross section according to Fig. 11 shows that the plug 10 'has a sealing portion 11', in whose lateral surface a slot-shaped recess 14 is formed to form the passage.
  • the slot-shaped recess 14 extends approximately from the center of the sealing portion 11 'to its upper end 12' remote from the end.
  • the plug 10 ' has a sealing portion 11' with a concave cavity, which allows a radial compression of the sealing portion 11 'during insertion into the container 1.
  • the plug 10 ' has a sealing portion 11' and an upper portion 12 'which is widened with respect to the sealing portion 11'.
  • Fig. 12 shows the closure and the container 1 Fig. 11 with inserted into the cap 20 plug 10 '.
  • the holding pieces 22 engage the plug 10 'in such a way that it is fixed in a predetermined position in the axial direction.
  • the cap 20 has spacers 23 which protrude into the inner space 29 and cooperate with the holding pieces 22 during the axial fixing of the plug 10 '.
  • the upper portion 12 ' between the holding pieces 22 and the spacers 23, wherein the holding pieces 22 engage behind the upper portion 12', and wherein the sealing portion 11 'protrudes axially in the direction of the container 1.
  • Fig. 13 shows the closure and the container 1 Fig. 12 in the drying position with partially attached cap 20.
  • the sealing portion 11 ' protrudes into the container 1, however, a passage 13 is formed by the slot-shaped recess 14 in the lateral surface of the sealing portion 11'. Through the passage 13, the container interior is connected to the atmosphere.
  • FIG. 14 shows Fig. 14 the closure and the container 1 from Fig. 13 in the closed position.
  • the upper portion 12 'of the plug 10' is sealingly on the container edge 3.
  • the sealing portion 11 ' is received in the container 1 and is sealingly against the container interior.
  • the container edge 3 has pressed the retaining pieces 22 radially outwardly when pressing the closure onto the container 1.
  • the holding pieces 22 are no longer on the plug 10 'on.
  • the plug 10 ' is positioned between the container rim 3 and the spacers 23 of the cap 20.
  • the clamping pieces 21 of the cap 20 engage behind the container edge.
  • FIGS. 1 to 14 used like reference numerals designate like components of the container 1 and the closure. Reference is made to the relevant parts of the description.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
EP09012723A 2008-10-10 2009-10-08 Fermeture à appliquer et à encliqueter sur un récipient Not-in-force EP2174884B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008050931 2008-10-10
DE102008051351A DE102008051351A1 (de) 2008-10-10 2008-10-15 Verschluss zum Aufpressen und Verrasten mit einem Behälter

Publications (2)

Publication Number Publication Date
EP2174884A1 true EP2174884A1 (fr) 2010-04-14
EP2174884B1 EP2174884B1 (fr) 2011-05-25

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ID=41514961

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09012723A Not-in-force EP2174884B1 (fr) 2008-10-10 2009-10-08 Fermeture à appliquer et à encliqueter sur un récipient

Country Status (4)

Country Link
US (1) US20100089862A1 (fr)
EP (1) EP2174884B1 (fr)
AT (1) ATE510780T1 (fr)
DE (1) DE102008051351A1 (fr)

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WO2012138496A1 (fr) * 2011-04-04 2012-10-11 Genesis Packaging Technologies Systèmes de capuchon et procédés pour sceller de façon étanche des flacons pharmaceutiques
WO2015002768A1 (fr) * 2013-07-03 2015-01-08 Capitol Medical Devices, Inc. Capuchon de flacon de substance parentérale
US10195112B2 (en) 2012-11-26 2019-02-05 Becton Dickinson France Adaptor for multidose medical container
US10219983B2 (en) 2016-08-03 2019-03-05 Genesis Packaging Technologies Cap systems with piercing member for pharmaceutical vials

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FR2950035B1 (fr) * 2009-09-15 2011-09-02 Raymond A & Cie Coiffe de verrouillage pour recipient a col
FR2950865B1 (fr) 2009-10-01 2011-10-28 Raymond A & Cie Coiffe de verrouillage pour recipient a col avec une capsule a pattes de fixation
DE102010016866B4 (de) * 2010-05-10 2018-06-21 Helvoet Pharma Belgium N.V. Verschluss für ein Behältnis und Verfahren zur Durchführung eines Gefrier-Trocknungsverfahrens
DE102011050983A1 (de) * 2010-09-09 2012-03-15 Helvoet Pharma Belgium N.V. Verschlussstopfen für pharmazeutische Anwendungen
FR2967655B1 (fr) * 2010-11-24 2014-03-14 Biocorp Rech Et Dev Dispositif de bouchage d'un recipient, recipient equipe d'un tel dispositif et procede de fermeture d'un lot de tels recipients
FR2975976B1 (fr) * 2011-06-06 2014-08-29 Biocorp Rech Et Dev Dispositif de bouchage et recipient equipe d'un tel dispositif
US10723497B2 (en) 2014-11-03 2020-07-28 Vanrx Pharmasystems Inc. Apparatus and method for monitoring and controlling the filling of a container with a pharmaceutical fluid in an aseptic environment
FR2986782B1 (fr) 2012-02-13 2014-03-07 Raymond A & Cie Dispositif de verrouillage de bouchon sur recipient a collerette, recipient a collerette obture par bouchon pourvu d'un tel dispositif de verrouillage
FR2987825B1 (fr) 2012-03-09 2015-06-05 Biocorp Rech Et Dev Dispositif de bouchage et recipient equipe d'un tel dispositif
DK3033276T3 (en) 2013-08-16 2019-04-23 Vanrx Pharmasystems Inc PROCEDURE FOR FILLING PHARMACEUTICAL CONTAINERS
EP3106145B1 (fr) 2013-09-02 2018-05-23 Taisei Kako Co., Ltd. Capuchon pour flacon
DE102014110327B4 (de) * 2014-07-22 2016-02-11 App Biomaterials Gmbh Verschluss für pharmazeutische Gebinde sowie Verfahren zum Verschließen eines Fläschchens
US9926114B2 (en) 2014-09-18 2018-03-27 HCT Group Holdings Limited Quick release base and lid assembly container
GB201506691D0 (en) * 2015-04-20 2015-06-03 Greif Int Holding Bv Closure caps
US10039913B2 (en) 2015-07-30 2018-08-07 Carefusion 303, Inc. Tamper-resistant cap
GB201610368D0 (en) * 2016-06-15 2016-07-27 Tech Partnership The Plc Integrated cap and seal system
US20220241149A1 (en) * 2019-07-02 2022-08-04 Taisei Kako Co., Ltd. Cap and capped vial
FR3098504B1 (fr) * 2019-07-09 2021-06-04 A Raymond Et Cie coiffe de verrouillage pour récipient à col
EP4085892B1 (fr) 2021-05-06 2023-12-20 KAISHA PACKAGING Private Ltd. Fermeture en plastique inviolable pour des flacons destinés au stockage de substances pour applications médicales ou pharmaceutiques et son utilisation
CA208550S (en) 2021-06-11 2023-07-10 Kaisha Packaging Private Ltd Tamper evident plastic closure for vials for medical purposes

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DE29710136U1 (de) 1996-09-12 1997-08-14 Comar Inc Überdeckelbaugruppe für Fläschchen oder Glasbehälter mit Verzahnungsabschluß
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DE102008051351A1 (de) 2010-04-15
EP2174884B1 (fr) 2011-05-25
US20100089862A1 (en) 2010-04-15

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