EP2149598A1 - Verfahren zur Herstellung eines auf mit Ozon angereichertem Öl basierten Mediums - Google Patents

Verfahren zur Herstellung eines auf mit Ozon angereichertem Öl basierten Mediums Download PDF

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Publication number
EP2149598A1
EP2149598A1 EP08425531A EP08425531A EP2149598A1 EP 2149598 A1 EP2149598 A1 EP 2149598A1 EP 08425531 A EP08425531 A EP 08425531A EP 08425531 A EP08425531 A EP 08425531A EP 2149598 A1 EP2149598 A1 EP 2149598A1
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EP
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Prior art keywords
oil
ozone
based vehicle
tank
gaseous flow
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EP08425531A
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English (en)
French (fr)
Inventor
Roberto Ghiringhelli
Renato Gandolfi
Daniela De Bona
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Sanipan Srl
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Sanipan Srl
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Priority to EP08425531A priority Critical patent/EP2149598A1/de
Publication of EP2149598A1 publication Critical patent/EP2149598A1/de
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/006—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by oxidation

Definitions

  • the present invention refers, in its most general aspect, to a method of production of an ozonized oil-based vehicle or substrate.
  • the invention refers to a method of the aforesaid type wherein such oil-based vehicle or substrate, for example an unsaturated vegetable oil such as virgin or extra-virgin olive oil, corn oil, sunflower oil, linseed oil, almond oil, walnut oil, poppy oil, sesame oil, soy oil, palm oil, peanut oil, jojoba oil and similar oils, is ozonized until saturation with ozone is obtained and stabilized in such a manner that such saturation is long-preserved, and in any case for a time useful for its use as saturated ozonized oil.
  • an unsaturated vegetable oil such as virgin or extra-virgin olive oil, corn oil, sunflower oil, linseed oil, almond oil, walnut oil, poppy oil, sesame oil, soy oil, palm oil, peanut oil, jojoba oil and similar oils
  • the present method provides an oil-based vehicle or substrate as considered above, i.e. ozonized, saturated and stable, particularly suitable for being used for cosmetic purposes and/or as medicament for the treatment of numerous pathologies and/or diseases, both pure and diluted with another oil that is not ozone-saturated, of same or different nature, and also in association with further substances for example in formulations, compositions, suspensions etc.
  • the invention also provides an apparatus for carrying out the aforesaid method.
  • ozone has in fact long been used for its high bactericide and antiseptic capacity, both in gaseous flow and in other vehicles such as for example oil-based substrates.
  • ozone must account for its high instability and for the fact that, in particular in the case of oil-based substrates comprising unsaturated fatty acids, its use determines the formation of undesired by-products, mainly aldehydes and ketones.
  • the prior art therefore, provided a large number of methods of production of ozonized oil-based substrates that were particularly aimed at stabilizing the presence of the ozone in the oil-based vehicle and at minimizing the final content of undesired by-products.
  • the method described in the aforesaid document comprises an ozone saturation step, conducted by means of bubbling a mixture of oxygen and ozone in the vegetable oil, and an extraction step of the by-products formed during such ozone-saturation step.
  • the by-products extraction step is preceded by an acidification step, by a dilution step with aqueous solution, and it is followed by a removing step of the aqueous phase.
  • the product obtained from such method is a stable ozonized oil comprising peroxides and essentially without aldehydes.
  • an oil-based vehicle or substrate here also simply identified as oil, which allows to make a complete saturation of such oil-based vehicle without forming undesired by-products, as well as a stabilization of the same, so as to provide an ozonized oil which preserves the saturation ozone content for a long period of time, in any case for a time interval useful for its use particularly in cosmetic treatments and/or as medicament for therapeutic treatments.
  • the present invention provides a method of production of an ozonized oil-based vehicle or substrate which overcomes the drawbacks mentioned with reference to the prior art, i.e. a method of production of a saturated and stable ozonized oil, lacking undesired substances, such as in particular aldehydes and ketones which are advantageously not formed during the method, but also lacking nitrogen oxides and compounds deriving from such oxides such as nitrates, micro-particulates and other substances generally comprised in the surronding air, wherein with the term saturated it is intended that the oil is saturated with ozone, and with the term stable it is intended that the ozone-saturation is preserved for a long time, and in any case preserved for a time interval useful for the use of such oil as an ozone-saturated product, also after a stocking and/or preservation period of the oil itself.
  • a saturated and stable ozonized oil lacking undesired substances, such as in particular aldehydes and ketones which are advantageously not
  • the process according to the invention comprises:
  • the presence of at least one noble or inert gas in the gaseous flow insufflated in the oil-based vehicle prevents the formation of aldehydes from the respective fatty acids, which otherwise would occur due to the action of the ozone both during the first insufflation step, i.e. during the saturation step, and during the second insufflation step, i.e. during the stabilization step of the saturated oil-based vehicle.
  • the aforesaid gaseous flow insufflated in the oil-based vehicle in the aforesaid first and second insufflation steps comprises at least one noble or insert gas in a quantity comprised between 4 and 8% by weight.
  • the at least one noble or inert gas is selected from the group comprising helium, neon, argon, krypton, xenon, radon, and similar inert gases or their mixtures, such that the total quantity is in the aforesaid range of 4-8% by weight.
  • the aforesaid gaseous flow comprising oxygen, ozone and noble gases is obtained via electrical discharge of a gaseous flow comprising ultrafiltrated oxygen in an amount at least equal to 92% by weight.
  • the aforesaid first and second insufflation steps are consecutively carried out without interruption.
  • the aforesaid first and second insufflation steps are carried out such that the respective gas flows bubble from the bottom towards the top in said tank.
  • the aforesaid first and second insufflation steps are carried out at low pressure, preferably not greater than 185 KPa and at constant temperature, advantageously room temperature.
  • the ozone concentration in said insufflated gaseous flow insufflated in said second insufflation step is greater than the ozone concentration in the gaseous flow insufflated in said first insufflation step.
  • the aforesaid ozone-saturation of the oil-based vehicle is indicated by an ozone concentration value measured in the aforesaid gaseous flow at an outlet point from said tank, that is, downstream thereof, equal to an ozone concentration value measured at an inlet point to said tank, that is, upstream thereof or in any case by equivalent concentration values measured before and after the transit through the oil-based liquid head, i.e. in the gaseous flow insufflated into the oil-based vehicle and in the residual gaseous flow.
  • the aforesaid ozone-saturation of the oil-based vehicle is indicated by a maximum value of the residence time (or a minimum value of the speed of transit) through the liquid head of the oil-based vehicle measured for the gaseous flow.
  • the aforesaid stabilization of the ozone content in the saturated oil-based vehicle is indicated by a constant value, measured for a predetermined time interval or number of measurements, of the differential percentage of the aforesaid ozone concentration in the gaseous flow upstream and downstream of said tank, or in any case determined by concentration values measured before and after the transit through the oil-based vehicle by the gaseous flow, i.e. in the gaseous flow insufflated into the oil-based vehicle and in the residual gaseous flow.
  • the aforesaid stabilization of the ozone content in the saturated oil-base vehicle is indicated by a constant value, measured for a predetermined time interval or number of measurements, of the aforesaid maximum value of the residence time (or minimum speed of transit) through the oil-based vehicle head measured for the aforesaid gaseous flow.
  • the present method can be standardized, so that, for a given oil-based vehicle, the attainment time of said constant ozone concentration value is based on a predetermined quantity of ozone insufflated in said oil-based vehicle.
  • a given oil-based vehicle which has been saturated with ozone and stabilized in accordance with the present method, comprises a specific (constant) concentration of ozone and derived compounds, concentration which, at the aforesaid temperature and pressure values, is reached upon the insufflation of a predetermined total amount of ozone insufflated into the oil-based vehicle, amount which is proportional to the quantity of, and specific for, the given oil-based vehicle.
  • the aforesaid constant ozone concentration value in the oil-based vehicle is reached on the basis of a predetermined (pre-calculated) total amount of ozone insufflated in the oil-based vehicle in a predetermined time interval (also pre-calculated), advantageously reducing the number of the aforesaid measurements to one, i.e. one single control upon completion of the process, if not even zero controls, since the aforesaid process is standardized and thus tested for obtaining the saturation with ozone and the stabilization of a given quantity of a given oil.
  • a first aspect of the present invention is a method of production of an ozonized oil-based (oil) vehicle or substrate, with saturation and stability characteristics, which does not comprise undesired by-products, particularly indicated for being used in cosmetic treatments and also as medicament, for the topical treatment of numerous pathologies and diseases.
  • the present invention has shown that, in particular conditions, an unsaturated vegetable oil can be ozonized until complete ozone saturation is attained, without forming undesired by-products, and that such saturation can be preserved for an extended time interval, useful for using the oil as saturated ozone product, i.e. as a product whose effectiveness in cosmetic treatments or as medicament for topical use is considered maximum, due to the high content of ozone and peroxides.
  • a vegetable oil was obtained saturated with ozone, stable and lacking undesired by-products such as aldehydes and nitrogen oxides, through a process which comprises:
  • the present invention has shown that the presence of noble or insert gases in the gaseous flow insufflated into the oil prevents the formation of undesired by-products, mainly aldehydes, which would otherwise be obtained via reaction of the ozone with the unsaturated fatty acids present in the oil.
  • the present invention has shown that the presence of noble or inert gases in the gaseous flow insufflated in the oil also prevents the formation of undesired by-products which would be obtained if the gaseous flow insufflated into the oil-based vehicle comprised nitrogen, which even if not provided in the flow supplied and insufflated into the oil, as will appear in the following description, can also by chance be present in traces.
  • the present invention has shown that even if it is possible to rather easily obtain a saturation with ozone of the oil, without a stabilization of the oil itself, i.e. of the ozone and the peroxides formed in the oil, the ozone content and the same peroxides will not remain at the saturation value for a prolonged time interval, useful for using the oil as saturated ozone product, but to the contrary almost instantaneously decreases, and in any case rather quickly due to the instability of the ozone itself and of the peroxides.
  • the present method provides for ozonizing the oil up to saturation by means of a gaseous mixture comprising oxygen, ozone and noble or inert gases, the latter present in the gaseous flow insufflated into the oil in a quantity preferably comprised between 4 and 8% by weight.
  • the aforesaid gaseous flow comprising oxygen, ozone and noble or insert gases is obtained by electrical discharge of a gaseous flow comprising ultrafiltrate oxygen in an amount at least equal to 92% by weight.
  • the gaseous flow insufflated into the oil can comprise any one of the following: helium, neon, argon, krypton, xenon, radon or also their mixtures, since it was verified, without wishing to be bound to any scientific theory, that their presence ensures a kind of "chemical mediation" which does not allow the formation of the aldehydes from the respective fatty acids due both to the action of the ozone and possibly to the presence of nitrogen, also in traces.
  • Preventing the formation of aldehydes in the present oil signifies preventing the astringent action that the aldehydes intrinsically possess, which could cancel or substantially reduce the effectiveness of the tissue or vasal neoformation or reparation mechanism which one wishes to obtain with the topical application on humans of the saturated and stable ozonized oil in accordance with the invention, as will be clearer from the following description.
  • the present method is preferably conducted at low pressure, advantageously not over 185 KPa and still more advantageously is conducted at room temperature, preferably at a temperature of 16-22°C, better yet 18-20°C.
  • the aforesaid saturation and stabilization steps i.e. the first and the second insufflation steps, are carried out consecutively without interruption.
  • the ozone concentration in the gaseous flow insufflated in the second insufflation step is greater than the ozone concentration in the gaseous flow insufflated in the first insufflation step.
  • the increase of the ozone amount insufflated per cubic meter of gaseous flow or per time unit in the oil after its saturation is preferred, since it has been shown that the stabilization step is facilitated by a greater supply of ozone, an over-saturation equilibrium in such a manner being forced.
  • the first and second insufflation steps are carried out such that the respective gaseous flows bubble from the bottom towards the top in the crossing of the oil, i.e. in the tank.
  • the saturation with ozone of the oil is indicated through a measurement of the ozone concentration, and in particular in accordance with the invention by measuring the ozone concentration in the gaseous flow in a measurement point placed at the outlet of said tank (thus downstream of the oil or tank in a residual gaseous flow) and in a measurement point placed at the inlet of said tank (thus upstream of the oil or tank in an insufflated gaseous flow), or in any case before and after the passage of the gaseous flow in the oil.
  • the saturation with ozone of the oil can also be detected by measuring the residence time that the insufflated gaseous flow takes for crossing the oil, i.e. the oil head inside said tank.
  • a maximum residence time value corresponds with a minimum speed of transit value through the oil by the gaseous flow.
  • the stabilization of the ozone content in the saturated oil is indicated by a constant value, measured for a predetermined time interval or number of measurements, of the differential percentage of the aforesaid ozone concentration in the gaseous flow measured at a point upstream and downstream of said tank, or in any case determined by the gaseous flow insufflated in the oil head and in the residual gaseous flow.
  • the stabilization of the ozone content in the saturated oil can also be indicated by a constant value, obtained for a predetermined time interval or number of measurements, of the aforesaid maximum value of the residence or travel time (or minimum speed of transit) through said head measured for the gaseous flow.
  • the insufflation in the oil of the gaseous flow comprising oxygen, ozone and noble or inert gases is continuous and extends for a time interval sufficient for oil saturation, and necessary for the stabilization of the saturated oil.
  • the ozone (O 3 ), allotrope of oxygen (O 2 ), is composed of two stable oxygen atoms and a third unstable oxygen atom in so-called singlet configuration, characterized by a high tendency to accept electrons.
  • This tendency which can be defined as “electron suction” capacity, is at the base of the ozone's oxidizing action.
  • this oxidizing capacity causes, over time, the saturation of the oil.
  • the ozone tends to occupy all of the sites provided with available electrons provided by the base components of the oil, oxidizing them, and moreover tends to dissolve itself in the oil-based vehicle.
  • the unsaturated fatty acids contained in the oil are then saturated.
  • the exposure of the oil to the gaseous flow comprising oxygen, ozone and noble or inert gases ensures that all the free electrons are "picked up or caught” (oxidation process) until the oil itself is saturated.
  • the difference of ozone concentration in the gaseous flow insufflated into the oil from the ozone concentration in the residual gaseous flow determines the concentration index of the ozone in the oil.
  • the ozone concentration in the residual gaseous flow is about zero, until the saturation step has been completed which, therefore, in accordance with the present method, occurs from the bottom towards the top.
  • the aforesaid stabilization is necessary so that the ozone saturated oil does not lose the saturation in a short time period, with consequent depletion of the high therapeutic capacities marking it, due to the dispersion of the ozone and alterations of the same oil due to the passing of time, and also to a possible unsuitable preservation of the oil as will be better illustrated below.
  • the ozone concentration in the gaseous flow insufflated into the oil is generally determined also by the quantity and type of oil to be saturated, but in any case always comprised in the medical ozone concentration range for human applications, i.e. between 10 and 80 g/m 3 .
  • the surface tension forces increase the viscosity of the oil until a certain maximum level is reached, which can be inferred from the decrease of the gaseous flow residence or transit speed in the oil, which reaches a minimum value.
  • the saturation and the stabilization cannot be superimposed, if not after a certain over-insufflation period, probably since the saturation with a highly unstable gas like ozone allows the free electrons to occupy all the available sites, but with a bond that at first is extremely weak.
  • the over-saturation with ozone instead allows the stabilization of the oil, allowing the strengthening of all the bonds.
  • the saturated and stabilized oil can transfer ozone and peroxides in particular thermal and pressure conditions, as will be clearer below.
  • a second aspect of the present invention is an apparatus for actuating the method described above, which essentially comprises, as illustrated in figure 1 :
  • the present apparatus also comprises a flow meter 9 arranged between the oxygen generator-synthesizer 1 and the ozone generator 2, as illustrated in figure 2 .
  • the flow meter 9 can possibly be equipped with a humidifier in the figures, not shown.
  • the aforesaid first and second detection units consist of a first and a second spectrophotometer, still indicated with 3 and 6, which preferably are arranged on respective branches of the duct 8.
  • the present apparatus comprises related first 10 and second 11 deflection valves for directing the insufflation gaseous flow and respectively the residual gaseous flow into such branches of the duct 8 towards the spectrophotometers 3 and 6, as illustrated in the example of figure 2 .
  • the present apparatus comprises a pair of first deflection valves, hermetically sealed and ozone-resistant, which interrupt the flow in turn towards the tank 4 or towards the first spectrophotometer_3, alternatively deflecting the gaseous flow either towards the first spectrophotometer for measuring the concentration, in particular of ozone, of the gaseous flow entering the tank (insufflated gaseous flow), or towards the tank containing the oil for its ozonification.
  • a second pair of deflection valves are also provided, hermetically sealed and ozone-resistant, positioned downstream of the tank 4, and respectively a second deflection valve 11a positioned upstream of the ozone removal unit 7, and the aforesaid second deflection valve 11 arranged upstream of the second spectrophotometer 6 at the aforesaid branch of the duct 8, which interrupt the gaseous flow either towards the ozone removal unit or towards the second spectrophotometer, deflecting the gaseous flow either towards the second spectrophotometer, for measuring the concentration, in particular of ozone, of the gaseous flow exiting from the tank, or towards the removal unit of the residual ozone ( figure 2 ).
  • the ozone removal unit 7 consists of a catalyst filter for the conversion of residual ozone into oxygen.
  • the present apparatus also comprises ozone indicators 12 (chemical nose) for indicating possible dispersions of the gaseous flow, thus of ozone, both in the insufflated gaseous flow and in the residual gaseous flow, as illustrated in the example of figure 2 .
  • ozone indicators 12 chemical nose
  • the aforesaid ozone detectors 12 are three in number and are arranged downstream of the ozone generator 2, upstream of the ozone removal unit 7 and downstream of the same ozone removal unit 7.
  • the containment tank 4 of the pre-established oil-based (oil) vehicle is of the so-called vertical type, for example a column or drum with vertical axis, with height preferably equal to or greater than 200 cm.
  • the aforesaid openings of the tank are specifically an inlet opening 13 and an opposite outlet opening 14 placed at related end portions of the tank, for the coupling respectively in inlet and in outlet of the gaseous flow transport duct 8.
  • the transport duct 8 of the gaseous flow is a connector duct between the different units or components of the present apparatus and therefore a duct which can be defined discontinuous, and which in the above-considered case does not physically cross the tank 4, as illustrated in the example of figure 2 .
  • the inlet opening 13 is formed at a base of the tank 4, i.e. the lower base or bottom of the vertical tank, while the ozone generator 2 is placed substantially at the same height as such inlet opening 13 in order to reduce to a minimum the resistances of the internal empty spaces of the duct 8 and of the entire apparatus.
  • the present apparatus comprises two to four ozone generators arranged in series and actuatable independently from each other, such ozone generators being represented in the figures as single block 2.
  • the present apparatus also comprises a controlling-governing PLC capable of automating the functioning, and thus all of the steps and functions previously described with reference to the production method of the ozonized oil according to the present invention.
  • a controlling-governing PLC capable of automating the functioning, and thus all of the steps and functions previously described with reference to the production method of the ozonized oil according to the present invention.
  • the tank 4 comprises an inlet opening 22 placed at an upper end portion thereof, advantageously at an upper base or head of the same tank, in which an outlet opening 23 is also provided.
  • the inlet 22 and outlet 23 openings allow the coupling in inlet and outlet of the transport duct 8 of the gaseous flow insufflated into the oil and residual gaseous flow, respectively.
  • the gaseous flow transport duct 8 also comprises an inner portion 28, inside the tank 4, which physically crosses the entire oil head contained in the tank 4.
  • the portion 28 of the duct 8 has a closed and sealed end, in particular the lower end placed at the bottom of the tank 4, while it is distally provided, i.e. at the same lower end and for a length preferably comprised between 15 and 20 cm, with a series of lateral holes/nozzles 29, for the exit of the gaseous flow in the form of the smallest possible bubbles.
  • the ozone generator 2 is positioned at the same height as the inlet opening of the tank, thus at the head of the tank 4, in order to reduce to a minimum the internal empty spaces and the related resistances to the gaseous flow passage, as illustrated in the example of figure 3 .
  • the transport duct 8 of the gaseous flow is coupled in the tank 4 at the upper portion thereof, and crosses it with the aforesaid inner portion 28 immersed in the oil head, but the actual insufflation and bubbling of the gaseous flow in the oil head occurs in any case from the bottom towards the top by means of the aforesaid holes/nozzles 29 ( figure 3 ).
  • the apparatus described above in its different embodiments is possibly provided with a first piston 34 slidable in the tank 4 for drawing the saturated and stabilized oil, which prevents an excessive remixing of the oil and thus prevents the dispersion of the ozone contained therein, along with other possible alterations of the oil.
  • the tank 4 provides, at the bottom, at least one discharge opening 30, provided with hermetic shutter closure, housed in a threaded external pipe union 31 (male or female), of suitable caliber, from which it is possible to make the saturated and stabilized oil exit.
  • a threaded external pipe union 31 male or female
  • the pipe union 31 is in turn connected, by means of the screw thread, with a draw duct 32, it too provided with a corresponding screw terminal (not represented in the figures), which inserts the oil directly in pre-set suitable storage containers 33.
  • the aforesaid slidable piston 34 of the same caliber as the cylindrical tank 4, is hermetically sealed on the side wall of the tank, and is adapted to be pushed by a rear force from the top towards the bottom, allowing upon process completion the "squeezing" of the oil from the tank 4.
  • the aforesaid rear force can be obtained in various modes, for example by means of manual pushing, by pressure provided from suitably growing adjusted weights, correctly placed on the upper part of the piston 34, or by means of an electrical or mechanical hydraulic pump.
  • the present invention provides the possibility to mix/ dilute the oil at the suitable and desired ozone percentage.
  • the present apparatus can possibly comprise a suitable mixing/dilution duct, in practice a sort of automatic mixing/dilution system, as illustrated with reference to the example of figure 5 , wherein the present apparatus is partial represented.
  • a mixing duct 40 is provided, interposed between the tank 4 and the storage containers 33, wherein the ozonized oil coming from the tank 4 by means of the drawing duct 32 and a different diluent vehicle, for example a natural non-ozonized oil contained in a respective second tank 42 and conveyed by means of a dilution duct 43, are mixed.
  • a different diluent vehicle for example a natural non-ozonized oil contained in a respective second tank 42 and conveyed by means of a dilution duct 43
  • the mixing duct 40 comprises respective portions of the aforesaid drawing 32 and dilution 43 ducts therein; such ducts independently convey therein, and extend counter-rotating spiral paths, one dextrorotary and one levorotary, in a number at least equal to ten.
  • the respective portions inside the mixing duct 40 of the aforesaid drawing 32 and dilution ducts 43 comprise, distributed along the aforesaid spirals, surface openings of progressively growing width which the duct 40 extends towards the storage containers 33.
  • the aforesaid openings of progressively growing size make, inside the mixing duct 40, a progressively growing fluid communication between the saturated ozonized oil and the non-ozonized dilution oil.
  • the drawing duct and the dilution duct are initially isolated from each other, then in fluid communication by means of respective surface openings of reduced size, then in fluid communication by means of respective surface openings of increasing size, until there is a single common outflow or outlet mouth, coinciding with the outflow or outlet mouth of the mixing duct suitable for the direct communication with the storage tanks ( figure 5 ).
  • the saturated ozonized oil and the non-ozonized oil are progressively mixed by the counter-rotating whirling path by means of a progressively growing contact, also maintaining at the same time a close contact with the walls respectively of the drawing duct and dilution duct, then as a single mixed and diluted oil of the mixing duct.
  • the diameters of the drawing ducts and dilution ducts can be provided with proportional caliber according to the dilution percentage that one wishes to obtain.
  • the present apparatus is preferably governed by a PLC, which advantageously can be the same type previously considered for the production process of the saturated and stable ozonized oil according to the invention.
  • the already considerably regenerating capacities of the present oil can be improved for the topical application in the treatment of specific pathologies, by means of addition of liposoluble vitamins, such as for example retinoid.
  • Retinoid is a compound chemically connected to Vitamin A, regulator of the growth of the epithelial cells, of cellular differentiation and proliferation, of bone tissue growth, of immune function as well as activator of tumor suppressor genes.
  • a further liposoluble vitamin compound, also of synthetic origin, which advantageously can be added to the saturated and stabilized oil according to the invention, is the menadione, or Vitamin K3.
  • Menadione is active in blood coagulation mechanisms.
  • infective inflammatory lesions of the teguments with hemorrhage risk are positively affected by a treatment via topical use with saturated and stable ozonized oil according to the invention.
  • the present invention was advantageously made through the use of ozone derived from the ultrafiltrate oxygen with percentages not less than 92%.
  • the ozone derived by electrification of the atmospheric air is always polluted and is also produced with an unsatisfactory concentration percentage (too low).
  • the present invention is advantageously actuated by means of the use of an oxygen generator-synthesizer, since this solution ensures quite limited risks, if not nearly entirely absent, both since an oxygen synthesizer constitutes an inexhaustible source of oxygen, thus an absolute freedom of use, and also since it permits the production of a saturated and stable ozonized oil which is particularly suitable for human use.
  • the oxygen synthesizer or concentrator is an ultrafiltration apparatus which allows the extraction of a gaseous mixture containing 94 +/- 2% oxygen from the atmospheric air.
  • the ultrafiltrating or ultrafiltration apparatus allows the passage of oxygen molecules and that which, in the atmospheric air, has a molecular weight or size equal to or less than the oxygen itself.
  • the gas exiting from the oxygen synthesizer is purified from the presence of nitrogen, which as considered above, in the passage into the ozone generator, would transform into nitrogen monoxide due to the excitation provided by the electrodes of the generator itself, with consequent pollution of the final oil-based vehicle , production of nitrates, and negative effects on the health of the patient in the topical use as medicament.
  • the ultrafiltration also allows eliminating further undesired substances, such as micro-particulates of various nature and other polluting gases present in the ambient air which have a molecular weight or size greater than that of the oxygen molecule (O 2 ).
  • the oxygen synthesizer also supplies the operating pressure of the insufflated gaseous flow (up to 185 kPa), and is suitable for supplying an oxygen flow with purity of not less than 96% for a gaseous flow up to 20 liters/minute and continuously supplied.
  • the present apparatus preferably comprises two to four ozone generators arranged in series, each prearranged for the independent production of a specific hourly quantity of ozone.
  • the flow meter is preferably arranged which regulates the speed of the oxygen flow (in liters/minute) that passes through the ozone generators.
  • the ozone concentration in gaseous mixture is inversely proportional to the speed of the oxygen flow which crosses the ozone generators, it is possible, by regulating the flow meter, to vary such speed and consequently control the ozone concentration available at the outlet in the gaseous flow which is insufflated into the oil.
  • the oil head contained therein preferably reaches 200 cm, since such height has been shown to be particularly suitable, at the method operating pressure, for obtaining a complete and quick saturation with ozone and stabilization of the oil.
  • an oil head of 200 cm also allows a facilitated timing of the residence time of the gaseous flow through the oil-based vehicle, and a facilitated calculation of the related speed of transit, as well as a residence of the gaseous flow (per unit of volume flow) in the oil-based vehicle sufficient for ensuring that all of the ozone is dissolved, without there being ozone dispersions, at least until the start of the saturation step.
  • the ozone quantity insufflated into the oil per unit of gaseous flow volume is completely dissolved, and it is not possible to detect the rate of residual ozone if not at the start of the saturation step.
  • a tank of this type particularly facilitates the observation for carrying out the aforesaid operation.
  • the internal path of the insufflation duct of the gaseous flow is reduced to a minimum and the unidirectional antireflux valve always exerts the same resistance to the "rear power" of the gaseous flow pushed by the oxygen synthesizer.
  • the "timing” therefore only and exclusively regards the residence time of the gaseous flow (gas bubble) through the oil head, from the entrance time to the outlet time in the same head.
  • the transparency of the container is well adapted for carrying out this timing maneuver.
  • the insufflation duct in its portion inside the oil head (immersed in the oil head) provides for being sealed at the top and laterally and distally perforated for a length of 15-20 cm with a plurality of nozzles with smallest possible caliber.
  • the beginning of the timing is detected upstream of the aforesaid unidirectional antireflux valve.
  • a visual inspection from above allows detecting the time at which the gaseous flow penetrates into the oil-based vehicle to be saturated contained in the tank, after traveling through the hollow interior of the duct transporting the gaseous flow and moving through the antireflux valve.
  • treatment start or sol phase the bubbling of the non-saturated oil
  • expansion towards the top of the saturated oil continuation of the treatment or gel phase
  • the gas bubble begins its path inside the tank and the timing of the time when it penetrates in the tank itself, shown from that stated above, up to the time when it reaches the surface, gives the residence time of the gas through the oil head.
  • the two data (residence time through the hollow transport interiors plus the residence time of the bubble through the oil head) tend, as said, to progressively expand as the saturation process advances and is completed.
  • this maximum time limit is repeated several times, there is the proof both of the saturation and stabilization of the ozonification process of the oil-based vehicle according to the present invention.
  • the portion of the insufflation duct immersed in the oil head is sealed at the top and laterally and distally perforated for a length of 15-20 cm, with several nozzles of the smallest possible caliber.
  • a visual inspection from above allows detecting the time at which the gaseous flow penetrates into the containment tank, after traveling through the hollow interior of the insufflation duct, detected at the start by the bubbling of the non-saturated liquid (treatment start or sol phase), and then of the upward expansion of the saturated liquid (treatment continuation or gel phase).
  • the two data (residence time through the hollow interior of the insufflation duct and the residence time of the gas bubble inside the oil head) tend to progressively expand as the saturation process is completed.
  • these data reach the maximum limit, and when this datum is repeated several times, the stabilization of the medium is obtained.
  • the data In the second case (saturation), the data must reach zero, in the first case (stabilization) they must be repeatedly superimposed for several measurements (preferably at least 3, carried out at time intervals of 24 hours from each other).
  • the method requires the use of considerable quantities of high concentration ozone, it is suitable to provide for an apparatus which is overall hermetically sealed, and an ozone removal unit, so as to reconvert the residual ozone into oxygen, of proven effectiveness.
  • ozone detectors calibrated for detecting the ozone rate, preferably equal to 10 parts per billion.
  • That stated above also advantageously allows standardizing the present saturation and stabilization process of an ozonized oil, precisely calculating the total quantity (amount) of ozone necessary for the saturation and stabilization of a certain quantity of a specific oil.
  • a gaseous flow comprising oxygen, ozone and noble gases of 1.5 liters per minute, with ozone concentration of 31 grams x m 3 , in the span of 24 hours (1.5 liters/minute for 1440 minutes, number of minutes in 24 hours) corresponds with 2160 liters of gaseous mixture insufflated into the tank.
  • the present method on the aforesaid sunflower oil carried out for experimental purposes as a non-limiting descriptive example, lead to the obtainment of saturated and stable ozonized oil with characteristics as illustrated in table 2 of figure 7 .
  • the invention provides a method and a related apparatus for making a saturated and stabilized ozonized oil-based vehicle as considered above, free of undesired substances including mainly aldehydes, carried out at low pressure and room temperature, therefore particular safe, easy to carry out and economical.
  • the saturated ozonized oil obtained by means of the present method has shown to be particularly effective in releasing ozone and peroxides passing from a temperature comprised between +4 and +10°C, at which it can advantageously be better preserved, to a temperature comprised between +30 and +37°C, which advantageously corresponds to the normal application temperature (body temperature).
  • the topical application of the oil (pure and impure) on the human organism leads to a heating of the oil, which slows the cohesion forces (surface tension), passing from sol to gel and allows the on-site [in situ] release of the dissolved ozone.
  • the biocide capacity of the oil has its logical explanation in this method (ozone release) and the oxidizing action of ozone.
  • the oil is "loaded” with ozone, since later, under specific conditions, the ozone is “unloaded” (when necessary).
  • Ozone is a strong oxidizing agenty; nevertheless, at specific concentrations and in specific administration modes, it paradoxically acts as an antioxidant.
  • reaction via adaptation to the oxidative stress" and also leads to a violent excitation of the immune system.
  • the action of the present oil is extremely specific and is briefly exhausted on the target tissues, without directly or indirectly involving other apparatuses, due to the capacity of the ozone to bind itself to the electron donors in very short time periods.
  • the preferred clinical indications of the present oil given its organoleptic characteristics, used at the most suitable dilution concentration established from time to time according to the treated pathologies, are the following:

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
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  • Apparatus For Disinfection Or Sterilisation (AREA)
EP08425531A 2008-07-31 2008-07-31 Verfahren zur Herstellung eines auf mit Ozon angereichertem Öl basierten Mediums Withdrawn EP2149598A1 (de)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102406549A (zh) * 2011-09-08 2012-04-11 李明利 一种高效制取稳定臭氧(o3)油膏生产装置和方法
ITMI20110354A1 (it) * 2011-03-07 2012-09-08 Neovalis S R L Composizione a base di olio ozonizzato per uso topico
IT201600078872A1 (it) * 2016-07-27 2018-01-27 Fb Vision S R L Olio e dispositivo per l'igiene dell'area oculare e perioculare

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB838233A (en) * 1957-08-02 1960-06-22 Welsbach Corp Prevention of combustion in oxygen-ozone mixtures
GB1434461A (en) * 1973-05-17 1976-05-05 Emery Industries Inc High molecular weight monocarboxylic acids and ozonization process for their preparation
US5183911A (en) 1986-03-01 1993-02-02 Dr. J. Hansler Gmbh Process for the production of stable ozonized oils from unsaturated vegetable oils
EP0555472A1 (de) * 1991-08-06 1993-08-18 Lion Corporation Verfahren zur ozonisierung ungesättigter fettsäuren oder deren niedriger alkylester und zum oxidativen abbau der resultierenden ozonide
DE102005053358A1 (de) * 2005-11-07 2007-05-10 Lenk, Norbert, Dr. Vorrichtung zur gesteuerten Bereitstellung von Ozon

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB838233A (en) * 1957-08-02 1960-06-22 Welsbach Corp Prevention of combustion in oxygen-ozone mixtures
GB1434461A (en) * 1973-05-17 1976-05-05 Emery Industries Inc High molecular weight monocarboxylic acids and ozonization process for their preparation
US5183911A (en) 1986-03-01 1993-02-02 Dr. J. Hansler Gmbh Process for the production of stable ozonized oils from unsaturated vegetable oils
EP0555472A1 (de) * 1991-08-06 1993-08-18 Lion Corporation Verfahren zur ozonisierung ungesättigter fettsäuren oder deren niedriger alkylester und zum oxidativen abbau der resultierenden ozonide
DE102005053358A1 (de) * 2005-11-07 2007-05-10 Lenk, Norbert, Dr. Vorrichtung zur gesteuerten Bereitstellung von Ozon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANON: "Ozonated Olive Oil", INTERNET CITATION, 2005, XP002496589, Retrieved from the Internet <URL:http://www.archive.org/web/20051025040955/http://www.gindrat.co.uk> [retrieved on 20080918] *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20110354A1 (it) * 2011-03-07 2012-09-08 Neovalis S R L Composizione a base di olio ozonizzato per uso topico
WO2012120454A1 (en) 2011-03-07 2012-09-13 Neovalis S.R.L. Composition for topical use based on ozonized oil
CN102406549A (zh) * 2011-09-08 2012-04-11 李明利 一种高效制取稳定臭氧(o3)油膏生产装置和方法
IT201600078872A1 (it) * 2016-07-27 2018-01-27 Fb Vision S R L Olio e dispositivo per l'igiene dell'area oculare e perioculare
WO2018020456A1 (en) * 2016-07-27 2018-02-01 Fb Vision S.R.L. Oil and device for cleaning the ocular and periocular area

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