EP2113466B1 - Method of making a tube of antibacterial plastic material - Google Patents

Method of making a tube of antibacterial plastic material Download PDF

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Publication number
EP2113466B1
EP2113466B1 EP08425297.2A EP08425297A EP2113466B1 EP 2113466 B1 EP2113466 B1 EP 2113466B1 EP 08425297 A EP08425297 A EP 08425297A EP 2113466 B1 EP2113466 B1 EP 2113466B1
Authority
EP
European Patent Office
Prior art keywords
plastic material
tube
creams
weight
additive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08425297.2A
Other languages
German (de)
French (fr)
Other versions
EP2113466A1 (en
Inventor
Fabio Amilcare Gussoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scandolara SpA
Original Assignee
Scandolara SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scandolara SpA filed Critical Scandolara SpA
Priority to EP08425297.2A priority Critical patent/EP2113466B1/en
Priority to PL08425297T priority patent/PL2113466T3/en
Priority to PT84252972T priority patent/PT2113466E/en
Priority to ES08425297.2T priority patent/ES2473619T3/en
Publication of EP2113466A1 publication Critical patent/EP2113466A1/en
Application granted granted Critical
Publication of EP2113466B1 publication Critical patent/EP2113466B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
    • B65D35/02—Body construction
    • B65D35/04—Body construction made in one piece
    • B65D35/08—Body construction made in one piece from plastics material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes

Definitions

  • the present invention refers to a flexible tube made of an antibacterial plastic material of the type used to package cosmetics and/or creams for personal care, food pastes or pharmaceutical products like ointments and creams with a medicinal active ingredient.
  • an antibacterial product preferably consisting of nanometric silver (that is, silver powder in which the granules measure a few nanometres) of a commercially available type is added to the plastic material used to produce the tube.
  • the antiseptic and antibacterial properties of the silver are well known and have long been used in the medical field, but they have never been used, to the Applicant's knowledge, in the specific field of the flexible tubes for cosmetic, pharmaceutical or food products.
  • the bodies of the flexible tubes for cosmetic, pharmaceutical or food products are generally produced by extrusion of plastic materials, particularly polyethylene, with various densities and degrees of polymerisation.
  • tubes having a more or less smooth and shiny surface are obtained, which are then decorated and customised for the various products contained and for the various clients, with different types of printing, also starting from extruded articles which can be coloured in bulk with various shades and depths of colour.
  • the tubes can also be decorated with self-adhesive labels, which determine their aesthetic appearance.
  • Object of the present invention is to eliminate the possibility that such bacterial colonies might develop by providing a tube for cosmetic, pharmaceutical or food products that is able to destroy and to eliminate the bacterial flora in a short time and for the whole duration of use of the tube, and which maintains said antiseptic characteristic unchanged over time.
  • the Applicant has obtained a tube with the above mentioned antibacterial characteristics by adding an additive, preferably consisting of nanometric silver dispersed in pure polyethylene powder, to the plastic material (normally polyethylene or mixtures thereof) commonly used for the production of the tubes; the additive advantageously contains from 1.8 ⁇ to 2.5 ⁇ (preferably 2 ⁇ ) in weight of nanometric silver.
  • the mixture thus obtained is thoroughly homogenised, extruded and granulated to obtain the additive to be added to the polyethylene (or to mixtures thereof) to obtain tubes with the characteristics necessary to meet the requirements of various clients depending upon the content.
  • US 2006/207961 discloses water containers including a body made of several intertwined arced sidewalls, some or all of the sidewalls are provided with longitudinal grooves.
  • the body of the container includes several compartments namely a mouth, a neck, and a stem comprising shoulders, a waist, and a base.
  • the compartments have dimensions that maintain a constant mathematical ratio in compliance with the golden phi ratio with respect to each other.
  • EP 1616549 A1 discloses a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability said plastic ampoule including a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion.
  • US 6179141 discloses a container assembly provided with an antibacterial agent against "slow-leak” bacteria, comprising a container such as a plastic bottle which has a mouth portion having a rim; and a seal member such as a crown cap fitted to the mouth portion at the rim, wherein at least either a surface portion of the rim or the rim-contacting surface portion of the seal member includes an antibacterial agent such as silver zeolite in the form of a coating or a liner.
  • EP 1795449 A1 disclsoes a flat container molded by blow molding, in which the wall thickness of a container wall is made uniform, the flat container having a flatness ratio of not less than 1.3, and a body wall thickness ratio of a maximum wall thickness to a minimum wall thickness of not more than 1.6, a difference in elongation between a maximally stretched portion and a minimally stretched portion of not more than 150% in a tensile test at 95 DEG C, a crystallinity of not less than 30%, and a difference in TMA non-load change between a maximally stretched portion and a minimally stretched portion of not more than 500 [mu]m at 75 DEG C and 100 DEG C.
  • KR 10 200 500 28 251 A discloses an airtight container comprising nanosilver particles mixed in plastic resin powder in a proportion of 200-600 ppm.
  • the additive thus obtained is added, in the extrusion stage, to the plastic material (polyethylene or mixtures thereof) in a percentage between 4.8% and 5.5% (preferably 5%) in weight of the plastic material.
  • the mixture for extrusion can be obtained by adding to the plastic material from 70 to 135 (preferably 100) parts per million in weight of nanometric silver.
  • the production by extrusion of the tubes produced according the present invention is done by using the apparatuses and the manufacturing methods that are used to produce a normal polyethylene tube since careful theoretical studies and experimental tests performed by the Applicant have shown that the addition of the additive to the polyethylene (or to the mixtures thereof) does not change its behaviour during the production of the tubes.
  • the cap closing the tube is advantageously made of a plastic material suited to the purpose like a high-density polypropylene or a polyethylene with an anti-bacterial product added.

Description

  • The present invention refers to a flexible tube made of an antibacterial plastic material of the type used to package cosmetics and/or creams for personal care, food pastes or pharmaceutical products like ointments and creams with a medicinal active ingredient.
  • For this purpose, an antibacterial product preferably consisting of nanometric silver (that is, silver powder in which the granules measure a few nanometres) of a commercially available type is added to the plastic material used to produce the tube.
  • The antiseptic and antibacterial properties of the silver are well known and have long been used in the medical field, but they have never been used, to the Applicant's knowledge, in the specific field of the flexible tubes for cosmetic, pharmaceutical or food products.
  • The bodies of the flexible tubes for cosmetic, pharmaceutical or food products, with different diameters and lengths, are generally produced by extrusion of plastic materials, particularly polyethylene, with various densities and degrees of polymerisation.
  • With the extrusion of said plastic materials, tubes having a more or less smooth and shiny surface are obtained, which are then decorated and customised for the various products contained and for the various clients, with different types of printing, also starting from extruded articles which can be coloured in bulk with various shades and depths of colour.
  • The tubes can also be decorated with self-adhesive labels, which determine their aesthetic appearance.
  • These tubes present the risk that, during the use, the bacteria always present on the user's hands may be deposited on the outer surfaces of the tube and especially on the opening through which the product leaves the tube: this can lead to the formation of bacterial colonies which can proliferate even rapidly inside the tube in the product and can pollute or in any case alter the product contained in the tube.
  • This drawback also occurs if air is sucked into the tube when, through the "shape-memory effect", the tube returns to its original shape after squeezing to allow the dispensing of the product.
  • Object of the present invention is to eliminate the possibility that such bacterial colonies might develop by providing a tube for cosmetic, pharmaceutical or food products that is able to destroy and to eliminate the bacterial flora in a short time and for the whole duration of use of the tube, and which maintains said antiseptic characteristic unchanged over time.
  • This object is achieved in accordance with the invention with the characteristics listed in appended independent claim 1.
  • Further advantageous characteristics of the invention are apparent from the dependent claims.
  • The Applicant has obtained a tube with the above mentioned antibacterial characteristics by adding an additive, preferably consisting of nanometric silver dispersed in pure polyethylene powder, to the plastic material (normally polyethylene or mixtures thereof) commonly used for the production of the tubes; the additive advantageously contains from 1.8‰ to 2.5‰ (preferably 2‰) in weight of nanometric silver.
  • After mixing of the nanometric silver and of the pure polyethylene powder, the mixture thus obtained is thoroughly homogenised, extruded and granulated to obtain the additive to be added to the polyethylene (or to mixtures thereof) to obtain tubes with the characteristics necessary to meet the requirements of various clients depending upon the content.
  • US 2006/207961 discloses water containers including a body made of several intertwined arced sidewalls, some or all of the sidewalls are provided with longitudinal grooves. The body of the container includes several compartments namely a mouth, a neck, and a stem comprising shoulders, a waist, and a base. The compartments have dimensions that maintain a constant mathematical ratio in compliance with the golden phi ratio with respect to each other.
  • EP 1616549 A1 discloses a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability said plastic ampoule including a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion.
  • US 6179141 discloses a container assembly provided with an antibacterial agent against "slow-leak" bacteria, comprising a container such as a plastic bottle which has a mouth portion having a rim; and a seal member such as a crown cap fitted to the mouth portion at the rim, wherein at least either a surface portion of the rim or the rim-contacting surface portion of the seal member includes an antibacterial agent such as silver zeolite in the form of a coating or a liner.
  • EP 1795449 A1 disclsoes a flat container molded by blow molding, in which the wall thickness of a container wall is made uniform, the flat container having a flatness ratio of not less than 1.3, and a body wall thickness ratio of a maximum wall thickness to a minimum wall thickness of not more than 1.6, a difference in elongation between a maximally stretched portion and a minimally stretched portion of not more than 150% in a tensile test at 95 DEG C, a crystallinity of not less than 30%, and a difference in TMA non-load change between a maximally stretched portion and a minimally stretched portion of not more than 500 [mu]m at 75 DEG C and 100 DEG C.
  • KR 10 200 500 28 251 A discloses an airtight container comprising nanosilver particles mixed in plastic resin powder in a proportion of 200-600 ppm.
  • The additive thus obtained is added, in the extrusion stage, to the plastic material (polyethylene or mixtures thereof) in a percentage between 4.8% and 5.5% (preferably 5%) in weight of the plastic material.
  • Without departing from the scope of the invention, the mixture for extrusion can be obtained by adding to the plastic material from 70 to 135 (preferably 100) parts per million in weight of nanometric silver.
  • The production by extrusion of the tubes produced according the present invention is done by using the apparatuses and the manufacturing methods that are used to produce a normal polyethylene tube since careful theoretical studies and experimental tests performed by the Applicant have shown that the addition of the additive to the polyethylene (or to the mixtures thereof) does not change its behaviour during the production of the tubes.
  • Lastly, in order to provide the user with a better protection against the formation and the development of bacterial colonies, the cap closing the tube is advantageously made of a plastic material suited to the purpose like a high-density polypropylene or a polyethylene with an anti-bacterial product added.

Claims (5)

  1. A method for obtaining a flexible tube for packaging cosmetics and/or creams for personal care, food pastes or pharmaceutical products like ointments and creams with a medicinal active ingredient,
    the tube being made of a plastic material constituted by polyethylene or mixtures thereof and containing powdery nanometric silver as antibacterial product,
    said method consisting of the following steps of
    - preparing an additive in the form of granules containing from 1.8‰ to 2.5‰ by weight of powdery nanometric silver by dispersing the powdery nanometric silver in amount between from 1.8‰ to 2.5‰ by weight of powdery nanometric silver in pure polyethylene powder to obtain a mixture,
    - then homogenising, extruding and granulating the mixture to obtain said additive;
    - adding, in the extrusion stage, the so obtained additive in form of granules to said plastic material in amount between 4.8% and 5.5% by weight of said plastic material, without changing the behaviour of the plastic material during the production of the tube,
    the tube including an antibacterial closure cap made of polypropylene or polyethylene with an antibacterial product added.
  2. A method according to claim 1, characterised in that the additive contains 2‰ in weight of nanometric silver.
  3. A method according to claim 1 or 2, characterised in that said additive is 5% by weight of said plastic material.
  4. A method according to any one of the preceding claims characterised in that the powdery nanometric silver added to said plastic material is 100 parts per million (0,1‰) by weight of said plastic material.
  5. Use of the method of claims 1 to 4 for packaging cosmetics and/or creams for personal care, food pastes or pharmaceutical products like ointments and creams with a medicinal active ingredient consisting of packaging said cosmetics and/or creams for personal care, food pastes or pharmaceutical products like ointments and creams with a medicinal active ingredient.
EP08425297.2A 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material Active EP2113466B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08425297.2A EP2113466B1 (en) 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material
PL08425297T PL2113466T3 (en) 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material
PT84252972T PT2113466E (en) 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material
ES08425297.2T ES2473619T3 (en) 2008-04-29 2008-04-29 Flexible tube made of an antibacterial plastic material, especially for the packaging of cosmetic, pharmaceutical and food products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08425297.2A EP2113466B1 (en) 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material

Publications (2)

Publication Number Publication Date
EP2113466A1 EP2113466A1 (en) 2009-11-04
EP2113466B1 true EP2113466B1 (en) 2014-04-09

Family

ID=39591995

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08425297.2A Active EP2113466B1 (en) 2008-04-29 2008-04-29 Method of making a tube of antibacterial plastic material

Country Status (4)

Country Link
EP (1) EP2113466B1 (en)
ES (1) ES2473619T3 (en)
PL (1) PL2113466T3 (en)
PT (1) PT2113466E (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015111582A1 (en) * 2015-07-16 2017-01-19 Bsn Medical Gmbh Packaging for a medical product

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1401452B1 (en) * 2010-06-10 2013-07-26 S M P S R L CONTAINER AND RELATED CLOSURE FOR STERILE AND / OR LOW BACTERIAL PRODUCTS WITHOUT PRESERVATIVES
ITRM20110382A1 (en) * 2011-07-20 2013-01-21 Gm S R L Unipersonale PLASTIC CONTAINER FOR PHASE CHANGE MATERIAL MATERIAL (PHASE CHANGE MATERIAL) WITH MICROBICIDE, BACTERICIDAL, SPORICIDE AND FUNGICIDE BEHAVIOR
EP2977400A1 (en) 2014-07-25 2016-01-27 Roberto Rossi Product having antimicrobial and/or antibacterial characteristics designed for contact with milk for administration to infants and method of producing such product
DE202015103747U1 (en) 2015-07-16 2015-07-28 Bsn Medical Gmbh Packaging for a medical product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179141B1 (en) 1996-08-06 2001-01-30 Kenji Nakamura Container assembly provided with anitbacterial agent against slow-leak bacteria
WO2004093775A1 (en) 2003-04-23 2004-11-04 Otsuka Pharmaceutical Factory, Inc. Drug solution filling plastic ampoule and process for producing the same
KR101237729B1 (en) 2004-09-17 2013-02-26 도요 세이칸 가부시키가이샤 Flat container comprising thermoplastic resin and method for molding the same
US20060207961A1 (en) 2005-03-18 2006-09-21 Sacred Water Of Hawaii Llc Water containers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015111582A1 (en) * 2015-07-16 2017-01-19 Bsn Medical Gmbh Packaging for a medical product

Also Published As

Publication number Publication date
PL2113466T3 (en) 2014-09-30
ES2473619T3 (en) 2014-07-07
EP2113466A1 (en) 2009-11-04
PT2113466E (en) 2014-07-10

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