EP2104485A1

EP2104485A1 - Oral and dental hygiene and cleaning products with improved fluoride deposition

Info

Publication number: EP2104485A1
Application number: EP07847724A
Authority: EP
Inventors: Adolf Peter Barth; Ullrich Bernecker
Original assignee: Henkel AG and Co KGaA
Current assignee: Henkel AG and Co KGaA
Priority date: 2006-12-20
Filing date: 2007-12-04
Publication date: 2009-09-30
Also published as: DE102006060946A1; WO2008074625A1

Abstract

The invention relates to oral and dental hygiene and cleaning products containing, in relation to the weight thereof, between 0.1 and 10 wt. % of carboxymethylcellulose and between 10 and 60 wt. % of at least one polyvalent alcohol from the group containing sorbite and/or glycerin and/or 1,2-propylene glycol. Said products effectively combat the formation of caries and promote the absorption of fluoride into the tooth enamel and the dentin.

Description

"Oral and dental care and cleaning products with improved fluoride deposition"

The invention relates to preparations for oral and dental care and cleaning, which support the landfilling of fluoride in the tooth due to special ingredients.

Dentifrices are available in various forms on the market and are primarily used to clean the tooth surface and to prevent tooth and gum disease. They usually contain a combination of polishes, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. Liquid or liquid toothpastes and mouthwashes have also become increasingly important in recent years.

In addition to the cleaning of the teeth, the consumer of the generic products also expected a care of the teeth and the oral cavity. In particular, a "clean" feel, ie a smooth and shiny tooth surface as well as a fresh mouthfeel are essential aspects for the buying incentive of oral and dental care and cleaning preparations. A successful remedy of the generic type should therefore thoroughly clean the teeth without damaging the tooth or tooth surface while reducing and / or preventing bad breath.

Another important aspect in addition to the cleaning of the mouth and teeth is the prophylaxis of diseases of the gums and teeth, especially against tooth decay. In the case of caries prevention in particular the use of fluorides has been proven, as these compounds inhibit the extraction of minerals from the enamel, promote the incorporation of minerals in the enamel, increase the chemical resistance of the enamel, obstruct the colonization of the tooth surfaces by caries causing bacteria and inhibit the metabolism of bacteria and thus their acid production. In some countries of the world, in addition to the use of oral and dental care products, foods such as table salt or drinking water are fluoridated to prevent tooth decay.

To act in the manner described above, the fluoride must be transported to the destination, i. get into the enamel and the dentin. The deposition of the fluoride is therefore of great importance. Agents that promote this deposition are therefore desirable. Agents that also encourage fluoride intake from other sources, and not just from the agent itself, are even more desirable.

There is therefore a need to combat tooth decay and to provide active ingredients or drug combinations for improving fluoride uptake.

The object of the present invention was to provide preparations for oral and dental care and cleansing, which effectively combat caries and promote the uptake of fluoride into the enamel and the dentin. The incorporation of fluoride from other sources (e.g., food) should also be allowed, so that the agents to be delivered can themselves be formulated with low fluoride or fluoride-free content.

It has now been found that an active ingredient combination of defined amounts of carboxymethylcellulose and certain humectants in preparations for oral and dental care and cleaning, especially in toothpastes or toothpastes or toothbrush gels, solves the above objects.

The present invention is in a first embodiment, an oral and dental care and cleaning compositions containing - based on its weight - a) 0.1 to 10 wt .-% carboxymethylcellulose; b) 10 to 60 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-%.

Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes as well as oral and dental gels. Preferably suitable are toothpastes and liquid dentifrices. For this purpose, the oral and dental care and cleaning agents, for example in the form of toothpastes, liquid toothpastes, tooth powders, mouthwashes or possibly also as gum, z. B. as chewing gum, present. Prefers However, they are available as more or less flowable or plastic toothpastes, such as those used to clean the teeth using a toothbrush.

The oral and dental care and cleaning agents of the present invention aid in the deposition of fluoride ions into the enamel and dentin. It does not matter whether the fluoride ions to be deposited originate from the mouth and dental care and cleaning agent of the invention or from other sources (food, drinking water and thus saliva). During the Zahnputzvorgangs or the mouth cleaning or care in the mouth existing fluoride ions are better stored by the products of the invention in tooth enamel and dentin.

The oral and dental care and cleaning agents according to the invention contain carboxymethylcellulose (CMC) as the essential ingredient.

The carboxymethyl cellulose used in oral and dental care and cleaning agents according to the invention is prepared by chemical reaction (etherification) of cellulose. By controlling the reaction conditions, it is possible to precisely adjust the degree of etherification. As a measure of the degree of etherification, the degree of substitution (abbreviation DS) is given. The degree of substitution indicates the average number of etherified hydroxyl groups on a glucose unit. Since one glucose unit has three hydroxyl groups available for one reaction, the maximum achievable degree of substitution is DS = 3.

It has been found that fluoride deposition is further improved when the carboxymethylcellulose used has degrees of substitution of from 0.5 to 2.5, preferably from 0.65 to 1.54. Corresponding products according to the invention which contain CMCs of the stated degrees of substitution are particularly preferred according to the invention.

Another way to improve fluoride deposition is to give the mouth and dentifrice and cleanser of the invention a defined rheological profile. Primarily, this can be done by using CMCs, which in turn have defined rheological profiles.

Viscosities of CMC solutions are determined, for example, using Brookfield viscometers, rotational viscometers or Höppler viscometers. The viscosities are given in pas or mPa s. Depending on the method, the stated viscosities can be clear differ. According to the invention, the use of CMCs having in a 2 wt .-% aqueous solution at 20 ⁰ C the following viscosities:

1,000 to 100,000 mPas, preferably 2,000 to 50,000 mPas and in particular 5,000 to 25,000 mPas with a rotational viscometer at a shear rate of 2.55 1 / s

5,000 to 100,000 mPas, preferably 10,000 to 70,000 mPas, and especially 35,000 to 50,000 mPas with a Brookfield LVT viscometer

• 50,000 to 250,000 mPas, preferably 75,000 to 200,000 mPas and in particular 120,000 to 140,000 mPas with a Höppler viscometer

The viscosity of an aqueous CMC solution is therefore not an absolute value, but is strongly determined by the measurement parameters.

To ensure comparability of indicated viscosities, we generally specify Walocel® CRT A - Cellulose Gum and Walocel® CRT products with Brookfield viscometers at 25 ° C. Walocel® CRT ... PV products are specified using a rotation at 20 ⁰ C.

Based on the ready-to-use agent according to the invention those oral and dental care and cleaning agents are preferred which at 20 ⁰ C, a viscosity (measured with Brookfield Synchro-Lectric viscometer, type RVT with Helipath tripod, spindle 3 and 20 rev / min) of 100 to 1000 Pas (100,000 to 1,000,000 mPas), preferably from 200 to 750 Pas (200,000 to 750,000 mPas), more preferably from 350 to 650 Pas (350,000 to 650,000 mPas) and especially from 450 to 550 Pas (450,000 to 550,000 mPas).

The amount of CMC used in preferred inventive agents is typically above 0.1% by weight and below 10% by weight. Preferred oral and dental care and cleaning compositions according to the invention are characterized in that they contain, based on their weight, from 0.2 to 7.5% by weight, preferably from 0.3 to 6% by weight, more preferably from 0.4 to 5 wt .-%, more preferably 0.5 to 3.5 wt .-%, still more preferably 0.6 to 2.5 wt .-% and in particular 0.7 to 1, 5 wt .-% carboxymethylcellulose ,

The oral and dental care and cleaning compositions according to the invention contain as the second essential ingredient, based on their weight, from 10 to 60% by weight of at least one polyhydric alcohol from the group of sorbitol and / or glycerol and / or 1,2-propylene glycol. Preferably, the polyhydric alcohol (s) is / are used within narrower ranges. Here, oral and dental care and cleaning agents according to the invention are preferred, which are 10 to 60 wt .-%, preferably 15 to 55 wt .-%, particularly preferably 20 to 50 wt .-% and in particular 30 to 40 wt .-% at least a polyhydric alcohol from the group of sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-%, each based on the weight of the total composition.

Sorbitol (also called glucitol) is a sugar alcohol of glucose, which is a hexitol. Sorbitol can be prepared by hydrogenation of glucose, it breaks down intramolecularly relatively easily one or two molecules of water and forms cyclic ethers. Sorbitol can be expressed by the formula

CHUOH j

-C-OH ϊ

HO- "O" ™ "H

R-C-OH

R- C-OH

CN ₂ OH

describe and comes in the form of colorless, moderately hygroscopic, optically active needles, which dissolve easily in water, in the trade.

Glycerol (1,2,3-propanetriol, 1,2,3-trihydroxypropane, glycerol, oil sweet, INCI name: Glycerin, E 422) is a colorless, clear, heavy-bodied, odorless, sweet-tasting, hygroscopic liquid that combines with water and alcohol is miscible in any ratio.

Glycerol can be defined by the formula

HX-OH * l HC-OH

H ₂ C-OH

describe. The production of glycerin was originally as a by-product of fat saponification. Today's technical processes are based on propene, which is processed into glycerol via the intermediates allyl chloride and epichlorohydrin. Another technical process is the hydroxylation of allyl alcohol with hydrogen peroxide at the WO ₃ contact via the step of the glycide. 1, 2-Propylene glycol (1, 2-propanediol) is a colorless and highly hygroscopic liquid which is miscible in any ratio with water and alcohols (such as methanol, ethanol, propanols, butanols). Technical 1,2-propanediol is a racemate of (-) - (f?) - and (+) - (S) -1, 2-propylene glycol. The preparation is carried out by direct hydrolysis of propylene oxide. Because 1, 2-P. further reacted with propylene oxide, thereby forming a mixture of 1, 2 and tripropylene glycol, which must be separated by distillation. 1,2-propylene glycol can also be made from renewable resources via three different routes: a) catalytic hydrogenation of sugars; b) fermentation of sugars to lactic acid and then hydrogenation of the lactic acid ester; c) direct fermentation of sugars.

For certain applications, it may be advantageous to use only one of the three ingredients mentioned above. In most cases, sorbitol is preferred. However, in other applications, mixtures of two of the three or all three may be preferred. Here, a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1): (0.1-0.5) has proved particularly advantageous.

In addition to sorbitol or glycerol or 1,2-propylene glycol, suitable further polyhydric alcohols are those having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof.

Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1, 2-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 are used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used.

Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols.

As preferred further polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.

Particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol are particularly preferred. The use of abrasive articles (abrasives) is also preferred. Cleaning bodies are amorphous, predominantly inorganic, largely water-insoluble, smallest-particle powders which have no sharp edges. In dental and oral care products, they promote the cleaning of the teeth and at the same time polish the tooth surface (polishing agent).

As a polishing agent are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions. Preferably suitable polishing agent components are therefore silicic acids, aluminum hydroxide, aluminum oxide, sodium aluminum silicates, organic polymers or mixtures of such friction bodies.

Calcium containing polishing components such as e.g. However, chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can be present in amounts of up to 5% by weight, based on the total composition.

The total content of polishing agents is preferably in the range of 5 to 50% by weight of the dentifrice.

Toothpastes and liquid dentifrices containing silicic acids as a polishing agent are particularly preferred. Suitable silicas are e.g. Gel silicas, hydrogel silicas and precipitated silicas. Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying takes place under mild conditions to water contents of 15 to 35 wt .-%, the so-called hydrogel silicas are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.

A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15-110 m ² / g, a particle size of 0.5-20 μm, wherein at least 80% by weight of the primary particles should be below 5 μm, and a viscosity in 30% glycerol-water (1: 1) - dispersion of 30 - 60 Pa.s (20 ⁰ C) in an amount of 10 - 20 wt .-% of the toothpaste. Particularly suitable precipitated silicas of this type have rounded corners and edges and are commercially available under the trade name ^® Sident 12 DS (DEGUSSA). Other precipitated silicas of this type are Sident 8 (DEGUSSA) and Sorbosil AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 .mu.m at a specific surface area of 40-75 m ² / g (according to BET) and are particularly suitable for liquid toothpastes. These should have a viscosity (25 ° C, shear rate D = 10 s ^-1 ) of 10-100 Pa. s have.

Toothpastes, which have a significantly higher viscosity of more than 100 Pa. On the other hand, s (25 ° C., D = 10 s ^-1 ) require a sufficiently high proportion of silicas having a particle size of less than 5 μm, preferably at least 3% by weight, of a silica having a particle size of 1 to 3 μm. Is therefore such toothpastes Besides said precipitated silicas, even finer so-called thickening silicas with a BET surface area of 150 -250 m ² / g, for example the commercial products Sipernat 22 LS or Sipernat ^® 320 DS.

As a further polishing agent component, e.g. Aluminum oxide in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-%. Such a suitable alumina is available under the trade designation "Polianton earth P10 finest" (Giulini Chemie).

As a polishing agent are all further known for toothpastes friction body such. B. sodium aluminum silicates such. As zeolite A, organic polymers such. As polymethacrylate or mixtures of these and the aforementioned friction body.

In summary, oral and dental care and cleaning compositions according to the invention are preferred which additionally contain cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ 2H ₂ O),

Sodium aluminum silicates, in particular zeolite A, organic polymers, especially polymethacrylates or mixtures of these friction bodies, preferably in amounts of 1 to 30 wt.%, Preferably from 2.5 to 25 wt.% And in particular from 5 to 22 wt.%, In each case based on the entire remedy, included.

The stated amounts relate to the total amount of friction bodies, wherein individual friction bodies are preferably used in narrower ranges. Agents preferred according to the invention contain, for example, 5 to 20% by weight, preferably 8 to 21% by weight, more preferably 9 to 20% by weight and in particular 11 to 19% by weight of silica (s). Further preferred Agents according to the invention are characterized in that they contain 0.25 to 2 wt .-%, preferably 0.5 to 1, 5 wt .-% and in particular 0.75 to 1, 25 wt .-% alumina.

Oral and dental care and cleaning agents, in particular toothpastes, may e.g. also contain substances that are effective against plaque and / or tartar.

Plaque is a rough, sticky deposit on the teeth that consists of saliva, bacteria and food remnants. If mineral salts (for example calcium, phosphate) are released from the saliva in the dental plaque, hard, white or yellowish deposits on the tooth called tartar form. In the porous calculus, in turn, easily deposit plaque that attacks the gums.

The bacteria on the tooth surface reduce carbohydrates, especially sugars, from food to acid. This acid dissolves the tooth substance and it comes to tooth decay (tooth rot). In particular, the minerals calcium and phosphate are extracted from the enamel. After the enamel coat also inner layers of the tooth are attacked. Bacteria can invade the dental pulp and cause inflammation there. Mostly it comes then to stinging toothache.

As already mentioned, plaque contains bacteria, so that antimicrobials are suitable for controlling plaque. These also have an effect as a preservative.

Sorbic acid (E 200), potassium sorbate (E 202), calcium sorbate (E 203), benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212 ), Calcium benzoate (E 213), ethyl 4-hydroxybenzoate (E 214), ethyl 4-hydroxybenzoate, sodium salt (E 215), propyl 4-hydroxybenzoate (E 216), propyl 4-hydroxybenzoate, sodium salt (E 217 ), Methyl 4-hydroxybenzoate (E 218), methyl 4-hydroxybenzoate, sodium salt (E 219), sulfur dioxide (sulfurous acid), (E 220), sodium sulfite (E 221), sodium hydrogen sulfite (E 222), sodium disulfite (E. 223), potassium bisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227), potassium bisulfite (E 228), biphenyl (E 230), orthophenylphenol (2-biphenylol), (E 231), sodium orthophenylphenolate (E 232) , Nisin (E 234), natamycin (E 235), formic acid (E 236), sodium formate (E 237), calcium formate (E 238), hexamethylenetetramine (E 239), dimethy idicarbonate (E 242), potassium nitrite (E 249), sodium nitrite (E 250), sodium nitrate (E 251), potassium nitrate (E 252), acetic acid (E 260), potassium acetate (E 261), sodium acetate (E 262), calcium acetate ( E 263), lactic acid (E 270), propionic acid (E 280), sodium propionate (E 281), Calcium propionate (E 282), potassium propionate (E 283), boric acid (E 284), sodium tetraborate (E 285), malic acid (malic acid), (E 296), fumaric acid (E 297), lysozyme (E 1105).

Preferred substances are selected from methyl p-hydroxybenzoate, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylic acid esters, biguanides, for example. Chlorhexidine (1, 1'-hexamethylene bis [5- (4-chlorophenyl) biguanide), thymol, etc.

In accordance with the invention preferred oral and Zahnpflege- and -reinigungsmittel are characterized in that they additionally antiplaque agents, preferably p-hydroxybenzoic acid methyl, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl salicylic, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the total Means, included.

The stated amounts are based on the total amount of antiplaque active ingredients, wherein individual active ingredients are preferably used in narrower ranges. Agents preferred according to the invention contain, for example, 0.1 to 2% by weight, preferably 0.2 to 1.75% by weight, more preferably 0.3 to 1.5% by weight and in particular 0.4 to 1.0 Wt .-% sodium benzoate. Further preferred agents according to the invention are characterized in that they contain 0.005 to 0.1 wt .-%, preferably 0.01 to 0.075 wt .-% and in particular 0.02 to 0.05 wt .-% chlorhexidine. Chlorhexidine is preferably used together with alkylpolyglycosides (APG), wherein in preferred agents according to the invention as alkyl glycosides those having 8-18 carbon atoms in the alkyl group and a mean degree of oligomerization of the glycoside of 1-3 in an amount of 0.025 to 2.5 wt. -% are included.

Anti-calculus substances may be, for example, chelating agents such. As ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na ₄ P ₂ O ₇ , K ₄ P ₂ O ₇ , Na ₂ K ₂ P ₂ O ₇ , Na ₂ H ₂ P ₂ O ₇ and K ₂ H ₂ P ₂ O ₇ or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.

Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they additionally contain phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of from 1 to 10% by weight, especially preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.

In addition, oral and dental care and cleaning agents may more preferably contain anti-caries agents. These may be selected, for example, from organic or inorganic fluorides, for. Example of sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, stannous fluoride are preferred. An amount of 0.01-0.2% by weight of fluorine should preferably be present in the form of the compounds mentioned.

Oral and dental care and cleaning compositions according to the invention, which additionally contain anticaries drugs, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride,

Sodium monofluorophosphate, zinc fluoride, stannous fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt.%, Preferably from 0.1 to 2.5 wt.% And in particular from 0.2 to 1, 1 wt.%, Each based on contain the entire agent are preferred according to the invention.

In another preferred embodiment of the present invention, the agents according to the invention are formulated with low fluoride content. Such agents of the invention also support fluoride deposition, but reduce the risk of fluorosis and are therefore particularly suitable for fluoride sensitive users. According to preferred oral and dental care and cleaning compositions of this embodiment contain - based on their weight - less than 0.5 wt .-%, preferably less than 0.4 wt .-%, more preferably less than 0.3 wt. %, more preferably less than 0.2% by weight and in particular less than 0.1% by weight of sodium fluoride and / or sodium monofluorophosphate.

Since the fluoride deposition is also supported by other sources, the products according to the invention can also be formulated without fluoride ions in order to open up further user circles. Another preferred embodiment of the present invention therefore provides oral and dental care and cleaning agents that are free of intentionally added fluorides.

It has been found that high-ionic salts can attenuate the fluoride deposition of the oral and dental care and cleaning compositions according to the invention in certain cases. In particular, salts of the AB type, ie salts of a cation and an anion, can have a negative influence on the fluoride deposition, so that preferred oral and dental care and cleaning compositions according to the invention are less than 5% by weight, preferably less as 4% by weight %, more preferably less than 3% by weight, more preferably less than 2% by weight and in particular less than 1% by weight of salts of the AB type.

Salts of the type AB, in particular salts of the type A ⁺ B ^{", have} potential effects on the fluoride deposition, and therefore the limits mentioned above are particularly preferred for salts of this type.

As a consistency regulator (or binder) z. Natural and / or synthetic water soluble polymers such as alginates, carrageenans, tragacanth, starch and starch ethers, guar, acacia, agar, xanthan gum, succinoglycan gum, locust bean gum, pectins, water soluble carboxyvinyl polymers (e.g., CarbopoKD types ), Polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000 are used.

Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.

Surface-active substances are also present in the toothpastes in support of the cleaning action and, if desired, also for the development of foam in brushing teeth and for stabilizing the polishing body dispersion in the carrier in an amount of 0.1-5% by weight.

Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque. Other suitable surfactants are alkali metal salts, preferably sodium salts of Alkylpolyglycolethersulfat with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ₁₂ - C ₁₈₎ sulfonate, (Ci Sulfobernsteinsäuremonoalkyl of ₂ -C ₁₈ ) esters of sulfated fatty acid monoglycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (Ci ₂ -C ₁₆ ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group. Also zwitterionic, ampholytic and nonionic surfactants are suitable, for. B. Oxethylates of fatty acid mono- and - diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides. The oral and dental care products, especially the toothpastes, may also contain the insensitivity of the teeth-enhancing substances, such as potassium salts such. As potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate. In accordance with the invention preferred oral and dental care and cleaning agents are characterized in that they the insensitivity of the teeth-enhancing substances, preferably potassium salts, more preferably potassium nitrate and / or potassium citrate and / or potassium chloride and / or potassium bicarbonate and / or potassium oxalate, preferably in amounts of 0.5 to 20 wt.%, Particularly preferably from 1, 0 to 15 wt.%, More preferably from 1, 5 to 5 wt .-% and in particular from 1, 75 to 2.5 wt.%, Each based on the entire remedy, included.

The compositions according to the invention, in particular the toothpastes, can also additionally other wound-healing and anti-inflammatory substances, eg. B. agents for gingivitis included. Such substances may, for. B. be selected from allantoin, azulen, chamomile extracts, tocopherol, panthenol, bisabolol, sage extracts.

As a non-cationic, bactericidal component, e.g. Phenols, resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated diphenyl ethers, e.g. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan). They are preferably used in amounts of from 0.01 to 1% by weight in the dentifrices according to the invention. Triclosan is particularly preferably used in an amount of 0.01-0.3% by weight.

D-panthenol D - (+) - 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethyl-butyramide exhibits a biological activity corresponding to pantothenic acid. The pantothenic acid (R - (+) - N - (2,4-dihydroxy-3,3-dimethylbutyryl-β-alanine) is a precursor in the biosynthesis of coenzyme A and is counted to the vitamin B complex (B3). These substances are known to promote wound healing and have a beneficial effect on the skin and have therefore been occasionally described in toothpastes The dentifrices of the invention preferably contain 0.05-5% by weight of panthenol or a salt of pantothenic acid ,

Retinol (3,7-dimethyl-9- (2,6,6-trimethyl-1-cyclohexenyl) -2,4,6,8-nonatetraen-1-ol is the international common name for vitamin A1, but may also be used instead of retinol one of its derivatives having a similar biological activity, for example an ester or the retinoic acid (tretinoin), one of its salts or its esters, is preferred A retinol ester is preferred, in particular a fatty acid ester of a fatty acid used with 12 - 22 carbon atoms. Retinol palmitate is particularly preferred. When using a retinol ester, eg retinol palmitate with an activity of 1, 7 10 ⁶ IU per g is an amount of

0.001 to 0.1% by weight is preferred. When using other retinol derivatives, one is recommended

Amount corresponding to a concentration of 10 ³ to 10 ⁶ IU (International Units) per 100 g.

Preferred dentifrices according to the present invention contain, in addition to polishing agents,

Fluorine compounds, humectants and binders are preferred

0.01 - 1 wt .-% of a halogenated diphenyl ether

0.05 - 5 wt .-% panthenol or a salt of pantothenic acid and

0.01-0.1% by weight of a retinol ester, preferably retinol palmitate.

In accordance with the invention preferred oral and dental care and cleaning agents are characterized in that they additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent included.

The agents according to the invention, in particular the toothpastes, may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products.

In addition to the compulsory components mentioned, the dentifrices according to the invention may contain further adjuvants and additives known per se. An additive which has been known for a long time as a toothpaste component is particularly effective in the dentifrices according to the invention: calcium glycerophosphate, the calcium salt of glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or of the glycerol-1-phosphoric acid enantiomer Glycerol-3-phosphoric acid - or a mixture of these acids. The compound has one in dentifrices remineralizing effect since it provides both calcium and phosphate ions. In the dentifrices according to the invention calcium glycerophosphate is preferably used in amounts of 0.01 to 1 wt .-%. Overall, the dentifrices according to the invention may contain customary auxiliaries and additives in amounts of up to 10% by weight.

The dentifrices according to the invention may e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.

As aroma oils, all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.

Suitable flavors are e.g. Peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and mixtures of these components.

Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, meltose, fructose.

Further customary auxiliaries and additives for toothpastes are

Surface-active substances, preferably anionic, zwitterionic, amphoteric, nonionic surfactants or a combination of several different surfactants

Solvents and solubilizers, e.g. lower monohydric or polyhydric alcohols or

Ethers, e.g. Ethanol, 1, 2-propylene glycol, diethylene glycol or Butyldi- glycol

Pigments, e.g. Titanium dioxide

dyes

Buffer substances, e.g. primary, secondary or tertiary alkali phosphates or citric acid

/ Na citrate other wound healing or anti-inflammatory substances, e.g. Allantoin, urea, azulene,

Chamomile agents, acetylsalicylic acid derivatives or rhodanide, other vitamins, e.g. Ascorbic acid, biotin, tocopherol or rutin

Mineral salts such as e.g. Manganese, zinc or magnesium salts.

Another important group of ingredients that may be included in the compositions of the invention are the so-called bioactive glasses. In the context of the present application, the term "bioactive glasses" encompasses glasses which are biologically active and / or biologically active The biological effectiveness of a glass can be demonstrated in its antimicrobial properties, for example, biologically active glass differs from conventional lime-sodium silicate For example, biologically active glass refers to a glass that forms a firm bond with body tissue to form a hydroxylapatite layer.A bioactive glass is also understood to mean a glass that has antimicrobial and / or anti-inflammatory properties The glass powders have a biocidal or biostatic effect against bacteria, fungi and viruses, are tolerated by the skin in contact with humans, are toxicologically harmless and are especially suitable for consumption.

Oral and dental care and cleaning agents which are particularly preferred according to the invention are characterized in that they contain from 0.2 to 20% by weight, preferably from 0.4 to 14% by weight, more preferably from 0.5 to 3% by weight, and in particular 0.6 to 2 wt .-% of at least one bioactive glass.

The oral and dental care and cleaning compositions of this embodiment contain bioactive glass or glass powder or glass ceramic powder or composite materials comprising such a bioactive glass. For the purposes of the present application, glass powders are also understood as meaning granules and glass beads.

Due to the requirements for the toxicological safety of the glass and its suitability for consumption, the glass powder should be particularly pure. The burden of heavy metals is preferably low. Thus, the maximum concentration in the range of cosmetic formulations is preferably for Pb <20 ppm, Cd <5 ppm, As <5 ppm, Sb <10 ppm, Hg <1 ppm, Ni <10 ppm.

The unfused starting glass, which is contained directly in the preferred compositions according to the invention or is optionally used for the production of a glass ceramic which can be used according to the invention, contains SiO ₂ as a network former, preferably between 35-80% by weight. At lower concentrations, the spontaneous tendency to crystallize increases greatly and the chemical resistance decreases sharply. At higher SiO ₂ values, the crystallization stability may decrease and the processing temperature is significantly increased, so that the hot-forming properties deteriorate. Na ₂ O is used as a flux when melting the glass. At concentrations of less than 5%, the melting behavior is adversely affected. Sodium is a constituent of the phases which form during the ceramization and must, if high crystalline phase proportions are to be adjusted by the ceramization, be correspondingly high Concentrations should be contained in the glass. K ₂ O acts as a flux when melting the glass. In addition, potassium is released in aqueous systems. If high potassium concentrations are present in the glass, potassium-containing phases such as calcium silicates are also eliminated. The P ₂ O ₅ content of silicate glasses, glass ceramics or composites can be used to adjust the chemical resistance of the glass and thus the release of ions in aqueous media. For Phospaht glasses, P ₂ O _{5 is} network images. The P ₂ O ₅ content is preferably between 0 and 80 wt .-%. In order to improve the meltability, the glass may contain up to 25% by weight of B ₂ O ₃ . Al ₂ O ₃ is used to adjust the chemical resistance of the glass.

To enhance the antimicrobial, in particular the antibacterial properties of the glass-ceramic antimicrobial acting ions such. B. Ag, Au, I, Ce, Cu, Zn in concentrations less than 5 wt .-% may be included.

Coloring ions such. As Mn, Cu, Fe, Cr, Co, V, may be contained individually or in combination, preferably in a total concentration less than 1 wt .-%.

Usually, the glass or the glass ceramic is used in powder form. The ceramization can be done either with a glass block or Glasribbons or with glass powder. After ceramization, the glass ceramic blocks or ribbons must be ground to powder. If the powder has been ceramified, it may also be necessary to re-mill to remove agglomerates formed during the ceramification step. The grinding can be carried out both dry and in aqueous or non-aqueous grinding media. Usually, the particle sizes are less than 500 microns. As appropriate, particle sizes <100 microns or <20 microns have been found. Particularly suitable are particle sizes <10 microns and less than 5 microns and less than 2 microns, see below.

The bioactive glasses or glass powder or glass ceramic powder or composite compositions contained in the preferred compositions according to the invention comprise glasses which preferably comprise the following components: SiO ₂ : 35-80% by weight, Na ₂ O: 0-35% by weight, P ₂ O ₅ : 0-80 wt%, MgO: 0-5 wt%, Ag ₂ O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ : 0-5 wt.%, TiO ₂ : 0-5 wt.%, K ₂ O: 0-35 wt.%, ZnO: 0-10 wt.%, Al ₂ O ₃ : 0-25 Wt% and B ₂ O ₃ : 0-25 wt%.

Furthermore, the base glass according to the above composition to achieve further effects such as color or UV filtering ions such as Fe, Co, Cr, V, Ce, Cu, Mn, Ni, Bi, Sn, Ag, Au, J individually or in total to be added to 10 wt .-%. A further glass composition may be as follows: SiO ₂ : 35-80 wt%, Na ₂ O: 0-35 wt%, P ₂ O ₅ : 0-80 wt%, MgO: 0-5 wt %, Ag ₂ O: 0-0.5 wt%, AgJ: 0-0.5 wt%, NaJ: 0-5 wt%, TiO ₂ : 0-5 wt% , K ₂ O: 0-35 parts by weight %, ZnO: 0-10 wt .-%, Al ₂ O _3: 0-25 wt .-%, B ₂ O _3: 0- 25 wt .-%, SnO: 0-5 wt .-% CeO ₂ : 0-3% by weight and Au: 0.001-0.1% by weight.

Particularly preferred oral and dental care and cleaning agents according to the invention are characterized in that the bioactive glass - based on its weight - has the following composition:

SiO ₂ 35 to 60% by weight, preferably 40 to 60% by weight,

Na ₂ O 0 to 35 wt .-%, preferably 5 to 30 wt .-%,

K ₂ O 0 to 35 wt .-%, preferably 0 to 20 wt .-%,

P ₂ O ₅ O to 10 wt .-%, preferably 2 to 10 wt .-%,

MgO 0 to 10% by weight, preferably 0 to 5% by weight,

CaO 0 to 35% by weight, preferably 5 to 30% by weight,

Al ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

B ₂ O ₃ 0 to 25 wt .-%, preferably 0 to 5 wt .-%,

TiO ₂ 0 to 10 wt .-%, preferably 0.1 to 5 wt .-%.

As already mentioned above, the bioactive glass is preferably used in particulate form. Here are particularly preferred oral and dental care and cleaning agent according to the invention characterized in that the antimicrobial glass particle sizes <10 .mu.m, preferably from 0.5 to 4 .mu.m, more preferably from 1 to 2 microns having.

It has been found that the fluoride deposition of the oral and dental care and cleaning agents according to the invention can be further increased if the agents contain salivationsfördernde substances. This is the case in particular in the case of low-fluoride or free inventive agents, since the fluoride to be deposited in this case is provided from the saliva.

Salivation is the production and release of saliva, in a broader sense also in an unphysiologically increased amount. Substances that stimulate salivary flow and increase the amount and / or release of saliva can come from a wide variety of substance classes.

An example of a suitable substance according to the invention is the pilocarpine, which may be present in the oral and dental care and cleaning compositions according to the invention.

pilocarpine

Other salivation-promoting substances are in particular so-called sharp substances, i. sharp tasting and / or a feeling of heat generating substances. Oral and dental care and cleaning agents which are preferred according to the invention are characterized in that they contain at least one pungent-tasting and / or heat-generating substance as the salivation-promoting substance.

As a salivation-promoting ingredient, the products of this embodiment of this invention contain a pungent-tasting and / or a feeling of heat-generating substance. These substances give the user a sharp, tingling, mouthwashing or heat generating effect, i. they cause a sensation of warmth or burning, or tingling, beads, tickling or bubbling, thereby promoting salivation.

Products of this embodiment which are preferred according to the invention contain the pungent-tasting and / or a feeling of heat-generating substance (s) in amounts of from 0.00001 to 5% by weight, preferably from 0.0005 to 2.5% by weight .-%, more preferably from 0.001 to 1 wt .-%, particularly preferably from 0.005 to 0.75 wt .-% and in particular from 0.01 to 0.5 wt .-%, each based on the weight of the total composition ,

As a pungent or a feeling of heat generating substance, a number of substances can be used. Preference is given in particular to N-alkyl-substituted amides of unsaturated carboxylic acids, for example

2E, 4E-decadienoic-N-methyl amide

2E, 4E-decadienoic-N-ethyl amide

2E, 4E-decadienoic acid-N-n-propylamide

2E, 4E-decadienoic-N-lsopropylamid

2E, 4E-decadienoic acid-N-n-butyl amide

2E, 4E-decadienoic acid-N- (1-methylpropyl) -amide E, 4E-decadienoic acid N-isobutylamide E, 4E-decadienoic acid N-tert-butylamide E, 4Z-decadienoic acid N-methylamide E, 4Z-decadienoic acid N-ethylamide E, 4Z-decadienoic acid Nn-propylamide E, 4Z -Decadienoic acid N-isopropylamide E, 4Z-decadienoic acid Nn-butylamide E, 4Z-decadienoic acid N- (1-methylpropyl) -amide E, 4Z-decadienoic acid N-isobutylamide E, 4Z-decadienoic acid N-tert-butylamide E , 4E, 8Z-decatrienoic acid N-methylamide E, 4E, 8Z-decatrienoic acid N-ethylamide E, 4E, 8Z-decatrienoic acid Nn-propylamide E, 4E, 8Z-decatrienoic acid N-isopropylamide E, 4E, 8Z-decatrienoic acid Nn Butylamide E, 4E, 8Z-decatrienoic acid N- (1-methylpropyl) -amideE, 4E, 8Z-decatrienoic acid N-isobutylamide E, 4E, 8Z-decatrienoic acid N-tert-butylamide E, 4Z, 8Z-decatrienoic acid-N -Methylamide E, 4Z, 8Z-decatrienoic acid N-ethylamide E, 4Z, 8Z-decatrienoic acid Nn-propylamide E, 4Z, 8Z-decatrienoic acid N-isopropylamide E, 4Z, 8Z-decatrienoic acid Nn-butylamide E, 4Z, 8Z- Decatrienoic acid N- (1-methylpropyl) -amideE, 4Z, 8Z-decatrienoic acid N-isobutylamide E, 4Z, 8Z-decatrienoic acid N-tert-butylamide E, 4E, 8E-decatrienoic acid Re-N-methylamide E, 4E, 8E-decatrienoic acid N-ethylamide E, 4E, 8E-decatrienoic acid Nn-propylamide E, 4E, 8E-decatrienoic acid N-isopropylamide E, 4E, 8E-decatrienoic acid Nn-butylamide E, 4E , 8E-Decatriensäure-N- (1-methylpropyl) -amide E, 4E, 8E-decatrienoic acid N-isobutylamide E, 4E, 8E-decatrienoic acid N-tert-butylamide E, 4Z, 8E-decatrienoic acid N-methylamide E, 4Z, 8E-decatrienoic acid N-ethylamide E, 4Z, 8E -Decatrienoic acid-Nn-propylamide E, 4Z, 8E-decatrienoic acid N-isopropylamide E, 4Z, 8E-decatrienoic acid Nn-butylamide E, 4Z, 8E-decatrienoic acid N- (1-methylpropyl) amide E, 4Z, 8E-decatrienoic acid N-isobutylamide E, 4Z, 8E-decatrienoic acid N-tert-butylamide E, 6Z, 8E-decatrienoic acid N-methylamide E, 6Z, 8E-decatrienoic acid N-ethylamide E, 6Z, 8E-decatrienoic acid Nn-propylamide E, 6Z , 8E-Decatrienoic acid N-isopropylamide E, 6Z, 8E-decatrienoic acid Nn-butylamide E, 6Z, 8E-decatrienoic acid N- (1-methylpropyl) -amideE, 6Z, 8E-decatrienoic acid N-isobutylamide E, 6Z, 8E- Decatrienoic acid N-tert-butylamide E, 6E, 8E-decatrienoic acid N-methylamide E, 6E, 8E-decatrienoic acid N-ethylamide E, 6E, 8E-decatrienoic acid Nn-propylamide E, 6E, 8E-decatrienoic acid N-isopropylamide E , 6E, 8E-Decatrienoic acid-Nn-butylamide E, 6E, 8E-decatrienoic acid N- (1-methylpropyl) -amideE, 6E, 8E-decatrienoic acid-N-isobutylamide E, 6E, 8E-decatrienoic acid N- Tert-butylamide E, 6Z, 8Z-decatrienoic acid N-methylamide E, 6Z, 8Z-decatrienoic acid N-ethylamide E, 6Z, 8Z-decatrienoic acid Nn-propylamide E, 6Z, 8Z-decatrienoic acid N-isopropylamide E, 6Z, 8Z -Decatrienoic acid-Nn-butylamide E, 6Z, 8Z-decatrienoic acid N- (1-methylpropyl) -amide E, 6Z, 8Z-decatrienoic acid N-isobutylamide E, 6Z, 8Z-decatrienoic acid N-tert-butylamide E, 6E, 8Z-decatrienoic acid N-methylamide E, 6E, 8Z-decatrienoic acid N-ethylamide E, 6E, 8Z-Decatrienoic acid Nn-propylamide E, 6E, 8Z-decatrienoic acid N-isopropylamide E, 6E, 8Z-decatrienoic acid Nn-butylamide E, 6E, 8Z-decatrienoic acid N- (1-methylpropyl) -amideE, 6E, 8Z -Decatrienoic acid N-isobutylamide E, 6E, 8Z-decatrienoic acid N-tert-butylamide E, 7Z, 9E-undecatrienoic acid-N-methylamide E, 7Z, 9E-undecatrienoic acid-N-ethylamide E, 7Z, 9E-undecatrienoic acid -Nn -Propylamide E, 7Z, 9E-undecatrienoic acid -N-isopropylamideE, 7Z, 9E-undecatrienoic acid -n-butylamide E, 7Z, 9E-undecatrienoic acid -N- (1-methylpropyl) -amideE, 7Z, 9E-undecatrienoic acid N-isobutylamide E , 7Z, 9E-undecatrienoic acid-N-tert-butylamide E, 7E, 9E-undecatrienoic acid-N-methylamide E, 7E, 9E-undecatrienoic acid-N-ethylamide E, 7E, 9E-undecatrienoic acid -Nn-propylamideE, 7E, 9E- Undecatrienoic acid -N-isopropylamideE, 7E, 9E-undecatrienoic acid -Nn-butylamide E, 7E, 9E-undecatrienoic acid -N- (1-methylpropyl) -amideE, 7E, 9E-undecatalyst N-isobutylamide E, 7E, 9E-undecatrienoic acid-N-tert-butylamide E, 7Z, 9Z-undecatrienoic acid-N-methylamide E, 7Z, 9Z-undecatrienoic acid-N-ethylamide E, 7Z, 9Z-undecatrienoic acid -Nn- Propylamide E, 7Z, 9Z-undecatrienoic acid -N-isopropylamideE, 7Z, 9Z-undecatrienoic acid -n-butylamide E, 7Z, 9Z-undecatrienoic acid -N- (1-methylpropyl) -amide 2E, 7Z, 9Z-undecatrienoic acid N-isobutylamide 2E, 7Z, 9Z-undecatrienoic acid-N-tert-butylamide

2E, 7Z, 9E-undecatrienoic acid-N-methylamide 2E, 7Z, 9E-undecatrienoic acid-N-ethylamide 2E, 7Z, 9E-undecatrienoic acid -Nn-propylamide 2E, 7Z, 9E-undecatrienoic acid -N-isopropylamide 2E, 7Z, 9E- Undecatrienoic acid -Nn-butylamide 2E, 7Z, 9E-undecatrienoic acid-N- (1-methylpropyl) -amide 2E, 7Z, 9E-undecatrienoic acid N-isobutylamide 2E, 7Z, 9E-undecatrienoic acid-N-tert-butylamide

Of course, other substitution patterns on the nitrogen atom are possible and preferred, for example, longer-chain n-alkyl radicals (... Nn-Pentylamid, ... Nn-pentylamide, ... Nn-pentylamide, ... Nn-pentylamide,. ..- Nn-pentylamide, ...- Nn-hexylamide, ...- Nn-heptylamide, ...- Nn-octylamide, ...- Nn-nonylamide, ...- Nn-decylamide, ... -Nn-undecylamide, ... -Nn-dodecylamide, ... -Nn-tridecylamide, etc.) or disubstituted... N, N-dialkylamides such as... N, N-dimethylamide,... N, N-diethylamide,... N, N-di-n-propylamide,... N, N-diisopropylamide,... N, N-di-n-butylamide,.. N-di (1-methylpropyl) amide,... N, N-diisobutylamide,... N, N-di-tert-butylamide,... N, N-methyl-ethylamide,... N, N-methyl-n-propylamide, N, N-methyl-isopropylamide, N, N-ethyl-n-propylamide, N, N-ethyl-isopropylamide, etc. ,

Among the compounds mentioned, some are particularly preferred in the context of the present invention. These are listed below:

2E, 6Z, 8E-decatrienoic acid N-isobutylamide (N-isobutyl-2E, 6Z, 8E-decatrienamide, also called spilanthol or affinin):

2E, 4E, 8Z-decatrienoic acid N-isobutylamide (N-isobutyl-2E, 4E, 8Z-decatrienamide, also called isoaffinin):

2E, 7Z, 9E-undecatrienoic acid N-isobutylamide (N-isobutyl-2E, 7Z, 9E-undecatrienamide):

2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin):

2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin):

Ferulic acid amides, for example ferulic acid N-vanillylamide:

Λ / - [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxy-phenyl) - (2E) -propenoic acid amide

(Trans-feruloylmethoxytyramine):

Λ / - [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloylmethoxytyramine):

Λ / - [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) propanoic acid amide (dihydroferuloylmethoxytyramine):

Λ / - [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) - propenoic acid amide (trans -feruloyldopamine):

Λ / - [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloyldopamine):

Λ / - [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2E) -propenoic acid amide (trans-caffeoyltyramine):

Λ / - [2- (4-Hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) - propenoic acid amide (cis-caffeoyltyramine):

Λ / - [2- (3,4-Dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide (trans-Rubenamine): Λ / - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide (cis-Rubenamine):

Other useful in the context of the present invention Scharfstoffe are, for example, extracts of natural plants. Hot-tasting herbal extracts can be any physiologically harmless herbal extract that produces a sharp or warm sensory impression. Pepper extract (Piper ssp., In particular Piper nigrum), water pepper extract (Polygonum spp., In particular Polygonum hydropiper), extracts of Allium ssp. (In particular onion and garlic extracts), extracts of radish (Raphanus ssp.), Are preferred as pungent-tasting herbal extracts. Horseradish extracts (Cochlearia armoracia), extracts of black (Brassica nigra), wild or yellow mustard (Sinapis ssp., In particular Sinapis arvensis and Sinapis alba), Bertram root extracts (Anacyclus ssp., Especially Anacyclus pyrethrum L.), sun hatch extracts (Echinaceae ssp. Extracts of Szechuan pepper (Zanthoxylum spp., In particular Zanthoxylum piperitum), spilanthic extract (Spilanthes spp., In particular Spilanthes acmella), chile extract (Capsicum spp., In particular Capsicum frutescens), grains of paradise extract (Aframomum ssp., In particular Aframomum melegueta [Rose] K. Schum.), Ginger extract (Zingiber ssp. Especially Zingiber officinale) and galangae extract (Kaem pferia galanga or alpinia galanga).

A particularly suitable substance is the gingerol derived from the ginger extract:

It is also possible to use N-ethyl-p-menthane-3-carboxamide (N-ethyl-5-methyl-2-isopropylcyclohexanecarboxamide):

Other pungent-tasting or heat-generating substances may e.g. its capsaicin, dihydrocapsaicin, gingerol, paradole, shogaol, piperine, carboxylic acid N-vanillylamide, in particular nonanoic acid N-vanillylamide, 2-alkeneamic acid amides, in particular 2-nonenoic acid N-isobutylamide, 2-nonenoic acid N-4-hydroxy-3 4-hydroxy-3-methoxybenzyl alcohol, in particular 4-hydroxy-3-methoxybenzyl n-butyl ether, alkyl ether of 3-hydroxy-4-methoxybenzyl alcohol, alkyl ether of 3,4-dimethoxybenzyl alcohol, alkyl ether of 3-ethoxy 4-hydroxybenzyl alcohol, alkyl ethers of 3,4-methylenedioxybenzyl alcohol, nicotinaldehyde, methyl nicotinate, propyl nicotinate, 2-butoxyethyl nicotinate, benzyl nicotinate, 1-acetoxychavicol, polygodial or isodrimeninol.

Preferred remineralizing products according to the invention are characterized in that they contain at least one Scharfstoff from the group of N-alkyl-substituted amides of unsaturated carboxylic acids, preferably a. 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (Spilanthol) and / or b. 2E, 4E, 8Z-decatrienoic acid N-isobutylamide and / or c. 2E, 7Z, 9E undecatrienoic acid N-isobutylamide and / or d. 2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin) and / or e. 2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin) and / or f. Ferulic acid N-vanillylamide and / or g. Λ / - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) - propenoic acid amide (trans -feruloylmethoxytyramine) and / or h. Λ / - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) - propenoic acid amide (cis -feruloylmethoxytyramine) and / or i. Λ / - [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) propanoic acid amide (dihydroferuloylmethoxytyramine) and / or j. Λ / - [2- (3,4-dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) - propenoic acid amide (trans -feruloyldopamine) and / or k. Λ / - [2- (3,4-dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) - propenoic acid amide (cis-feruloyldopamine) and / or I. Λ / - [2 - (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2E) -propenoic acid amide (trans-

Caffeoyltyramine) and / or m. Λ / - [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) - propenoic acid amide (cis)

Caffeoyltyramine) and / or n. Λ / - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide

(trans-Rubenamine) and / or o. Λ / - [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide

(cis-Rubenamine).

In addition to or in place of the above-mentioned sharp substances, other pungent-tasting and / or a feeling of heat-generating substances may also be incorporated into the products according to the invention.

Particularly suitable within the scope of the present invention are alkyl-substituted dioxanes of the formula

proved, in which R1 and R2 are independently selected from -H, -CH _3, -CH ₂ CH ₃ and R3 and R4 are independently selected from -H, -CH _3, -CH ₂ CH _3, -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ .

As further particularly suitable in the context of the present invention phenyl esters of the formula proved, in which R 5 is -CH ₃ or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms, and R6 is _-CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 Carbon atoms

Further particularly suitable within the scope of the present invention are carvone acetals of the formula

in which R 7 to R 12 are independently selected from -H, -CH ₃ , -CH ₂ CH ₃ , -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ , -CH ₂ CH ₂ CH ₂ CH ₃ , -CH ₂ CH (CH ₃ ) ₂ , -CH (CH ₃ ) CH ₂ CH _3, -C (CH ₃ ) ₃ or R 9 and R 10 together represent a chemical bond or a group - (CR 13 R 14) _X where x is the values 1 or 2 and R 13 and R 14 are independently selected from -H, -CH ₃ , - OH ₂ OH ₃ , -OH ₂ OH ₂ OH ₃ , -OH (OH ₃ ) ₂ , -OH ₂ OH ₂ OH ₂ OH ₃ , -OH ₂ OH (OH ₃ ) ₂ , -OH (OH ₃ ) OH ₂ OH ₃₅ _O (OH ₃ ) ₃

Another object of the present invention is the use of carboxymethylcellulose in oral and dental care and cleaning agents to improve the fluoride uptake of the enamel and / or dentin.

Particularly preferred uses are characterized in that carboxymethylcellulose is used in fluoride-poor, and also in fluoride-free, mouth and dental care and cleaning agents.

Another object of the present invention is a method for improving the uptake of fluoride in the enamel, in which a preparation of the invention is applied to a toothbrush and brushed with the teeth. With regard to preferred embodiments of the uses according to the invention and of the method according to the invention, what has been said about the agents according to the invention applies mutatis mutandis.

Claims

claims:

1. Oral and dental care and cleaning compositions containing - based on its weight - a) 0.1 to 10 wt .-% carboxymethylcellulose; b) 10 to 60 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-%.

2. oral and dental care and cleaning agent according to claim 1, characterized in that it - based on its weight - 0.2 to 7.5 wt .-%, preferably 0.3 to 6 wt .-%, particularly preferably 0.4 to 5% by weight, more preferably 0.5 to 3.5% by weight, even more preferably 0.6 to 2.5% by weight and in particular 0.7 to 1.5% by weight Contains% carboxymethylcellulose.

3. oral and dental care and cleaning agent according to claim 1 or 2, characterized in that it is 10 to 60 wt .-%, preferably 15 to 55 wt .-%, particularly preferably 20 to 50% by weight and in particular 30th to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1, 2-Propylenglycol .-%, each based on the weight of the total composition contains.

4. Oral and dental care and cleaning agent according to one of claims 1 to 3, characterized in that it - based on its weight - less than 0.5 wt .-%, preferably less than 0.4 wt .-%, more preferably less than 0.3% by weight, more preferably less than 0.2% by weight and in particular less than 0.1% by weight of sodium fluoride and / or sodium monofluorophosphate.

5. Oral and dental care and cleaning agent according to one of claims 1 to 4, characterized in that it is free of intentionally added fluorides.

6. oral and dental care and cleaning agent according to one of claims 1 to 5, characterized in that it at 20 ⁰ C, a viscosity (measured with Brookfield Synchro-Lectric viscometer, type RVT with Helipath stand, spindle 3 and 20 U from 100 to 1000 Pas (100,000 to 1,000,000 mPas), preferably from 200 to 750 Pas (200,000 to 750,000 mPas), more preferably from 350 to 650 Pas (350,000 to 650,000 mPas), and especially from 450 to 550 Pas (450,000 to 550,000 mPas).

7. Oral and Zahnpflege- and -reinigungsmittel according to any one of claims 1 to 6, characterized in that it - based on its weight - less than 5 wt .-%, preferably less than 4 wt .-%, more preferably less than 3 wt .-%, more preferably less than 2 wt .-% and in particular less than 1 wt .-% salts of the type AB contains.

8. Oral and dental care and cleaning agent according to any one of claims 1 to 7, characterized in that it additionally cleaning body, preferably silicic acid, aluminum hydroxide, alumina, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ -2H ₂ O), sodium aluminum silicates , in particular zeolite A, organic polymers, in particular polymethacrylates or mixtures of these friction bodies, preferably in amounts of from 1 to 30% by weight, preferably from 2.5 to 25% by weight and in particular from 5 to 22% by weight, in each case based on the entire means, contains.

9. Oral and dental care and cleaning agent according to one of claims 1 to 8, characterized in that it additionally phosphate (s), preferably alkali metal phosphate (s) and in particular sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8 wt .-% and in particular from 3 to 7 wt .-%, each based on the total agent contains.

10. Oral and dental care and cleaning agent according to any one of claims 1 to 9, characterized in that it additionally antiplaque agents, preferably p-Hydroxybenzoesäuremethyl-, ethyl or propyl esters, sodium sorbate, sodium benzoate, bromochlorophene, triclosan, phenyl- Salicylic acid esters, biguanides z. As chlorhexidine, thymol, preferably in amounts of 0.1 to 5 wt.%, Preferably from 0.25 to 2.5 wt.% And in particular from 0.5 to 1, 5 wt.%, Each based on the total Means containing.

1 1. Oral and dental care and cleaning agent according to any one of claims 1 to 10, characterized in that it the insensitivity of the teeth-enhancing substances, preferably potassium salts, more preferably potassium nitrate and / or potassium citrate and / or potassium chloride and / or potassium bicarbonate and or potassium oxalate, preferably in amounts of from 0.5 to 20% by weight, particularly preferably from 1, 0 to 15% by weight, more preferably from 1, 5 to 5% by weight and in particular from 1, 75 to 2, 5% by weight, based in each case on the total agent.

12. Oral and dental care and cleaning agent according to one of claims 1 to 11, characterized in that it is 0.2 to 20 wt .-%, preferably 0.4 to 14 wt .-%, especially preferably 0.5 to 3 wt .-% and in particular 0.6 to 2 wt .-% of at least one bioactive glass.

13. Use of carboxymethylcellulose in the mouth and dentifrices and cleaners to improve the fluoride uptake of the enamel and / or dentin.

14. Use according to claim 13, characterized in that carboxymethylcellulose is used in low-fluoride, and in fluoride-free, mouth and Zahnpflege- and -reinigungsmitteln.

15. A method for improving the uptake of fluoride in the enamel, characterized in that a preparation according to one of claims 1 to 11 is applied to a toothbrush and brushed with this teeth.