DE102009029164A1 - Mouth- and tooth care-cleansing agent, useful for preventing and treating caries, controlling halitosis and/or treating gingivitis or periodontitis, comprises taurine (2-aminoethanesulfonic acid) and an antibacterial compound - Google Patents

Abstract

Mouth- and tooth care-cleansing agent comprises 0.001-10 wt.% of taurine (2-aminoethanesulfonic acid) and 0.001-5 wt.% of at least an antibacterial compound. Independent claims are included for preventing and treating caries, controlling halitosis and/or treating gingivitis or periodontitis comprising either applying the mouth- and tooth care-cleansing agent on toothbrush and brushing the teeth with the cleansing agent or bringing the mouth- and tooth care-cleansing agent in the form of mouthwash in the oral cavity and leaving for a period of at least 10 seconds, preferably 45 seconds. ACTIVITY : Antibacterial; Antiinflammatory. MECHANISM OF ACTION : None given.

Description

The Invention relates to preparations for oral and dental care and cleaning, due to special ingredients an excellent gum-care and -sustainable effect.

Dentifrice are in different forms in the market and serve first Line of cleaning the tooth surface and prevention of Tooth and gum disease. They usually contain a combination of polishes, humectants, surfactants, Binders, flavorings and fluoride-containing and antimicrobial Agents. In addition to toothpowder, because of their increased abrasiveness a subordinate Dentifrices, especially in paste, Creamy and translucent or transparent gel form offered. In Liquid or liquid toothpastes and mouthwashes have also been increasing in recent years gained in importance.

Next cleaning the teeth the consumer expects the generic products also a care the teeth and the oral cavity. In particular, a "clean" feeling, i. H. a smooth and shiny tooth surface as well as a fresh feeling in the mouth essential aspects for the incentive to buy preparations for oral and dental care and cleaning. A successful remedy of the generic type should therefore thoroughly clean the teeth, without damaging the tooth or the tooth surface and at the same time halitosis reduce and / or prevent.

Bad breath, also halitosis or "fetor called "ex ore", can have different causes. In healthy people, halitosis but in most cases by bacteria in the mouth or throat caused the body cells or food residues, using as degradation products of proteins u. a. volatile Sulfur compounds ("volatile sulfur compounds ", VSC) arise for the bad smell be held responsible.

In particular, these sulfur compounds are: H ₂ S = hydrogen sulfide (about 30%), CH ₃ -SH = methylmercaptan (about 60%), and CH ₃ -S-CH ₃ = dimethylsulfide (about 10%).

The volatile Sulfur compounds are sometimes very aggressive and can Damage the gums and oral mucosa. Such is for example known that hydrogen sulfide and methylmercaptan permeability increase the oral mucosa and so can promote gum disease.

Gum disease represent a high risk factor for health Studies by the World Health Organization (WHO) suffer over 50% the adult German citizen urgently in need of treatment Periodontal disease. By periodontitis one understands by bacteria inflammatory change of the tissue surrounding the tooth, especially of the jawbone. A periodontitis (= involving the periodontal pockets and the bone) developed always from a gingivitis (gingivitis) and attacks first the least accessible interdental spaces for cleaning. The bacteria in the periodontal pocket act through their metabolites, especially those produced by you VSC, destructive to gums, tooth substance and bones and strengthen so constantly the already existing periodontitis.

It has not lacked attempts, bad breath and inflammatory conditions in the oral cavity to fight, and a variety of agents are used in preparations for this purpose used for oral and dental care and cleaning. As antibacterial Agents find, for example, triclosan, tin salts or chlorhexidine Use. However, the use of these products can in individual cases with Be associated with disadvantages that are partly of a tasteful nature, partly aesthetic reasons have, as the product and / or teeth through excessive use of the agents discolored can be. In individual cases Can the fight The bacteria may not be sufficient to reverse the inflammatory process State to reach.

It Therefore, there is still the need to combat halitosis and To provide agents or drug combinations for that, the free of the disadvantages mentioned are.

The object of the present invention was to provide preparations for oral and dental care and cleaning, which effectively combat halitosis and are effective against gingivitis and periodontitis. In one aspect of the invention, the disadvantages of the use of triclosan, tin salts or chlorhexidine should be avoided, the amount used can be reduced or natural antimicrobial substances can be used. In a further aspect of the invention, the care of the oral cavity by the Un Support the natural regeneration of the oral mucosa and gums can be improved.

It it has now been found that certain ingredients to the solution the above-mentioned task complex are suitable.

• a) 0,001 bis 10 Gew.-% Taurin (2-Aminoethansulfonsäure)
• b) 0,001 bis 5 Gew.-% mindestens einer antibakteriellen Verbindung.

The present invention is in a first embodiment, an oral and Zahnpflege- and -reinigungsmittel containing - based on its weight -

• a) 0.001 to 10% by weight of taurine (2-aminoethanesulfonic acid)
• b) 0.001 to 5 wt .-% of at least one antibacterial compound.

Mouth- and dentifrices as well as mouth and tooth cleaning agents in the sense oral and dental powders, oral and toothpastes, liquid mouthwashes, and toothpastes, mouth and tooth rinses as well Oral and dental gels. Preferably suitable are toothpastes and liquid dentifrices. You can do this the oral and dental care and cleaning agents z. B. in the form of Toothpastes, liquid Toothpastes, toothpowder, mouthwash or optionally as gum, z. B. as chewing gum, present. Preferably, however, they are more or less flowable or plastic toothpastes in front, as they are used to clean the teeth Use of a toothbrush be used. Another particularly preferred embodiment The present invention includes mouthwashes and mouthwashes to rinse the oral cavity be used.

The agents according to the invention included - related on the weight of the remedy - as first ingredient 0.001 to 10 wt .-% taurine (2-aminoethanesulfonic acid). Preferably taurine is used within narrower ranges, with preferred mouthpiece according to the invention and dentifrices and cleaners - by weight - 0.001-5% by weight, preferably 0.001-4 Wt .-%, particularly preferably 0.005-1 wt .-%, extraordinarily preferably 0.006-1 Wt .-% taurine (2-aminoethanesulfonic acid) included.

When second essential component contain the agents according to the invention 0.001 to 5 wt .-% of at least one antibacterial compound. According to the invention preferred Oral and dental care and cleaning products are characterized that they - related on her weight - 0.0025 to 2.5% by weight, preferably 0.005 to 1% by weight, more preferably From 0.01 to 0.5% by weight and in particular from 0.025 to 0.1% by weight of antibacterial (s) Active substance (s) included.

In For example, mouth and teeth care and cleaners can do the same food preservatives preservative sorbic acid (E 200), Potassium sorbate (E 202), calcium sorbate (E 203), benzoic acid (E 210), Sodium benzoate (E 211), potassium benzoate (E 212), calcium benzoate (E. 213), ethyl 4-hydroxybenzoate (E 214), ethyl 4-hydroxybenzoate, sodium salt (E 215), propyl 4-hydroxybenzoate (E 216), propyl 4-hydroxybenzoate, sodium salt (E 217), methyl 4-hydroxybenzoate (E 218), methyl 4-hydroxybenzoate, sodium salt (E 219), sulfur dioxide (sulphurous acid), (E 220), sodium sulfite (E 221), sodium hydrogen sulfite (E 222), sodium disulfite (E 223), potassium bisulfite (E 224), calcium sulfite (E 226), calcium hydrogen sulfite (E 227), potassium hydrogen sulfite (E 228), biphenyl (E 230), orthophenylphenol (2-biphenylol), (E 231), sodium orthophenylphenolate (E 232), nisin (E 234), natamycin (E 235), formic acid (E 236), sodium formate (E 237), calcium formate (E 238), hexamethylenetetramine (E 239), dimethyl dicarbonate (E 242), potassium nitrite (E 249), sodium nitrite (E 250), sodium nitrate (E 251), potassium nitrate (E 252), acetic acid (E 260), potassium acetate (E. 261), sodium acetate (E 262), calcium acetate (E 263), lactic acid (E 270), propionic (E 280), sodium propionate (E 281), calcium propionate (E 282), potassium propionate (E 283), boric acid (E 284), sodium tetraborate (E 285), malic acid, (E. 296), fumaric acid (E 297), lysozyme (E 1105).

preferred Fabrics are selected from p-hydroxybenzoic acid methyl, ethyl or propyl ester, sodium sorbate, sodium benzoate, bromochlorophen, Triclosan, phenyl salicylic acid ester, 1-hexadecylpyridinium chloride, Biguanids z. Chlorhexidine (1,1'-hexamethylenebis [5- (4-chlorophenyl) -biguanide), Thymol etc.

When non-cationic, bactericidal component are suitable for. Phenols, Resorcinols, bisphenols, salicylanilides and their halogenated derivatives, halogenated carbanilides and p-hydroxybenzoic acid esters. Particularly preferred antimicrobial components are halogenated Diphenyl ether, e.g. B. 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether and 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan).

In preferred oral and dental care and cleaning agents according to the invention, the antibacterial active ingredient (s) is / are selected from methyl p-hydroxybenzoate, ethyl or propyl ester and / or bromochlorophene and / or triclosan and / or phenyl salicylic acid ester and / or 1 -Hexadecylpyridi ammonium chloride and / or biguanides, preferably chlorhexidine.

Out taste reasons or for reasons the abandonment of synthetic compounds may be natural antimicrobials be preferred. Their effect is achieved by the component according to the invention a) also synergistically reinforced, so they look highly effective even in small doses. Especially preferred Therefore, oral and dentifrices and cleaners containing the antibacterial agent (s) Active ingredients selected is / are from thymol and / or eugenol and / or eucalyptol and / or Extracts of myrrh and / or extracts of sage and / or extracts of carnation, and / or extracts of tea, and / or extracts of propolis, and / or extracts of Echinacea.

The mouthpiece according to and dentifrices and cleaners contain other ingredients. Prefers Here is the use of so-called humectants, the prevent toothpaste from drying out. In so-called liquid tooth creams with flowable rheology These serve as a matrix and are used in higher quantities. at mouthwashes and mouthwashes these alcohols serve as consistency regulators and additional Sweeteners.

Here are oral and dental care and cleaning agents, which - based on her weight - 0.5 to 60% by weight, preferably 0.75 to 55% by weight, more preferably 1 to 50 wt .-% and in particular 2 to 40 wt .-% of at least one polyhydric alcohol from the group of sorbitol and / or glycerol and / or 1,2-propylene glycol .-% or mixtures thereof.

For certain Areas of application may be advantageous, just one of the three use the above ingredients. In most cases it is while sorbitol preferred. However, on other application areas Mixtures of two of the three substances or all three substances are preferred be. Particularly advantageous here is a mixture of glycerol, Sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1) :( 0.1-0.5).

Next Sorbitol or glycerol or 1,2-propylene glycol are suitable as further polyhydric alcohols such having at least 2 OH groups, preferably Mannitol, xylitol, polyethylene glycol, polypropylene glycol and theirs Mixtures. Among these compounds are those with 2 to 12 OH groups and especially those with 2, 3, 4, 5, 6 or 10 OH groups preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1,2-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH ( OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used. Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols. As preferred further polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.

Especially the use of sorbitol is preferred so that agents other than sorbitol contain no other polyhydric alcohols, more preferably are.

mouth and dentifrices and cleaners may also be particularly preferred Anticaries drugs included. These can be made, for example, from organic or inorganic fluorides, e.g. As sodium fluoride, Potassium fluoride, sodium monofluorophosphate and sodium fluorosilicate. Also zinc fluoride, tin (II) fluoride are preferred. Preferred should an amount of 0.01-0.2 % By weight of fluorine in the form of said compounds.

Mouthpiece according to the invention and dentifrices and cleaners which additionally contain anti-caries agents, preferably Fluorine compound (s), especially sodium fluoride, potassium fluoride, Sodium monofluorophosphate, zinc fluoride, tin fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt .-%, preferably in amounts from 0.01 to 5 wt .-%, preferably from 0.02 to 2.5 wt .-% and in particular from 0.04 to 1.1 wt .-%, each based on the total Agents containing, are preferred in the invention.

The oral and dental care products, especially the toothpastes, may also contain the insensitivity of the teeth-enhancing substances, such as potassium salts such. As potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate. Oral and dental care and cleaning agents which are preferred according to the invention are characterized by the fact that they increase the insensitivity of the teeth potassium, preferably potassium, potassium nitrate and / or potassium citrate and / or potassium chloride and / or potassium bicarbonate and / or potassium oxalate, preferably in amounts of 0.5 to 20 wt .-%, particularly preferably from 1.0 to 15 wt. %, more preferably from 1.5 to 5 wt .-% and in particular from 1.75 to 2.5 wt .-%, each based on the total agent.

The agents according to the invention can also in addition further wound healing and anti-inflammatory Fabrics, e.g. B. agents for gingivitis included. such Substances can z. B. selected be from allantoin, azulene, chamomile extracts, tocopherol, panthenol, Bisabolol, sage extracts.

Of the Use of plaster bodies (Abrasives) is also preferred. Cleaning bodies are amorphous, predominantly inorganic, largely water-insoluble, very small-particle powders, which have no sharp edges. They favor in dental and oral care products the cleaning of the teeth and simultaneously polish the tooth surface (polishing agent).

When Polishing agents are in principle all known for toothpastes friction body, in particular those that do not contain calcium ions. Preferably suitable polishing agent components are therefore silicas, aluminum hydroxide, Alumina, sodium aluminosilicates, organic polymers or Mixtures of such friction bodies.

calcium-containing Polishing components such. Chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can but in amounts up to 5 wt .-% - related on the overall composition - included be.

Of the Total content of polishing agents is preferably in the range of 5-50% by weight of the dentifrice.

Especially preferred are toothpastes and liquid Dentifrices containing silicic acids as a polishing agent. Suitable silicic acids are z. For example, silicic acids, hydrogels and precipitated silicas. Gel silicas are by reaction of sodium silicate solutions with strong, aqueous mineral acids Formation of a hydrosol, aging to hydrogel, washing and drying produced. Drying takes place under mild conditions to water contents of 15 to 35 wt .-%, so are the so-called hydrogels receive. By drying to water contents below 15% by weight There is an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.

A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15-110 m ² / g, a particle size of 0.5-20 microns, wherein at least 80 wt .-% of the primary particles should be less than 5 microns, and a viscosity in 30% glycerol-water (1: 1) dispersion of 30-60 Pa.s (20 ° C) in an amount of 10-20% by weight of the dentifrice. Particularly suitable precipitated silicas of this type have rounded corners and edges and are commercially available under the trade name ^® Sident 12 DS (DEGUSSA).

Other precipitated silicas of this type are ident ^® 8 (DEGUSSA) and Sorbosil® ^® AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 microns with a specific surface area of 40-75 m ² / g (according to BET) and are particularly well suited for liquid toothpastes These should have a viscosity (25 ° C, shear rate D = 10 s ^-1 ) of 10-100 Pa · s.

On the other hand, toothpastes which have a significantly higher viscosity of more than 100 Pa.s (25 ° C., D = 10 s ^-1 ) require a sufficiently high proportion of silicas having a particle size of less than 5 μm, preferably at least 3% by weight. -% of a silica with a particle size of 1-3 microns. Such toothpastes are therefore preferred in addition to the mentioned precipitated silicas even finer, so-called thickening silicic acids having a BET surface area of 150-250 m ² / g, z. As the commercial products Sipernat 22 LS or Sipernat ^® 320 DS.

As a further polish component can also z. For example, alumina in the form of weakly calcined clay containing - and -Aluminiumoxid in an amount of about 1-5 wt .-% may be included. Such a suitable alumina is marketed under the trade designation "Polished clay P10 finest" (Giulini Che available).

When Polishing agents are also suitable for all known for toothpastes friction body as z. B. sodium aluminum silicates such. As zeolite A, organic polymers such as As polymethacrylate or mixtures of these and the above called friction body.

In summary, oral and dental care and cleaning compositions according to the invention are preferred which additionally comprise cleaning bodies, preferably silicic acids, aluminum hydroxide, aluminum oxide, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ .2H ₂ O), sodium aluminum silicates, in particular zeolite A, organic polymers, in particular Polymethacrylates or mixtures of these friction bodies, preferably in amounts of from 1 to 30 wt .-%, preferably from 2.5 to 25 wt .-% and in particular from 5 to 22 wt .-%, each based on the total agent.

The indicated amounts refer to the total amount of friction, wherein single friction body preferably be used in narrower ranges. According to the invention preferred Agents contain, for example, 5 to 20% by weight, preferably 8 to 21 wt .-%, more preferably 9 to 20 wt .-% and in particular 11 to 19% by weight of silica (s). Further preferred agents according to the invention are characterized in that they 0.25 to 2 wt .-%, preferably 0.5 to 1.5 wt .-% and in particular Contain 0.75 to 1.25 wt .-% alumina.

Mouth- and dental care and cleaning agents may, for. B. also substances contained, which are effective against plaque and / or tartar.

Anti-calculus substances may be, for example, chelating agents such. As ethylenediaminetetraacetic acid and its sodium salts, pyrophosphate salts such as the water-soluble dialkali or Tetraalkalimetallpyrophosphat- salts, z. B. Na ₄ P ₂ O ₇ , K ₄ P ₂ O ₇ , Na ₂ K ₂ P ₂ O ₇ , Na ₂ H ₂ P ₂ O ₇ and K ₂ H ₂ P ₂ O ₇ or polyphosphate salts, the z. B. from water-soluble Alkalimethalltripolyphosphaten as sodium tripolyphosphate and potassium tripolyphosphate can be selected.

According to the invention preferred Oral and dental care and cleaning products are characterized that she additionally Phosphate (s), preferably alkali metal phosphate (s) and in particular Sodium tripolyphosphate, preferably in amounts of from 1 to 10% by weight, particularly preferably from 2 to 8% by weight and in particular from 3 to 7 wt .-%, each based on the total agent included.

As a consistency regulator (or binder) serve z. As natural and / or synthetic water-soluble polymers such as alginates, carrageenan, tragacanth, starch and starch ethers, cellulose ethers such. As carboxymethyl cellulose (Na salt), hydroxyethyl cellulose, methyl hydroxypropyl cellulose, guar, Akaziengum, agar-agar, xanthan gum, succinoglycan gum, locust bean flour, pectins, water-soluble carboxyvinyl polymers (eg. Carbopol ^® types), polyvinyl alcohol, polyvinyl pyrrolidone, Polyethylene glycols, in particular those having molecular weights of 1 500-1 000 000.

Further Substances that are used for viscosity control are suitable, z. B. phyllosilicates such. B. montmorillonite clays, colloidal thickening silicas such as B. airgel silicas, fumed silicas or finely ground precipitated silicas. It can also viscosity-stabilizing additions from the group of cationic, zwitterionic or ampholytic nitrogen-containing surfactants, the hydroxypropyl-substituted hydrocolloids or the polyethylene glycol / polypropylene glycol copolymers having a average molecular weight of 1000 to 5000 or a combination of mentioned compounds are used in the toothpastes.

Also surfactants Substances can be used in the agents according to the invention. she used for example in toothpastes to support the cleaning effect and if desired also for the development of foam during tooth brushing or mouthwash as well for stabilizing the polishing body dispersion in the carrier and are used both in mouthwashes as also in toothpastes usually in an amount of 0.1-5 % By weight used.

Suitable surfactants are, for. B. linear sodium alkyl sulfates having 12-18 C atoms in the alkyl group. These substances additionally have an enzyme-inhibiting effect on the bacterial metabolism of the dental plaque. Further suitable surfactants are alkali metal salts, preferably sodium salts of alkylpolyglycol ether sulfate having 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the molecule, of linear alkane (C ₁₂ -C ₁₈ ) sulfonate, of sulfosuccinic acid monoalkyl (C ₁₂ -C ₁₈ ) esters, of sulfated fatty acid mono glycerides, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (C ₁₂ -C ₁₆ ) esters, acylsarcosines, acyl taurides and acyl isothionates each having 8-18 C atoms in the acyl group. Also zwitterionic, ampholytic and nonionic surfactants are suitable, for. B. Oxethylate of fatty acid mono- and diglycerides, of fatty acid sorbitan esters and alkyl (oligo) glucosides and Fettsäureamidoalkylbetaine.

The agent according to the invention, especially the toothpastes, can also substances to increase the containing mineralizing potential, for example, calcium-containing Substances such. Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility the substance and the interaction with others in the mouth and Dentifrice contained substances.

Next said compulsory components can the dentifrices of the invention contain further, known per se auxiliaries and additives. there is an additive that has long been known as a toothpaste component is, in the dentifrices according to the invention particularly effective: calcium glycerophosphate, the calcium salt of Glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or to the glycerol-1-phosphoric acid enantiomeric glycerol-3-phosphoric acid - or a mixture of these Acids. The compound has a remineralizing in dentifrices Effect of providing both calcium and phosphate ions. In the dentifrices according to the invention Calcium glycerophosphate is preferably used in amounts of 0.01-1% by weight. used. Overall, you can the dentifrices according to the invention conventional auxiliaries and additives in amounts up to 10 wt .-%.

The dentifrice according to the invention can z. B. by the addition of aroma oils and sweeteners be improved in their organoleptic properties.

When aromatic oils can all for Oral and dental care usual natural and synthetic flavors. Natural flavors can be both in the form of the natural essential oils isolated from drugs as well as those isolated from them Be contained individual components.

suitable Flavors are z. Peppermint oil, spearmint, Eucalyptus oil, anise oil, Fennel oil, Caraway oil, menthyl acetate, Cinnamaldehyde, anethole, vanillin, thymol and mixtures of these components.

suitable sweeteners are z. Saccharin sodium, sodium cyclamate, sucrose, lactose, Meltose, fructose.

• – Oberflächenaktive Stoffe, bevorzugt anionische, zwitterionische, amphotere, nichtionische Tenside oder eine Kombination mehrerer verschiedener Tenside
• – Lösungsmittel und Lösungsvermittler, z. B. niedere einwertige oder mehrwertige Alkohole oder Ether, z. B. Ethanol, 1,2-Propylenglycol, Diethylenglycol oder Butyldi-glycol
• – Pigmente, wie z. B. Titandioxid
• – Farbstoffe
• – Puffersubstanzen, z. B. primäre, sekundäre oder tertiäre Alkaliphosphate oder Citronensäure-/Na-Citrat
• – weitere wundheilende oder entzündungshemmende Stoffe, z. B. Allantoin, Harnstoff, Azulen, Kamillewirkstoffe, Acetylsalicylsäurederivate oder Rhodanid
• – weitere Vitamine wie z. B. Ascorbinsäure, Biotin, Tocopherol oder Rutin
• – Mineralsalze wie z. B. Mangan-, Zink- oder Magnesiumsalze.

Other common auxiliaries and additives for toothpastes and mouthwashes or mouthwashes are

• - Surface-active substances, preferably anionic, zwitterionic, amphoteric, nonionic surfactants or a combination of several different surfactants
• - Solvents and solubilizers, eg. As lower monohydric or polyhydric alcohols or ethers, for. For example, ethanol, 1,2-propylene glycol, diethylene glycol or butyl di-glycol
• - pigments, such as. For example, titanium dioxide
• - Dyes
• - Buffer substances, for. As primary, secondary or tertiary alkali metal phosphates or citric acid / Na citrate
• - other wound-healing or anti-inflammatory substances, eg. Allantoin, urea, azulene, chamomile agents, acetylsalicylic acid derivatives or rhodanide
• - other vitamins such. As ascorbic acid, biotin, tocopherol or rutin
• - Mineral salts such. For example, manganese, zinc or magnesium salts.

It has been shown that the mouthpiece according to and dental care and cleaning agents in their performance further increased can be if the means salivating Contain substances. In particular, the antibacterial effect and with it the anticaries effect and the effect against gingivitis and / or Periodontitis is thereby amplified.

Under Salivation is the production and release of saliva, in a broader sense also in an unphysiologically increased amount. Substances that stimulate the salivation and increase the amount of saliva and / or release, can from the most diverse Substance classes come.

A according to the invention for example suitable substance is the pilocarpine which is present in the mouth and dentifrices and cleaners.

Pilocarpin

pilocarpine

Further salivationsfördernde Substances are in particular so-called Scharfstoffe, d. H. nice tasting and / or a feeling of heat generating substances. According to preferred oral and dental hygiene and cleaners are characterized by being referred to as salivationsfördernde Substance has at least one pungent-tasting and / or a feeling of heat-producing Contain substance.

When salivationsfördernden Ingredient contain the products of this embodiment of the invention a sharp-tasting and / or a feeling of heat generating substance. These Substances give the user a sharp, tingling, mouth watering or heat-producing Effect, d. H. they call a sensation of warmth or burning, or a tingling, pearls, tickling or bubbling, thereby promoting the salivation.

According to the invention preferred Products of this embodiment contain the pungent-tasting and / or a feeling of heat-producing (s) Substance (s) in amounts of 0.00001 to 5 wt .-%, preferably from From 0.0005 to 2.5% by weight, more preferably from 0.001 to 1% by weight, more preferably from 0.005 to 0.75 wt .-% and in particular of 0.01 to 0.5 wt .-%, each based on the weight of the total Agent.

• – 2E,4E-Decadiensäure-N-Methylamid
• – 2E,4E-Decadiensäure-N-Ethylamid
• – 2E,4E-Decadiensäure-N-n-Propylamid
• – 2E,4E-Decadiensäure-N-Isopropylamid
• – 2E,4E-Decadiensäure-N-n-Butylamid
• – 2E,4E-Decadiensäure-N-(1-Methylpropyl)-amid
• – 2E,4E-Decadiensäure-N-Isobutylamid
• – 2E,4E-Decadiensäure-N-tert-Butylamid
• – 2E,4Z-Decadiensäure-N-Methylamid
• – 2E,4Z-Decadiensäure-N-Ethylamid
• – 2E,4Z-Decadiensäure-N-n-Propylamid
• – 2E,4Z-Decadiensäure-N-Isopropylamid
• – 2E,4Z-Decadiensäure-N-n-Butylamid
• – 2E,4Z-Decadiensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z-Decadiensäure-N-Isobutylamid
• – 2E,4Z-Decadiensäure-N-tert-Butylamid
• – 2E,4E,8Z-Decatriensäure-N-Methylamid
• – 2E,4E,8Z-Decatriensäure-N-Ethylamid
• – 2E,4E,8Z-Decatriensäure-N-n-Propylamid
• – 2E,4E,8Z-Decatriensäure-N-Isopropylamid
• – 2E,4E,8Z-Decatriensäure-N-n-Butylamid
• – 2E,4E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4E,8Z-Decatriensäure-N-Isobutylamid
• – 2E,4E,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,4Z,8Z-Decatriensäure-N-Methylamid
• – 2E,4Z,8Z-Decatriensäure-N-Ethylamid
• – 2E,4Z,8Z-Decatriensäure-N-n-Propylamid
• – 2E,4Z,8Z-Decatriensäure-N-Isopropylamid
• – 2E,4Z,8Z-Decatriensäure-N-n-Butylamid
• – 2E,4Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z,8Z-Decatriensäure-N-Isobutylamid
• – 2E,4Z,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,4E,8E-Decatriensäure-N-Methylamid
• – 2E,4E,8E-Decatriensäure-N-Ethylamid
• – 2E,4E,8E-Decatriensäure-N-n-Propylamid
• – 2E,4E,8E-Decatriensäure-N-Isopropylamid
• – 2E,4E,8E-Decatriensäure-N-n-Butylamid
• – 2E,4E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4E,8E-Decatriensäure-N-Isobutylamid
• – 2E,4E,8E-Decatriensäure-N-tert-Butylamid
• – 2E,4Z,8E-Decatriensäure-N-Methylamid
• – 2E,4Z,8E-Decatriensäure-N-Ethylamid
• – 2E,4Z,8E-Decatriensäure-N-n-Propylamid
• – 2E,4Z,8E-Decatriensäure-N-Isopropylamid
• – 2E,4Z,8E-Decatriensäure-N-n-Butylamid
• – 2E,4Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,4Z,8E-Decatriensäure-N-Isobutylamid
• – 2E,4Z,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6Z,8E-Decatriensäure-N-Methylamid
• – 2E,6Z,8E-Decatriensäure-N-Ethylamid
• – 2E,6Z,8E-Decatriensäure-N-n-Propylamid
• – 2E,6Z,8E-Decatriensäure-N-Isopropylamid
• – 2E,6Z,8E-Decatriensäure-N-n-Butylamid
• – 2E,6Z,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6Z,8E-Decatriensäure-N-Isobutylamid
• – 2E,6Z,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6E,8E-Decatriensäure-N-Methylamid
• – 2E,6E,8E-Decatriensäure-N-Ethylamid
• – 2E,6E,8E-Decatriensäure-N-n-Propylamid
• – 2E,6E,8E-Decatriensäure-N-Isopropylamid
• – 2E,6E,8E-Decatriensäure-N-n-Butylamid
• – 2E,6E,8E-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6E,8E-Decatriensäure-N-Isobutylamid
• – 2E,6E,8E-Decatriensäure-N-tert-Butylamid
• – 2E,6Z,8Z-Decatriensäure-N-Methylamid
• – 2E,6Z,8Z-Decatriensäure-N-Ethylamid
• – 2E,6Z,8Z-Decatriensäure-N-n-Propylamid
• – 2E,6Z,8Z-Decatriensäure-N-Isopropylamid
• – 2E,6Z,8Z-Decatriensäure-N-n-Butylamid
• – 2E,6Z,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6Z,8Z-Decatriensäure-N-Isobutylamid
• – 2E,6Z,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,6E,8Z-Decatriensäure-N-Methylamid
• – 2E,6E,8Z-Decatriensäure-N-Ethylamid
• – 2E,6E,8Z-Decatriensäure-N-n-Propylamid
• – 2E,6E,8Z-Decatriensäure-N-Isopropylamid
• – 2E,6E,8Z-Decatriensäure-N-n-Butylamid
• – 2E,6E,8Z-Decatriensäure-N-(1-Methylpropyl)-amid
• – 2E,6E,8Z-Decatriensäure-N-Isobutylamid
• – 2E,6E,8Z-Decatriensäure-N-tert-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-Methylamid
• – 2E,7Z,9E-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9E-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9E-Undecatriensäure-N-tert-Butylamid
• – 2E,7E,9E-Undecatriensäure-N-Methylamid
• – 2E,7E,9E-Undecatriensäure-N-Ethylamid
• – 2E,7E,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7E,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7E,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7E,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7E,9E-Undecatriensäure-N-isobutylamid
• – 2E,7E,9E-Undecatriensäure-N-tert-Butylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Methylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9Z-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9Z-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9Z-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9Z-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9Z-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9Z-Undecatriensäure-N-tert-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-Methylamid
• – 2E,7Z,9E-Undecatriensäure-N-Ethylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Propylamid
• – 2E,7Z,9E-Undecatriensäure-N-Isopropylamid
• – 2E,7Z,9E-Undecatriensäure-N-n-Butylamid
• – 2E,7Z,9E-Undecatriensäure-N-(1-Methylpropyl)-amid
• – 2E,7Z,9E-Undecatriensäure-N-isobutylamid
• – 2E,7Z,9E-Undecatriensäure-N-tert-Butylamid

As a pungent or a feeling of heat generating substance, a number of substances can be used. Preference is given in particular to N-alkyl-substituted amides of unsaturated carboxylic acids, for example

• 2E, 4E-decadienoic acid N-methylamide
• 2E, 4E-decadienoic acid N-ethylamide
• 2E, 4E-decadienoic acid-Nn-propylamide
• 2E, 4E-decadienoic acid N-isopropylamide
• 2E, 4E-decadienoic acid-Nn-butylamide
• 2E, 4E-decadienoic acid N- (1-methylpropyl) -amide
• 2E, 4E-decadienoic acid N-isobutylamide
• 2E, 4E-decadienoic acid N-tert-butylamide
• 2E, 4Z-decadienoic acid N-methylamide
• 2E, 4Z-decadienoic acid N-ethylamide
• 2E, 4Z-decadienoic acid-Nn-propylamide
• 2E, 4Z-decadienoic acid N-isopropylamide
• 2E, 4Z-decadienoic acid-Nn-butylamide
• 2E, 4Z-decadienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z-decadienoic acid N-isobutylamide
• 2E, 4Z-decadienoic acid N-tert-butylamide
• 2E, 4E, 8Z-decatrienoic acid N-methylamide
• 2E, 4E, 8Z-decatrienoic acid N-ethylamide
• 2E, 4E, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 4E, 8Z-decatrienoic acid N-isopropylamide
• 2E, 4E, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 4E, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4E, 8Z-decatrienoic acid N-isobutylamide
• 2E, 4E, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 4Z, 8Z-decatrienoic acid N-methylamide
• 2E, 4Z, 8Z-decatrienoic acid N-ethylamide
• 2E, 4Z, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 4Z, 8Z-decatrienoic acid N-isopropylamide
• 2E, 4Z, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 4Z, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z, 8Z-decatrienoic acid N-isobutylamide
• 2E, 4Z, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 4E, 8E-Decatrienoic acid N-methylamide
• 2E, 4E, 8E-decatrienoic acid N-ethylamide
• 2E, 4E, 8E-decatrienoic acid-Nn-propylamide
• 2E, 4E, 8E-decatrienoic acid N-isopropylamide
• 2E, 4E, 8E-decatrienoic acid-Nn-butylamide
• 2E, 4E, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4E, 8E-decatrienoic acid N-isobutylamide
• 2E, 4E, 8E-Decatrienoic acid N-tert-butylamide
• 2E, 4Z, 8E-decatrienoic acid N-methylamide
• 2E, 4Z, 8E-decatrienoic acid N-ethylamide
• 2E, 4Z, 8E-decatrienoic acid-Nn-propylamide
• 2E, 4Z, 8E-decatrienoic acid N-isopropylamide
• 2E, 4Z, 8E-decatrienoic acid-Nn-butylamide
• 2E, 4Z, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 4Z, 8E-decatrienoic acid N-isobutylamide
• 2E, 4Z, 8E-decatrienoic acid N-tert-butylamide
• 2E, 6Z, 8E-decatrienoic acid N-methylamide
• 2E, 6Z, 8E-decatrienoic acid N-ethylamide
• 2E, 6Z, 8E-decatrienoic acid-Nn-propylamide
• 2E, 6Z, 8E-decatrienoic acid N-isopropylamide
• 2E, 6Z, 8E-decatrienoic acid-Nn-butylamide
• 2E, 6Z, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6Z, 8E-decatrienoic acid N-isobutylamide
• 2E, 6Z, 8E-decatrienoic acid N-tert-butylamide
• 2E, 6E, 8E-Decatrienoic acid N-methylamide
• 2E, 6E, 8E-decatrienoic acid N-ethylamide
• 2E, 6E, 8E-decatrienoic acid-Nn-propylamide
• 2E, 6E, 8E-decatrienoic acid N-isopropylamide
• 2E, 6E, 8E-decatrienoic acid-Nn-butylamide
• 2E, 6E, 8E-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6E, 8E-decatrienoic acid N-isobutylamide
• 2E, 6E, 8E-Decatrienoic acid N-tert-butylamide
• 2E, 6Z, 8Z-decatrienoic acid N-methylamide
• 2E, 6Z, 8Z-decatrienoic acid N-ethylamide
• 2E, 6Z, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 6Z, 8Z-decatrienoic acid N-isopropylamide
• 2E, 6Z, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 6Z, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6Z, 8Z-decatrienoic acid N-isobutylamide
• 2E, 6Z, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 6E, 8Z-decatrienoic acid N-methylamide
• 2E, 6E, 8Z-decatrienoic acid N-ethylamide
• 2E, 6E, 8Z-decatrienoic acid-Nn-propylamide
• 2E, 6E, 8Z-decatrienoic acid N-isopropylamide
• 2E, 6E, 8Z-decatrienoic acid-Nn-butylamide
• 2E, 6E, 8Z-decatrienoic acid N- (1-methylpropyl) -amide
• 2E, 6E, 8Z-decatrienoic acid N-isobutylamide
• 2E, 6E, 8Z-decatrienoic acid N-tert-butylamide
• 2E, 7Z, 9E undecatrienoic acid N-methylamide
• 2E, 7Z, 9E undecatrienoic acid N-ethylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9E undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9E undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9E undecatrienoic acid N-tert-butylamide
• 2E, 7E, 9E undecatrienoic acid N-methylamide
• 2E, 7E, 9E undecatrienoic acid N-ethylamide
• 2E, 7E, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7E, 9E undecatrienoic acid N-isopropylamide
• 2E, 7E, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7E, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7E, 9E undecatrienoic acid N-isobutylamide
• 2E, 7E, 9E undecatrienoic acid N-tert-butylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-methylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-ethylamide
• 2E, 7Z, 9Z-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9Z-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9Z-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9Z-undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9Z-undecatrienoic acid N-tert-butylamide
• 2E, 7Z, 9E undecatrienoic acid N-methylamide
• 2E, 7Z, 9E undecatrienoic acid N-ethylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-propylamide
• 2E, 7Z, 9E undecatrienoic acid N-isopropylamide
• 2E, 7Z, 9E-undecatrienoic acid-Nn-butylamide
• 2E, 7Z, 9E-undecatrienoic acid N- (1-methylpropyl) -amide
• 2E, 7Z, 9E undecatrienoic acid N-isobutylamide
• 2E, 7Z, 9E undecatrienoic acid N-tert-butylamide

Of course they are also other substitution patterns on the nitrogen atom possible and preferred, for example, longer-chain n-alkyl radicals (... N-n-pentylamide,... N-n-pentylamide,... N-n-pentylamide,.. N-n-pentylamide, ...- N-n-pentylamide, ...- N-n-hexylamide, ...- N-n-heptylamide, ...- N-n-octylamide, ...- N-n-nonylamide, ... -N-n-decylamide, ... -N-n-undecylamide, ... -N-n-dodecylamide, ... -N-n-tridecylamide, etc.) or disubstituted... N, N-dialkylamides such as... N, N-dimethylamide, ...- N, N-diethyl amide, N, N-di-n-propylamide, N, N-diisopropylamide, N, N-di-n-butylamide, ...- N, N-di (1-methylpropylamide, N, N-diisobutylamide, N, N-di-tert-butylamide, N, N-methyl-ethylamide, ...- N, N-methyl-n-propylamide, N, N-methyl-isopropylamide, N, N-ethyl-n-propylamide, N, N-ethyl-isopropylamide, etc.

2E,4E,8Z-Decatriensäure-N-isobutylamid (N-Isobutyl-2E,4E,8Z-decatrienamid, auch Isoaffinin genannt):

2E,7Z,9E-Undecatriensäure-N-isobutylamid (N-Isobutyl-2E,7Z,9E-undecatrienamid):

2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin):

2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin):

Ferulasäureamide, beispielsweise Ferulasäure-N-Vanillylamid:

N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloylmethoxytyramin):

N-[2-(4-Hydroxy-3-methoxyphenygethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloylmethoxytyramin):

N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-propansäureamid (Dihydroferuloylmethoxytyramin):

N-[2-(3,4-Dihydroxyphenygethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloyldopamin):

N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloyldopamin):

N-[2-(4-Hydroxyphenygethyl]-3-(3,4-dihydroxyphenyl)-(2E)-propensäureamid (trans-Caffeoyltyramin):

N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)-propensäureamid (cis-Caffeoyltyramin):

N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans-Rubenamin):

N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4-dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin):

Among the compounds mentioned, some are particularly preferred in the context of the present invention. These are listed below: 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (N-isobutyl-2E, 6Z, 8E-decatrienamide, also called spilanthol or affinin):

2E, 4E, 8Z-Decatrienoic acid N-isobutylamide (N-isobutyl-2E, 4E, 8Z-decatrienamide, also called isoaffinin):

2E, 7Z, 9E-undecatrienoic acid N-isobutylamide (N-isobutyl-2E, 7Z, 9E-undecatrienamide):

2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin):

2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin):

Ferulic acid amides, for example ferulic acid N-vanillylamide:

N- [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) -propenoic acid amide (trans -feruloylmethoxytyramine):

N- [2- (4-Hydroxy-3-methoxy-phenylethyl) -3- (4-hydroxy-3-methoxy-phenyl) - (2Z) -propenoic acid amide (cis -feruloylmethoxy-tyramine):

N- [2- (4-Hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) -propanoic acid amide (dihydroferuloylmethoxytyramine):

N- [2- (3,4-Dihydroxyphenylgethyl] -3- (4-hydroxy-3-methoxy-phenyl) - (2E) -propenoic acid amide (trans -feruloyldopamine):

N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloyldopamine):

N- [2- (4-Hydroxyphenylgethyl] -3- (3,4-dihydroxyphenyl) - (2E) -propenoic acid amide (trans-caffeoyltyramine):

N- [2- (4-Hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) -propenoic acid amide (cis-caffeoyltyramine):

N- [2- (3,4-Dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide (trans-Rubenamine):

N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide (cis-Rubenamine):

Other useful in the context of the present invention Scharfstoffe are, for example, extracts of natural plants. Hot-tasting herbal extracts can be any physiologically harmless herbal extract that produces a sharp or warm sensory sensation. Pepper extract (Piper ssp., In particular Piper nigrum), water pepper extract (Polygonum ssp., In particular Polygonum hydropiper), extracts of Allium ssp. Are preferred as pungent-tasting plant extracts. (especially onion and garlic extracts), extracts of radish (Raphanus ssp.), horseradish extracts (Cochlearia armoracia), extracts of black (Brassica nigra), wild or yellow mustard (Sinapis ssp., especially Sinapis arvensis and Sinapis alba), Bertram root extracts (Anacyclus ssp., In particular Anacardus pyrethrum L.), sun hatch extracts (Echinaceae ssp.), Extracts of Szechuan pepper (Zanthoxylum spp., In particular Zanthoxylum piperitum), spilanthate extract (Spilanthes spp., In particular Spilanthes acmella), chile extract (Capsicum spp., Capsicum frutescens in particular), grains of paradise extract (Aframomum ssp., especially Aframomum melegueta [Rose] K. Schum.), ginger extract (Zingiber ssp., Especially Zingiber officinale) and galangae extract (Kaempferia galanga or Alpinia galanga).

A particularly suitable substance is the gingerol derived from the ginger extract:

It is also possible to use N-ethyl-p-menthane-3-carboxamide (N-ethyl-5-methyl-2-isopropylcyclohexanecarboxamide):

Other pungent or a feeling of heat generating substances can z. B. Capsaicin, Dihydrocapsaicin, Gingerol, Paradol, Shogaol, Piperine, carboxylic acid N-vanillylamide, in particular Nonanoic-N-vanillylamide, 2-Alkensäureamide, in particular 2-nonenoic acid N-isobutylamide, 2-nonenoic acid N-4-hydroxy-3-methoxyphenyl amide, Alkyl ethers of 4-hydroxy-3-methoxybenzyl alcohol, especially 4-hydroxy-3-methoxybenzyl-n-butyl ether, alkyl ether of 3-hydroxy-4-methoxybenzyl alcohol, alkyl ether of 3,4-dimethoxybenzyl alcohol, Alkyl ethers of 3-ethoxy-4-hydroxybenzyl alcohol, alkyl ethers of 3,4-methylenedioxybenzyl alcohol, Nicotinaldehyde, methyl nicotinate, propyl nicotinate, 2-butoxyethyl nicotinate, Benzyl nicotinate, 1-acetoxychavicol, Polygodial or isodrimeninol.

• a. 2E,6Z,8E-Decatriensäure-N-isobutylamid (Spilanthol) und/oder
• b. 2E,4E,8Z-Decatriensäure-N-isobutylamid und/oder
• c. 2E,7Z,9E-Undecatriensäure-N-isobutylamid und/oder
• d. 2E,4Z-Decadiensäure-N-isobutylamid (cis-Pellitorin) und/oder
• e. 2E,4E-Decadiensäure-N-isobutylamid (trans-Pellitorin) und/oder
• f. Ferulasäure-N-Vanillylamid und/oder
• g. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloylmethoxytyramin) und/oder
• h. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloylmethoxytyramin) und/oder
• i. N-[2-(4-Hydroxy-3-methoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-propansäureamid (Dihydroferuloylmethoxytyramin) und/oder
• j. N-[2-(3,4-Dihydroxyphenupethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2E)-propensäureamid (trans-Feruloyldopamin) und/oder
• k. N-[2-(3,4-Dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxy-phenyl)-(2Z)-propensäureamid (cis-Feruloyldopamin) und/oder
• l. N-[2-(4-Hydroxyphenupethyl]-3-(3,4-dihydroxyphenyl)-(2E)-propensäureamid (trans-Caffeoyltyramin) und/oder
• m. N-[2-(4-Hydroxyphenyl)ethyl]-3-(3,4-dihydroxyphenyl)-(2Z)-propensäureamid (cis-Caffeoyltyramin) und/oder
• n. N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-(3,4-dimethoxyphenyl)-(2E)-propensäureamid (trans-Rubenamin) und/oder
• o. N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(3,4-dimethoxy-phenyl)-(2Z)-propensäureamid (cis-Rubenamin)

enthalten.Preferred remineralizing products according to the invention are characterized in that they contain at least one Scharfstoff from the group of N-alkyl-substituted amides of unsaturated carboxylic acids, preferably

• a. 2E, 6Z, 8E-decatrienoic acid N-isobutylamide (Spilanthol) and / or
• b. 2E, 4E, 8Z-decatrienoic acid N-isobutylamide and / or
• c. 2E, 7Z, 9E-undecatrienoic acid N-isobutylamide and / or
• d. 2E, 4Z-decadienoic acid N-isobutylamide (cis-pellitorin) and / or
• e. 2E, 4E-decadienoic acid N-isobutylamide (trans-pellitorin) and / or
• f. Ferulic acid N-vanillylamide and / or
• G. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2E) -propenoic acid amide (trans -feruloylmethoxytyramine) and / or
• H. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloylmethoxytyramine) and / or
• i. N- [2- (4-hydroxy-3-methoxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) -propanoic acid amide (dihydroferuloylmethoxytyramine) and / or
• j. N- [2- (3,4-dihydroxyphenupethyl) -3- (4-hydroxy-3-methoxy-phenyl) - (2E) -propenoic acid amide (trans -feruloyl-dopamine) and / or
• k. N- [2- (3,4-Dihydroxyphenyl) ethyl] -3- (4-hydroxy-3-methoxyphenyl) - (2Z) -propenoic acid amide (cis -feruloyldopamine) and / or
• l. N- [2- (4-hydroxyphenupethyl) -3- (3,4-dihydroxyphenyl) - (2E) -propenoic acid amide (trans-caffeoyltyramine) and / or
• m. N- [2- (4-hydroxyphenyl) ethyl] -3- (3,4-dihydroxyphenyl) - (2Z) -propenoic acid amide (cis-caffeoyltyramine) and / or
• n, N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2E) -propenoic acid amide (trans-Rubenamine) and / or
• o. N- [2- (3,4-dimethoxyphenyl) ethyl] -3- (3,4-dimethoxyphenyl) - (2Z) -propenoic acid amide (cis-Rubenamine)

contain.

In addition to The mentioned Scharfstoffen or in their place can also more pungent tasting and / or a feeling of heat generating substances in the products of the invention be incorporated.

erwiesen, in der R1 und R2 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃ und R3 und R4 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂.Particularly suitable within the scope of the present invention are alkyl-substituted dioxanes of the formula

proved, in which R1 and R2 are independently selected from -H, -CH _3, -CH ₂ CH ₃ and R3 and R4 are independently selected from -H, -CH _3, -CH ₂ CH _3, -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ .

erwiesen, in der R5 für -CH₃ oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen und R6 für -CH₃ oder einen geradkettigen oder verzweigten Alkyl- oder Alkenylrest mit 2 bis 8 Kohlenstoffatomen oder eine Alkoxygruppe mit 1 bis 3 Kohlenstoffatomen stehtAs further particularly suitable in the context of the present invention phenyl esters of the formula

proved, in which R 5 is -CH ₃ or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms, and R6 is _-CH3 or a straight-chain or branched alkyl or alkenyl radical having 2 to 8 carbon atoms or an alkoxy group having 1 to 3 Carbon atoms

erwiesen, in der R7 bis R12 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂, -CH₂CH₂CH₂CH₃, -CH₂CH(CH₃)₂, -CH(CH₃)CH₂CH_{3 ,} -C(CH₃)₃ oder R9 und R10 zusammen eine chemische Bindung oder eine Gruppe -(CR13R14)_x bedeuten, worin x für die Werte 1 oder 2 steht und R13 und R14 unabhängig voneinander ausgewählt sind aus -H, -CH₃, -CH₂CH₃, -CH₂CH₂CH₃, -CH(CH₃)₂, -CH₂CH₂CH₂CH₃, -CH₂CH(CH₃)₂, -CH(CH₃)CH₂CH_{3 ,} -C(CH₃)₃ Further particularly suitable within the scope of the present invention are carvone acetals of the formula

in which R 7 to R 12 are independently selected from -H, -CH ₃ , -CH ₂ CH ₃ , -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ , -CH ₂ CH ₂ CH ₂ CH ₃ , -CH ₂ CH (CH ₃ ) ₂ , -CH (CH ₃ ) CH ₂ CH _{3 ,} -C (CH ₃ ) ₃ or R 9 and R 10 together represent a chemical bond or a group - (CR 13 R 14) _x , where x is the values 1 or 2 and R 13 and R 14 are independently selected from -H, -CH ₃ , -CH ₂ CH ₃ , -CH ₂ CH ₂ CH ₃ , -CH (CH ₃ ) ₂ , -CH ₂ CH ₂ CH ₂ CH ₃ , -CH ₂ CH (CH ₃ ) ₂ , -CH (CH ₃ ) CH ₂ CH _{3 ,} -C (CH ₃ ) ₃

One Another object of the present invention is the use of taurine (2-aminoethanesulfonic acid) together with at least one antibacterial compound in the mouth and dental care and cleaners.

By the use of taurine (2-Aminoethansulfonsäure) is the anti-inflammatory, anti-gingivitis and anti-periodontitis effect of antibacterial substances elevated. Especially for herbal antibacterial agents, which are usually a weaker and have less long-lasting effect, is the additional Use of taurine (2-aminoethanesulfonic acid) helpful. This substance shows support for suppressing the inflammatory response in in vitro experiments and an increase in cell activity and thus potentially one Increasing cell growth, which in turn improves the healing process the inflammatory reaction caused damage supported. The use of taurine (2-Aminoethansulfonsäure) leads to a faster decay of the inflammatory process and better regeneration of the oral mucosa.

One Another object of the present invention is therefore the use of taurine (2-aminoethanesulfonic acid) Increase the effect of antibacterial compounds.

Compositions according to the invention can be formulated as toothpastes or toothpastes. Another item The present invention provides a method for preventing and treatment of caries and / or combating halitosis and / or for the treatment of gingivitis or periodontitis, in which a preparation according to the invention on a toothbrush applied and with this the teeth be cleaned.

The Compositions of the invention can also be used as mouthwashes or mouthwashes formulate. Another object of the present invention is a method for the prevention and treatment of caries and / or fight halitosis and / or for the treatment of gingivitis or periodontitis, in which a preparation according to the invention in the form of a mouthwash in the oral cavity introduced and there for a period of at least 10 seconds, preferably at least 20 seconds and in particular at least 45 seconds left.

With regard to preferred embodiments of the uses according to the invention and the methods according to the invention, what has been said about the agents according to the invention applies mutatis mutandis. Examples: Mouth rinsing solution (all data in% by weight): Sorbitol 70% 3.0 cetylpyridinium 0.05 sodium fluoride 0,045 sodium saccharine 0.03 Fatty acid amidoalkylbetaine (30% active substance) 0.86 Aroma 0.1 Taurine (2-aminoethanesulfonic acid) 1.0 Water, demineralized ad 100

Toothpastes of the following composition (all data in% by weight) were prepared: E1 E2 E3 E4 E5 Sorbitol (70% DAB) 60 62.5 65 67.5 70.0 Ethanol (96%) - - - - 2.0 Precipitated silica: sident 8 10.0 10.0 10.0 10.0 12.0 Precipitated silica: Sident 22S 8.5 8.5 8.5 8.5 - Poliertonerde P10 finest - 1.0 - - - Disodium phosphate, anhydrous 0.1 0.1 0.1 0.1 0.1 Trisodium phosphate, anhydrous 0.2 0.2 0.2 0.2 - Na monofluorophosphate Na 2 PO 3 F - - 1.0 1.0 1.0 sodium fluoride 0.32 0.32 - - - Polyethylene glycol (MW: 1500) 1.5 1.5 1.5 1.5 1.5 Titanium dioxide 0.5 0.5 0.5 0.5 - Na lauryl sulfate 1.5 1.5 1.5 1.5 1.5 Saccharin-Na 0.1 0.1 0.1 0.1 0.1 xanthan 0.4 0.4 0.4 0.4 0.4 Aroma 1.2 1.2 1.2 1.2 1.2 taurine 1.0 1.0 1.0 1.0 1.0 water ad 100 ad 100 ad 100 ad 100 ad 100

Claims (14)

Oral and dental care and cleaning products, containing - related on his weight - a) 0.001 to 10% by weight of taurine (2-aminoethanesulfonic acid) b) 0.001 to 5% by weight at least one antibacterial compound. Oral and dental care and cleaning agent according to claim 1, characterized in that it - based on its weight - 0.001-5 wt .-%, preferably 0.001-4 wt .-%, particularly preferably 0.005-1 Wt .-%, most preferably 0.006-1 wt .-% taurine (2-aminoethanesulfonic acid). Oral and dental care and cleaning agents after one of the claims 1 or 2, characterized in that it - based on its weight - 0.0025 to 2.5% by weight, preferably 0.005 to 1% by weight, more preferably 0.01 to 0.5 wt .-% antibacterial (s) drug (s). Oral and dental care and cleaning agents after one of the claims 1 to 3, characterized in that the antibacterial or the Active ingredients selected is / are from p-hydroxybenzoic acid methyl, ethyl or propyl ester and / or bromochlorophene and / or triclosan and / or phenyl salicylic acid ester and / or 1-hexadecylpyridinium chloride and / or biguanides, preferably Chlorhexidine. Oral and dental care and cleaning agents after one of the claims 1 to 4, characterized in that the antibacterial or the Active ingredients selected is / are from thymol and / or eugenol and / or eucalyptol and / or Extracts of myrrh and / or extracts of sage and / or extracts of carnation, and / or extracts of tea, and / or extracts of propolis, and / or extracts of Echinacea. Mouth and teeth care and cleanser after one the claims 1 to 5, characterized in that - based on its weight - 0.5 to 60% by weight, preferably 0.75 to 55% by weight, more preferably 1 to 50 wt .-% and in particular 2 to 40 wt .-% of at least one polyhydric alcohol from the group of sorbitol and / or glycerol and / or Contains 1,2-propylene glycol .-% or mixtures thereof. Oral and dental care and cleaning agents after one of the claims 1 to 6, characterized in that it additionally anti-caries agents, preferably fluorine compound (s), in particular sodium fluoride, potassium fluoride, Sodium monofluorophosphate, zinc fluoride, tin fluoride and sodium fluorosilicate, preferably in amounts of 0.01 to 5 wt .-%, preferably of 0.02 to 2.5 wt .-% and in particular from 0.04 to 1.1 wt .-%, respectively based on the total mean. Oral and dental care and cleaning agents after one of the claims 1 to 7, characterized in that it insensitivity the teeth enhancing substances, preferably potassium salts, more preferably Potassium nitrate and / or potassium citrate and / or potassium chloride and / or Potassium bicarbonate and / or potassium oxalate, preferably in amounts of 0.5 to 20 wt .-%, particularly preferably from 1.0 to 15 wt .-%, more preferably from 1.5 to 5 wt .-% and in particular from 1.75 to 2.5 Wt .-%, each based on the total agent contains. Oral and dental care and cleaning agent according to one of claims 1 to 8, characterized in that it additionally cleaning body, preferably silicic acids, aluminum hydroxide, alumina, calcium pyrophosphate, chalk, dicalcium phosphate dihydrate (CaHPO ₄ · 2H ₂ O), sodium aluminum silicates, in particular Zeolite A, organic polymers, in particular polymethacrylates or mixtures of these friction bodies, preferably in amounts of 1 to 30 wt .-%, preferably from 2.5 to 25 wt .-% and in particular from 5 to 22 wt .-%, each based on the entire remedy, contains. Oral and dental care and cleaning agents after one of the claims 1 to 9, characterized in that it additionally phosphate (s), preferably Alkali metal phosphate (s) and especially sodium tripolyphosphate, preferably in amounts of 1 to 10 wt .-%, particularly preferably from 2 to 8% by weight and especially from 3 to 7% by weight, respectively based on the total mean. Use of taurine (2-aminoethanesulfonic acid) together with at least one antibacterial compound in the mouth and dental care and cleaners. Use of taurine (2-aminoethanesulfonic acid) for Increase the effect of antibacterial compounds. Method for the prevention and treatment of Tooth decay and / or combat halitosis and / or for the treatment of gingivitis or periodontitis, characterized in that a Preparation according to one of the claims 1 to 10 on a toothbrush applied and with this the teeth be cleaned. A method for the prevention and treatment of caries and / or combating halitosis and / or for the treatment of gingivitis or periodontitis, characterized in that a preparation according to one of claims 1 to 10 introduced in the form of a mouthwash in the oral cavity and there for a period of at least 10 seconds, preferably at least 20 seconds and in particular min for at least 45 seconds.