EP2089366A2 - Pyrazol-3-one and/or pyridazin-3-one derivatives used as inhibitors of lysyl oxidase - Google Patents

Pyrazol-3-one and/or pyridazin-3-one derivatives used as inhibitors of lysyl oxidase

Info

Publication number
EP2089366A2
EP2089366A2 EP05818002A EP05818002A EP2089366A2 EP 2089366 A2 EP2089366 A2 EP 2089366A2 EP 05818002 A EP05818002 A EP 05818002A EP 05818002 A EP05818002 A EP 05818002A EP 2089366 A2 EP2089366 A2 EP 2089366A2
Authority
EP
European Patent Office
Prior art keywords
turbocharger
passage
insert
housing according
main body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05818002A
Other languages
German (de)
French (fr)
Inventor
Erfindernennung liegt noch nicht vor Die
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2089366A2 publication Critical patent/EP2089366A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A turbocharger housing comprises a main body (1) for bearing a shaft (2) for carrying a turbine wheel and a compressor wheel (3), and a seal portion (4) to seal a clearance between the shaft (2) and the turbocharger housing, wherein said seal portion (4) is formed by an insert (5) being fitted to the main body (1), wherein said insert (5) comprises a passage (6, 7) for supplying a fluid to said seal portion (4).

Claims

Claims
1. A turbocharger housing comprising a main body (1; 101) for bearing a shaft (2; 102) for carrying a turbine wheel and a compressor wheel (3; 103), and a seal portion (4; 104) for sealing a clearance between the shaft (2; 102) and the turbocharger housing, characterized in that said seal portion (4; 104) is formed by an insert (5; 105) fitted to the main body (1; 101) , wherein said insert (5; 105) comprises a passage (6, 7; 106, 107) for supplying a fluid to said seal portion (4; 104).
2. A turbocharger housing according to claim 1, wherein said seal portion (4; 104) of said insert (5) is opposed to a seal bushing (22; 122) provided on the shaft (2; 102), wherein said seal bushing (22; 122) supports a first piston ring (18; 118), and said passage (6, 7; 106, 107) supplies the fluid to one side of said first piston ring (18) .
3. A turbocharger housing according to claim 2, wherein said seal bushing (22; 122) supports a second piston ring (19; 119) and said passage (6, 7; 106, 107) supplies the fluid to a space formed between first and second piston rings (18, 19; 118, 119) .
4. A turbocharger housing according to any one of claims 1 to 3, wherein said passage (6, 7; 106, 107) is formed by a radial bore (6; 106) and an axial bore (7; 107) which are formed in the insert (5; 105) .
5. A turbocharger housing according to any one of claims 1 to 4, wherein the insert (5; 105) comprises, on a plane surface thereof which faces the main body (1; 101), protrusions (120) for passing screws (14; 114) therethrough for fixing the insert (5; 105) to the main body.
6. A turbocharger housing according to any one of claims 1 to 5, wherein said insert (5; 105) forms a backplate member at a compressor side of the turbocharger.
7. A turbocharger housing according to any one of claims 1 to
' 6, wherein said insert (5; 105) is a substantially ring-shaped member, the inner periphery of which forms said seal portion (4; 104) .
8. A turbocharger housing according to any one of claims 1 to 7, wherein said passage (6, 7; 106, 107) comprises an inlet opening (7; 107) which communicates with an outlet opening (8; 108) of a fluid feeding passage (9; 109) formed in the main body (1; 101) .
9. A turbocharger comprising a turbocharger housing according to any one of claims 1 to 8.
10. A turbocharger according to claim 9, wherein the passage (6, 7; 106, 107) communicates with air outside the turbocharger.
11. A turbocharger according to claim 9, wherein the passage (6, 7; 106, 107) communicates with a compressor output and/or a turbine input of the turbocharger.
12. A turbocharger according to claim 9, wherein said passage (6, 7; 106, 107) communicates with a space (12; 112) where said turbine wheel or said compressor wheel (3; 103) of the turbocharger is located.
13. A multi-turbocharger boosting system comprising at least a first turbocharger (A) and a second turbocharger (B) , wherein at least the first turbocharger (A) is a turbocharger according to any one of claims 9 to 12, wherein the passage (6, 7; 106, 107) thereof communicates with a compressor output and/or a turbine input of said second turbocharger (B) .
14. The multi-turbocharger boosting system according to claim 13, wherein the first turbocharger (A) and the second turbocharger (B) are connected in parallel.
EP05818002A 2004-11-22 2005-11-20 Pyrazol-3-one and/or pyridazin-3-one derivatives used as inhibitors of lysyl oxidase Withdrawn EP2089366A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004056226A DE102004056226A1 (en) 2004-11-22 2004-11-22 Novel inhibitors of lysyl oxidase
PCT/DE2005/002086 WO2006053555A2 (en) 2004-11-22 2005-11-20 Pyrazol-3-one and/or pyridazin-3-one derivatives used as inhibitors of lysyl oxidase

Publications (1)

Publication Number Publication Date
EP2089366A2 true EP2089366A2 (en) 2009-08-19

Family

ID=36177758

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05818002A Withdrawn EP2089366A2 (en) 2004-11-22 2005-11-20 Pyrazol-3-one and/or pyridazin-3-one derivatives used as inhibitors of lysyl oxidase

Country Status (3)

Country Link
EP (1) EP2089366A2 (en)
DE (2) DE102004056226A1 (en)
WO (1) WO2006053555A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3265445B1 (en) 2015-03-06 2021-05-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
ES2838977T3 (en) * 2015-03-06 2021-07-02 Pharmakea Inc Fluoridated lysyl oxidase type 2 inhibitors and their uses
US20180186755A1 (en) * 2015-07-01 2018-07-05 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
ES2880766T3 (en) 2016-02-09 2021-11-25 Pharmakea Inc Quinolinone lysyl oxidase inhibitors similar to type 2 and uses thereof
GB201602934D0 (en) 2016-02-19 2016-04-06 Cancer Res Inst Royal Compounds
CA3036062A1 (en) 2016-09-07 2018-03-15 Pharmakea, Inc. Uses of a lysyl oxidase-like 2 inhibitor
JP7079772B2 (en) 2016-09-07 2022-06-02 ファーマケア，インク． Crystal form and production method of lysyl oxidase-like 2 inhibitor
GB201809295D0 (en) 2018-06-06 2018-07-25 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors
JP7414803B2 (en) 2018-08-03 2024-01-16 ファーマクシス リミテッド Haloallylamine sulfone derivative inhibitors of lysyl oxidase and their use
GB201818750D0 (en) 2018-11-16 2019-01-02 Institute Of Cancer Res Royal Cancer Hospital Lox inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328913A (en) * 1992-12-11 1994-07-12 Duke University Minoxidil analogs as inhibitors of cell proliferation and lysyl hydroxylase
AU756275B2 (en) * 1998-08-14 2003-01-09 Nihon Nohyaku Co., Ltd. Pyridazinone derivatives
DE10216144A1 (en) * 2002-04-12 2003-11-06 Bayer Ag New 2-phenyl-4-phenoxy-3(2H)-pyridazinone derivatives useful as lysyl oxidase inhibitors for preventing or treating fibrotic diseases

Also Published As

Publication number Publication date
WO2006053555A3 (en) 2006-07-27
DE102004056226A1 (en) 2006-05-24
WO2006053555A2 (en) 2006-05-26
DE112005003431A5 (en) 2007-10-31

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Legal Events

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Extension state: AL BA HR MK YU

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BURCHARDT, ELMAR REINHOLD, DR. DR.

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Effective date: 20110608

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Effective date: 20110601