EP2087237B1 - Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique - Google Patents

Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique Download PDF

Info

Publication number
EP2087237B1
EP2087237B1 EP07821910A EP07821910A EP2087237B1 EP 2087237 B1 EP2087237 B1 EP 2087237B1 EP 07821910 A EP07821910 A EP 07821910A EP 07821910 A EP07821910 A EP 07821910A EP 2087237 B1 EP2087237 B1 EP 2087237B1
Authority
EP
European Patent Office
Prior art keywords
finger
fingers
peristaltic pump
pump
downstream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07821910A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2087237A1 (fr
Inventor
Rémy WOLFF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Vial SAS
Original Assignee
Fresenius Vial SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Vial SAS filed Critical Fresenius Vial SAS
Priority to PL07821910T priority Critical patent/PL2087237T3/pl
Publication of EP2087237A1 publication Critical patent/EP2087237A1/fr
Application granted granted Critical
Publication of EP2087237B1 publication Critical patent/EP2087237B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
    • F04B49/06—Control using electricity
    • F04B49/065—Control using electricity and making use of computers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/082—Machines, pumps, or pumping installations having flexible working members having tubular flexible members the tubular flexible member being pressed against a wall by a number of elements, each having an alternating movement in a direction perpendicular to the axes of the tubular member and each having its own driving mechanism
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1223—Machines, pumps, or pumping installations having flexible working members having peristaltic action the actuating elements, e.g. rollers, moving in a straight line during squeezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing

Definitions

  • the invention relates to a peristaltic pump according to the preamble of claim 1.
  • Such peristaltic pumps are commonly used in the medical field, especially for infusions. They have the advantage of reliably delivering to the patient a relatively constant volume of the liquid to be infused.
  • roller pumps There are two main types of peristaltic pumps: roller pumps and finger pumps.
  • the roller pumps generally consist of two to four rollers placed on a roller carrier driven in rotation by a motor.
  • a flexible tube is placed in a groove in an arc.
  • the rollers moving in rotation crush the tube in the groove causing behind them a suction zone and in front of them a discharge zone.
  • the finger pumps consist of a series of fingers cyclically crushing a flexible tube against a counter surface.
  • the fingers move essentially vertically in wave forming an occlusion zone that moves from upstream to downstream.
  • the last finger, the most downstream, is raised when the first finger, the most upstream, is against the counter-surface.
  • the most common finger pumps are linear, that is, the counter surface is flat and the fingers are parallel.
  • the finger control is by a series of cams arranged one behind the other, each cooperating with a finger. These cams are placed, shifted in the manner of a helix, on a common axis rotated by a motor.
  • curvilinear finger pumps that combine the advantages of the roller pumps with those of the finger pumps.
  • Such pumps can be found in the documents EP 1 13 609 A1 and US 5,575,631 A .
  • the counter-surface is not flat, but in an arc and the fingers are arranged radially to inside the counter-surface.
  • a common cam several bumps and placed in the center of the arc, which actuates the fingers.
  • peristaltic pumps have a major disadvantage: the flow of the pumped liquid is not quite regular and especially it has what is called a "retrograde flow" (back flow) which results in a suction of the downstream part to the upstream part of the liquid at the precise moment when the cycle begins again. Indeed, at each end of the cycle, the most downstream fingers recede, which causes suction, while the fingers upstream advance, causing pumping, but for a short time, the suction is more important than pumping. From a therapeutic point of view, this phenomenon is not desirable.
  • back flow back flow
  • the objective of the invention is therefore to develop peristaltic pumps according to the preamble, which propose other solutions to suppress the phenomenon of retrograde flow and which do not have the disadvantages mentioned above.
  • the occlusion means in the most downstream portion of the pump remain in occlusive position on a portion of the cycle greater than the occlusion means in a part further upstream of the pump, preferably that the compression means in the most upstream part of the pump.
  • the occlusion zone in the most downstream position is suppressed only when the pressure in the section of the tube directly upstream of this occlusion zone is equal to or greater than the pressure prevailing in the section of the tube located directly downstream of this occlusion. Even if it is not easy to measure the pressure in the part of the tube located in the peristaltic pump, at least it is possible to size the pump so that the pressure difference between the section of the tube located directly upstream of this occlusion zone and the section of the tube directly downstream of this occlusion is positive at the moment when the occlusion is removed. This results in a peak pressure on the pressure curve recorded downstream of the pump.
  • the objective of the invention is achieved by bringing the counter-surface closer to the axis of rotation of the control means of the compression means at its most downstream point than it is at another point, preferably that it is at its most advanced point.
  • control means of the finger furthest downstream are dimensioned to maintain said finger in occlusive position on a portion of the cycle greater than the other fingers, including the finger most upstream.
  • control means of the most downstream finger it is possible to size the control means of the most downstream finger to maintain said finger in occlusive position when the most upstream finger enters the occlusive position.
  • the method is applied to a linear finger pump.
  • the counter surface is plane and, on the other hand, the counter surface and the axis of rotation of the finger control means are closer in the downstream zone than in the upstream zone. pump. This may result in the counter surface being inclined relative to the plane perpendicular to the fingers. It is also possible that the counter-surface is perpendicular to the fingers and that the axis of rotation of the finger control means is inclined relative to the plane perpendicular to the fingers.
  • the counter-surface between the most upstream finger and the most downstream finger is concave.
  • the method is applied to a curvilinear finger pump.
  • the downstream end of the counter-surface is closer to the axis of rotation of the finger control cam than is another point of the counter-surface, preferably than the upstream end of the counter-surface. This can easily be achieved by giving the counter-surface the shape of a spiral arc whose center coincides with the axis of rotation of the finger control cam.
  • the length of the finger furthest downstream is greater than the length of the one of the other fingers, preferably the length of the finger furthest upstream.
  • control means of the finger most downstream for example a cam
  • the height defined as the difference between, on the one hand, the distance between the point of the counter-surface closest to the axis of rotation of the finger control means. and said axis of rotation, and secondly the distance between the point of the counter surface furthest from the axis of rotation of the finger control means and said axis, is between one tenth and one half of the inner diameter of the flexible tube for which the pump is provided, preferably the height is equal to about one-fifth of the inside diameter.
  • the counter-surface be provided with means to modify its longitudinal orientation and / or be removable and replaceable.
  • the peristaltic pump is a traditional linear finger pump. It consists of a series of fingers (1) which, as mobile compression means, crush a tube (2) against a counter-surface (3). This counter-surface is placed in the door (4) of the pump.
  • cams (5) is placed on an axis (6).
  • These cams (5), as control means actuating the mobile compression means, are constituted for example by cylinder sections mounted eccentrically on the axis (6) and angularly offset relative to each other so that the movement of each finger is slightly delayed compared to the previous one and slightly ahead of the next.
  • the fingers are all the same length, the counter-surface is parallel to the axis of the cams and each finger remains in the occlusion position on a portion of the cycle identical for all.
  • the figure 1 represents the instantaneous flow rate (ml / h) as a function of the time indicated in minutes.
  • the arrow shows the retrograde flow.
  • the liquid thus sucked from the section (2c) of the tube located downstream of the pump partially fills the section of the tube (2b) located in the pump, thereby decreasing the volume of liquid pumped from the section ( 2a) located upstream of the pump.
  • the invention provides that the most downstream finger (1b) remains in an occlusion position on a larger portion of the cycle than the other fingers, allowing time for the occlusion forming upstream to begin moving forward.
  • the pressure in the section (2b) of tube located between the two occlusions increases and the downstream occlusion is removed only when this pressure is equal to or greater than the pressure prevailing in the section (2c) located downstream of the pump. Thanks to this solution, we obtain a flow curve such as that presented to the figure 2 . It can be seen that the retrograde flow has completely disappeared and that it has been replaced by a pumping peak indicated by the arrow, which is preferable from the clinical point of view.
  • the volume pumped at each cycle is higher because the section (2b) of the tube in the pump fills with liquid from the upstream of the pump. The pump has a better performance. This results in lower energy consumption, less dimensioning of the motor and reduced operating noise.
  • variable angular sectors will be chosen which may, for some in any case, overlap. For example, it is possible to choose a sector of 27 ° for the most upstream finger (1a) and 33 ° for the most downstream finger (1b), these two sectors overlapping partially.
  • the simplest method is to use a counter surface inclined relative to the axis of rotation (6) of the control cams (5) of the fingers (1).
  • This is shown by the example of figure 3 .
  • the axis of rotation (6) is perpendicular to the fingers (1), while the counter-surface deviates from the perpendicular to the fingers.
  • the inclination shown at figure 3 is exaggerated.
  • the fingers (1) are actuated by the cams (5) while being subjected to the effect of a spring (7) tending to bring them closer to the counter-surface (3).
  • the cams are designed so that the fingers can remain in the occlusion position on a portion of the cycle all the more important that they are placed downstream of the pump.
  • the finger most upstream (1a) must go lower to begin to act on the tube (2) and to compress it than does the finger most downstream (1b). As a result, he remains in a used position on a shorter cycle portion than the latter.
  • the cam axis (6) rotates, it drives the cam (5b) of the finger (1b) further downstream causing it to approach the counter surface (3) until it compresses the tube (2) against the latter.
  • the cam (5b) continues to rotate without driving the finger which is held in this position under the effect of the spring (7). After a certain angle of rotation of the axis (6), the cam (5b) starts to move the finger (1b) this time up against the effect of the spring (7).
  • the finger upstream (1a) In order for the finger upstream (1a) to compress the tube (2), it must have traveled a greater distance than the downstream finger (1b) because of the inclination of the counter-surface. While the finger (1b) further downstream is still in the occlusion position, the most upstream finger (1a) arrives in the occlusion position. In other words, the portion of the cycle in which the most downstream finger (1b) is in the occlusion position overlaps the portion of the cycle in which the most upstream finger (1a) is in turn in the occlusion position. The more the fingers are placed downstream of the pump, the larger the portion of the cycle in which they are in the occlusion position is important and their control is close to that of the finger further downstream (1b).
  • the counter surface (3) is removable and can be replaced by another counter surface of another inclination. Another solution is to provide means for inclining more or less against the surface (3) depending on the tube (2) used.
  • Another solution is to provide a concave counter-surface (3) as shown in FIG. figure 4 .
  • the portion of the cycle in which both the upstream fingers and downstream fingers are in the occlusion position is greater than the portion of the cycle of the fingers in the center.
  • the fingers of the pump do not have the same length. The more they are placed downstream of the pump, the longer the fingers are. Thus, the portion of the cycle in which the most downstream finger (1b) will be in contact with the counter-surface will be larger than the portion of the cycle of the finger most upstream (1a).
  • Another solution is to tilt the axis (6) of cams so that it is closer to the counter-surface (3) downstream than upstream of the pump.
  • the counter surface (3) is perpendicular to the fingers, as in the state of the art, but the axis of rotation (6) of the control means (5) of the fingers deviates from the perpendicular to the fingers. fingers.
  • the most downstream finger (1b) will crush the tube (2) earlier and compress it longer, so that it will always be in the occlusion position when the upstream finger (1a) will go into the occlusion position.
  • this acceleration serves to reduce the retrograde flux effect, in the context of the invention it serves to reduce the execution time of the portion of the cycle where the flow rate is close to zero. . Because of this cyclic acceleration, it is quite possible that the downstream finger (1b) remains less in the occlusion position than the other fingers, and in particular that the upstream finger (1 a).
  • a first solution consists in bringing the counter-surface of the cam into the downstream part.
  • the counter-surface instead of being in an arc, the counter-surface will be in a helix, coming closer to the cam as it will be close to the downstream zone of the pump.
  • the control of the fingers will be done here also by cooperating a spring and the cam.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Reciprocating Pumps (AREA)
  • External Artificial Organs (AREA)
EP07821910A 2006-11-08 2007-10-26 Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique Active EP2087237B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL07821910T PL2087237T3 (pl) 2006-11-08 2007-10-26 Sposób sterowania wydajnością pompy perystaltycznej i pompa perystaltyczna

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609754A FR2908165A1 (fr) 2006-11-08 2006-11-08 Procede de controle du debit d'une pompe peristaltique et pompe peristaltique
PCT/EP2007/061550 WO2008055794A1 (fr) 2006-11-08 2007-10-26 Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique

Publications (2)

Publication Number Publication Date
EP2087237A1 EP2087237A1 (fr) 2009-08-12
EP2087237B1 true EP2087237B1 (fr) 2010-08-11

Family

ID=37964025

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07821910A Active EP2087237B1 (fr) 2006-11-08 2007-10-26 Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique

Country Status (10)

Country Link
US (1) US8133035B2 (zh)
EP (1) EP2087237B1 (zh)
JP (1) JP5116121B2 (zh)
CN (1) CN101529093B (zh)
AT (1) ATE477419T1 (zh)
DE (1) DE602007008459D1 (zh)
ES (1) ES2348819T3 (zh)
FR (1) FR2908165A1 (zh)
PL (1) PL2087237T3 (zh)
WO (1) WO2008055794A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046439A2 (en) * 2003-11-07 2005-05-26 Nxstage Medical, Inc. Improved methods and apparatus for leak detection in blood processing systems
US8303275B2 (en) * 2006-12-07 2012-11-06 Seiko Epson Corporation Micropump, tube unit, and control unit
JP5298699B2 (ja) * 2008-08-20 2013-09-25 セイコーエプソン株式会社 制御ユニット、チューブユニット、マイクロポンプ
JP5282508B2 (ja) * 2008-09-29 2013-09-04 セイコーエプソン株式会社 制御ユニット、チューブユニット、マイクロポンプ
JP5195368B2 (ja) * 2008-12-05 2013-05-08 セイコーエプソン株式会社 チューブユニット、制御ユニット、マイクロポンプ
EP2373221B1 (en) * 2008-12-05 2013-07-17 Fluisense Aps A body fluid sampling device
CN102174933B (zh) * 2011-03-11 2013-03-06 北京华科仪电力仪表研究所 自动输送装置
WO2013057109A1 (en) * 2011-10-21 2013-04-25 Fresenius Vial Sas Peristaltic pump for pumping a liquid and method for operating a peristaltic pump
US9163623B2 (en) * 2011-12-08 2015-10-20 Carefusion 303, Inc. System and method for improved flow uniformity in a peristaltic pump mechanism
US10094367B2 (en) * 2012-02-22 2018-10-09 Technion Research & Development Foundation Limited Method and system for generating mechanical waves
JP6019718B2 (ja) * 2012-05-02 2016-11-02 セイコーエプソン株式会社 液体輸送装置、及び、液体輸送方法
WO2014201358A2 (en) 2013-06-14 2014-12-18 Bayer Medical Care Inc. Portable fluid delivery system
WO2015106107A1 (en) 2014-01-10 2015-07-16 Bayer Medical Care Inc. Single-use disposable set connector
WO2016112163A1 (en) 2015-01-09 2016-07-14 Bayer Healthcare Llc Multiple fluid delivery system with multi-use disposable set and features thereof
TWI651107B (zh) 2016-06-15 2019-02-21 拜耳保健公司 多次使用可棄式系統及用於該系統之注射器
US11162486B2 (en) 2017-11-28 2021-11-02 Ivenix, Inc. Fluid pump providing balanced input/output flow rate
CA3144706A1 (en) * 2019-07-25 2021-01-28 Altop Patents Iii B.V. Cyclic operating pumping method and system
CN110630479B (zh) * 2019-09-28 2021-04-02 深圳市乐创享科技有限公司 蠕动泵的滑靴副挤压装置及蠕动泵
US11446431B2 (en) * 2019-11-14 2022-09-20 Zevex, Inc. Infusion pump apparatus having convex platen surface
CN111891755B (zh) * 2020-07-22 2021-07-06 苏州维格纳信息科技有限公司 使用软质喉管的胶体态介质输送装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190171B (en) * 1983-10-10 1986-08-28 Labor Mueszeripari Muevek,Hu Peristaltic pump
DE4035182C1 (zh) * 1990-11-06 1992-01-02 B. Braun Melsungen Ag, 3508 Melsungen, De
DE29724578U1 (de) * 1997-04-18 2002-03-28 Société des Produits Nestlé S.A., Vevey Peristaltische Pumpe
IL120697A (en) * 1997-04-18 2003-03-12 Nestle Sa Peristaltic pump
US6666665B1 (en) * 1999-03-04 2003-12-23 Baxter International Inc. Fluid delivery mechanism having a plurality of plungers for compressing a metering chamber
CN201068852Y (zh) * 2007-06-08 2008-06-04 诚展实业有限公司 蠕动泵

Also Published As

Publication number Publication date
CN101529093B (zh) 2013-03-06
DE602007008459D1 (de) 2010-09-23
ES2348819T3 (es) 2010-12-15
US8133035B2 (en) 2012-03-13
US20100021315A1 (en) 2010-01-28
ATE477419T1 (de) 2010-08-15
CN101529093A (zh) 2009-09-09
PL2087237T3 (pl) 2011-05-31
JP5116121B2 (ja) 2013-01-09
WO2008055794A1 (fr) 2008-05-15
EP2087237A1 (fr) 2009-08-12
FR2908165A1 (fr) 2008-05-09
JP2010509525A (ja) 2010-03-25

Similar Documents

Publication Publication Date Title
EP2087237B1 (fr) Procédé de contrôle du débit d'une pompe péristaltique et pompe péristaltique
FR2528123A1 (fr) Pompe hydraulique pour liquides
FR2530217A1 (fr) Dispositif a lames de coupes tournant en sens inverse pour la coupe d'une bande d'etiquettes de liaison d'ensembles filtre-cigarettes dans des machines de mise en place de filtres a tres grand vitesse
EP0026704B1 (fr) Pompe péristaltique
EP3623618B1 (fr) Pompe avec système de va-et-vient à pignon et crémaillère et utilisation d'une telle pompe
FR2834317A1 (fr) Pompe
FR2559264A1 (fr) Microtome pourvu de moyens de retrait du specimen
FR2488819A1 (fr) Appareil a redresser les tubes d'acier et analogues
WO2017109329A1 (fr) Système de refroidissement et lubrification pour dispositif d'étanchéité pour piston
WO2003002435A2 (fr) Dispositif de transport de pieces pour l'alimentation de machines
FR2888521A1 (fr) Machine de formage ayant des mecanismes de transmission ameliores
EP2484511A1 (fr) Dispositif de soudure par ultrasons
FR2831221A1 (fr) Dispositif de pompe hydraulique basse pression pour l'alimentation d'au moins un moteur hydraulique, notamment destine a equiper une bicyclette a entrainement hydraulique
FR2492902A1 (fr) Pompe volumetrique a perfusion a doigts et le dispositif d'entrainement de ces doigts
FR2582738A1 (fr) Machine hydraulique a pistons axiaux a distributeur central et flottant pouvant fonctionner soit en moteur, soit en pompe
EP1887222B1 (fr) Perfectionnement aux pompes à barillet
EP4409139A1 (fr) Pompe volumetrique a lobes
FR2673084A1 (fr) Appareil a epiler a organe d'epilation rotatif.
FR2473129A2 (fr) Pompe peristaltique
EP1660788A1 (fr) Reducteur coaxial d'aide au demarrage a rapport croissant jusqu'a la prise directe
FR3004224A1 (fr) Pompe hydraulique a double sens de rotation
FR2813159A1 (fr) Dispositif selecteur pour semoir de precision
EP2422087A1 (fr) Pompe volumetrique comprenant un absorbeur de pression
EP0109323B1 (fr) Procédé de conduite d'un laminoir planétaire
BE499816A (zh)

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20090313

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20090827

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

DAX Request for extension of the european patent (deleted)
GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REF Corresponds to:

Ref document number: 602007008459

Country of ref document: DE

Date of ref document: 20100923

Kind code of ref document: P

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: FIAMMENGHI-FIAMMENGHI

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Effective date: 20101201

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20100811

LTIE Lt: invalidation of european patent or patent extension

Effective date: 20100811

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101211

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101111

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101213

REG Reference to a national code

Ref country code: IE

Ref legal event code: FD4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20101112

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

BERE Be: lapsed

Owner name: FRESENIUS VIAL SAS

Effective date: 20101031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

REG Reference to a national code

Ref country code: PL

Ref legal event code: T3

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20110512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101031

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602007008459

Country of ref document: DE

Effective date: 20110512

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101026

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20100811

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110212

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20101026

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20141010

Year of fee payment: 8

Ref country code: ES

Payment date: 20141027

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20141020

Year of fee payment: 8

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20141023

Year of fee payment: 8

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151026

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20161202

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151026

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151027

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20151026

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230528

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231027

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20231025

Year of fee payment: 17

Ref country code: DE

Payment date: 20231027

Year of fee payment: 17

Ref country code: CH

Payment date: 20231102

Year of fee payment: 17