EP2074958A2 - Dispositif de contact pour l'ostéosynthèse - Google Patents

Dispositif de contact pour l'ostéosynthèse Download PDF

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Publication number
EP2074958A2
EP2074958A2 EP08020988A EP08020988A EP2074958A2 EP 2074958 A2 EP2074958 A2 EP 2074958A2 EP 08020988 A EP08020988 A EP 08020988A EP 08020988 A EP08020988 A EP 08020988A EP 2074958 A2 EP2074958 A2 EP 2074958A2
Authority
EP
European Patent Office
Prior art keywords
contact device
bone screw
cavity
contact
coil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08020988A
Other languages
German (de)
English (en)
Other versions
EP2074958A3 (fr
Inventor
Werner Kraus
Heribert Stephan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neue Magnetodyn GmbH
Original Assignee
Neue Magnetodyn GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neue Magnetodyn GmbH filed Critical Neue Magnetodyn GmbH
Publication of EP2074958A2 publication Critical patent/EP2074958A2/fr
Publication of EP2074958A3 publication Critical patent/EP2074958A3/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/076—Permanent implantations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4504—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A61C8/0007—Stimulation of growth around implant by electrical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells

Definitions

  • the invention relates to a contact device for electrically contacting a cavity having, at least partially electrically conductive bone screw, wherein arranged in an implanted end state of the assembly of bone screw and contact device, a first part of the contact device outside the cavity and a second part of the contact device within the cavity of the bone screw is, the first part and the second part of the contact device at least partially form counter-counter electrodes and the second part of the contact device electrically contacts the bone screw, while the first part of the contact device is insulated against the bone screw, so that an outer surface the bone screw acts at least partially as a counterelectrode to the electrode formed by the first part of the contact device, wherein the contact device has a cavity and in the cavity at least one voltage source is arranged, the poles of the first part and the second part of the contact device each directly or indirectly electrically to contact.
  • osteosynthesis serves to load-stable fixation of the fragments of a broken or diseased bone in its uninjured, natural shape by implanted screws, support plates, wires, bone marrow nails and the like, which are generally made of stainless steel or titanium alloys.
  • These osteosynthetic agents allow for rapid mobilization of the patient while immobilizing the damaged bone, which is an essential prerequisite for its healing.
  • MRSA multi-resistant Staphylococcus aureus
  • the invention has the object of developing a generic contact device to the effect that an increased volume is available for the accommodation of electrical components.
  • the handling and flexible usability of the contact device during surgery, the biological effect, the therapeutic efficacy and the economy are to be improved.
  • the invention is based on the generic contact device in that the first part of the contact device is arranged proximally in an implanted final state of the bone screw and contact device arrangement.
  • an enlarged volume is available within the contact device.
  • the contact device can be easily inserted during the operation in the already implanted bone screw, without the need for special preparatory measures would be required, in particular those in FIG. 4 of the US 6,778,861 B1 Exists existing tip at the distal end of the arrangement and so far no pre-drilling or any measures for sufficient electrical contact with this now no longer existing tip of the contact device must be taken.
  • virtually any conventional cannulated screw can be equipped with the contactor.
  • the surgeon only has to decide after inserting the bone screw whether he wants to leave it in this way or equip it with the contact device. This is particularly relevant when multiple bone screws are used to fix a bone plate, which then becomes part of the electrified components.
  • One or more bone screws can then be equipped with the contact device according to the invention, while the other bone screws can remain without contact device. In any case, it must be decided only after fully implanted arrangement of bone plate and bone screw, which screws are equipped with the contact device.
  • the entire bone screw becomes the cathode, whereas the first part of the contact device lying outside the bone screw at least partially forms the anode.
  • the magnetically induced osteogenesis is concentrated on the stabilization region of the bone screw, that is, the screw shaft, since the osteogenesis depends on the polarity of the respective electrodes, namely favored at the cathode and obstructed at the anode. Consequently, the formation of bones in the vicinity of the proximal part of the contact device is impeded, avoided, and / or osteolysis occurs while in the area of the fracture bone formation is desirably enhanced. In particular, this simplifies the explantation of the bone screw, because the contact device can be easily removed for the purpose of explantation, without this being hindered by bone tissue.
  • the contact device can be inserted into the bone screw.
  • the contact device according to the invention can be practically inserted into any bone screw, since no special means for receiving the contact device must be provided on the inner wall of the bone screw.
  • the second part of the contact device contacts the bone screw via at least one spring contact.
  • One or more spring contacts are useful when inserting the contact device with this in conjunction and then rely from a certain insertion position and especially in the final state of the arrangement of bone screw and contact device on the inner wall of the hollow bone screw.
  • the contact device can be equipped from the outset with one or more such spring contacts.
  • the one or more spring contacts act as an adapter between the contact device and the bone screw, so that identical contact devices can cooperate with the mediation of different spring contacts with different bone screws.
  • the contact device can be screwed into the bone screw.
  • the contact device must have an external thread, while an internal thread is provided in the cavity of the bone screw.
  • the at least one voltage source comprises an accumulator.
  • a rechargeable battery for example a lithium-ion rechargeable battery
  • a sufficient volume is now available, in particular within the first part of the contact device arranged outside the bone screw.
  • the at least one voltage source comprises a capacitor.
  • a so-called supercap may be provided for energy storage.
  • the at least one voltage source comprises a coil.
  • the coil is connected in parallel with the accumulator and / or the capacitor. Even if a rechargeable battery or a condenser suffices as energy sources without a coil and, conversely, a coil for receiving the energy of an external magnetic field is sufficient to electrify the bone screw, a combination of coil and rechargeable battery and / or capacitor can be particularly useful; This can be done by magnetic induction use the coil to charge the energy storage or stores, so that the energy required for the electrification of the device is indeed supplied by an external magnetic field, but also in the absence of an external magnetic field is available. On this basis, it may be sufficient, for example, for an implant to be exposed once a day for a short time to an external alternating magnetic field, through which the energy store (s) will be charged and the stored energy is then available for the remainder of the day.
  • a function generator is arranged in the cavity of the contact device. Such preferably produces sinusoidal or similar alternating voltages. If the energy is supplied by an accumulator within the contact device, then a DC voltage is initially available, which is basically suitable for electrifying a bone screw in the appropriate manner. However, it may be desirable to provide an AC electrical voltage to produce comparable electrical conditions in this manner as are known by the known alternating field therapy with external magnetic field and internal transformer coil.
  • a measuring circuit and a circuit for high-frequency identification for detecting and transmitting signals is arranged, wherein the signals correspond in particular physiologically relevant parameters.
  • the measuring device can be used to measure an impedance or a pH value dependent on the tissue state.
  • the applied voltage can be continuously monitored.
  • the corresponding signals can then be transmitted via the circuit for high-frequency identification (RFID) to an external evaluation device.
  • RFID high-frequency identification
  • the contact device for receiving an implanted final state of the arrangement of bone screw and contact device enters into a snap or latching connection with the bone screw.
  • the surgeon thus has a further clue to the correct arrangement of the contact device within the bone screw even under difficult conditions.
  • the snap or locking connection can furthermore prevent an unintentional subsequent misplacement of the contact device with respect to the bone screw.
  • the invention further relates to an osteosynthesis device with a bone screw according to the invention.
  • FIG. 1 shows a guided in the axial direction section through a first embodiment of an arrangement of bone screw and contact device.
  • a bone screw 14 and a contact device 10 inserted into a cavity 12 of the bone screw 14 are shown.
  • the bone screw 14 has a screw shaft 34 and a threaded portion 36 provided on the screw shank 34.
  • a screw head 38 connects, preferably with a device equipped, in which a tool for screwing the bone screw 14 can engage.
  • the cavity 12 of the bone screw 14 in the region of the screw head 38 is limited by a hexagon socket or similar form and / or force-locking devices.
  • the contact device 10 comprises a proximal cap-shaped first part 16 and a distally arranged elongated second part 18, the distal second part 18 protruding into the cavity 12 of the bone screw 14.
  • electrically conductive spring contacts 28 are provided for mechanical and electrical contacting of the contact device 10 with the bone screw 14 .
  • a plurality of spring contacts may be provided at different axial coordinates.
  • the cap-shaped first part 16 of the contact device 10 includes a cavity 20, in which various electrical components are arranged, in the present embodiment, an accumulator 24, a circuit 32 for radio frequency identification (RFID) 32, a diode 40 and a resistor 42.
  • RFID radio frequency identification
  • the provision of electrical Energy is used by the accumulator 24, whose cathode is electrically contacted with the elongate second part 18 of the contact device 10 and whose anode contacts an electrically conductive outer shell 44 of the cap-shaped first part 16 of the contact device 10.
  • the accumulator 24 whose cathode is electrically contacted with the elongate second part 18 of the contact device 10 and whose anode contacts an electrically conductive outer shell 44 of the cap-shaped first part 16 of the contact device 10.
  • the cap-shaped first part 16 of the contact device 10 has an electrically insulating region 46 which forms the distal boundary of the cap-shaped first part 16 of the contact device 10.
  • further insulating means may be provided between the cap-shaped first part 16 of the contact device 10 and the bone screw 14. These insulating devices may be fixed to the bone screw 14, fixed to the cap-shaped first part 16 of the contact device 10 or as a separate component.
  • the final state of the implanted arrangement of contact device 10 and bone screw 14 may be firmly defined, such as by a stop, which is formed for example by contact between the insulating part 46 of the cap-shaped first part 16 of the contact device, or by a snap or latching connection can be realized. Also, the final state of the implanted assembly of contactor 10 and bone screw 14 may be variable so that during operation the operator may decide to insert the contactor 10 further or less into the bone screw.
  • the electrical components within the cavity 20 of the cap-shaped first part 16 of the contact device 10 are embedded in an electrically insulating mass, such as a tissue-compatible casting resin.
  • an electrically insulating mass such as a tissue-compatible casting resin.
  • the cavity 22 which is located within the elongated second part 18 of the contact device 10.
  • a coil 26 which preferably has a soft-magnetic core, is arranged within this hollow space 22. This coil serves as an energy supplier for charging the accumulator 24, namely, when the assembly of bone screw 14 and contact device 10 is in an external alternating magnetic field.
  • the coil 26 is electrically connected in parallel to the accumulator 24, that is, one pole of the coil is connected to the anode of the accumulator 24 in connection, while the other pole of the coil is connected to the cathode of the accumulator 24, here with the interposition of electrically conductive elongate second part 18 of the contact device 10. Also, a direct contacting of the electrical components is possible.
  • the further electrical components arranged in the first part 16 of the contact device 10 serve various purposes.
  • the arrangement of the RFID 32 in the cap-shaped first part 16 of the contact device 10 is to be understood schematically. It is essential that this RFID can pass 32 signals to an external evaluation device, which are based on output signals from internal measurement circuits.
  • the diode 40 serves to rectify the voltage, namely when it is supplied directly through the coil 26 becomes.
  • the ohmic resistor 42 is representative of various other electrical components over which the voltage waveforms can be modified.
  • FIG. 2 shows a guided in the axial direction section through a second embodiment of an arrangement of bone screw and contact device.
  • a function generator 30 is used, which is powered by its input terminals of the accumulator 24 with energy, while its output terminals, the two parts 16, 18 of the contact device 10 contact.
  • the diode can in turn ensure that the proximal cap-shaped first part 16 has predominantly positive potential, while the bone screw 14 receives a predominantly cathodic component.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Optics & Photonics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
EP08020988A 2007-12-28 2008-12-03 Dispositif de contact pour l'ostéosynthèse Withdrawn EP2074958A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007063027A DE102007063027A1 (de) 2007-12-28 2007-12-28 Kontaktvorrichtung für die Osteosynthese

Publications (2)

Publication Number Publication Date
EP2074958A2 true EP2074958A2 (fr) 2009-07-01
EP2074958A3 EP2074958A3 (fr) 2009-07-29

Family

ID=40473919

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08020988A Withdrawn EP2074958A3 (fr) 2007-12-28 2008-12-03 Dispositif de contact pour l'ostéosynthèse

Country Status (6)

Country Link
US (1) US20100298886A1 (fr)
EP (1) EP2074958A3 (fr)
JP (1) JP2011507643A (fr)
CN (1) CN101965158A (fr)
DE (1) DE102007063027A1 (fr)
WO (1) WO2009083086A2 (fr)

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EP2113284A1 (fr) * 2008-04-30 2009-11-04 Neue Magnetodyn GmbH Dispositif de stimulation d'un processus de guérison
WO2009132733A1 (fr) * 2008-04-30 2009-11-05 Neue Magnetodyn Gmbh Dispositif pour stimuler un processus de guérison dans la zone d'un implant
US20120232330A1 (en) * 2009-10-13 2012-09-13 Bjarne Geiges Device for Administering Drugs and for Influencing the Effects of Drugs
WO2012093277A3 (fr) * 2010-10-25 2012-11-01 Vladila Bogdan Constantin Traitement cellulaire électromagnétique
US20120277812A1 (en) * 2009-06-30 2012-11-01 Werner Kraus Polarization Device and Implantation Device
WO2016157062A1 (fr) * 2015-03-27 2016-10-06 Iwańczyk Bartłomiej Dispositif pour l'élimination du biofilm des implants dentaires
EP3589351A4 (fr) * 2017-03-02 2020-12-02 Osteovantage, Inc Piliers ostéogéniques pour implants dentaires
US11305112B2 (en) 2018-05-16 2022-04-19 DePuy Synthes Products, Inc. Electrical stimulation implants

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US20150150653A1 (en) * 2010-10-25 2015-06-04 Bogdan Constantin Vladila System and method for increasing organic cell regeneration in a cellular medium
JP5489317B2 (ja) 2011-03-27 2014-05-14 鹿島建設株式会社 水熱反応利用の汚泥メタン発酵処理方法及びシステム
US20130165733A1 (en) * 2011-12-27 2013-06-27 Richard A. Rogachefsky Orthopedic fixation device with magnetic field generator
RO128805B1 (ro) * 2012-03-21 2014-03-28 Bogdan-Constantin Vlădilă Echipament pentru aplicarea locală a unui câmp electromagnetic de extrem de joasă frecvenţă, în cavitatea bucală
DE102012022593B8 (de) * 2012-11-14 2014-05-15 Urs Brodbeck Behandlungselement zur Verwendung mit einem Dental-Implantat-Teil und Behandlungssystem zur Reinigung eines Dental-Implantat-Teils
AU2013347233B2 (en) 2012-11-14 2018-06-14 Zyfoma Gmbh Treatment element for use together with a dental implant part, treatment system and method for cleaning a dental implant part
DE102014216294A1 (de) * 2014-08-15 2016-02-18 Urs Brodbeck Reinigungssystem für ein in den Kieferknochen eines Patienten eingebrachtes Dental-Implantat-Teil
CN104399181A (zh) * 2014-12-01 2015-03-11 苏州景昱医疗器械有限公司 脑深部电刺激装置
KR101739207B1 (ko) 2015-12-30 2017-05-24 재단법인대구경북과학기술원 임플란트 충전 시스템
US10335282B2 (en) 2016-02-09 2019-07-02 Richard A. Rogachefsky Magnetic joint replacement
RO131383A0 (ro) * 2016-04-11 2016-09-30 Bogdan Constantin Vlădilă Echipament electromagnetic pentru creşterea elasticităţii ţesuturilor, folosit în cosmetică
US10751527B2 (en) 2016-10-03 2020-08-25 II Erich W. Wolf Device and method for percutaneous placement and anchoring of stimulating electrodes in spine
WO2019197994A1 (fr) * 2018-04-10 2019-10-17 DePuy Synthes Products, Inc. Ancrage osseux bipolaire avec connexion pour électrostimulation
US11351381B2 (en) 2018-05-18 2022-06-07 Washington University Systems and methods for stimulating sympathetic nervous system
US11529208B2 (en) 2018-07-19 2022-12-20 Warsaw Orthopedic, Inc. Break-off set screw
US11707299B2 (en) 2018-07-19 2023-07-25 Warsaw Orthopedic, Inc. Antenna placement for a digital set screw
US11589905B2 (en) 2018-07-19 2023-02-28 Warsaw Orthopedic, Inc. Set screw sensor placement
US11298162B2 (en) 2018-07-19 2022-04-12 Warsaw Orthopedic, Inc. Load sensing assembly for a spinal implant
US11596803B2 (en) 2018-08-02 2023-03-07 Richard A. Rogachefsky Orthopedic treatment device with electromagnetic field generator
WO2020165905A1 (fr) * 2019-02-13 2020-08-20 Magdent Ltd. Générateur de champ électromagnétique implantable pour thérapie orthopédique
US11915089B2 (en) 2021-07-09 2024-02-27 Warsaw Orthopedic, Inc. Faraday cage for digital set screw probe reader

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2113284A1 (fr) * 2008-04-30 2009-11-04 Neue Magnetodyn GmbH Dispositif de stimulation d'un processus de guérison
WO2009132733A1 (fr) * 2008-04-30 2009-11-05 Neue Magnetodyn Gmbh Dispositif pour stimuler un processus de guérison dans la zone d'un implant
WO2009132732A1 (fr) * 2008-04-30 2009-11-05 Neue Magnetodyn Gmbh Dispositif pour stimuler un processus de guérison
US8702581B2 (en) 2008-04-30 2014-04-22 Neue Magnetodyn Gmbh Apparatus for stimulating a healing process
US20120277812A1 (en) * 2009-06-30 2012-11-01 Werner Kraus Polarization Device and Implantation Device
US9474900B2 (en) * 2009-06-30 2016-10-25 Bjarne Geiges Polarization device and implantation device
US20120232330A1 (en) * 2009-10-13 2012-09-13 Bjarne Geiges Device for Administering Drugs and for Influencing the Effects of Drugs
WO2012093277A3 (fr) * 2010-10-25 2012-11-01 Vladila Bogdan Constantin Traitement cellulaire électromagnétique
WO2016157062A1 (fr) * 2015-03-27 2016-10-06 Iwańczyk Bartłomiej Dispositif pour l'élimination du biofilm des implants dentaires
EP3589351A4 (fr) * 2017-03-02 2020-12-02 Osteovantage, Inc Piliers ostéogéniques pour implants dentaires
US11305112B2 (en) 2018-05-16 2022-04-19 DePuy Synthes Products, Inc. Electrical stimulation implants

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DE102007063027A1 (de) 2009-07-09
US20100298886A1 (en) 2010-11-25
WO2009083086A2 (fr) 2009-07-09
JP2011507643A (ja) 2011-03-10
CN101965158A (zh) 2011-02-02
EP2074958A3 (fr) 2009-07-29
WO2009083086A3 (fr) 2009-09-11

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