EP2056303B1 - Liquid isotope delivery system - Google Patents
Liquid isotope delivery system Download PDFInfo
- Publication number
- EP2056303B1 EP2056303B1 EP07119545A EP07119545A EP2056303B1 EP 2056303 B1 EP2056303 B1 EP 2056303B1 EP 07119545 A EP07119545 A EP 07119545A EP 07119545 A EP07119545 A EP 07119545A EP 2056303 B1 EP2056303 B1 EP 2056303B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- regulating valve
- delivery system
- target chamber
- liquid
- liquid isotope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
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Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
- G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0015—Fluorine
Definitions
- the present invention relates to a liquid isotope delivery system and, more particularly, to a liquid isotope delivery system that can stabilize the pressure of liquid isotope, thus ensuring security.
- PET Positron emission tomography
- Fluorine-18 fluoride made by a liquid target technology is the primary nucleus used in the PET. Fluorine-18 fluoride targets are used in almost every cyclotron center. Based on fluorine-18 fluorination labeling, fluorine-18 fluoride targets are used in various chemicals, thus providing PET radiopharmaceuticals.
- a liquid target delivery system is important for providing stable radiation on the fluorine-18 fluoride while delivering the same because the half-life of the fluorine-18 fluoride is only 110 minutes. Therefore, a liquid target delivery system is used in almost every cyclotron center.
- a worker While making liquid isotope, a worker draws a predetermined amount of liquid from a storage bottle.
- the liquid is oxygen-18 water for example.
- the worker opens a liquid-injecting valve and a gas-venting valve of a target chamber to inject the liquid into the target chamber.
- the worker closes the liquid-injecting valve and the gas-venting valve, but opens a pressurizing valve to supply fluorine into the target chamber.
- the target chamber is irradiated with a proton beam for causing the oxygen-18 water to react with the fluorine, thus providing fluorine-18 water.
- the worker injects the oxygen-18 water into the target chamber before irradiating the oxygen-18 water and the fluorine. It is however difficult for the worker to precisely inject a desired amount of oxygen-18 water into the target chamber. Moreover, the safety of the worker could be jeopardized because of the intense radiation in the target chamber. Furthermore, the proton beam inevitably entails unstable pressure of the liquid isotope.
- a liquid isotope delivery system comprising the features of the preamble portion of claim 1 is known from WO 02/101758 A1 .
- the invention provides a liquid isotope delivery system comprising the features of claim 1.
- Advantageous embodiments are laid down in further claims.
- Fig. 1 is a block diagram of a liquid isotope delivery system according to the preferred embodiment of the present invention.
- Fig. 2 is a more detailed block diagram of the liquid isotope delivery system shown in Fig. 1 .
- Fig. 3 shows a first mode of operation of the liquid isotope delivery system shown in Fig. 2 .
- Fig. 4 shows a second mode of operation of the liquid isotope delivery system shown in Fig. 2 .
- Fig. 5 shows a third mode of operation of the liquid isotope delivery system shown in Fig. 2 .
- a liquid isotope delivery system includes a pressure-controlling unit 1, an input unit 2, a target chamber 3, a proton-radiating unit 4, a storage unit 5 and a cleaning unit 6 according to the preferred embodiment of the present invention.
- the liquid isotope delivery system can stabilize the pressure of liquid isotope while making and delivering the same, thus ensuring security.
- the pressure-controlling unit 1 includes a first regulating valve 11, a second regulating valve 12, a third regulating valve 13, a fourth regulating valve 14 and a pressure regulator 15.
- the first regulating valve 11 is a high-pressure regulating valve.
- the first regulating valve 11 is connected to a gas tank 111.
- the second regulating valve 12 is a low-pressure regulating valve.
- the second regulating valve 12 is connected to the first regulating valve 11.
- An on/off element 112 is provided between the first regulating valve 11 and the second regulating valve 12.
- the third regulating valve 13 is a low-pressure regulating valve.
- the third regulating valve 13 is connected to the first regulating valve 11.
- the fourth regulating valve 14 is connected to a gas tank 141.
- the pressure regulator 15 is connected to the fourth regulating valve 14.
- An on/off element 151 is provided between the pressure regulator 15 and the fourth regulating valve 14.
- a pressure transducer 152 is connected to the pressure regulator 15.
- An on/off element 153 is connected to the pressure regulator 15.
- the input unit 2 is connected to the second regulating valve 12.
- An on/off element 21 is provided between the input unit 2 and the second regulating valve 12.
- the target chamber 3 is connected to the third regulating valve 13.
- Two on/off elements 31 and 32 are provided between the target chamber 3 and the third regulating valve 13.
- the target chamber 3 is connected to the input unit 2.
- Two on/off elements 33 and 34 are provided between the target chamber 3 and the input unit 2.
- a recovery bottle 36 is connected to the third regulating valve 13.
- An on/off element 35 is provided between the recovery bottle 36 and the third regulating valve 13.
- the proton-radiating unit 4 is located near the target chamber 3.
- the storage unit 5 is connected to the target chamber 3.
- An on/off element 51 is provided between the storage unit 5 and the target chamber 3.
- the storage unit 5 is connected to the input unit 2.
- oxygen-18 water is provided from the input unit 2.
- the on/off elements 112, 21, 33 and 34 and the regulating valves 11 and 12 are opened so that the gas tank 111 provides gas to the first regulating valve 11, and provides gas to the input unit 2 through the second regulating valve 12.
- the oxygen-18 water is introduced into the target chamber 3 from the input unit 2.
- the on/off elements 32 and 35 are opened so that an overflow portion of oxygen-18 water is introduced into the recovery bottle 36.
- the proton-radiating unit 4 radiates a high-energy proton beam to turn the oxygen-18 water in the target chamber 3 into fluorine-18 water.
- the on/off elements 31 and 51 and the third regulating valve 13 are opened, thus allowing gas to travel into the target chamber 3 from the first regulating valve 11 through the third regulating valve 13, thus introducing the fluorine-18 water into the storage unit 5.
- the on/off element 154 is opened as well as the regulating valves 11, 12 and 13 in the radiation of the proton beam.
- the pressure regulator 15 cooperates with the pressure transducer 152 to constantly detect the pressure in the regulating valves 12, 13 and 14. If the pressure is too high, the on/off let 153 will be opened to reduce the pressure. If the pressure is too low, the on/off element 151 will be opened to allow the gas tank 141 to supply gas through the fourth regulating valve 14 under the control of the pressure regulator 15. Therefore, the pressure of the liquid isotope delivery system is retained in a predetermined range.
- a third mode of operation when the radiation of the proton beam is finished, the on/off elements 112, 21, 61, 34 and 51 are closed. Cleaning liquid or water is provided from the cleaning unit 6.
- the adjusting valves 11 and 12 are opened to allow the gas tank 111 to provide gas into the first regulating valve 11, and provide gas into the cleaning unit 6 through the second regulating valve 12.
- the cleaning liquid or water is introduced into the target chamber 3.
- wastewater is released from the storage unit 5.
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
Abstract
Description
- The present invention relates to a liquid isotope delivery system and, more particularly, to a liquid isotope delivery system that can stabilize the pressure of liquid isotope, thus ensuring security.
- Positron emission tomography ("PET") is developing fast around the world. Fluorine-18 fluoride made by a liquid target technology is the primary nucleus used in the PET. Fluorine-18 fluoride targets are used in almost every cyclotron center. Based on fluorine-18 fluorination labeling, fluorine-18 fluoride targets are used in various chemicals, thus providing PET radiopharmaceuticals. A liquid target delivery system is important for providing stable radiation on the fluorine-18 fluoride while delivering the same because the half-life of the fluorine-18 fluoride is only 110 minutes. Therefore, a liquid target delivery system is used in almost every cyclotron center.
- While making liquid isotope, a worker draws a predetermined amount of liquid from a storage bottle. The liquid is oxygen-18 water for example. Then, the worker opens a liquid-injecting valve and a gas-venting valve of a target chamber to inject the liquid into the target chamber. After that, the worker closes the liquid-injecting valve and the gas-venting valve, but opens a pressurizing valve to supply fluorine into the target chamber. Now, the target chamber is irradiated with a proton beam for causing the oxygen-18 water to react with the fluorine, thus providing fluorine-18 water.
- The worker injects the oxygen-18 water into the target chamber before irradiating the oxygen-18 water and the fluorine. It is however difficult for the worker to precisely inject a desired amount of oxygen-18 water into the target chamber. Moreover, the safety of the worker could be jeopardized because of the intense radiation in the target chamber. Furthermore, the proton beam inevitably entails unstable pressure of the liquid isotope.
- A liquid isotope delivery system comprising the features of the preamble portion of claim 1 is known from
WO 02/101758 A1 - It is the objective of the present invention to provide a liquid isotope delivery system that can stabilize the pressure of liquid isotope, thus ensuring security.
- To achieve the foregoing objective, the invention provides a liquid isotope delivery system comprising the features of claim 1. Advantageous embodiments are laid down in further claims.
- Other objectives, advantages and features of the present invention will become apparent from the following description referring to the attached drawings.
- The present invention will be described via the detailed illustration of the preferred embodiment referring to the drawings.
-
Fig. 1 is a block diagram of a liquid isotope delivery system according to the preferred embodiment of the present invention. -
Fig. 2 is a more detailed block diagram of the liquid isotope delivery system shown inFig. 1 . -
Fig. 3 shows a first mode of operation of the liquid isotope delivery system shown inFig. 2 . -
Fig. 4 shows a second mode of operation of the liquid isotope delivery system shown inFig. 2 . -
Fig. 5 shows a third mode of operation of the liquid isotope delivery system shown inFig. 2 . - Referring to
Figs. 1 and2 , a liquid isotope delivery system includes a pressure-controlling unit 1, aninput unit 2, atarget chamber 3, a proton-radiatingunit 4, astorage unit 5 and acleaning unit 6 according to the preferred embodiment of the present invention. The liquid isotope delivery system can stabilize the pressure of liquid isotope while making and delivering the same, thus ensuring security. - The pressure-controlling unit 1 includes a first regulating
valve 11, a second regulatingvalve 12, a third regulatingvalve 13, a fourth regulatingvalve 14 and apressure regulator 15. The first regulatingvalve 11 is a high-pressure regulating valve. The first regulatingvalve 11 is connected to agas tank 111. - The second regulating
valve 12 is a low-pressure regulating valve. The second regulatingvalve 12 is connected to the first regulatingvalve 11. An on/offelement 112 is provided between the first regulatingvalve 11 and the second regulatingvalve 12. - The third regulating
valve 13 is a low-pressure regulating valve. The third regulatingvalve 13 is connected to the first regulatingvalve 11. - The fourth regulating
valve 14 is connected to agas tank 141. - The
pressure regulator 15 is connected to the fourth regulatingvalve 14. An on/offelement 151 is provided between thepressure regulator 15 and the fourth regulatingvalve 14. Apressure transducer 152 is connected to thepressure regulator 15. An on/offelement 153 is connected to thepressure regulator 15. - The
input unit 2 is connected to the second regulatingvalve 12. An on/offelement 21 is provided between theinput unit 2 and the second regulatingvalve 12. - The
target chamber 3 is connected to the third regulatingvalve 13. Two on/offelements target chamber 3 and the third regulatingvalve 13. Thetarget chamber 3 is connected to theinput unit 2. Two on/offelements target chamber 3 and theinput unit 2. Arecovery bottle 36 is connected to the third regulatingvalve 13. An on/offelement 35 is provided between therecovery bottle 36 and the third regulatingvalve 13. - The proton-radiating
unit 4 is located near thetarget chamber 3. - The
storage unit 5 is connected to thetarget chamber 3. An on/offelement 51 is provided between thestorage unit 5 and thetarget chamber 3. Thestorage unit 5 is connected to theinput unit 2. - Referring to
Fig. 3 , in a first mode of operation, oxygen-18 water is provided from theinput unit 2. Then, the on/offelements valves gas tank 111 provides gas to the first regulatingvalve 11, and provides gas to theinput unit 2 through the second regulatingvalve 12. Thus, the oxygen-18 water is introduced into thetarget chamber 3 from theinput unit 2. The on/offelements recovery bottle 36. The proton-radiatingunit 4 radiates a high-energy proton beam to turn the oxygen-18 water in thetarget chamber 3 into fluorine-18 water. After that, the on/offelements third regulating valve 13 are opened, thus allowing gas to travel into thetarget chamber 3 from thefirst regulating valve 11 through thethird regulating valve 13, thus introducing the fluorine-18 water into thestorage unit 5. - Referring to
Fig. 4 , in a second mode of operation, the on/offelement 154 is opened as well as the regulatingvalves pressure regulator 15 cooperates with thepressure transducer 152 to constantly detect the pressure in the regulatingvalves let 153 will be opened to reduce the pressure. If the pressure is too low, the on/offelement 151 will be opened to allow thegas tank 141 to supply gas through thefourth regulating valve 14 under the control of thepressure regulator 15. Therefore, the pressure of the liquid isotope delivery system is retained in a predetermined range. - Referring to
Fig. 5 , in a third mode of operation, when the radiation of the proton beam is finished, the on/offelements cleaning unit 6. The adjustingvalves gas tank 111 to provide gas into thefirst regulating valve 11, and provide gas into thecleaning unit 6 through thesecond regulating valve 12. Thus, the cleaning liquid or water is introduced into thetarget chamber 3. Then, wastewater is released from thestorage unit 5. - The present invention has been described via the detailed illustration of the preferred embodiment. Those skilled in the art can derive variations from the preferred embodiment without departing from the scope of the present invention. Therefore, the preferred embodiment shall not limit the scope of the present invention defined in the claims.
Claims (13)
- A liquid isotope delivery system comprising:an input unit (2),a target chamber (3) connected to the input unit (2),a proton-radiating unit (4) located near the target chamber (3); anda storage unit (5),characterized bya pressure-controlling unit (1) comprising a first regulating valve (11), a second regulating valve (12) connected to the first regulating valve (11) and a third regulating valve (13) connected to the first regulating valve (11);whereinthe input unit (2) is connected to the second regulating valve (12);the target chamber (3) is connected to the third regulating valve (13);andthe storage unit (5) is connected to the target chamber (3).
- The liquid isotope delivery system according to claim 1, wherein the first regulating valve (11) is a high-pressure regulating valve.
- The liquid isotope delivery system according to claim 2 comprising a gas tank (111) connected to the first regulating valve (11).
- The liquid isotope delivery system according to one of claims 1 to 3 comprising an on/off element (112) between the first and second regulating valves (11, 12).
- The liquid isotope delivery system according to one of claims 1 to 4 comprising a cleaning unit (6) connected to the second regulating valve (12) on one hand and connected to the target chamber (3) on the other hand; and an on/off element (61) between the cleaning unit (6) and the target chamber (3).
- The liquid isotope delivery system according to one of claims 1 to 5 comprising an on/off element (21) between the second regulating valve (12) and the input unit (2).
- The liquid isotope delivery system according to one of claims 1 to 6, wherein the second and third regulating valves (12, 13) are low-pressure regulating valves.
- The liquid isotope delivery system according to one of claims 1 to 7 comprising two valves (31, 32) between the third regulating valve (13) and the target chamber (3).
- The liquid isotope delivery system according to one of claims 1 to 8 comprising:a pressure regulator (15) connected to the third regulating valve (13);an on/off element between the pressure regulator (15) and the third regulating valve (13);a gas tank (141) connected to the pressure regulator (15);a fourth regulating valve (14) connected to the gas tank (141);another on/off element (151) between the fourth regulating valve (14) and the pressure regulator (15); anda pressure transducer (152) connected to the pressure regulator (15).
- The liquid isotope delivery system according to one of claims 1 to 9 comprising two on/off elements (33, 34) between the input unit (2) and the target chamber (3).
- The liquid isotope delivery system according to one of claims 1 to 10, wherein the input unit (2) supplies oxygen-18 water.
- The liquid isotope delivery system according to one of claims 1 to 11 comprising an on/off element (51) between the target chamber (3) and the storage unit (5).
- The liquid isotope delivery system according to one of claims 1 to 12 comprising:a recovery bottle (36) connected to the target chamber (3); andan on/off element (35) between the recovery bottle (36) and the target chamber (3).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT07119545T ATE529866T1 (en) | 2007-10-29 | 2007-10-29 | LIQUID ISOTOPE RELEASE SYSTEM |
EP07119545A EP2056303B1 (en) | 2007-10-29 | 2007-10-29 | Liquid isotope delivery system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07119545A EP2056303B1 (en) | 2007-10-29 | 2007-10-29 | Liquid isotope delivery system |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2056303A1 EP2056303A1 (en) | 2009-05-06 |
EP2056303B1 true EP2056303B1 (en) | 2011-10-19 |
Family
ID=39177045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07119545A Not-in-force EP2056303B1 (en) | 2007-10-29 | 2007-10-29 | Liquid isotope delivery system |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2056303B1 (en) |
AT (1) | ATE529866T1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9183959B2 (en) * | 2009-08-25 | 2015-11-10 | Ge-Hitachi Nuclear Energy Americas Llc | Cable driven isotope delivery system |
RU2736600C1 (en) * | 2019-07-02 | 2020-11-19 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Method of producing actinium-228 radionuclide generator |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001011364A1 (en) * | 1999-08-09 | 2001-02-15 | Precision System Science Co., Ltd. | Method for automatic labeling using dispenser, method for automatically separating target substance, method for determining base sequence, and automatic dispensing system |
US6567492B2 (en) | 2001-06-11 | 2003-05-20 | Eastern Isotopes, Inc. | Process and apparatus for production of F-18 fluoride |
AU2003212892A1 (en) * | 2002-01-31 | 2003-09-02 | Bioscan, Inc. | Apparatus for synthesis of radiolabeled compounds |
-
2007
- 2007-10-29 AT AT07119545T patent/ATE529866T1/en not_active IP Right Cessation
- 2007-10-29 EP EP07119545A patent/EP2056303B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
ATE529866T1 (en) | 2011-11-15 |
EP2056303A1 (en) | 2009-05-06 |
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