EP2056303B1 - Freisetzungssystem für Flüssigisotope - Google Patents

Freisetzungssystem für Flüssigisotope Download PDF

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Publication number
EP2056303B1
EP2056303B1 EP07119545A EP07119545A EP2056303B1 EP 2056303 B1 EP2056303 B1 EP 2056303B1 EP 07119545 A EP07119545 A EP 07119545A EP 07119545 A EP07119545 A EP 07119545A EP 2056303 B1 EP2056303 B1 EP 2056303B1
Authority
EP
European Patent Office
Prior art keywords
regulating valve
delivery system
target chamber
liquid
liquid isotope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP07119545A
Other languages
English (en)
French (fr)
Other versions
EP2056303A1 (de
Inventor
Wuu-Jyh Lin
Mao-Hsung Chang
Kuo-Yuan Chu
Dow-Chi Chen
Ping-Yen Huang
Jenn-Tzong Chen
Ting-Shien c/o Atomic Energy Council Duh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Nuclear Energy Research
Atomic Energy Council
Original Assignee
Institute of Nuclear Energy Research
Atomic Energy Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Nuclear Energy Research, Atomic Energy Council filed Critical Institute of Nuclear Energy Research
Priority to AT07119545T priority Critical patent/ATE529866T1/de
Priority to EP07119545A priority patent/EP2056303B1/de
Publication of EP2056303A1 publication Critical patent/EP2056303A1/de
Application granted granted Critical
Publication of EP2056303B1 publication Critical patent/EP2056303B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0015—Fluorine

Definitions

  • the present invention relates to a liquid isotope delivery system and, more particularly, to a liquid isotope delivery system that can stabilize the pressure of liquid isotope, thus ensuring security.
  • PET Positron emission tomography
  • Fluorine-18 fluoride made by a liquid target technology is the primary nucleus used in the PET. Fluorine-18 fluoride targets are used in almost every cyclotron center. Based on fluorine-18 fluorination labeling, fluorine-18 fluoride targets are used in various chemicals, thus providing PET radiopharmaceuticals.
  • a liquid target delivery system is important for providing stable radiation on the fluorine-18 fluoride while delivering the same because the half-life of the fluorine-18 fluoride is only 110 minutes. Therefore, a liquid target delivery system is used in almost every cyclotron center.
  • a worker While making liquid isotope, a worker draws a predetermined amount of liquid from a storage bottle.
  • the liquid is oxygen-18 water for example.
  • the worker opens a liquid-injecting valve and a gas-venting valve of a target chamber to inject the liquid into the target chamber.
  • the worker closes the liquid-injecting valve and the gas-venting valve, but opens a pressurizing valve to supply fluorine into the target chamber.
  • the target chamber is irradiated with a proton beam for causing the oxygen-18 water to react with the fluorine, thus providing fluorine-18 water.
  • the worker injects the oxygen-18 water into the target chamber before irradiating the oxygen-18 water and the fluorine. It is however difficult for the worker to precisely inject a desired amount of oxygen-18 water into the target chamber. Moreover, the safety of the worker could be jeopardized because of the intense radiation in the target chamber. Furthermore, the proton beam inevitably entails unstable pressure of the liquid isotope.
  • a liquid isotope delivery system comprising the features of the preamble portion of claim 1 is known from WO 02/101758 A1 .
  • the invention provides a liquid isotope delivery system comprising the features of claim 1.
  • Advantageous embodiments are laid down in further claims.
  • Fig. 1 is a block diagram of a liquid isotope delivery system according to the preferred embodiment of the present invention.
  • Fig. 2 is a more detailed block diagram of the liquid isotope delivery system shown in Fig. 1 .
  • Fig. 3 shows a first mode of operation of the liquid isotope delivery system shown in Fig. 2 .
  • Fig. 4 shows a second mode of operation of the liquid isotope delivery system shown in Fig. 2 .
  • Fig. 5 shows a third mode of operation of the liquid isotope delivery system shown in Fig. 2 .
  • a liquid isotope delivery system includes a pressure-controlling unit 1, an input unit 2, a target chamber 3, a proton-radiating unit 4, a storage unit 5 and a cleaning unit 6 according to the preferred embodiment of the present invention.
  • the liquid isotope delivery system can stabilize the pressure of liquid isotope while making and delivering the same, thus ensuring security.
  • the pressure-controlling unit 1 includes a first regulating valve 11, a second regulating valve 12, a third regulating valve 13, a fourth regulating valve 14 and a pressure regulator 15.
  • the first regulating valve 11 is a high-pressure regulating valve.
  • the first regulating valve 11 is connected to a gas tank 111.
  • the second regulating valve 12 is a low-pressure regulating valve.
  • the second regulating valve 12 is connected to the first regulating valve 11.
  • An on/off element 112 is provided between the first regulating valve 11 and the second regulating valve 12.
  • the third regulating valve 13 is a low-pressure regulating valve.
  • the third regulating valve 13 is connected to the first regulating valve 11.
  • the fourth regulating valve 14 is connected to a gas tank 141.
  • the pressure regulator 15 is connected to the fourth regulating valve 14.
  • An on/off element 151 is provided between the pressure regulator 15 and the fourth regulating valve 14.
  • a pressure transducer 152 is connected to the pressure regulator 15.
  • An on/off element 153 is connected to the pressure regulator 15.
  • the input unit 2 is connected to the second regulating valve 12.
  • An on/off element 21 is provided between the input unit 2 and the second regulating valve 12.
  • the target chamber 3 is connected to the third regulating valve 13.
  • Two on/off elements 31 and 32 are provided between the target chamber 3 and the third regulating valve 13.
  • the target chamber 3 is connected to the input unit 2.
  • Two on/off elements 33 and 34 are provided between the target chamber 3 and the input unit 2.
  • a recovery bottle 36 is connected to the third regulating valve 13.
  • An on/off element 35 is provided between the recovery bottle 36 and the third regulating valve 13.
  • the proton-radiating unit 4 is located near the target chamber 3.
  • the storage unit 5 is connected to the target chamber 3.
  • An on/off element 51 is provided between the storage unit 5 and the target chamber 3.
  • the storage unit 5 is connected to the input unit 2.
  • oxygen-18 water is provided from the input unit 2.
  • the on/off elements 112, 21, 33 and 34 and the regulating valves 11 and 12 are opened so that the gas tank 111 provides gas to the first regulating valve 11, and provides gas to the input unit 2 through the second regulating valve 12.
  • the oxygen-18 water is introduced into the target chamber 3 from the input unit 2.
  • the on/off elements 32 and 35 are opened so that an overflow portion of oxygen-18 water is introduced into the recovery bottle 36.
  • the proton-radiating unit 4 radiates a high-energy proton beam to turn the oxygen-18 water in the target chamber 3 into fluorine-18 water.
  • the on/off elements 31 and 51 and the third regulating valve 13 are opened, thus allowing gas to travel into the target chamber 3 from the first regulating valve 11 through the third regulating valve 13, thus introducing the fluorine-18 water into the storage unit 5.
  • the on/off element 154 is opened as well as the regulating valves 11, 12 and 13 in the radiation of the proton beam.
  • the pressure regulator 15 cooperates with the pressure transducer 152 to constantly detect the pressure in the regulating valves 12, 13 and 14. If the pressure is too high, the on/off let 153 will be opened to reduce the pressure. If the pressure is too low, the on/off element 151 will be opened to allow the gas tank 141 to supply gas through the fourth regulating valve 14 under the control of the pressure regulator 15. Therefore, the pressure of the liquid isotope delivery system is retained in a predetermined range.
  • a third mode of operation when the radiation of the proton beam is finished, the on/off elements 112, 21, 61, 34 and 51 are closed. Cleaning liquid or water is provided from the cleaning unit 6.
  • the adjusting valves 11 and 12 are opened to allow the gas tank 111 to provide gas into the first regulating valve 11, and provide gas into the cleaning unit 6 through the second regulating valve 12.
  • the cleaning liquid or water is introduced into the target chamber 3.
  • wastewater is released from the storage unit 5.

Landscapes

  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Claims (13)

  1. Freisetzungssystem für Flüssigisotope, umfassend:
    eine Eingangseinheit (2);
    eine Zielkammer (3), die mit der Eingangseinheit (2) verbunden ist;
    eine Protonen-Aussendungseinheit (4) nahe der Zielkammer (3); und
    eine Speichereinheit (5);
    gekennzeichnet durch
    eine Druck-Steuerungseinheit (1), die ein erstes Regelventil (11) aufweist, ein zweites Regelventil (12), das mit dem ersten Regelventil (11) verbunden ist und ein drittes Regelventil (13), das mit dem ersten Regelventil (11) verbunden ist;
    wobei
    die Eingangseinheit (2) mit dem zweiten Regelventil (12) verbunden ist;
    die Zielkammer (3) mit dem dritten Regelventil (13) verbunden ist;
    und
    die Speichereinheit (5) mit der Zielkammer (3) verbunden ist.
  2. Freisetzungssystem für Flüssigisotope nach Anspruch 1, wobei das erste Regelventil (11) ein Hochdruck-Regelventil ist.
  3. Freisetzungssystem für Flüssigisotope nach Anspruch 2, das einen Gastank (111) umfasst, der mit dem ersten Regelventil (11) verbunden ist.
  4. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 3, das ein Ein-/Aus-Element (112) zwischen dem ersten und dem zweiten Regelventil (11, 12) aufweist.
  5. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 4, das eine Reinigungseinheit (6) umfasst, die einerseits mit dem zweiten Regelventil (12) und andererseits mit der Zielkammer (3) verbunden ist; und
    ein Ein-/Aus-Element (61) zwischen der Reinigungseinheit (6) und der Zielkammer (3).
  6. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 5, das ein Ein-/Aus-Element (21) zwischen dem zweiten Regelventil (12) und der Eingangseinheit (2) aufweist.
  7. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 6, wobei das zweite und dritte Regelventil (12, 13) Niederdruck-Regelventile sind.
  8. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 7, das zwei Ventile (31, 32) zwischen dem dritten Regelventil (13) und der Zielkammer (3) aufweist.
  9. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 8, umfassend:
    einen Druckregler (15), der mit dem dritten Regelventil (13) verbunden ist;
    ein Ein-/Aus-Element zwischen dem Druckregler (15) und dem dritten Regelventil (13);
    einen Gastank (141), der mit dem Druckregler (15) verbunden ist;
    ein viertes Regelventil (14), das mit dem Gastank (141) verbunden ist,
    ein weiteres Ein-/Aus-Element (15) zwischen dem vierten Regelventil (14) und dem Druckregler (15); und
    einen Druckwandler (152), der mit dem Druckregler (15) verbunden ist.
  10. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 9, das zwei Ein-/Aus-Elemente (33, 34) zwischen der Eingangseinheit (2) und der Zielkammer (3) aufweist.
  11. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 10, wobei die Eingangseinheit (2) Sauerstoff-18-Wasser liefert.
  12. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 11, das ein Ein-/Aus-Element (51) zwischen der Zielkammer (3) und der Speichereinheit (5) aufweist.
  13. Freisetzungssystem für Flüssigisotope nach einem der Ansprüche 1 bis 12, das umfasst:
    einen Ausgleichsbehälter (36), der mit der Zielkammer (3) verbunden ist; und
    ein Ein-/Aus-Element (35) zwischen dem Ausgleichsbehälter (36) und der Zielkammer (3).
EP07119545A 2007-10-29 2007-10-29 Freisetzungssystem für Flüssigisotope Not-in-force EP2056303B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT07119545T ATE529866T1 (de) 2007-10-29 2007-10-29 Freisetzungssystem für flüssigisotope
EP07119545A EP2056303B1 (de) 2007-10-29 2007-10-29 Freisetzungssystem für Flüssigisotope

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07119545A EP2056303B1 (de) 2007-10-29 2007-10-29 Freisetzungssystem für Flüssigisotope

Publications (2)

Publication Number Publication Date
EP2056303A1 EP2056303A1 (de) 2009-05-06
EP2056303B1 true EP2056303B1 (de) 2011-10-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP07119545A Not-in-force EP2056303B1 (de) 2007-10-29 2007-10-29 Freisetzungssystem für Flüssigisotope

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EP (1) EP2056303B1 (de)
AT (1) ATE529866T1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9183959B2 (en) * 2009-08-25 2015-11-10 Ge-Hitachi Nuclear Energy Americas Llc Cable driven isotope delivery system
RU2736600C1 (ru) * 2019-07-02 2020-11-19 Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" Способ получения радионуклидного генератора актиния-228

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001011364A1 (fr) * 1999-08-09 2001-02-15 Precision System Science Co., Ltd. Procede d'etiquetage automatique faisant appel a un distributeur automatique, procede de separation automatique d'une substance cible, procede permettant de determiner la sequence de base et systeme de distribution automatique
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
AU2003212892A1 (en) * 2002-01-31 2003-09-02 Bioscan, Inc. Apparatus for synthesis of radiolabeled compounds

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Publication number Publication date
ATE529866T1 (de) 2011-11-15
EP2056303A1 (de) 2009-05-06

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