EP2050498A1 - Dispositif de manipulation de fluides pour analyse d'échantillons de fluides - Google Patents

Dispositif de manipulation de fluides pour analyse d'échantillons de fluides Download PDF

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Publication number
EP2050498A1
EP2050498A1 EP07118889A EP07118889A EP2050498A1 EP 2050498 A1 EP2050498 A1 EP 2050498A1 EP 07118889 A EP07118889 A EP 07118889A EP 07118889 A EP07118889 A EP 07118889A EP 2050498 A1 EP2050498 A1 EP 2050498A1
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EP
European Patent Office
Prior art keywords
chamber
sample
fluid
vent
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP07118889A
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German (de)
English (en)
Inventor
designation of the inventor has not yet been filed The
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Priority to EP07118889A priority Critical patent/EP2050498A1/fr
Priority to PCT/IB2008/054252 priority patent/WO2009050666A1/fr
Publication of EP2050498A1 publication Critical patent/EP2050498A1/fr
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs

Definitions

  • the invention relates to fluid handling devices for analysis of fluid samples, to cartridges having such devices, to systems having such cartridges, and to corresponding methods of manufacturing and using of such devices.
  • EP1285628 It is known from EP1285628 to provide a device for transferring small blood samples from a patient to a laboratory chip for analysis or to a point of care testing cartridge.
  • a given amount of blood is drawn into a fluid transfer device by capillary action, and the device may be transported manually to a position over an analysis chip.
  • a technician can inwardly press a deformable dimple to provide controlled air pressure upon a channel. This displacement pressure exerts an expelling hydraulic force on the blood retained in the capillary channel. This provides an expelling force to expel a pre-selected known quantity of the blood sample through a tip end on to the analysis chip.
  • US patent 6926225 by the present applicant shows a fluid movement system for moving a sample fluid to a sensing element.
  • the sample fluid is first provided into a cartridge, and the cartridge is inserted into a reading device.
  • a pressure variation is provided in the cartridge, and the sample fluid will be moved to a sensing element by using the provided pressure variation.
  • a timing means controls the timing of releasing a pressure in the pressure variation means.
  • the pressure variation means further comprises a resilient member for counter-acting against the volumetric variation applied to the volume-variation means.
  • US patent 5,096,669 discloses a system with a disposable device and a handheld reader, which can perform a variety of electrochemical measurements on blood or other fluids.
  • a fluid sample is drawn into the disposable device through an orifice by capillary action.
  • the orifice is sealed off and the disposable device is inserted into the reader.
  • the reader which controls the test sequence and flow of fluid causes a calibrant pouch located inside the device to be pierced, releasing the calibrant fluid to flow across the sensor arrays to perform calibration.
  • an air bladder located in the device is depressed, forcing the sample across the sensors where measurements are performed and read by the reader which performs the calibrations.
  • the device can be withdrawn from the reader and discarded. While in the first step the fluid sample has to be manually inserted into the disposable device, the reader further controls displacing the calibrant fluid as well as the fluid sample within the disposable device.
  • An object of the invention is to provide improved devices for analysis of fluid samples, cartridges having such devices, systems having such cartridges, and corresponding methods of manufacturing and use of such devices apparatus or methods. According to a first aspect, the invention provides:
  • a fluid handling device for use in analysing a sample fluid, the device having a sample chamber for retaining a predetermined amount of the sample fluid during the analysis, a pre-chamber for retaining the sample fluid before an analysis, an entry to the pre-chamber being arranged to require pressure for injection of the sample fluid into the pre-chamber, a vent in the pre-chamber, and a connecting passage from the pre-chamber to the sample chamber and arranged to allow the predetermined amount of the fluid to flow to the sample chamber by capillary action.
  • the fluid handling device is preferably a micro fluidic device.
  • the fluid can be a liquid. Compared to known devices allowing injection to the sample chamber, by providing the pre-chamber and the connecting passage to the sample chamber allowing a fluid flow by capillary action, this fluid flow can be better regulated.
  • the pre-chamber may be smaller than the amount of the sample and the connecting channel may be arranged to resist fluid flow from the pressure of the injection.
  • this fluid flow can be better regulated.
  • the sample flow can be less sensitive to any variability in the injection.
  • Previously the features of this aspect of the invention can enable simpler or more cost effective apparatus, with similar consequences.
  • the vent may be provided to prevent pressure build-up by injection of the fluid into the pre-chamber when no pressure is required to force the sample fluid from the pre-chamber to the sample chamber. Otherwise the vent may be a further channel that takes any excess sample fluid after the pre-chamber is full.
  • Embodiments of the invention can have any additional features without departing from the scope of the claims. Some such additional features are set out in dependent claims and exemplified below. Other aspects of the invention include corresponding methods of manufacturing or using the apparatus.
  • references to a "chamber" are intended to encompass any size or shape of chamber suitable for retaining the fluid, of any material, rigid or flexible, and can encompass multiple chambers, or a part of a chamber or part of a passageway used as a chamber, or any kind of physical 'room' that can retain fluid or allow, at least temporarily, changing the pressure conditions against its environment.
  • Chamber thus can mean e.g. an entire conduit system but also a more or less separated room only.
  • the term 'capillary action' is intended to encompass any kind of capillary forces in order to direct or move fluids in a predetermined way/direction.
  • the connecting passage which allows such action can be in any shape, such as round, elliptical, square, etc. and combinations thereof.
  • the connecting passage may be circumferentially closed like a tube or open like a channel.
  • the embodiments described relate to types of analysis such as those in which the fluid is injected into a cartridge.
  • the cartridge can be transported manually to a reader having a sensor.
  • a force is needed to bring the sample into the cartridge, for example to squeeze the sample from a porous medium or to eject a droplet from a bottle or syringe.
  • the sample may also need to be forced through a filter, especially when raw sample is used (which is often the case in point of care applications).
  • the device can be for use with or may have a sensor for analysing the fluid sample in the chamber.
  • a sensor for analysing the fluid sample in the chamber.
  • the sensor could also be on a separate reader device to which the fluid handling device is attached or to which it can be attached or brought into juxtaposition.
  • the device can be part of a cartridge for inserting into a reader. This is an arrangement, for which the advantages of simplicity and low cost are well suited.
  • the entry to the pre-chamber can have a filter. This can help avoid contamination of the fluid.
  • the entry can have a receiving surface for a user to press an absorbent material against, to cause the pressure for the injection and to cause release of the sample from a porous sample taking medium (e.g. a cotton swab). This can be convenient for the user.
  • the receiving surface can be conical to drain into the entry. This can also assist in creating more pressure for the injection.
  • the entry can have a mechanical injector.
  • the entry can have a one way valve.
  • the entry can be above the pre-chamber.
  • the sample chamber can have a valve to restrict the flow when it reaches the vent.
  • the vent may be located so as to enable the predetermined amount of the fluid into the sample chamber.
  • the device may be a microfluidic device.
  • the present invention provides at least two different ways to decouple the pressure (required for entry of fluid into the pre-chamber) from the sample transfer to the sample chamber.
  • an injector 10 of any suitable type, including manual, pneumatic, hydraulic, electrical or mechanical, separate or incorporated into the fluid handling device in the form of a cartridge 80.
  • the device has a pre-chamber 20, an entry 30 to the pre-chamber, a connecting passage 40 for capillary flow to a sample chamber 50, a first vent 25 to release pressure from the pre-chamber.
  • a reader 60 has a sensor 70 provided close enough to analyse the fluid sample in the sample chamber, when the device is located adjacent to or attached to the reader, such as by insertion into a slot for example.
  • the sensor can be in the cartridge and the reader used to receive and process readings from the sensor.
  • the injector injects the fluid into the pre-chamber.
  • the entry to the pre-chamber has a filter, so that the injection causes the sample to be forced through the filter. Then the sample ends up in the pre-chamber which functions as a reservoir (and hence to store excess fluid) to which the capillary uptake channel is connected.
  • the pre-chamber is vented by any suitable means, e.g. via a first vent, to release the fluid or air pressure build up by forcing the sample into the pre-chamber.
  • the dosing or metering of the sample flow can be regulated by appropriate dimensioning of the capillary uptake channel, for example in terms of diameter, length, bends and so on, for a given viscosity of the fluid.
  • Such a channel can have a width, for example, between 0.1 and 5 mm, more preferably between 0.5 and 2 mm, and a height of between 10 and 1000 microns, more preferably between 50 and 200 microns.
  • the cross-sectional area of the channel determines the filling of the channel in any orientation, even against gravitational forces.
  • the length of the channel can be between 1 and 100 mm, more preferably between 5 and 15 mm.
  • the volume of the sample chamber is preferably in the order of a few microliters.
  • the cross-sectional area of the capillary uptake channel is preferably 3 times smaller than the cross-sectional area of the pre-chamber that receives fluid during the sample injection.
  • the fluid will fill the pre-chamber through the capillary uptake channel without buidling up pressure in the sample chamber during the sample injection time.
  • the dosing can also be regulated by stopping the liquid flow with a second venting hole, which makes it very reproducible.
  • FIGS. 2-5 three cross section views of a cartridge are shown at different stages of operation.
  • the sample is contained in a porous medium (e.g. a cotton swab).
  • a porous medium e.g. a cotton swab.
  • the sample is squeezed through a filter into a reservoir by operator action.
  • the sample chamber of the cartridge is filled autonomously by capillary action.
  • Figure 5 shows method steps corresponding to this or other embodiments.
  • the sample is contained in a compressible piece 100 of hollow or porous material.
  • the sample can be squeezed from the hollow or porous medium, in this case by pressing against a shaped receiving surface 110 above a pre-chamber in the form of a vented reservoir 130.
  • the receiving surface 110 may be conically shaped.
  • the receiving surface may be adapted for finger operation, e.g. in size and operative pressure.
  • a filter 120 can be placed through which the sample is forced in the same squeezing action by the user pressing downwards.
  • the liquid is then collected in the vented reservoir 130. This is connected to an interconnecting passage 140 in the form of a micro-channel which draws sample fluid from the reservoir by capillary action to fill the sample chamber 150.
  • a vent 160 may be located, which stops the filling process thus achieving accurate metering.
  • the vent can implemented via a nozzle to external (i.e. to the environment or the outside world).
  • a curved fluid front will form.
  • the curved fluid front now needs to increase its area and reduce its curvature to continue flowing to the outside world (i.e. wetting the cartridge on the outside). This will not happen because a capillary force at the other end of the capillary uptake channel counteracts this further flow.
  • the capillary force balance shifts to the internal end of the uptake channel.
  • a sensor 170 is arranged adjacent to the sample chamber, in this case underneath.
  • the sensor may be separate from the sample chamber, i.e. in another device or integrated with the sample chamber.
  • the entry 30 may optionally have a one way valve (e.g. implemented by rubber flaps or a septum) to avoid spillage and to regulate the pressure needed for injection, to reduce the risk of unwanted contamination.
  • Figure 2 shows the fluid in the porous material before the user injects it by pressing downwards.
  • Figure 3 shows the same embodiment with the user pressing the porous material and capillary action starting.
  • Figure 4 shows the same embodiment after the capillary action has filled the sample chamber and the vent has stopped further flow.
  • step 200 shows injecting fluid into the pre-chamber without pressured flow into the sample chamber.
  • Step 210 shows using capillary action to cause a predetermined amount of fluid to flow into the sample chamber.
  • Step 220 shows analysing the sample in the sample chamber. In principle once the sample has been isolated in the sample chamber, it could be moved if desired to another chamber or other location for the analysis.
  • the device as described above may be a microfluidic device.
  • the microchannel dimensions such as diameter, cross section, length and bends, can be set as desired to cause the pre determined flow rate or volume to suit the sensor and according to the viscosity of the fluid.
  • the dimensions of the microchannel are chosen such that the channel fills in any orientation for the biological fluids that need to be measured.
  • the present invention includes an arrangement of multiple sample chambers that can be arranged to be accessible from one pre-chamber to enable many different tests, or many instances of the same type of test to enable averaging.
  • Many pre-chambers can be arranged on one substrate to enable multiple tests.
  • the substrate can have other fluid handling elements such as valves, pumps, mixers and splitters to enable more complex tests to be carried out on the same sample or on other samples.
  • Other types of injectors can be used to provide the pressure.
  • Any type of sensor can be used including optical, mechanical, magnetic or electrical detection types.
  • the sensor can be part of the cartridge or separate. The readings of the sensor can be shown on the cartridge, or transferred to a separate reader or processing system for further processing for example.
  • Analysing fluids for biological or chemical molecules or constituents can take many forms, such as optical or electrical detection types.
  • Applications can include biosensors which measure the presence of certain biochemical agents (analytes), based on molecular capture and labelling with magnetic beads.
  • a GMR-type magneto-resistive sensor or other sensor can be used to measure the magnetic stray-field of the bound magnetic beads. From this signal the concentration of the biological agent can be calculated.
  • biosensors can be useful for example in point-of-care applications where a low analyte concentration in the sample is to be measured.
  • Analytes can be measured in whole blood, plasma, (filtered) saliva, urine, cell-punctures, etc.
  • Analytes that can be measured are proteins, cells, metabolites, small molecules, electrolytes, antibodies, DNA, RNA, etc.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP07118889A 2007-10-19 2007-10-19 Dispositif de manipulation de fluides pour analyse d'échantillons de fluides Ceased EP2050498A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07118889A EP2050498A1 (fr) 2007-10-19 2007-10-19 Dispositif de manipulation de fluides pour analyse d'échantillons de fluides
PCT/IB2008/054252 WO2009050666A1 (fr) 2007-10-19 2008-10-16 Dispositif de manipulation de fluide pour l'analyse d'échantillons de fluide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07118889A EP2050498A1 (fr) 2007-10-19 2007-10-19 Dispositif de manipulation de fluides pour analyse d'échantillons de fluides

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EP2050498A1 true EP2050498A1 (fr) 2009-04-22

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EP07118889A Ceased EP2050498A1 (fr) 2007-10-19 2007-10-19 Dispositif de manipulation de fluides pour analyse d'échantillons de fluides

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WO (1) WO2009050666A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010055466A1 (fr) * 2008-11-13 2010-05-20 Koninklijke Philips Electronics N.V. Interfaçage entre une entrée et un canal capillaire dans un système microfluidique
CN103447103A (zh) * 2013-08-27 2013-12-18 苏州文曲生物微系统有限公司 一种微电极芯片的封装结构
US8797527B2 (en) 2011-08-24 2014-08-05 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge
KR20160045150A (ko) * 2013-03-11 2016-04-26 큐 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
USD774407S1 (en) 2014-05-12 2016-12-20 Cue Inc. Cartridge of an analyte detection system
US9579651B2 (en) 2009-12-18 2017-02-28 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US9696252B2 (en) 2005-10-19 2017-07-04 Abbott Laboratories Apparatus for performing counts within a biologic fluid sample
US9718058B2 (en) 2015-07-17 2017-08-01 Cue Inc. Cartridges, kits, and methods for enhanced detection and quantification of analytes
US9873118B2 (en) 2010-12-30 2018-01-23 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US10578602B2 (en) 2004-04-07 2020-03-03 Abbott Laboratories Disposable chamber for analyzing biologic fluids
WO2020178563A1 (fr) * 2019-03-01 2020-09-10 Vidya Holdings Ltd Perfectionnements apportés ou se rapportant à un module de gestion d'échantillon
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes

Citations (5)

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EP0397424A2 (fr) * 1989-05-08 1990-11-14 Biotrack, Inc. Système d'analyse multiple
WO1995006868A1 (fr) * 1993-08-31 1995-03-09 Boehringer Mannheim Corporation Reactif et procede d'utilisation dudit reactif
WO1999041147A1 (fr) * 1998-02-13 1999-08-19 Roche Diagnostics Corporation Dispositif a remplissage capillaire permettant un apport de fluide ameliore
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
DE102004063438A1 (de) * 2004-12-23 2006-07-06 Oktavia Backes Neuartige mikrofluidische Probenträger

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0397424A2 (fr) * 1989-05-08 1990-11-14 Biotrack, Inc. Système d'analyse multiple
WO1995006868A1 (fr) * 1993-08-31 1995-03-09 Boehringer Mannheim Corporation Reactif et procede d'utilisation dudit reactif
WO1999041147A1 (fr) * 1998-02-13 1999-08-19 Roche Diagnostics Corporation Dispositif a remplissage capillaire permettant un apport de fluide ameliore
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
DE102004063438A1 (de) * 2004-12-23 2006-07-06 Oktavia Backes Neuartige mikrofluidische Probenträger

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10578602B2 (en) 2004-04-07 2020-03-03 Abbott Laboratories Disposable chamber for analyzing biologic fluids
US9696252B2 (en) 2005-10-19 2017-07-04 Abbott Laboratories Apparatus for performing counts within a biologic fluid sample
WO2010055466A1 (fr) * 2008-11-13 2010-05-20 Koninklijke Philips Electronics N.V. Interfaçage entre une entrée et un canal capillaire dans un système microfluidique
US9993817B2 (en) 2009-12-18 2018-06-12 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US9579651B2 (en) 2009-12-18 2017-02-28 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge
US11583851B2 (en) 2010-12-30 2023-02-21 Abbott Point Of Care Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US10391487B2 (en) 2010-12-30 2019-08-27 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US9873118B2 (en) 2010-12-30 2018-01-23 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
US8797527B2 (en) 2011-08-24 2014-08-05 Abbott Point Of Care, Inc. Biologic fluid sample analysis cartridge
US9636676B2 (en) 2013-03-11 2017-05-02 Cue Inc. Systems and methods for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US11845078B2 (en) 2013-03-11 2023-12-19 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9522397B2 (en) 2013-03-11 2016-12-20 Cue Inc. Systems and methods for detection and quantification of analytes
US11717822B2 (en) 2013-03-11 2023-08-08 Cue Health Inc. System for portable and easy-to-use detection of analytes with mobile computing device
US10603664B2 (en) 2013-03-11 2020-03-31 Cue Health Inc. Cartridges, kits, and methods for amplification and detection of analytes
US9789483B2 (en) 2013-03-11 2017-10-17 Cue Inc. System for portable and easy-to-use detection of analytes with mobile computing device
KR102094496B1 (ko) 2013-03-11 2020-03-30 큐 헬스 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
US10589267B2 (en) 2013-03-11 2020-03-17 Cue Health Inc. System for portable and easy-to-use detection of analytes with mobile computing device
US9962703B2 (en) 2013-03-11 2018-05-08 Cue Inc. Cartridges, kits, and methods for amplification and detection of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
EP2861996A4 (fr) * 2013-03-11 2016-08-24 Cue Inc Systèmes et procédés pour la détection et la quantification d'analytes
KR20160045150A (ko) * 2013-03-11 2016-04-26 큐 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
US10195606B2 (en) 2013-03-11 2019-02-05 Cue Health Inc. Systems and methods for detection and quantification of analytes
US10272434B2 (en) 2013-03-11 2019-04-30 Cue Health Inc. Cartridges, kits, and methods for amplification and detection of analytes
WO2015027922A1 (fr) * 2013-08-27 2015-03-05 苏州文曲微生物系统有限公司 Structure d'encapsulation pour puce mems
CN103447103A (zh) * 2013-08-27 2013-12-18 苏州文曲生物微系统有限公司 一种微电极芯片的封装结构
USD789815S1 (en) 2014-05-12 2017-06-20 Cue Inc. Reader of an analyte detection system
USD820130S1 (en) 2014-05-12 2018-06-12 Cue Health Inc. Analyte detection system
USD774407S1 (en) 2014-05-12 2016-12-20 Cue Inc. Cartridge of an analyte detection system
USD994516S1 (en) 2014-05-12 2023-08-08 Cue Health Inc. Reader device for an analyte detection system
USD869311S1 (en) 2014-05-12 2019-12-10 Cue Health Inc. Analyte detection system
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