EP2015745A4 - Inhibiteurs de kinase macrocycliques - Google Patents

Inhibiteurs de kinase macrocycliques

Info

Publication number
EP2015745A4
EP2015745A4 EP07755007A EP07755007A EP2015745A4 EP 2015745 A4 EP2015745 A4 EP 2015745A4 EP 07755007 A EP07755007 A EP 07755007A EP 07755007 A EP07755007 A EP 07755007A EP 2015745 A4 EP2015745 A4 EP 2015745A4
Authority
EP
European Patent Office
Prior art keywords
kinase inhibitors
macrocyclic kinase
macrocyclic
inhibitors
kinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07755007A
Other languages
German (de)
English (en)
Other versions
EP2015745A2 (fr
Inventor
Hong Fu
Yue Chen
Daniel V Santi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of EP2015745A2 publication Critical patent/EP2015745A2/fr
Publication of EP2015745A4 publication Critical patent/EP2015745A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
EP07755007A 2006-05-11 2007-04-05 Inhibiteurs de kinase macrocycliques Withdrawn EP2015745A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79978606P 2006-05-11 2006-05-11
US81726006P 2006-06-28 2006-06-28
US11/729,327 US7601852B2 (en) 2006-05-11 2007-03-27 Macrocyclic kinase inhibitors
PCT/US2007/008591 WO2007133352A2 (fr) 2006-05-11 2007-04-05 Inhibiteurs de kinase macrocycliques

Publications (2)

Publication Number Publication Date
EP2015745A2 EP2015745A2 (fr) 2009-01-21
EP2015745A4 true EP2015745A4 (fr) 2011-03-09

Family

ID=38685942

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07755007A Withdrawn EP2015745A4 (fr) 2006-05-11 2007-04-05 Inhibiteurs de kinase macrocycliques

Country Status (6)

Country Link
US (1) US7601852B2 (fr)
EP (1) EP2015745A4 (fr)
JP (1) JP2009536946A (fr)
CN (1) CN101489547B (fr)
NO (1) NO20084583L (fr)
WO (1) WO2007133352A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546404B2 (en) * 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
WO2007097937A1 (fr) * 2006-02-16 2007-08-30 Schering Corporation Nouveaux composés inhibiteurs erk
MX2010005960A (es) * 2007-11-30 2010-06-11 Schering Corp Biomarcadores de braf.
CA2714479A1 (fr) * 2008-02-21 2009-08-27 Schering Corporation Composes inhibiteurs de la voie erk
SG179172A1 (en) 2009-09-16 2012-04-27 Avila Therapeutics Inc Protein kinase conjugates and inhibitors
US20130053434A1 (en) * 2009-09-28 2013-02-28 Centre National De La Recherche Scientifique Irreversible inhibitors useful for the treatment of kinase-related pathologies
MX2012007684A (es) 2009-12-30 2012-10-05 Avila Therapeutics Inc Modificacion covalente ligando dirigida de proteina.
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
CN103173529B (zh) * 2011-12-23 2015-04-29 上海吉凯基因化学技术有限公司 人nlk基因相关的用途及其相关药物
GB201212690D0 (en) * 2012-07-16 2012-08-29 Cancer Res Inst Royal Materials and methods for treating pten mutated or deficient cancer
CN104342440A (zh) * 2013-07-30 2015-02-11 上海交通大学医学院附属新华医院 CDKL1基因及其siRNA和应用
EP4289950A3 (fr) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Composés macrocycliques participant à une liaison coopérative et leurs utilisations médicales
US9989535B2 (en) 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
CN108379583B (zh) * 2018-03-27 2021-08-17 北京大学 一种肿瘤转移药物治疗的靶标及其应用
MX2021007468A (es) * 2018-12-21 2021-08-05 Revolution Medicines Inc Compuestos que participan en la union cooperativa y usos de los mismos.
WO2021091982A1 (fr) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Inhibiteurs de ras
CA3160142A1 (fr) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Inhibiteurs de ras
CN115873020A (zh) 2019-11-04 2023-03-31 锐新医药公司 Ras抑制剂
PE20231207A1 (es) 2020-09-15 2023-08-17 Revolution Medicines Inc Derivados indolicos como inhibidores de ras en el tratamiento del cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036941A2 (fr) * 2004-09-27 2006-04-06 Kosan Biosciences Incorporated Inhibiteurs de kinases specifiques

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
JPH0840893A (ja) 1993-08-31 1996-02-13 Takeda Chem Ind Ltd インターロイキン−１産生抑制剤
US5795910A (en) * 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
GB2323845A (en) * 1997-03-31 1998-10-07 Merck & Co Inc MEK inhibiting lactones
US6635671B1 (en) * 1998-12-24 2003-10-21 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
JP2001294527A (ja) 2000-04-14 2001-10-23 Ajinomoto Co Inc Ｔｈ２反応に特異的な免疫寛容誘導剤
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
EP1450784A4 (fr) * 2001-11-09 2005-02-09 Conforma Therapeutics Corp Composes de zearalanol inhibant hsp90 et leurs procedes de production et d'utilisation
EP2308861B1 (fr) * 2002-03-08 2017-03-01 Eisai R&D Management Co., Ltd. Composes macrocycliques utiles en tant qu'agents pharmaceutiques
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
RU2312863C2 (ru) * 2002-04-17 2007-12-20 Тайсо Фармасьютикал Ко., Лтд. Тоник для роста волос
WO2004004644A2 (fr) * 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Association d'un inhibiteur de cible mammalienne de rapamycine (mtor) et d'un inhibiteur de la tyrosine kinase aux fins du de traitement de neoplasmes
EP1794062A1 (fr) * 2004-09-29 2007-06-13 Iventors Express Pty Ltd Support de boisson

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036941A2 (fr) * 2004-09-27 2006-04-06 Kosan Biosciences Incorporated Inhibiteurs de kinases specifiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IUPAC: "Aryl groups", INTERNET CITATION, 1997, pages 1, XP002582725, Retrieved from the Internet <URL:http://www.iupac.org/goldbook/A00464.pdf> [retrieved on 20100519] *

Also Published As

Publication number Publication date
CN101489547B (zh) 2012-08-08
NO20084583L (no) 2008-12-04
CN101489547A (zh) 2009-07-22
US20070265333A1 (en) 2007-11-15
EP2015745A2 (fr) 2009-01-21
US7601852B2 (en) 2009-10-13
JP2009536946A (ja) 2009-10-22
WO2007133352A2 (fr) 2007-11-22
WO2007133352A3 (fr) 2008-03-13

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: SANTI, DANIEL, V.

Inventor name: CHEN, YUE

Inventor name: FU, HONG

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Effective date: 20110204

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