EP1954132A4 - Dérivés amides en tant que ligands de canal ionique et compositions pharmaceutiques et procédés d'utilisation de tels dérivés - Google Patents
Dérivés amides en tant que ligands de canal ionique et compositions pharmaceutiques et procédés d'utilisation de tels dérivésInfo
- Publication number
- EP1954132A4 EP1954132A4 EP07751654A EP07751654A EP1954132A4 EP 1954132 A4 EP1954132 A4 EP 1954132A4 EP 07751654 A EP07751654 A EP 07751654A EP 07751654 A EP07751654 A EP 07751654A EP 1954132 A4 EP1954132 A4 EP 1954132A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ion
- methods
- same
- pharmaceutical compositions
- amide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/52—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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US83999406P | 2006-08-24 | 2006-08-24 | |
PCT/US2007/004912 WO2007100758A2 (fr) | 2005-02-28 | 2007-02-22 | Dérivés amides en tant que ligands de canal ionique et compositions pharmaceutiques et procédés d'utilisation de tels dérivés |
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EP1954132A2 EP1954132A2 (fr) | 2008-08-13 |
EP1954132A4 true EP1954132A4 (fr) | 2009-11-04 |
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EP06736043A Withdrawn EP1853269A4 (fr) | 2005-02-28 | 2006-02-24 | Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees |
EP07751654A Withdrawn EP1954132A4 (fr) | 2005-02-28 | 2007-02-22 | Dérivés amides en tant que ligands de canal ionique et compositions pharmaceutiques et procédés d'utilisation de tels dérivés |
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EP06736043A Withdrawn EP1853269A4 (fr) | 2005-02-28 | 2006-02-24 | Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees |
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JP (1) | JP2008531690A (fr) |
KR (1) | KR20070119655A (fr) |
AP (1) | AP2007004119A0 (fr) |
AU (2) | AU2006218824A1 (fr) |
CA (1) | CA2600933A1 (fr) |
NO (1) | NO20074739L (fr) |
WO (2) | WO2006093832A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2006093832A2 (fr) * | 2005-02-28 | 2006-09-08 | Renovis, Inc. | Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees |
EP2125816A2 (fr) | 2007-03-07 | 2009-12-02 | Alantos Pharmaceuticals Holding, Inc. | Inhibiteurs de métalloprotéase contenant une fraction hétérocyclique |
US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
WO2008151184A1 (fr) * | 2007-06-03 | 2008-12-11 | Vanderbilt University | Dérivés benzamides modulateurs allostériques positifs récepteurs métabotropiques du glutamate 5 (mglur5) et leurs procédés de fabrication et d'utilisation |
ATE522500T1 (de) * | 2007-11-13 | 2011-09-15 | Renovis Inc | Amidderivate als ionenkanalliganden sowie pharmazeutische zusammensetzungen und verwendungsverfahren dafür |
NZ586082A (en) * | 2007-11-16 | 2013-03-28 | Neuraxon Inc | Indole compounds and methods for treating visceral pain |
FR2933977B1 (fr) * | 2008-07-18 | 2013-04-26 | Centre Nat Rech Scient | Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives |
WO2011016234A1 (fr) | 2009-08-04 | 2011-02-10 | Raqualia Pharma Inc. | Dérivés de picolinamide bloqueurs de ttx-s |
US20140113824A1 (en) | 2011-05-10 | 2014-04-24 | Bayer Intellectual Property Gmbh | Bicyclic (thio)carbonylamidines |
JP5993860B2 (ja) * | 2011-09-29 | 2016-09-14 | 三井化学アグロ株式会社 | 4,4−ジフルオロ−3,4−ジヒドロイソキノリン誘導体の製造方法 |
US9193706B2 (en) * | 2011-09-29 | 2015-11-24 | Mitsui Chemicals Agro, Inc. | Method for producing 3,4-dihydroisoquinoline derivatives and production intermediates of same |
JP2014533747A (ja) | 2011-11-30 | 2014-12-15 | アクテリオン ファーマシューティカルズ リミテッドActelion Pharmaceuticals Ltd | 3,7−二置換オクタヒドロ−2H−ピリド[4,3−e][1,3]オキサジン−2−オン抗生物質 |
WO2014113467A1 (fr) * | 2013-01-15 | 2014-07-24 | Board Of Regents, The University Of Texas System | Inhibiteur de stat3 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046683A1 (fr) * | 2003-10-07 | 2005-05-26 | Renovis, Inc. | Derives d'amide utilises comme ligands du canal ionique et compositions pharmaceutiques et methodes d'utilisation de ces derives |
WO2006093832A2 (fr) * | 2005-02-28 | 2006-09-08 | Renovis, Inc. | Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees |
Family Cites Families (4)
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ATE144248T1 (de) * | 1992-07-01 | 1996-11-15 | Hoechst Ag | 3,4,5-substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
WO1999018105A1 (fr) * | 1997-10-07 | 1999-04-15 | Ortho-Mcneil Pharmaceutical, Inc. | Derives de dipyrido-imidazole utiles pour le traitement de troubles du systeme nerveux central |
AR045979A1 (es) * | 2003-04-28 | 2005-11-23 | Astrazeneca Ab | Amidas heterociclicas |
EP1775283A4 (fr) * | 2004-07-14 | 2008-12-10 | Japan Tobacco Inc | Compose 3-aminobenamide et inhibiteur d'activite a recepteur vanilloide 1 (vr1) |
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2006
- 2006-02-24 WO PCT/US2006/006615 patent/WO2006093832A2/fr active Application Filing
- 2006-02-24 AU AU2006218824A patent/AU2006218824A1/en not_active Abandoned
- 2006-02-24 CA CA002600933A patent/CA2600933A1/fr not_active Abandoned
- 2006-02-24 AP AP2007004119A patent/AP2007004119A0/xx unknown
- 2006-02-24 EP EP06736043A patent/EP1853269A4/fr not_active Withdrawn
- 2006-02-24 KR KR1020077022045A patent/KR20070119655A/ko not_active Application Discontinuation
- 2006-02-24 JP JP2007558085A patent/JP2008531690A/ja active Pending
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2007
- 2007-02-22 WO PCT/US2007/004912 patent/WO2007100758A2/fr active Application Filing
- 2007-02-22 AU AU2007221118A patent/AU2007221118A1/en not_active Abandoned
- 2007-02-22 EP EP07751654A patent/EP1954132A4/fr not_active Withdrawn
- 2007-09-17 NO NO20074739A patent/NO20074739L/no not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046683A1 (fr) * | 2003-10-07 | 2005-05-26 | Renovis, Inc. | Derives d'amide utilises comme ligands du canal ionique et compositions pharmaceutiques et methodes d'utilisation de ces derives |
WO2006093832A2 (fr) * | 2005-02-28 | 2006-09-08 | Renovis, Inc. | Derives d'amide en tant que ligands de canal ionique, compositions pharmaceutiques et methodes d'utilisation associees |
Also Published As
Publication number | Publication date |
---|---|
WO2007100758A2 (fr) | 2007-09-07 |
WO2007100758A3 (fr) | 2007-11-29 |
NO20074739L (no) | 2007-11-15 |
EP1853269A2 (fr) | 2007-11-14 |
JP2008531690A (ja) | 2008-08-14 |
WO2006093832A3 (fr) | 2007-03-22 |
EP1853269A4 (fr) | 2011-09-07 |
AP2007004119A0 (en) | 2007-08-31 |
AU2007221118A1 (en) | 2007-09-07 |
CA2600933A1 (fr) | 2006-09-08 |
KR20070119655A (ko) | 2007-12-20 |
AU2006218824A1 (en) | 2006-09-08 |
WO2006093832A2 (fr) | 2006-09-08 |
EP1954132A2 (fr) | 2008-08-13 |
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