EP1942968A1 - Inhalateur avec embout ayant une fonction de protection microbiologique - Google Patents

Inhalateur avec embout ayant une fonction de protection microbiologique

Info

Publication number
EP1942968A1
EP1942968A1 EP06807452A EP06807452A EP1942968A1 EP 1942968 A1 EP1942968 A1 EP 1942968A1 EP 06807452 A EP06807452 A EP 06807452A EP 06807452 A EP06807452 A EP 06807452A EP 1942968 A1 EP1942968 A1 EP 1942968A1
Authority
EP
European Patent Office
Prior art keywords
mouthpiece
amino
phenyl
inhaler
quinazoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06807452A
Other languages
German (de)
English (en)
Inventor
Johannes Geser
Burkhard Metzger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim International GmbH
Publication of EP1942968A1 publication Critical patent/EP1942968A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/11—General characteristics of the apparatus with means for preventing cross-contamination when used for multiple patients

Definitions

  • the present invention relates to an inhaler with a new mouthpiece which has a microbiological protective function.
  • the inhalers are used for the application of a pharmaceutical substance, substance formulation or mixture.
  • the patient To effectively inhale the drug, the patient must associate the mouthpiece of the inhaler with the oral mucosa (lips, mouth, throat).
  • Mouthpieces of existing on the market inhalers are usually made of plastics such as polyethylene, polypropylene, ABS (acrylonitrile / butadiene / styrene) u.a. manufactured.
  • the oral mucosa have in all people a varying number of different bacteria and other microorganisms that may be pathogens, on.
  • the object of the invention is to provide an inhaler which has a mouthpiece with a microbiological protective function.
  • the mouthpiece for an inhaler made of plastic with embedded silver ions.
  • the plastics are very preferably polymers, thermoplastic polycondensates, polyadducts, modified natural substances, such as rubbers or mixtures of these plastics.
  • plastics examples include polyethylene, polyvinyl chloride, polyoxymethylene, polyacetal, acrylonitrile / butadiene / styrene (ABS), acrylonitrile / styrene / acrylic ester (ASA), polyamides, polycarbonate, poly (ethylene terephthalate), poly (butylene terephthalate) or poly (phenylene ether).
  • ABS acrylonitrile / butadiene / styrene
  • ASA acrylonitrile / styrene / acrylic ester
  • polyamides polycarbonate
  • butylene terephthalate poly (butylene terephthalate)
  • phenylene ether poly (phenylene ether).
  • Such plastics can be obtained, for example, from Ensinger in Germany, Nufringen.
  • plastics incorporating silver ions are used in the manufacture of refrigerators to control the growth of microorganisms, such as e.g. As bacteria, yeasts, fungi and other microorganisms, to reduce or prevent.
  • microorganisms such as e.g. As bacteria, yeasts, fungi and other microorganisms
  • Additives containing silver ions for incorporation into the plastic are commercially available.
  • the silver ions containing in an additive known to the expert, can be introduced into the plastic together with a commercially available dye.
  • the silver ions contained in the additive can be introduced into the plastic with the aid of an inorganic carrier material.
  • the manufacture of the mouthpiece is carried out by conventional methods known to those skilled in the art (eg injection molding).
  • the essential advantage of the invention lies in the fact that the plastic with the embedded silver ions inhibits the growth of microorganisms and in particular bacteria and is tasteless and remains tasteless. Even after frequent use, there are no signs of wear which would impair the advantageous properties of the mouthpiece according to the invention.
  • the taste-neutrality of plastic with embedded silver ions is all the more surprising, since silver is one of the (non-toxic) heavy metals, which are usually not tasteless.
  • Salmonella typhimurium Salmonella typhimurium
  • yeasts and fungi Stachybotrys, Aspergillus niger, Candida albicans, Penicillium funiculosum.
  • powder inhalers soft inhalers, atomizers or propellant-operated metered dose inhalers, which may be single-dose or multi-dose units.
  • Powder inhalers are known in the art.
  • EP 0 703 800 B1 or EP 0 911 047 A1 which disclose a powder inhaler consisting of a cup-shaped lower part and a likewise cup-shaped lid.
  • the patient can press after inserting the capsule into the Kapseihalterung an actuator, which cooperates with at least one injectable into the Kapseihalterung needle.
  • the needle With the help of the needle (s), the capsule is pierced and the drug is released.
  • the mouthpiece which is located on the bowl-shaped base, the patient takes up the inhalable formulation.
  • the single or multi-dose powder inhalers preferably the Spinhaler ®, Rotahaler ®, Aerolizer ®, Inhalator ®, HandiHaler ®, Diskhaler ®, Diskus ®, Accuhaler ®, Aerohaler ®, Eclipse ®, Turbuhaler ®, Turbuhaler ®, Easyhaler ®, Novolizer ®, ® CLICKHALER, Pulvinal ®, Novolizer ®, SkyeHaler ®, ® Xcelovair, Pulvina ®, ® typhoon, MAGhaler ®, ® and the Twisthaler Jethaler ®.
  • the Softinhalatoren or Soft Mist inhalers, SMI: AERx ® from Aradym; Mystic ® from Ventaira, Touch Spray ® from ODEM, Aero Box ® from Aerogen.
  • the metered dose aerosols are the commercially available devices.
  • W is a pharmacologically active agent and (for example) selected from the group consisting of betamimetics, anticholinergics, corticosteroids, PDE4 inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, HIV antihistamines, PAF- Antagonists and PI3 kinase inhibitors.
  • a pharmacologically active agent selected from the group consisting of betamimetics, anticholinergics, corticosteroids, PDE4 inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, HIV antihistamines, PAF- Antagonists and PI3 kinase inhibitors.
  • two- or three-fold combinations of W can be combined and used for application in the device according to the invention. Exemplary combinations of W would be:
  • W represents a betamimetics combined with an anticholinergic, corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists,
  • W represents an anticholinergic agent combined with a betamimetics, corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists.
  • W represents a corticosteroid combined with a PDE4 inhibitor, EGFR inhibitor or LTD4 antagonist
  • W represents a PDE4 inhibitor combined with an EGFR inhibitor or LTD4 antagonist
  • W represents an EGFR inhibitor combined with a LTD4 antagonist.
  • Preferred betamimetics for this purpose are compounds selected from the group consisting of albuterol, arformoterol, bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, isoetharines, isoprenaline, levosalbutamol, mabuterol, meluadrine, metaproterenol , Orciprenaline, Pirbuterol, Procaterol, Reproterol, Rimiterol, Ritodrine, Salmefamol, Salmeterol, Soterenol, Sulphone terol, Terbutaline, Tiaramide, Tolubuterol, Zinterol, CHF-1035, HOKU-81, KUL-1248 and
  • R is either methyl or ethyl and in which X ⁇ may have the abovementioned meanings.
  • the compound of the formula AC-2 may also be present in the form of the free base AC-2-base.
  • Preferred LTD4 antagonists here are compounds selected from the group consisting of montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078 , VUF-K-8707, L-733321 and
  • HI-antihistamines here preferably compounds are used, which are selected from the group consisting of epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, Cexchlorpheniramin, pheniramine, doxylamine, chlorphenoxamine , Dimenhydrinate, diphenhydramine, promethazine, ebastine, desloratidine and meclocine, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates.
  • the present invention preferably relates to an ensemble according to FIG. 1 comprising an inhaler for the inhalation of powdered medicaments and a two-part capsule, the inhaler comprising the following elements: a) an upwardly open, cup-shaped lower part (1), which faces two in the casing lying window (2) and at the edge of the opening has a first hinge element with a hinge pin (3), b) a plate (9) which covers the opening of the lower part (1) and has a second hinge element, and a screen holder (11 c) a retractable capsule holder (4) for receiving the capsule, which is formed perpendicular to the plane of the plate on the lower-facing side of the plate (9) and on which a head movable against a spring is provided , wherein the head is provided with one or two ground needles (6), d) a mouthpiece (12) with a mouth tube and if necessary.
  • the inhaler comprising the following elements: a) an upwardly open, cup-shaped lower part (1), which faces two in the cas

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un inhalateur comportant un nouvel embout, ledit embout ayant une fonction de protection microbiologique. Cet inhalateur permet l'application d'une substance pharmaceutique, d'une formulation pharmaceutique ou d'un mélange de substances pharmaceutiques.
EP06807452A 2005-10-28 2006-10-20 Inhalateur avec embout ayant une fonction de protection microbiologique Withdrawn EP1942968A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005052126 2005-10-28
DE102006009637A DE102006009637A1 (de) 2005-10-28 2006-03-02 Inhalator mit Mundstück mit mikrobiologischer Schutzfunktion
PCT/EP2006/067640 WO2007048763A1 (fr) 2005-10-28 2006-10-20 Inhalateur avec embout ayant une fonction de protection microbiologique

Publications (1)

Publication Number Publication Date
EP1942968A1 true EP1942968A1 (fr) 2008-07-16

Family

ID=37622344

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06807452A Withdrawn EP1942968A1 (fr) 2005-10-28 2006-10-20 Inhalateur avec embout ayant une fonction de protection microbiologique

Country Status (6)

Country Link
US (1) US8397717B2 (fr)
EP (1) EP1942968A1 (fr)
JP (1) JP2009513203A (fr)
CA (1) CA2626295A1 (fr)
DE (1) DE102006009637A1 (fr)
WO (1) WO2007048763A1 (fr)

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DE102007036411A1 (de) * 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
EP2534957B1 (fr) 2007-12-14 2015-05-27 AeroDesigns, Inc Administration de produits sous forme d'aérosols
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JP2013523377A (ja) * 2010-04-13 2013-06-17 ビルギチ，マフムト 乾燥粉末吸入器のマウスピースボタン
GB201115154D0 (en) * 2011-09-01 2011-10-19 Clement Clarke Int Ltd Spacer
USD733288S1 (en) * 2012-12-13 2015-06-30 Interquim, S.A. Inhalator
USD739522S1 (en) * 2013-06-06 2015-09-22 Lupin Atlantis Holdings Sa Inhaler
AU356658S (en) * 2014-01-28 2014-07-29 Lupin Ltd Inhaler
AU356644S (en) * 2014-01-28 2014-07-29 Lupin Ltd Inhaler
AU356657S (en) * 2014-01-28 2014-07-29 Lupin Ltd Inhaler
AU355712S (en) * 2014-02-20 2014-05-22 Lupin Ltd Part of inhaler
CA173518S (en) 2016-02-08 2017-09-01 Nicoventures Holdings Ltd Cartridge for an electronic cigarette
GB201605102D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Mechanical connector for electronic vapour provision system
GB201605105D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Vapour provision apparatus
GB201605101D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Electronic vapour provision system
GB201605100D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Vapour provision system
EP3487776A1 (fr) 2016-07-22 2019-05-29 Nicoventures Holdings Limited Boîtier pour dispositif de fourniture de vapeur
US11730898B2 (en) * 2017-10-24 2023-08-22 Merxin Ltd Inhaler

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GB2398065A (en) * 2003-10-16 2004-08-11 Bespak Plc Dispensing apparatus

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GB2398065A (en) * 2003-10-16 2004-08-11 Bespak Plc Dispensing apparatus

Also Published As

Publication number Publication date
US20080295832A1 (en) 2008-12-04
US8397717B2 (en) 2013-03-19
DE102006009637A1 (de) 2007-05-03
CA2626295A1 (fr) 2007-05-03
JP2009513203A (ja) 2009-04-02
WO2007048763A1 (fr) 2007-05-03

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