EP1932492A1 - Lentille intraoculaire accommodative dotée d'une correction variable - Google Patents

Lentille intraoculaire accommodative dotée d'une correction variable Download PDF

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Publication number
EP1932492A1
EP1932492A1 EP06125992A EP06125992A EP1932492A1 EP 1932492 A1 EP1932492 A1 EP 1932492A1 EP 06125992 A EP06125992 A EP 06125992A EP 06125992 A EP06125992 A EP 06125992A EP 1932492 A1 EP1932492 A1 EP 1932492A1
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European Patent Office
Prior art keywords
optical
correction
optical elements
aberrations
variable
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EP06125992A
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German (de)
English (en)
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EP1932492B1 (fr
Inventor
Michiel Christiaan Rombach
Aleksey Nikolaevich Simonov
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Akkolens International BV
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Akkolens International BV
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Priority to ES06125992T priority Critical patent/ES2373566T3/es
Application filed by Akkolens International BV filed Critical Akkolens International BV
Priority to EP06125992A priority patent/EP1932492B1/fr
Priority to AT06125992T priority patent/ATE524139T1/de
Priority to JP2009540774A priority patent/JP5298026B2/ja
Priority to CN2007800461580A priority patent/CN101568312B/zh
Priority to PCT/EP2007/063871 priority patent/WO2008071760A2/fr
Priority to US12/518,458 priority patent/US10463473B2/en
Publication of EP1932492A1 publication Critical patent/EP1932492A1/fr
Priority to HK10103703.0A priority patent/HK1135595A1/xx
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1632—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing radial position, i.e. perpendicularly to the visual axis when implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses

Definitions

  • Lenses with variable optical power with optical components which shift perpendicular to the optical axis to vary said optical power have been first described by Louis Alvarez in 1967 ( US-A-3,350,294 ).
  • Such lenses with variable optical power comprise two optical elements mutually movable in a direction perpendicular to the optical axis and wherein the optical elements have such a form that the combination of the two optical elements results in a lens with different optical power at different relative positions of the optical elements.
  • variable focal length of which the focusing is driven by natural means, e.g. the ciliary muscle of the eye, to provide the patient with spectacle-free life.
  • natural means e.g. the ciliary muscle of the eye
  • the human eye does not only defocus at contraction/relaxation of the ciliary muscle but also shows a number of variable aberrations of higher orders which change along with defocus. These aberrations can be defined as "variable accommodation-induced aberrations" and are additional to fixed aberrations of the eye.
  • Constant and lower-order ocular aberrations of the natural eye can be successfully corrected by ophthalmic lenses, for example, by spectacles or contact lenses with sphero-cylindrical optics, laser treatment of the cornea, etc.
  • Variable accommodation-induced aberrations are well studied and are of significant importance for human vision, but current ophthalmic lenses such as spectacles, contact lenses and IOLs can not address these variable aberrations.
  • An ideal AIOL should correct for these variable accommodation-induced aberrations during the focus/defocusing process. In the latter AIOLs the defocus term can be corrected, but an option to correct for other aberrations is likely impossible to be implemented on spherical surfaces moving along the optical axis.
  • variable lenses for AIOLs can include variable correctors which affect various higher-order aberrations simultaneously.
  • these AIOLs can be defined as AIOLs with variable Zernike correctors for correction of variable accommodation-dependent aberrations.
  • the cornea is considered to be one of the main sources of accommodation-dependent aberrations.
  • the shape of the cornea changes mainly due to changes in the overall shape of the eye and partly due to increased fluid pressure during the accommodative process.
  • the shape change can be measured by corneal topography for which various measuring apparatus are commercially available. These corneal topographers can measure and define the variations in corneal shape during the accommodation process.
  • the measurement can also be performed on cataract and presbyopic eyes because the accommodation-induced changes in the corneal shape are not related with variations in the natural lens geometry.
  • Aberrations induced during the accommodation process by corneal surfaces can be deducted from the measured corneal shape.
  • This intraocular lens comprises at least two refractive elements with the profiles that combine cubic terms for the verifocal effect and higer-order (anti-derivatives of Zernike polynomials) terms providing correction of Zernike aberration terms.
  • This document introduces and explains the various concepts in variable control of aberrations in the eye and provides one realistic example of a lens design which variably corrects accommodation induced spherical monochromatic aberration.
  • the human eye can have a number of higher-order aberrations (trefoils, comas, spherical aberration etc.) of which spherical aberration is the most profound in practice and which aberration is well documented to vary in accordance with the accommodation status of the eye.
  • spherical aberration is the most profound in practice and which aberration is well documented to vary in accordance with the accommodation status of the eye.
  • H. Cheng et al. A population study on changes in wave aberrations with accommodation, J. Vis. 3, 272-280, 2004 ). This study also provided the basic data for the example described below.
  • the optical parameters of various elements of the eye change in combination with a change in the sizes and overall shape of the eye. These changes can induce variable aberrations which can decrease or increase depending on an individual during the accommodative process.
  • Spherical aberration, Z 12 shows the greatest change in amplitude with accommodation that is approximately 0.06 waves for an accommodation of 1 diopter (D) of a 5-mm pupil of the eye, measured at a wavelength of 0.83 ⁇ m.
  • D diopter
  • Conventional bespoke spectacles can only compensate for the second-order terms defocus and astigmatism.
  • IOLs which allow simultaneous correction of higher-order aberrations together with defocus are their insensitivity to the pupil position and its size.
  • the variable IOLs based on cubic optical elements described in this document will provide correction of ocular aberrations irrespective of the pupil position and size, in contrast to correcting phase plates or ophthalmic lenses utilizing the refractive surfaces of an order higher than two in terms of Zernike aberrations.
  • the eye has several refractive surfaces which determine its optical properties of which the most important are the anterior and posterior surfaces of the cornea, and the anterior and posterior surfaces of the crystalline lens.
  • the shape of the cornea changes to a steepened and flattened corneal curvature.
  • a change in the shape of the crystalline lens also contributes to the change in the ocular aberrations.
  • the cornea remains the main factor for accommodation-induced aberrations because the crystalline lens is removed from the eye prior to implantation of an IOL.
  • no IOL design has, or is likely to have, properties which can realistically correct for these variable aberrations.
  • this patent is described how monochromatic aberrations of different orders can be simultaneously corrected in an AIOL with two shifting cubic optical elements. So, the IOL with a two-element shifting optics with the element shaped as described in this patent will not only provide variable focus/defocus to restore accommodation of the eye, but also variable correction of higher-order ocular aberrations which are aberrations induced by the accommodation process.
  • such lenses with two cubic optical elements can correct for astigmatic aberrations without additional surfaces or changes in or additions to the basic formulas to which the cubic elements are shaped. Shifting the elements in the y direction will astigmatism cause to occur.
  • By choosing the correct combination of shift in the x (focus/defocus) direction and y (astigmatism) direction one can control the level of astigmatic aberration and focus/defocus simultaneously.
  • spherical aberration Z 12 shows the greatest change with accommodation (Cheng et al., 2004).
  • the change of spherical aberration is also always negative, whereas other Zernike aberration coefficients have no preferable direction of the change and is conditioned by the individual features of the human eye.
  • the aim of this invention is to provide methods for simultaneous correction of the accommodation-dependent corneal aberrations by the intraocular ophthalmic lens which comprises varifocal effect and variable correction of higer-order aberrations and consists of at least two movable optical elements.
  • the invention provides an accomodating intraocular lens with variable optical power, comprising at least two optical elements, at least one of which is movable relative to the other in a direction perpendicular to the optical axis, wherein the optical elements have such a form as to result in a lens with different optical power at different relative positions of the optical elements, wherein at least two of the optical elements of the lens comprises at least one additional optical correction surface which correction surfaces are adapted for simultaneous variable correction of one or more optical aberrations of the natural eye in which the degree of correction depends on the relative position of the optical elements.
  • Zernike correcting surfaces are added to at least one optical surface of optical elements of an AIOL with shifting cubic optical elements for simultaneous variable correction of accommodation-induced optical aberrations in which the degree of said Zernike correction depends on the relative position of both optical elements.
  • the features of the invention are well suited for correction of aberrations of different orders.
  • this optical design is particularly suited for implementation in an accommodating intraocular lens, AIOL, which adaptively corrects for defocus in combination with higher-order aberrations produced by the cornea during the accommodation process. Consequently a preferred embodiment of the invention provides a lens of kind referred to above wherein that the lens is adapted for variable focusing and for variable correction of higher-order aberrations of the remaining parts of the human eye.
  • the invention is adapted to correct for one single aberrations of any order but according to a preferred embodiment the corrections surfaces can be adapted to simultaneously correct multiple aberrations of more than one order supplementing variable focal power of the ophthalmic lens.
  • additional optical surfaces providing simultaneous variable correction of optical aberrations of different orders of which the magnitude of corrective contributions depends on the degree of shift of the optical elements.
  • US-A-3,583,790 which describes only one particular case of spherical aberration which is corrected using specific "quintic" optical surfaces.
  • x ay + cy 3 + 3 ⁇ cyz 2 + gy 5 + 10 3 ⁇ gy 3 ⁇ z 2 + 5 ⁇ gyz 4
  • OPD optical path difference
  • the parabolic, Z 4 , and quadric terms, Z 12 , in Eq. 4 vary linearly with ⁇ y .
  • the amplitudes of defocus and spherical aberration are intrinsically interrelated.
  • the optical element using a tandem pair of the quintic phase plates as given by Eq. 1 is a narrow subclass of two-element varifocal Alvarez lenses as described in US-A-3,350,294 and this optical system is a varifocal lens which additionally generates spherical aberration that linearly follows ⁇ y .
  • Such an optical element has a very specific range of applications where defocus and spherical aberration should be changed simultaneously.
  • variable correction of spherical aberration is provided below.
  • Yet another preferred embodiment provides the feature that the lens is adapted to correct variable optical aberrations of the human eye caused by changing of the shape of the cornea due to accommodation.
  • a fixed parabolic lens can be added to this accommodating surface to correct for the basic refraction of the human eye.
  • AIOL can be designed in practice providing, for example, a fixed +22 D refractive power to which an accommodative power of 0-4 D can be added for accomodation.
  • the focal power of the additional parabolic lens is 2 C ( n -1), where n is the refractive index of the material.
  • r x 2 + y 2
  • R is the radius of curvature
  • k is the conic parameter that specifies the type of conicoid
  • a n is the (2n+2)-th order polynomial coefficient which is, in most cases, n ⁇ 2.
  • L nh 1 + nS ⁇ x - ⁇ ⁇ x , y + h 0 + nh 2 - nS ⁇ x + ⁇ ⁇ x , y ,
  • a pair of refractive elements shaped according the base function S(x, y) given above, provides linear change of the specified optical aberrations along with defocus/accommodation for use in AIOLs for treatment of cataracts, presbyopia and spectacle-replacement in general.
  • ocular aberrations expressed in terms of Zernike polynomials are accommodation-dependent and associated mainly with the change of the shape of the cornea, then they can be corrected simultaneously with defocus by using e. g. a two-element accommodative IOL with the specified above additional refractive surfaces shaped as S(x, y) .
  • Such AIOL provides a variable defocus of which the focus changes linearly with the lateral shift ⁇ x .
  • A is the amplitude of Alvarez term
  • C 4 is the magnitude of additional defocus.
  • the modal amplitudes of aberration terms change linearly with shift ⁇ x .
  • Reciprocal shift of the two refractive elements shaped as S(x, y) by ⁇ x in the opposite directions perpendicular to the optical axis results in the linear change of the q-th Zernike aberration term (excluding defocus, i. e. q ⁇ 4 ).
  • the first part in Eq. 15 is a combination of defocus (Z 4 ) and astigmatism ( Z 5 ) with amplitudes 4 B ⁇ 5 ⁇ x 3 and -4 B ⁇ 5 ⁇ x 3 , respectively; the last term is a piston ( Z 0 ).
  • ⁇ ⁇ x 0 [ 2 ⁇ A ⁇ n - 1 ⁇ ] - 1 and finally B ⁇ - 0.114 ⁇ A ⁇ , where ⁇ represents the wavelength of light.
  • W denotes the degree of spherical aberration measured in wavelength units (waves) at a 1-D accommodation or W ⁇ -0.06 waves in the example above.
  • All embodiments described in this document can also have GRIN and also Fresnel designs in addition to a traditional lens design. GRIN and Fresnel designs allow lenses to be manufactured significantly thinner compared to traditional lenses and the degree of chromatic aberrations can be reduced by Fresnel designs and GRIN designs offer alternatives with regard to distribution of optical quality over the surface of the optics.
  • the invention does not only provide IOL's as described above, but also a method for applying such lenses.
  • a correction surface adapted to the eye of the person in question requires the measurement of the aberrations of the eye. After the aberrations have been measured the correction surfaces must be calculated and subsequently the optical elements must be made, preferably by a machining process, like precision lathing.
  • Figure 1 shows a schematic representation of the components of the wide-angle model eye developed by Pomerantzeff (Wide angle optical model of the human eye, Ann. Ophthalmol. 3, 815-819, 1971 ; Wide-angle optical model of the eye, in Advances in Diagnostic Visual Optics, Breinin and Siegel, eds., Springer-Verlag, Berlin, 1983 ) implanted with a two-element lens described in this patent.
  • This Pomerantzeff model of the eye was used to for calculations to generate the example presented herein.
  • Figure 2 shows the schematics of the AIOL with two cubic surfaces on two optical elements for accommodation (focus/defocus), one parabolic lens on only the anterior element for a fixed basic focus and additional fifth order surfaces on both elements to correct for increasing spherical aberration which occurs along with variation in focal distance.
  • the simulated MTFs for the eye accommodated to -6 m (equal to infinity for acuity tests) and 25 cm (at 4 D accommodation) are depicted with solid circles and open triangles, respectively.
  • the AIOL with two cubic optical elements provides near-diffraction-limited performance of the eye in absence of accommodation induced spherical aberration.
  • Figure 4 shows the effect of accommodation induced spherical aberration on performance of the eye in abscnece of correction of this spherical aberration.
  • a spherical aberration of - 0.03 waves is generated per 1D accommodation.
  • the corresponding monochromatic on-axis MTFs are presented for the model eye implanted with the AIOL with two cubic elements lens accommodated at 25 cm, 50 cm and 1 m and vision at near distances is degraded leading to loss of sharpness, contrast and detail.
  • Figure 5 Results when the accommodation induced spherical aberration is corrected for additional fifth order surfaces for variable correction of spherical aberration to the cubic optical elements.
  • the monochromatic on-axis MTFs of the model eye with the two-element ophthalmic lens correcting spherical aberration simultaneously with accommodation are shown for the eye accommodated to 25 cm, 50 cm and 1 m.
  • Figure 6 gives a graphical representation of the relationship of accommodation status of the AIOL with shifting cubic elements with variable focus/defocus and variable correction of spherical aberration and degree of correction of spherical aberration.
  • the spherical aberration of the cornea can be measured via various corneal topography measuring apparatus, the AIOL design adapted accordingly and that the AIOL can be manufactured with precision lathing technologies. It shows that shifting the optical elements by 0.18mm each provides ⁇ 1D of accommodation in combination with a spherical aberration term which decreases by ⁇ 0.03 waves. This lens provides a focus/defocus function to the eye as well as a complete correction of accommodation induced spherical aberration.
  • the back (inner) side of the anterior element is a plane.
  • a 2 is the amplitude of Alvarez term
  • Q 2 is the amplitude of the fifth order term in x term
  • the inner side is a plane.
  • optical surface of an optical element as used throughout the text and claims refers to the shape of an actual surface but also includes its “optical properties” and the resulting “optical effects” in addition to a traditional definition of an "optical surface”.
  • lens surface is assumed to be a smooth and homogenious surface shaped according to the model function and fabricated by using, for example, modem advanced precision lathing technologies by which various, often bespoke, IOLs and contact lenses are currently manufactured.
EP06125992A 2006-12-13 2006-12-13 Lentille intraoculaire accommodative dotée d'une correction variable Active EP1932492B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP06125992A EP1932492B1 (fr) 2006-12-13 2006-12-13 Lentille intraoculaire accommodative dotée d'une correction variable
AT06125992T ATE524139T1 (de) 2006-12-13 2006-12-13 Akkommodierende intraokularlinse mit variabler korrektur
ES06125992T ES2373566T3 (es) 2006-12-13 2006-12-13 Lente intraocular acomodativa con corrección variable.
CN2007800461580A CN101568312B (zh) 2006-12-13 2007-12-13 带有可变修正功能的可调节人工晶状体
JP2009540774A JP5298026B2 (ja) 2006-12-13 2007-12-13 可変補正により調節を行う眼内レンズ
PCT/EP2007/063871 WO2008071760A2 (fr) 2006-12-13 2007-12-13 Lentille intraoculaire d'accommodation avec correction variable
US12/518,458 US10463473B2 (en) 2006-12-13 2007-12-13 Accommodating intraocular lens with variable correction
HK10103703.0A HK1135595A1 (en) 2006-12-13 2010-04-16 Accommodating intraocular lens with variable correction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06125992A EP1932492B1 (fr) 2006-12-13 2006-12-13 Lentille intraoculaire accommodative dotée d'une correction variable

Publications (2)

Publication Number Publication Date
EP1932492A1 true EP1932492A1 (fr) 2008-06-18
EP1932492B1 EP1932492B1 (fr) 2011-09-14

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Country Status (8)

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US (1) US10463473B2 (fr)
EP (1) EP1932492B1 (fr)
JP (1) JP5298026B2 (fr)
CN (1) CN101568312B (fr)
AT (1) ATE524139T1 (fr)
ES (1) ES2373566T3 (fr)
HK (1) HK1135595A1 (fr)
WO (1) WO2008071760A2 (fr)

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WO2010024668A1 (fr) * 2008-08-25 2010-03-04 Akkolens International B.V. Système d’éclairage avant adaptatif
EP2221024A1 (fr) * 2009-02-19 2010-08-25 Alcon Research, Ltd. Lentille intra-oculaire prévue pour compenser les effets optiques provoqués par déformation optique
WO2011102719A1 (fr) * 2010-02-17 2011-08-25 Akkolens International B.V. Lentille ophtalmique chirale réglable
US8167941B2 (en) 2008-01-03 2012-05-01 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
US20120257278A1 (en) * 2009-08-14 2012-10-11 Akkolens International B.V. Optics with Simultaneous Variable Correction of Aberrations
EP2539762A1 (fr) * 2010-02-25 2013-01-02 Abbott Medical Optics Inc. Elément optique torique à usage ophtalmique
US8414646B2 (en) 2007-12-27 2013-04-09 Forsight Labs, Llc Intraocular, accommodating lens and methods of use
WO2013055212A1 (fr) * 2011-10-11 2013-04-18 Akkolens International B.V. Cristallin artificiel adaptatif comportant des surfaces de correction optiques
NL2012420A (en) * 2013-03-14 2014-09-16 Akkolens Int Bv Variable lens with distributed cubic optical surfaces.
GB2517531A (en) * 2013-08-12 2015-02-25 London Eye Hospital Pharma Intraocular lens system
US9668917B2 (en) 2006-01-17 2017-06-06 Novartis Ag Drug delivery treatment device
US9814568B2 (en) 2005-03-30 2017-11-14 Forsight Vision6, Inc. Accommodating intraocular lens having dual shape memory optical elements
US9913712B2 (en) 2011-02-04 2018-03-13 Forsight Labs, Llc Intraocular accommodating lens and methods of use
WO2019022608A1 (fr) 2017-07-27 2019-01-31 Akkolens International B.V. Cristallin artificiel adaptatif avec des surfaces optiques de forme irrégulière
US10285805B2 (en) 2014-03-28 2019-05-14 Forsight Labs, Llc Accommodating intraocular lens
WO2020027652A1 (fr) 2018-08-03 2020-02-06 Akkolens International B.V. Lentille à foyer variable avec masque de phase de codage de front d'onde pour profondeur de champ étendue variable
WO2020076154A1 (fr) 2018-10-08 2020-04-16 Akkolens International B.V. Lentille intraoculaire adaptative avec combinaison d'aberrations variables pour l'extension de la profondeur du champ
WO2020197386A1 (fr) 2019-03-25 2020-10-01 Akkolens International B.V. Combinaison de lentilles intraoculaires permettant la restauration de la réfraction et de l'accommodation
NL2025405A (en) 2019-04-23 2020-10-30 Akkolens Int B V Accommodating intraocular lens with elastically contracting haptics
WO2021034187A1 (fr) 2019-08-19 2021-02-25 Akkolens International B.V. Combinaison de lentille intraoculaire accommodative à sections de lentille à puissance fixe et variable indépendantes
NL2027301A (en) 2020-01-13 2021-08-17 Akkolens Int B V Mechanical means for accommodative intraocular lens
US11523898B2 (en) 2016-10-28 2022-12-13 Forsight Vision6, Inc. Accommodating intraocular lens and methods of implantation

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WO2010131955A1 (fr) * 2009-05-12 2010-11-18 Akkolens International B.V. Lentille intraoculaire avec décalage variable
JP2013509234A (ja) * 2009-10-30 2013-03-14 アッコレンズ インターナショナル ビー．ヴイ． 可変焦点眼内レンズ
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WO2020076154A1 (fr) 2018-10-08 2020-04-16 Akkolens International B.V. Lentille intraoculaire adaptative avec combinaison d'aberrations variables pour l'extension de la profondeur du champ
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CN101568312A (zh) 2009-10-28
WO2008071760A3 (fr) 2008-09-18
WO2008071760A2 (fr) 2008-06-19
JP5298026B2 (ja) 2013-09-25
US20100094413A1 (en) 2010-04-15
US10463473B2 (en) 2019-11-05
HK1135595A1 (en) 2010-06-11
EP1932492B1 (fr) 2011-09-14
JP2010512814A (ja) 2010-04-30
ATE524139T1 (de) 2011-09-15
CN101568312B (zh) 2013-08-21
ES2373566T3 (es) 2012-02-06

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