EP1916492A1 - System zur Regelung einer Kryokonservierungsanlage - Google Patents

System zur Regelung einer Kryokonservierungsanlage Download PDF

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Publication number
EP1916492A1
EP1916492A1 EP06122896A EP06122896A EP1916492A1 EP 1916492 A1 EP1916492 A1 EP 1916492A1 EP 06122896 A EP06122896 A EP 06122896A EP 06122896 A EP06122896 A EP 06122896A EP 1916492 A1 EP1916492 A1 EP 1916492A1
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EP
European Patent Office
Prior art keywords
container
installation
room
refrigerator
data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06122896A
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English (en)
French (fr)
Inventor
Matteo Polese
Cristiano AIR LIQUIDE Sanita Serv. GUGLIELMETTI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Air Liquide Sanita Service SpA
Original Assignee
Air Liquide Sanita Service SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Liquide Sanita Service SpA filed Critical Air Liquide Sanita Service SpA
Priority to EP06122896A priority Critical patent/EP1916492A1/de
Priority to EP07858584A priority patent/EP2084475A2/de
Priority to CA2662957A priority patent/CA2662957C/fr
Priority to PCT/FR2007/052157 priority patent/WO2008050035A2/fr
Priority to US11/923,005 priority patent/US20080104976A1/en
Publication of EP1916492A1 publication Critical patent/EP1916492A1/de
Withdrawn legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D29/00—Arrangement or mounting of control or safety devices
    • F25D29/001—Arrangement or mounting of control or safety devices for cryogenic fluid systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B2600/00—Control issues
    • F25B2600/07—Remote controls
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2500/00—Problems to be solved
    • F25D2500/06—Stock management

Definitions

  • the subject of the present invention relates to a method and a system for controlling and managing, in particular at a distance, a plant for cryopreservation of samples or biological or similar materials.
  • a cryopreservation plant is an installation typically having one or more holding vessels or tanks, and / or one or more mechanical refrigerators, in which one or more are stored in a cooling atmosphere obtained with a cryogenic fluid, such as liquid nitrogen or similar, or by means of a mechanical system, for example by means of mechanical freezers or refrigerators with compressors or other technology, samples or biological products, such as cells, plasma, tissues, organs or other biological, chemical or biochemical and the like.
  • a cryogenic fluid such as liquid nitrogen or similar
  • the vessel or vessel is supplied with cryogenic fluid from, via a suitable line or supply line, a reservoir containing a cryogenic fluid, for example liquid nitrogen.
  • a cryogenic fluid for example liquid nitrogen.
  • one or a plurality of containers is, moreover, disposed in a closed room, in which only the personnel and / or authorized operators have access, including personnel with a key or an electronic access card. (badge) that allows them to enter this room.
  • cryopreservation room there are often present sensors or sensors of ambient conditions, such as temperature, humidity, etc., able to determine whether the conditions prevailing in the room correspond to parameters prefixed so as to have an operation. equipment and to ensure the safety of operators and samples or biological products.
  • sensors or sensors of ambient conditions such as temperature, humidity, etc.
  • alarm instruments such as flashing lights, audible alarms or the like, which are activated or which are activated automatically when a danger situation is detected, for example linked to a bad one. malfunction of a container, or the detection of incorrect or non-compliant ambient parameters.
  • the object of the present invention is therefore to provide an improved method and control system of an installation for cryopreservation of samples or other similar biological products.
  • an object of the invention is to propose such a control system which takes into account the different organs or devices for controlling the cryogenic conservation installations, which are currently independent of each other
  • Another aim is to propose a method and a control system of the aforementioned type which allow a collection and storage of a plurality of data from the various organs or controlled elements of the installation, and a management of these data in automatic mode. to generate an alarm adapted to the gravity of the situation and possibly corrective measures in the installation, when these data do not correspond to prefixed parameters.
  • Another aim is to carry out the control and management of the installation with a high level of security, from the point of view of the communication of the data recorded during the control, the resistance of said control devices to internal malfunctions and the resistance of said storage facility control devices to aggressive agents such as dust, gas or moisture.
  • Another purpose is to provide a high security of data storage, including in case of widespread damage of the installation.
  • Another aim is to propose a method and a control system of the aforementioned type which allow a remote control and / or local control of the cryopreservation installation via several communication systems, such as personal computer PC, cell phones, palm devices or the like.
  • Another aim is to propose a method that crosses all the data relating to the cryopreservation facility to check the quality of the conservation of samples or biological products.
  • Another aim is to propose a control system of the type raised which can be extended to all the apparatus and premises inherent to the cryopreservation installation.
  • FIG. 1 schematically shows a cryopreservation installation according to the invention which comprises a restricted access room A in which cryogenic containers 3 and mechanical freezers 4 are placed in which samples and / or chemical and biochemical products are housed. or biological to keep.
  • samples will be used to designate the different biological, biochemical, chemical or other preserving materials that are stored in the tanks 3 or the refrigerators. samples, after a timely treatment, are stored in the (or) container or tank 3 or freezer 4 until their removal, which can take place after a long period, for example after months or years.
  • each cryogenic container 3 is present a cryogenic fluid, which is usually nitrogen at cryogenic temperature serving to maintain in the container itself an appropriate temperature (eg ⁇ 150 ° C) for the preservation of samples.
  • the cryogenic fluid is stored in at least one tank 1 and is conveyed to the containers 3 via a supply line 2 in cryogenic fluid.
  • freezers 4 In room A, there are also one or more mechanical freezers 4 or refrigerators which allow the conservation of the samples according to another preservation technique usually used in a cryopreservation plant. These freezers 4 can also use cryogenic fluid in case of malfunction of their refrigeration system and, for this reason, they are also connected to line 2 to be supplied with liquid nitrogen from the tank 1.
  • the cryogenic fluid supply of the two types of devices 3, 4 is carried out through the control of a main valve 8 located on the line 2 and an exhaust valve 9 and supply valves 23 located on the lines connection 24 connected, on the one hand, to each container 3 or mechanical freezer 4 and, secondly, to the line 2 of nitrogen supply.
  • this atmosphere is preferably provided with room sensors 6, connected to sound and light alarm devices 5, which are internal and external to room 7, and to a ventilation system of room 7.
  • cryogenic receptacles 3 it must always be possible to control the correct level of liquid nitrogen present therein. This control must be operated in continuous mode and, preferably, without the dedicated personnel entering each room A where the containers 3 and / or the freezers 4 are located, and limiting the opening of the containers to a minimum. 3, in order to avoid the degradation of the biological material therein, to avoid possible contamination of the room A while reducing the management costs of the installation 1 and to prevent access to the room by persons not allowed.
  • the data network 16 is based on Ethernet technology. This allows an optimal connection between the various points of the installation and the control center 11 and allows, among other things, a quick connection and activation of the various members of the system according to the invention with said center 11, a significant simplification remote technical intervention on the various system components, a high flexibility of the installation insofar as new devices (sensors and devices) can be quickly connected to the system without any negative effect on the operation of the system and bodies present beforehand.
  • This network topology also allows a fast connection to an existing intranet network, for example a hospital.
  • the level relative to the field automation 32 and the level relative to the main database 33 represent the logic control center 11 of the entire system according to the invention.
  • Each level is characterized by a plurality of different process algorithms (software), which are detailed below.
  • This logic area takes care of collecting the physical signals from the field or the various sensors (13-15) and control devices 11, and to transform them by means of appropriate logic low level couplers, in intelligible data at the higher logical levels and vice versa, transforming the actions controlled by the higher levels into intelligible signals by the devices and the field actuators.
  • Special low level couplers are used for the management of these automation features which concern the safety of the operators in the installation or which are considered critical according to the proposed objectives of the installation. These are programmed through a logic PLC (Programmable Logic Controller) to ensure their operation also in case of serious malfunction of logic higher level.
  • logic PLC Processmatic Logic Controller
  • Such devices may be, for example, cryogenic tank supervision electronics or refrigerators 4, but also centrifuges or laboratory incubators.
  • the database 49 is the support database connected to this logical area 33. It contains the data read by the CrioFieldManager 47 service by the field devices and the current field configuration.
  • the communication via a logical area CrioDBInterface 41 of the supervisor 100 is a service via internet or network (web service) used by the service CrioFieldManager 47 and CrioLocalExchanger 48 to access the database 40 principal.
  • All the components that make up this area are always redundant: it is therefore always at least two processes of this type for each installation and as many databases 49, among which at least one is active; the other, passive, continuously check the functionality of the active process (s), ready to activate in the event of system failure, while at the same time triggering a malfunction alarm.
  • This logical area 33 collects all the data recorded by the databases 49 and consolidates them in the main database 40 permanently; and vice versa, as mentioned above, restores the usual configuration and the actions commanded by the operator on the database database (s) 49.
  • This database also contains all the commands and actions entered by the user.
  • the communication system via areas 32 and 33 (“Data Collection” 36 in Figure 3) is based on an evolved and asynchronous protocol, ie which guarantees the integrity of data and which also works in case of discontinuity communication via levels 32 and 33.
  • the main interface with the user is web-based and can work through any computer or PC with a standard internet browser.
  • the user interface access policy is based on user profiles: a user authenticates only once and only accesses the features for which they are authorized.
  • PDAs portable devices
  • the logical architecture of the invention described above can be broken down, in various ways, in the devices installed in the cryopreservation plant.
  • the physical configuration of the installation is determined in fact not only by the devices present in the installation but also by the requirements of redundancy and level of service required for the objectives prefixed in the installation itself.
  • FIGs 1 and 2 we see a part of an installation comprising in particular, the containers or tanks 3 and the mechanical freezers 4 in which are disposed the biological materials to be preserved.
  • the containers receive liquid nitrogen from a tank 1 through a feed line 2.
  • Each of said containers 3, tank 1 and line 2 is controlled by the control center 11 so as to maintain, for all the biological material, optimal conditions for its conservation over time (even prolonged).
  • each container or tank 3 is provided with dedicated sensors (not shown) able to record the level of nitrogen inside, the temperature, the state of the lid and the supply solenoid valve of the container.
  • Each container 3 is provided with a control device which is connected to said sensors which collects data from said container and makes them available on a network interface which is typically, but not necessarily, asynchronous serial, which may be connected in cascade to several containers, thus forming a chain.
  • asynchronous serial which may be connected in cascade to several containers, thus forming a chain.
  • couplers At the end of this chain are connected two couplers, the first being the main unit which, while the second (backup) intervenes in the event of damage to the main unit, guarantees the continuity of acquisition of the data that comes from devices.
  • the main coupler In order to allow the filling of the container with nitrogen in the liquid phase, the main coupler also manages the cooling of the nitrogen line 2, being connected to a solenoid valve 23 and to a temperature sensor (not shown) arranged on said line.
  • a container 3 needs a filling of cryogenic fluid
  • the solenoid valve 23 arranged at the end of the supply line, opens allowing gas-phase fluid to escape to the outside atmosphere.
  • the solenoid valve 23 is closed.
  • the system controls the filling of all the devices (3-4) present on the line 2.
  • an A / D (analog / digital) signal acquisition and control station 13 is connected to sensors 6 for oxygen, pressure, temperature and humidity 6. It also makes it possible to control sound and light warning devices 5, control conventional ventilation devices of the room 7 and control the main solenoid valve 8. In particular, the volume percentage of ambient oxygen must be monitored continuously.
  • the system allows the imposition of two alarm thresholds; typically a non-critical alarm threshold (% ⁇ 19%) and a critical alarm (% ⁇ 17%) are imposed.
  • the signal acquisition and control station A / D 13 activates the ventilation device 7 to obtain a maximum replacement of air; and a local, bright or / and audible alarm 5 is activated and alerts the staff.
  • the alarm condition disappears when returning the content to a normal level (greater than 19%).
  • the oxygen content falls below 17%, the high speed ventilation is confirmed and the main liquid nitrogen feed solenoid valve 8 is closed; and a local, bright and audible alarm 5 is activated to warn the personnel.
  • the system continuously records all ambience parameters: each collected data is sent to the control center 11 and then stored in the main database.
  • the couplers are connected to other couplers, via connecting members, and by means of these are connected to a programmable unit for the control of the data of the local A itself connected to the center 11.
  • the system continuously monitors the pressure and the level of the feed tank 1 by means of readings mounted on the tank.
  • the data is sent to the control center 11 via a series of appropriate couplers.
  • an alarm sounds to inform users of the need for filling.
  • This alarm is normally also sent to a cellular device (not shown) responsible for filling the cryogenic fluid of the supply tank 1.
  • the system also activates alarms in case of critical level and pressure values, which are indicative of potential malfunction of the cryogenic fluid distribution system.
  • the system allows a continuous control of the nitrogen level and the temperature of the cryogenic containers and at least the temperature of the containers with mechanical technology and the adequate activation of solenoid valves for filling the cryogenic fluid of the tanks.
  • the level of liquid nitrogen is continuously measured by a dedicated capacitive probe in the cryogenic containers 3. It responds in active mode to any filling levels outside critical values, by activating the automatic filling of the container.
  • Each piece of data collected is sent to the control center 11 and then stored by the main database of the server 12.
  • Suitable level alarms are provided and the system malfunctions with organization of critical level thresholds, which will have the filling function for the automatic filling system.
  • the automatic filling starts with an opening of the filling solenoid valve of the container 23.
  • the solenoid valve remains in the open state until reaching the final loading level (eg 80%), and the solenoid valve closes when it is reached.
  • the nitrogen supply is used only in case of malfunction of the mechanical cooling system, and arrives via the supply solenoid valve 23.
  • the control of the temperature of the nitrogen enables the continuous recording of the temperature values recorded by the probes dedicated to the cryogenic receptacles 3 and the mechanical freezers 4 and the loading of cryogenic fluid in the event of a temperature below the alarm threshold.
  • Two alarm thresholds are set, for example: non-critical threshold: T> -145 ° C and critical threshold: T> -135 ° C.
  • Each collected data is sent to the control center 11 and then stored in the main database 12.
  • Appropriate alarms of temperature and system malfunction are provided with setting of the critical temperature thresholds, which will have the cooling function for the filling system. automatic.
  • the system plans to monitor and delay the state of the lid (open-closed).
  • the data relating to changes in the state of the lid are recorded and stored so as to allow the traceability of the movements of the samples contained therein.
  • the system provides for the activation of an open lid alarm.
  • the system makes it possible to directly control the state of the filling solenoid valve of the containers, namely open or closed.
  • main solenoid valve 8 arranged between the tank 1 and the cryopreservation containers. This is normally closed but there is nevertheless a manual bi-pass useful in case of voltage drop. There may be more cascading main solenoid valves, depending on the topology of the installation.
  • the system reopens the solenoid valve 8 in case of return to normal of the aforementioned parameters or in case of manual intervention.
  • the system continuously records the state of the main solenoid valve 8. Each collected data is sent to the control center 11 and then stored in the main database 12.
  • the invention it is possible to supervise an installation of cryopreservation optimally, even remotely, by controlling the parameters specific to each container 3, 4 able to allow such preservation, the ambient parameters and also the accesses to each container and at each place where the biological material is conserved.
  • the system is connected to an intranet / internet network and has its own architecture for protecting data access (firewall). It can be accessed using an internet browser.
  • the system automatically adjusts its functionality according to the permissions of the connected user, regardless of the user platform, without demanding the installation of a specific software (and in any case a web portal). It is optionally open to communication with other national and transnational information systems via a dedicated interface.
  • each preserved sample with an own identification code, for example a barcode or any other marking or identification means capable of allowing identification of the sample considered.
  • an own identification code for example a barcode or any other marking or identification means capable of allowing identification of the sample considered.
  • Such a code refers for example to the position of the biological material in the room A, in particular a code that takes into account the container, support, level, box, position row / column in the box, visiotube, straw ...
  • an operator having self-identified via the card or badge and personal password, can easily receive information on the position and type of the sample or samples requested.
  • the user will have to co-validate via a code reader the containers as and when the samples taken by receiving a confirmation of the system and visual information on how to proceed. This makes it possible to record any movement of each sample or biological material.
  • system associates with the sample all the data collected in the installation that are related to the sample itself.
  • All this information of the sample history can be stored on the samples themselves and / or stored in a database in which the different samples are identified, listed, classified etc ... in association with all the information concerning their history. Thus, in case of need, all this information can be restored immediately and it is then easy to know all the events of the life of a given sample.
  • an operator selecting a given sample can immediately have important information relating to this sample and the life of this sample, that is to say its history.
  • the present invention is particularly useful in the cryopreservation of biological materials of human, animal or plant origin, such as samples of cells, blood, sperm, or other similar biological material.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)
  • Cold Air Circulating Systems And Constructional Details In Refrigerators (AREA)
  • Sampling And Sample Adjustment (AREA)
EP06122896A 2006-10-25 2006-10-25 System zur Regelung einer Kryokonservierungsanlage Withdrawn EP1916492A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP06122896A EP1916492A1 (de) 2006-10-25 2006-10-25 System zur Regelung einer Kryokonservierungsanlage
EP07858584A EP2084475A2 (de) 2006-10-25 2007-10-15 Verfahren und system zur überprüfung einer kryokonservierungsanlage
CA2662957A CA2662957C (fr) 2006-10-25 2007-10-15 Methode et systeme de controle d'une installation de cryoconservation
PCT/FR2007/052157 WO2008050035A2 (fr) 2006-10-25 2007-10-15 Methode et systeme de controle d'une installation de cryoconservation
US11/923,005 US20080104976A1 (en) 2006-10-25 2007-10-24 Method and system for monitoring a cryostorage installation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06122896A EP1916492A1 (de) 2006-10-25 2006-10-25 System zur Regelung einer Kryokonservierungsanlage

Publications (1)

Publication Number Publication Date
EP1916492A1 true EP1916492A1 (de) 2008-04-30

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EP06122896A Withdrawn EP1916492A1 (de) 2006-10-25 2006-10-25 System zur Regelung einer Kryokonservierungsanlage
EP07858584A Ceased EP2084475A2 (de) 2006-10-25 2007-10-15 Verfahren und system zur überprüfung einer kryokonservierungsanlage

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP07858584A Ceased EP2084475A2 (de) 2006-10-25 2007-10-15 Verfahren und system zur überprüfung einer kryokonservierungsanlage

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US (1) US20080104976A1 (de)
EP (2) EP1916492A1 (de)
CA (1) CA2662957C (de)
WO (1) WO2008050035A2 (de)

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EP3719421A1 (de) 2019-04-01 2020-10-07 Air Liquide Sanita Services SpA Transportierbare behälterstruktur zur kryokonservierung biologischer materialien
US10973226B2 (en) 2018-10-05 2021-04-13 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
WO2021229192A1 (fr) * 2020-05-13 2021-11-18 Linbox Salle de cryoconservation mobile
USD951481S1 (en) 2020-09-01 2022-05-10 TMRW Life Sciences, Inc. Cryogenic vial
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
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US8278779B2 (en) 2011-02-07 2012-10-02 General Electric Company System and method for providing redundant power to a device
WO2013119489A2 (en) 2012-02-10 2013-08-15 Carrier Corporation Method for detection of loss of refrigerant
DE102013216762B4 (de) * 2013-08-23 2017-08-17 BSH Hausgeräte GmbH Kältegerät mit einem Kameramodul
US10055781B2 (en) 2015-06-05 2018-08-21 Boveda Inc. Systems, methods and devices for controlling humidity in a closed environment with automatic and predictive identification, purchase and replacement of optimal humidity controller
US10909607B2 (en) 2015-06-05 2021-02-02 Boveda Inc. Systems, methods and devices for controlling humidity in a closed environment with automatic and predictive identification, purchase and replacement of optimal humidity controller
EP3467408B1 (de) * 2017-10-05 2024-02-21 Liconic AG Verfahren zum betreiben einer tieftemperaturspeicheranlage mit einer stickstoffabzugsvorrichtung in einem gebäude
US10935299B2 (en) * 2018-06-13 2021-03-02 Cedric Davis Quick freeze cooler
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CN113934967B (zh) * 2021-10-18 2022-09-09 英飞智信（苏州）科技有限公司 煤炭样品的智能化存储查样反馈监管系统
CN115407811A (zh) * 2022-09-21 2022-11-29 冰山松洋生物科技(大连)有限公司 一种基于Android系统实现样本管理的超低温冰箱
CN115930544B (zh) * 2023-03-13 2023-06-02 成都工业职业技术学院 用于仓储设备的温度控制装置及控制方法、仓储设备

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WO2008050035A3 (fr) 2008-06-19
CA2662957A1 (fr) 2008-05-02
EP2084475A2 (de) 2009-08-05
US20080104976A1 (en) 2008-05-08
WO2008050035A2 (fr) 2008-05-02

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