EP1893123B1 - Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre - Google Patents

Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre Download PDF

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Publication number
EP1893123B1
EP1893123B1 EP06764781.8A EP06764781A EP1893123B1 EP 1893123 B1 EP1893123 B1 EP 1893123B1 EP 06764781 A EP06764781 A EP 06764781A EP 1893123 B1 EP1893123 B1 EP 1893123B1
Authority
EP
European Patent Office
Prior art keywords
accessory
pipette tip
spout
receptacle
straw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP06764781.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1893123A1 (fr
Inventor
Alain Ehrsam
Christian Beau
Laurent Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cryo Bio System SAS
Original Assignee
Cryo Bio System SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryo Bio System SAS filed Critical Cryo Bio System SAS
Publication of EP1893123A1 publication Critical patent/EP1893123A1/fr
Application granted granted Critical
Publication of EP1893123B1 publication Critical patent/EP1893123B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A61D19/022—Containers for animal semen, e.g. pouches or vials ; Methods or apparatus for treating or handling animal semen containers, e.g. filling or closing

Definitions

  • the present invention relates to the conditioning of predetermined doses of liquid substance in flakes.
  • Document FR-A-2,810,535 describes the most relevant prior art. It is known that flakes are conditioning units formed of a thin plastic tube whose inner diameter is in particular sufficiently small to allow the retention in place of the dose of liquid substance by capillarity and a plug engaged in the thin tube near one end, having two porous pads and, between these two buffers, a volume of gelling powder, that is to say, turning into gel in contact with an aqueous liquid.
  • a packaging method comprising a filling step for penetrating a predetermined dose of liquid substance, initially contained in an open receptacle on top, in the thin tube of a straw.
  • This step is effected by sealingly fitting a filling accessory in a first end of the thin tube of the straw while the second end of this thin tube is connected to a vacuum source, with the straw which is in a supine position, and with a conduit of the filling accessory which is immersed in the liquid substance contained in the receptacle.
  • the depression generated in the straw by the vacuum source causes the flow of liquid substance from the receptacle to the straw, via the filling accessory.
  • the European patent application 0 856 298 describes an improved version of the filling accessory.
  • a machine on which the accessory and the receptacle are mounted manually respectively on an accessory holder and on a receptacle-holder of a moving carriage performing coordinated back and forth movements with the transverse displacement of a carpet carrying the flakes to fill so as to engage and then disengage the filling accessory in and out of a flake of the carpet, then in the next straw and so on with the sequins sequants.
  • the invention aims to further automate the filling of straws in a simple, convenient and economical way.
  • the capillary nature of the channel in the spout allows the content of the accessory, from the pipette tip, to remain in the the accessory as long as the source of vacuum has not generated in the straw the depression producing the flow of the liquid substance.
  • the invention also aims, in a second aspect, a device suitable for the implementation of the method set out above, this device comprising an accessory adapted to be fitted into a straw in the supine position to introduce a predetermined dose of liquid substance initially contained in a receptacle open on the top, characterized in that said accessory has a body adapted to cooperate with a standing pipette tip so that the contents of said pipette tip belong to this accessory, and has a channel nozzle capillary adapted to be fitted into said straw, projecting from said body and oriented transversely to said body so that when said body is in the upright position said nozzle is in the supine position.
  • the accessory 1 illustrated in Figures 1 to 5 comprises a spout 2 and a body 3.
  • the spout 2 is integral with the body 3 and protrudes transversely to the body.
  • the spout 2 is formed of a single molded piece of rigid plastic material and comprises a capillary channel 4 extending here over the entire length of the spout 2 between a first end having a passage 5, through which the channel 4 communicates with the space defined by the body 3, and a second end having an outlet port 6.
  • a first portion 7 'of the spout 2 having a frustoconical outer surface 7 "extends from the body 3 to mid-length of the spout 2 in a decreasing section and is extended by a second portion 8' of the spout having a cylindrical outer surface 8 "extending from the first portion 7 'to the distal end of the spout 2.
  • the cylindrical portion 8 ' has a draft of approximately 0.5 °.
  • the body 3 comprises a tubular wall subdivided into two portions 9 and 10 by a bottom wall 11.
  • the portion 9 delimits with the wall 11 a reservoir for containing a liquid substance.
  • This reservoir has an inlet opening 12 at the end opposite to the bottom wall 11.
  • the portion 10 forms a base on which the support is supported.
  • the bottom wall 11 is here inclined at an angle of 30 ° with respect to the spout 2.
  • the capillary channel 4 communicates with the body 3 through the passage 5 whose lower part opens flush with the lower part of the bottom wall 11 of the body 3, or at the lowest level of the tank.
  • the body 3 is generally oriented in a direction transverse to the general orientation of the spout 2, the accessory 1 thus having a generally bent shape.
  • the body 3 Opposite the spout 2, the body 3 comprises, on its outer face, a rigid rib 13, a single block with the body 3 and generally parallelepipedal shape.
  • Two tabs 14 of a single block with the body 3 and diametrically opposite one another, are arranged on the outer face of the body 3, at the same level and midway between the rib 13 and the beak 2.
  • Two tabs 15 are located on either side of each tab 14.
  • a notch 16 is formed at the end of the body 3 bordering the opening 12.
  • the accessory 1 ' is identical to the accessory 1 except that the bottom wall 11' of the body 3 has a lower inclination, here of 4.5 ° with respect to the spout 2.
  • the clamp 30 for grasping the accessory 1 comprises a central body 31 and two elastically deformable arms 34.
  • the central body 31 has a generally parallelepipedal shape having two square faces 32, and extending from one to the other on each side of the square faces, four similar rectangular faces 33.
  • One of the rectangular faces 33 has in its center a connection port 35 to a robotic arm.
  • the two arms 34 are connected transversely to the rectangular face 33 opposite to that having the orifice 35.
  • Each arm 34 has a section 36 of parallelepiped shape and a hook 37, in the extension of the section 36 and facing the hook 37 of the other arm.
  • Each hook 37 has a convex surface 38 and a recessed straight surface 39 with respect to the section 36, a straight surface 40 connecting the convex surface 38 to the recessed surface 39 and a surface 41 connecting the recessed surface 39 to the section 36.
  • junction of the convex surface 38 and the straight surface 40 points towards the other hook 37 while the junction between the straight surface 40 and the recessed surface 39 points towards the hook 37 to which it belongs.
  • junction of the recessed surface 39 with the surface 41 points towards the hook 37 to which it belongs while the junction of this surface 41 with the section 36 forms a shoulder 42.
  • the accessory holder 60 comprises a pedestal 61 of generally parallelepipedal shape and two tabs 62 projecting from the base 61.
  • the base 61 has two rectangular main faces 63, two rectangular faces 64 extending from one to the other of the long sides of the main faces 63 and two rectangular faces 65 extending from one to the other of the small sides of the main faces 63.
  • One of the faces 64 rests on a plate 70 belonging to a movable carriage which is not represented further.
  • the tabs 62 are connected to the base 61 by the other face 64, beyond it, in the extension of an angle between a face 63 and a face 65.
  • the tabs 62 are separated from each other for a groove 66 of frustoconical profile whose section is increasing from the face 65 closest to the face 65 farthest from the groove 66.
  • Each tab 62 has a section of generally triangular shape and has on its face adjacent to the groove 66 where the section is the widest, a recess in a circular arc 67 whose radius of curvature is identical to the radius of curvature of the body 3 and a flange 68 protruding in the extension of the recess 67 on the opposite side to the groove 66.
  • the pusher 50 comprises a presser 53 and a jack formed of a rod 51 and a body 52.
  • the rod 51 is connected at one end to the presser 53 and at the other end to a piston (not visible in the drawings) movable inside the body 52.
  • Presser 53 is here of parallelepipedic general shape.
  • the rectangular face opposite the face by which it is connected to the rod 51 has a recess in an arc of circle whose radius of curvature is identical to the radius of curvature of the body 3.
  • ancillary devices for carrying out the automatic filling cycle flakes in particular a clamp holder 80 for storing the clamp 30 when not connected to the robotic arm and means for clearing the flange. 1 accessory to the clamp 30.
  • the clamp holder 80 illustrated on the Figures 18 and 19 comprises a base 88 of generally parallelepipedal shape having two main faces 81 and, extending from one to the other of the long sides of the main faces, two similar rectangular faces 82, and from one to another of the small two faces 83.
  • the base 88 has a cavity 87 opening on one of the faces 83 through an opening 84.
  • a lug 85 controlled by a motor 86 is housed in the cavity 87.
  • the release device of the accessory shown on the Figures 20 and 21 has a rod 90 connected transversely to a fixed vertical wall 91.
  • the robotic arm 95 illustrated on the Figures 18 to 21 , has a pipette rod 96 whose distal end can, as will be seen below, be engaged in the orifice 35 of the clamp 30 as in a pipette tip 24.
  • the arm 95 comprises pneumatic means for producing a vacuum in a pipette tip for aspirating a liquid substance and for suppressing vacuum in the pipette tip to release the liquid contained in the pipette tip.
  • the containers open on the top containing the liquid substances to be packaged here are primary tubes 45 of glass (of the test tube type) previously arranged in a receptacle holder 46 ( Figures 22 and 23 ) such a carousel or rack with primary tubes.
  • This receptacle holder separate from the accessory holder 60 preinstalled in the machine, is manually loaded into the machine before starting a cycle.
  • tip holder here a pipette tip rack not shown
  • accessory box here an accessory rack not shown
  • Empty flakes 25 are also disposed manually in a glitter distribution hopper not shown in the figures.
  • the robotic arm 95 manipulable in the three dimensions of the space, is placed above the clamp holder 80.
  • the robotic arm 95 is lowered towards the clamp holder 80, the male end of the pipette rod 96 of the arm 95 snaps into the hole 35 of the clamp 30, as shown on the Figures 18 and 19 .
  • the motor 86 is then controlled to retract the lug 85.
  • the robotic arm 95 provided with the clamp 30 is then moved over the accessory rack (not shown).
  • the arm 95 and the clamp 30 are placed above the accessory and are lowered.
  • the arms 34 of the gripper 30 run along the external face of the body 3 until they bear against the tongues 14 by the convex surface 38.
  • the convex surface 38 at the free end of the hooks 37 tends to move the sections 36 away from each other.
  • each tongue 14 comes to engage a hook 37.
  • the arms 34 of the clamp 30 close around the tongues 14 while the shoulders 42 of the arms 34 are housed in the notches 16 of the body 3 formed for this purpose.
  • the seized accessory is moved from the accessory rack (not shown) to the top of the accessory holder 60 and is engaged from above in the accessory holder 60 to be removed as illustrated in FIG. figure 13 on the bearing surface 64 of the base 61 of the accessory-holder 60.
  • the spout 2 is oriented by the robotic arm 95 so as to engage in the frustoconical groove 66.
  • the presser 53 is then moved to come into contact with the accessory so that the arcuate recess 54 of the presser 53 bears against the portion 9 of the accessory 1 on the side opposite the spout 2, whereby the accessory slides horizontally on the accessory holder 60 from its removal position, illustrated in FIG. Figures 13 and 15 at an abutment position against the lugs 62 of the accessory holder 60, illustrated in FIG. figures 16 and 17 .
  • the frustoconical portion 7 'of the spout 2 of the accessory holder 60 is guided by the frustoconical groove 66, whereby the outlet orifice 6 is precisely positioned facing and in the center of the end 21 of the thin tube 20 of a straw 25 as illustrated in FIG. figure 22 .
  • the straw 25 has been brought by a conveyor belt not shown in the illustrated position, where it must be filled.
  • the embossment 10 makes it possible to orient the capillary channel 4 along the axis of the straw 25 independently of the inclination of the bottom wall 11, whereby in the abutment position on the accessory-holder 60, the capillary channel 4 is parallel and centered with respect to the flake 25.
  • the body 3 is then in the upright position, while the spout 2, oriented transversely to the body 3 is like the straw 25 in the supine position.
  • each lug 15 of the body 3 closest to the nose 2 abuts against the respective protruding edge 68 of the lug 62 of the accessory holder 60 while the rib 13 of the body 3 abuts against the lower surface 55 of the presser 53.
  • the robotic arm 95 can therefore be reassembled so as to elastically disengage the tongues 14 of the accessory 1 of the hooks 37 of the clamp 30, unlike the engagement operation described above, the inclination of the straight surface 40 of the hook 37 relative to the tongue 14 facilitates the stall.
  • the robotic arm 95 then rests the clamp 30 in the clamp holder 80.
  • the motor 86 is then controlled so that the lug 85 presses on one of the sections 36 of the clamp 30 in order to hold it in position when the arm is raised to be disconnected from the clamp 30.
  • the arm 95 is then placed on top of the pipette tip rack (not shown) in order to plug the male end of the pipette rod 96 of the robotic arm 95 into a pipette tip 24 (FIG. Figures 22 and 23 ).
  • the robotic arm 95 provided with the pipette tip 24 in the upright position is then placed above one of the open-top receptacles 45 containing the liquid substance to be conditioned in order to co-operate the pipette tip 24 with the receptacle 45.
  • a depression is then generated in the pipette tip 24 so that it can aspirate a quantity 26 of liquid substance ( figure 23 ), containing at least one predetermined dose 26 'of liquid substance ( figure 26 ).
  • the arm 95 provided with the pipette tip 24 filled with the quantity of liquid 26 that it contains is then, as shown on FIG. figure 23 disposed above the body 3 of the accessory 1, always in abutment position on the accessory holder 60.
  • the depression is then removed in the pipette tip 24, still in the upright position, so that the quantity of liquid 26 is released from the pipette tip 24 and is collected in the body 3 of the accessory 1 as shown on the figure 24 .
  • the distal end of the pipette tip 24 is here placed above the opening 12 but it is also possible to place it below, at the top of the reservoir of the accessory 1.
  • the capillary channel 4 of the spout 2 and the body 3 are dimensioned so that when the body 3 of the accessory is filled, as illustrated in FIG. figures 24 , and maintained at atmospheric pressure, the channel 4 is opposed by capillarity to the circulation of the liquid substance in the absence of depression, given the viscosity of this substance.
  • the liquid does not flow through the capillary duct 4 as the outlet port 6 is not subjected to a depression.
  • the straw 25 illustrated on the Figures 22 to 26 is arranged on a conveyor belt not shown, and more precisely in a group of calibrated notches where it was automatically engaged from a hopper, the carpet having a regular succession of groups of notches, glitters placed on the carpet being perpendicular to the direction of advance thereof.
  • the conveyor belt is stopped and the end 21 of the thin tube 20 of the straw 25 is opposite the groove 66 of the accessory holder 60, present but not shown on the Figures 22 to 26 , while the end 22 is disposed facing the suction nozzle 27 connected to a vacuum source 29 as illustrated in FIG. figure 22 .
  • the trolleys (not shown) on which the suction nozzle 27 and the accessory 1 are mounted respectively are movable in translation transversely to the conveyor belt, that is to say in the direction of the straw 25. They perform movements back and forth between a retracted position and a work position.
  • the accessory 1 is deposited in the accessory holder 60 while the carriage which carries it is in the retracted position.
  • the flexible nature of the plastic forming the tube 20 ensures a good seal with the spout 2 even if it is made of rigid plastic material.
  • the joint plane of the mold of the accessory 1 is here disposed away from the wall 7 "so as not to disturb the sealed cooperation of the flake 25 with the frustoconical surface 7".
  • the vacuum source 29 then generates a depression in the straw 25 which results in the flow of a predetermined dose 26 'of liquid substance from the reservoir of the accessory 1 to the tube 20 via the capillary channel 4.
  • the inclined bottom wall 11 facilitates the flow of the fluid and avoids or in any case limits the turbulence phenomena caused by sudden changes in direction.
  • the composite plug 23 of the straw 25 remains permeable to air as long as the powder 23 ', included between the two porous pads 23 ", has not gelled by contact with an aqueous liquid, in this case the liquid biological substance. to condition.
  • the carriages are then driven to the retracted position and the filled straw is thus released from the spout 2 and the nozzle 27.
  • the residual liquid substance 26 "contained in the reservoir after filling the straw does not flow through the capillary channel 4 for the same reasons as explained above.
  • the carpet is then advanced to place a new straw 25 to fill in the filling position and to place the filled straw in the welding position of its ends.
  • each accessory 1 may fill one or more sequins 25.
  • the accessory may also be filled one or several times by the robotic arm 95.
  • the replacement of the pipette tip 24 is well known and is conventionally effected by ejecting the used tip 24 out of the pipette rod 96 over a container for storing used consumables and by fitting the connection element.
  • the accessory 1 is grasped by the robotic arm 95 provided with the clamp 30 after the presser has moved back to the position it occupied when the accessory was in the removal position.
  • the clamp 30 provided with the accessory 1 is directed towards the release device in order to place the rod 90 between the central body 31 of the clamp 30 and the accessory 1, on either side of the sections 36 (FIG. Figures 20 and 21 ).
  • the rod 90 bears against the body 3 of the accessory 1 which is thus disengaged from the clamp 30 and falls into the used consumables storage container.
  • the clamp 30 is then available to enter a new accessory 1 in the accessory rack.
  • a standard robotic arm for example of the TECAN brand, is suitable for the 95 arm.
  • the accessory 101 comprises a body 103 having a frustoconical wall and has a spout 102 projecting transversely to the body 103.
  • the body 103 extends between an inlet opening 112 and a bottom wall 111.
  • the spout 102 has a cylindrical portion 108 ', one end of which is connected by interlocking in the body 103, and a pellet 107' attached to the cylindrical portion 108 'and having a frustoconical surface 107' '.
  • a capillary channel 104 formed in the portion cylindrical 108 ' extends from an outlet port 106 to a passage 105 through which the capillary channel 104 communicates with the space delimited by the body 103.
  • the accessory 201 is similar to the accessory 101 with the difference that the nozzle 202 of the accessory 201 is formed integrally with the body 203 also having a frustoconical wall.
  • the accessories 101 and 201 are used as the accessory 1 with the difference that they cooperate in mechanical connection with the pipette tip 24 since it is received interlocking in the frustoconical portion of the body 103 or 203 through the entrance opening 112 or 212.
  • the filling accessory 101 or 201 is provided, as the accessory 1, various elements for cooperation with a clamp such as the clamp 30, in this case a rib such as 13, tongues and tabs such as 14 and 15 and notches such as 16.
  • the filling accessory 101 or 201 is provided, as the accessory 1, a nozzle such as 2 having a cylindrical portion and a frustoconical portion such as 8 'and 7'.
  • the filling accessory 1 is provided, as the accessory 101 of a spout such as 102 having a cylindrical portion such as 108 'on which is reported a frustoconical pellet such as 107'.
  • the bottom wall 11 of the accessory 1 can be inclined at an angle of between 25 ° and 35 ° relative to the spout 2.
  • the bottom wall 11 'of the accessory 1' can be inclined at an angle of between 2.5 ° and 6.5 ° with respect to the spout 2.
  • the channel that includes the nozzle of the accessory is not capillary over the entire length of the nozzle but only on a portion located in the vicinity of the outlet to prevent spontaneous flow liquid through the spout.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Basic Packing Technique (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Packages (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
EP06764781.8A 2005-06-14 2006-06-13 Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre Not-in-force EP1893123B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0506014A FR2886931B1 (fr) 2005-06-14 2005-06-14 Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre
PCT/FR2006/001332 WO2006134265A1 (fr) 2005-06-14 2006-06-13 Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre

Publications (2)

Publication Number Publication Date
EP1893123A1 EP1893123A1 (fr) 2008-03-05
EP1893123B1 true EP1893123B1 (fr) 2017-08-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP06764781.8A Not-in-force EP1893123B1 (fr) 2005-06-14 2006-06-13 Procede pour conditionner dans une paillette une dose predeterminee de substance liquide et dispositif pour le mettre en oeuvre

Country Status (7)

Country Link
US (1) US9211171B2 (ru)
EP (1) EP1893123B1 (ru)
KR (1) KR101014212B1 (ru)
CN (1) CN101198292B (ru)
FR (1) FR2886931B1 (ru)
RU (1) RU2369357C1 (ru)
WO (1) WO2006134265A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951177B2 (en) * 2010-01-15 2015-02-10 Graphic Packaging International, Inc. Flight lug for octagonal cartons
EP3386297A1 (en) 2015-12-07 2018-10-17 CooperSurgical, Inc. Low temperature specimen carriers and related methods
US20170297013A1 (en) * 2016-04-14 2017-10-19 Jesse Cohen Universal Transfer Pipette
RU177752U1 (ru) * 2016-12-29 2018-03-12 Общество с ограниченной ответственностью "Фармпласт" Катетер для искусственного осеменения птиц и домашних животных
RU175564U1 (ru) * 2016-12-29 2017-12-11 Общество с ограниченной ответственностью "Фармпласт" Устройство для заполнения жидкостью катетера для искусственного осеменения птиц и домашних животных
CN114348321B (zh) * 2022-01-26 2023-08-04 江苏集萃药康生物科技股份有限公司 一种动物遗传物质自动装管设备

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Also Published As

Publication number Publication date
US9211171B2 (en) 2015-12-15
EP1893123A1 (fr) 2008-03-05
KR101014212B1 (ko) 2011-02-14
CN101198292A (zh) 2008-06-11
US20080202628A1 (en) 2008-08-28
CN101198292B (zh) 2010-09-01
FR2886931A1 (fr) 2006-12-15
RU2369357C1 (ru) 2009-10-10
RU2008101412A (ru) 2009-07-20
KR20080023321A (ko) 2008-03-13
FR2886931B1 (fr) 2007-08-17
WO2006134265A1 (fr) 2006-12-21

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