EP1891388B1 - Refrigerator for storing vials and cartridge for use in the same - Google Patents

Refrigerator for storing vials and cartridge for use in the same Download PDF

Info

Publication number
EP1891388B1
EP1891388B1 EP06763444.4A EP06763444A EP1891388B1 EP 1891388 B1 EP1891388 B1 EP 1891388B1 EP 06763444 A EP06763444 A EP 06763444A EP 1891388 B1 EP1891388 B1 EP 1891388B1
Authority
EP
European Patent Office
Prior art keywords
vials
refrigerator
guides
columns
internal space
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP06763444.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1891388A1 (en
Inventor
Stephen Murray
Gaynor Hillier
Philip Nigel Bordet-Stead
Tanja Langgner
David Helps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intervet International BV
Original Assignee
Intervet International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/144,955 external-priority patent/US8156755B2/en
Application filed by Intervet International BV filed Critical Intervet International BV
Priority to EP06763444.4A priority Critical patent/EP1891388B1/en
Publication of EP1891388A1 publication Critical patent/EP1891388A1/en
Application granted granted Critical
Publication of EP1891388B1 publication Critical patent/EP1891388B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D25/00—Charging, supporting, and discharging the articles to be cooled
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
    • F25D2400/10—Refrigerator top-coolers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D31/00—Other cooling or freezing apparatus
    • F25D31/006—Other cooling or freezing apparatus specially adapted for cooling receptacles, e.g. tanks

Definitions

  • the invention relates to a refrigerator for storing vials containing a (bio)pharmaceutical substance, in particular vaccines for animals, comprising a cabinet having an internal space for accommodating the vials arranged in columns, a cooling element for cooling the internal space and at least one door or dispenser for removing vials from the internal space.
  • the invention also relates to a cartridge suitable for use in such a refrigerator.
  • German utility model DE 20007889 U1 relates to an insulated case (denoted by numeral 1 in the Figures) for medication, having a thermal insulation layer (2), holders for ampoules, a heat deflection plate (4) linked to a Peltier module (5), and a fan.
  • An electronic control block (6) has a voltage control, an operating voltage control system, an overheating protection system and a thermostat. The control block (6) controls the Peltier module (5) and the fan. Further, the front wall of the case serves as a door.
  • WO 87/07704 relates to a refrigerant cell designed to receive insulin ampoules. Its size is such that it can accommodate ampoules of all European manufactures.
  • the refrigerant cell is suitable for a refrigeration unit designed for mains and battery use.
  • DK 468 380 relates to a device for a refrigerator driven by a compressor with a cold accumulator placed against the side walls in the storing compartment of the refrigerator in order to enable the use of the refrigerator with maintained storing temperature even under long-term conditions of disruption of the power supply to the compressor.
  • the cold accumulator consists of a number of vertical tubes 17 standing tightly against each other and containing a fluid having a freezing point around 0 degrees centigrade.
  • the tubes 17 are brought into place by means of a top frame 18 resting on a flat 19 in the upper edge of the refrigerator and having a chute for the tubes.
  • US 4,194,647 A1 discloses a refrigerator according to the preamble of claim 1.
  • each of the guides or each set of guides comprises a dispensing section where the vials can be readily removed from the guides, preferably on one end of the respective guide or set of guides.
  • the guides facilitate a more systematic, safe and/or hygienic use of the refrigerator and, as will explained below, enable the use of one or more relatively small entrances e.g. one or more relatively small doors or dispensers, such as a one or more drawers or air locks.
  • the columns extend in a direction having a vertical component, i.e. not horizontally, and/or that at least some of the guides are associated with a means, such as a spring, for biasing the vials towards the dispensing section.
  • a means such as a spring
  • gravity and/or a spring or the like can be employed to urge the vials towards e.g. a dispensing section at one end of the guides, thus holding the vial(s) at the said dispensing section in place and pushing remaining vials towards the dispensing section when a vial in that section is removed.
  • the door(s) respectively the dispenser(s) is (are) located at the dispensing section of one or more columns and allows (allow) access to a limited number of vials or even a single vial, fluctuations of temperature inside the internal space are effectively reduced.
  • the cabinet comprises at least two mutually detachable housings, a first housing containing the vials, and a second housing comprising the cooling element.
  • the first housing is portable and can be taken along by e.g. a doctor or veterinarian.
  • the means of transport of the said person(s) typically a car or van, or, for instance, a second surgery or annex, is equipped with an auxiliary second housing comprising a cooling element.
  • the invention also relates to a cartridge for use in a refrigerator described above, comprising guides adapted to slidingly accommodate a plurality of vials.
  • Such cartridges can be employed as a means for packaging a plurality of vials and facilitate distribution of the vials and refilling of the cabinet.
  • the word 'cartridge' includes cassettes, clips, and indeed any entity suitable for slidingly holding a column of vials.
  • FIG. 1 shows a refrigerator 1 according to the present invention for storing vials containing a pharmaceutical or biopharmaceutical substance, in particular vaccines for animals.
  • the refrigerator 1 comprises a cabinet 2 having a rear housing 3 to be mounted on a wall or inside a vehicle and a front housing 4 detachably mounted, e.g. by means of hooks and slots, magnets or Velcro, on the front side of the rear housing 3.
  • the rear housing 3 contains a cooling element (not shown), preferably a Peltier element sandwiched between two thermally conductive plates, e.g. two aluminium plates, the front one of which extends over a substantial section of the front wall of the rear housing 3. Ventilation grids 5 are included in the bottom and top surfaces. Further, the rear housing 3 comprises a ventilator for cooling the hot side of the cooling element, a control unit connected to the cooling element and the ventilator, as well as to a connector provided in the front wall of the rear housing 3, and a battery pack or a transformer to be connected to the mains or a battery of a vehicle.
  • a cooling element not shown
  • a Peltier element sandwiched between two thermally conductive plates, e.g. two aluminium plates
  • Ventilation grids 5 are included in the bottom and top surfaces.
  • the rear housing 3 comprises a ventilator for cooling the hot side of the cooling element, a control unit connected to the cooling element and the ventilator, as well as to a connector provided in the front wall of
  • the front housing 4 corresponds in width and height to the rear housing 3 and comprises three sets of doors 6, 7, 8, all providing access to an internal space 9 accommodating a large number of vials 10 arranged in substantially vertical columns along guides, as will be explained below.
  • the lowermost doors 8 extend substantially vertically and the upper rim of each of these doors 6 is pivotally connected to the front housing 4. By pivoting one of these doors 8 forwards and upwards, the lowermost vials 10 in a group of e.g. three adjacent columns is exposed, thus allowing removal of the vials 10 from the respective columns.
  • the uppermost doors 6 extend substantially horizontally and are pivotally mounted in the upper wall of the front housing 4. By pivoting one of these doors 6 upwards and backwards, again a group of e.g. three adjacent columns of vials 10 is exposed.
  • the rear wall of the front housing 4 abuts the Peltier element.
  • elongated cartridges 11 are removably mounted side-by-side in the space 9.
  • FIG. 2A and 2B An example of a preferred cartridge 11, intended for use in the present refrigerator 1, is shown in Figures 2A and 2B .
  • This preferred cartridge 11 comprises two parallel side walls 12 connected by a rear wall 13 and a bottom wall 14.
  • the side walls 12 are separated by a distance that is slightly larger than the width of the vials 10.
  • the bottom wall 14 has been adapted to the shape of the vials 10, i.e. has a semicircular cross-section.
  • Two retaining strips 15, inclined towards the plane of symmetry of the cartridge 11, extend along almost the entire length of the side walls 12, i.e. to a distance above the bottom wall 14 that corresponds to the width of the vials 10.
  • the retaining strips 15 form effective guides for slidingly holding a column of vials 10 and define a dispensing position at the bottom end of the cartridge 11, i.e. the lowermost vial 10 can be pulled out of the cartridge 11 in a direction substantially perpendicular to the column of remaining vials.
  • the cartridge 11 further comprise a filling section, preferably on the other end of the cartridge 11 as shown in Figures 2A and 2B .
  • the cartridge 11 can be filled by entering vials into a top opening of the cartridge 11 with the necks of the vials 10 sliding in between the retaining strips 15.
  • the front wall of the front housing 4 further comprises one or more e.g. two relatively large doors 7 providing access to the internal space 9 for maintenance or cleaning.
  • the front wall is fixedly attached to or forms an integral whole with the front housing 4.
  • the front wall further comprises a switch to turn the Peltier element on or off and a warning light to indicate that a selected threshold value, stored in the control unit, for minimum temperature has been reached.
  • the cabinet can be provided with e.g. a regulator for setting the required temperature, a small display showing the set and/or actual temperature (measured e.g. by means of thermocouples located in the internal space), and/or a speaker for sounding an alarm when the selected threshold has been reached.
  • the rear wall of the front housing is provided with a connector-counterpart, which is detachably connected to the connector on the front wall of the rear housing and which thus connects the said switch, warning light, regulator, display and other elements for operating the refrigerator to the control unit.
  • the walls of the rear and front sections are preferably made of an injection moulded thermoplastic polymer, such as ABS, PC or a fibre-filled PP.
  • the walls of at least the front housing are thermally insulated by means of e.g. a layer of an expanded polyurethane or polyester foam and, optionally, a reflective film of aluminium, sandwiched between inner and outer walls of the said injection moulded thermoplastic polymer. Insulated sections on the doors are preferably surrounded by seals (16), such as rubber rings.
  • part of the front wall e.g. the lower sections of the relatively large doors 7, are made of a transparent material, such as a clear double-skinned PS or PC, so as to allow personnel using the cabinet to see which vials, and hence which pharmaceutical substance, is in which row.
  • a transparent material such as a clear double-skinned PS or PC
  • the cartridges are also preferably made of an injection moulded thermoplastic polymer, in particular a clear PC.
  • the refrigerator is mounted on e.g. a wall of a surgery of a veterinarian, the Peltier element is switched on and, when a sufficiently low temperature has been reached, the top doors are opened and cartridges, each containing a plurality of vials, are loaded into the internal space.
  • the vials in each cartridges or group of cartridges contain a different vaccine and include, for instance, cartridges containing freeze-dried pellets (lyophilisates or "cakes") of PPi, Parvo-C, Corona, KC, DHPPI, and Puppy DP (as denoted in the Intervet product catalogue 2005).
  • a vial is taken from the appropriate column and a diluent, typically water, a water-in-oil emulsion or an oil-in-water emulsion is injected into the vial to obtain an injectable substance.
  • a diluent typically water, a water-in-oil emulsion or an oil-in-water emulsion is injected into the vial to obtain an injectable substance.
  • the refrigerator according to the present invention facilitates or even imposes a more systematic, safe and/or hygienic use and that only a limited amount of the cooled air inside the refrigerator will escape during the removal of a vial, substantially avoiding a significant reduction of the temperature inside.
  • the cartridges can be filled with individual vials by personnel using the present refrigerator, e.g. by a veterinary or an assistant, it is preferred to distribute, through existing channels, pre-filled cartridges or even pre-filled (front) housings containing columns of vials.
  • the cabinet preferably comprises an additional compartment for storing pre-filled syringes or a diluent.
  • the cooling (Peltier) element does not extend over the compartment for storing the diluent or that this compartment is isolated from the cooling element.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Refrigerator Housings (AREA)
EP06763444.4A 2005-06-03 2006-06-01 Refrigerator for storing vials and cartridge for use in the same Active EP1891388B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06763444.4A EP1891388B1 (en) 2005-06-03 2006-06-01 Refrigerator for storing vials and cartridge for use in the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05104880 2005-06-03
US11/144,955 US8156755B2 (en) 2005-06-03 2005-06-03 Refrigerator for storing vials and cartridge for use in the same
PCT/EP2006/062819 WO2006128897A1 (en) 2005-06-03 2006-06-01 Refrigerator for storing vials and cartridge for use in the same
EP06763444.4A EP1891388B1 (en) 2005-06-03 2006-06-01 Refrigerator for storing vials and cartridge for use in the same

Publications (2)

Publication Number Publication Date
EP1891388A1 EP1891388A1 (en) 2008-02-27
EP1891388B1 true EP1891388B1 (en) 2018-12-26

Family

ID=36748359

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06763444.4A Active EP1891388B1 (en) 2005-06-03 2006-06-01 Refrigerator for storing vials and cartridge for use in the same

Country Status (10)

Country Link
EP (1) EP1891388B1 (ja)
JP (1) JP5006872B2 (ja)
CN (1) CN101218478B (ja)
AU (1) AU2006254092B2 (ja)
BR (1) BRPI0611010B1 (ja)
DK (1) DK1891388T3 (ja)
ES (1) ES2714380T3 (ja)
PT (1) PT1891388T (ja)
RU (1) RU2367858C1 (ja)
WO (1) WO2006128897A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700055004A1 (it) * 2017-05-22 2018-11-22 Simone Morosini Contenitore porta-cartucce
CN114963640B (zh) * 2021-02-18 2024-05-24 内蒙古伊利实业集团股份有限公司 门组件及冷柜
CN113623914B (zh) * 2021-07-22 2023-05-02 肇庆医学高等专科学校 一种预防医学疫苗低温存放箱

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1695956A (en) * 1928-12-18 frig k
US1633588A (en) * 1923-04-30 1927-06-28 Klinenberg Edward Ice-cream cabinet
US2826471A (en) * 1953-09-22 1958-03-11 Gen Electric Frozen fruit juice dispenser
US4194647A (en) * 1978-01-30 1980-03-25 Spurrier Harry A Cooler chest and dispenser structure
JPS6333853U (ja) * 1986-08-21 1988-03-04
JPS6453885U (ja) * 1987-09-29 1989-04-03
US5142872A (en) * 1990-04-26 1992-09-01 Forma Scientific, Inc. Laboratory freezer appliance
JP3354219B2 (ja) * 1993-07-07 2002-12-09 三洋電機株式会社 薬品保管庫
US5950450A (en) * 1996-06-12 1999-09-14 Vacupanel, Inc. Containment system for transporting and storing temperature-sensitive materials
JP2001349653A (ja) * 2000-06-08 2001-12-21 Ishikawajima Harima Heavy Ind Co Ltd 冷温蔵容器
US6536609B2 (en) * 2000-12-29 2003-03-25 Merck & Co., Inc. Vial dispenser
CN2648362Y (zh) * 2003-08-10 2004-10-13 叶永丰 微型胰岛素冷藏盒

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
AU2006254092B2 (en) 2010-10-14
JP2008545485A (ja) 2008-12-18
CN101218478A (zh) 2008-07-09
EP1891388A1 (en) 2008-02-27
WO2006128897A1 (en) 2006-12-07
BRPI0611010B1 (pt) 2018-10-16
CN101218478B (zh) 2011-03-02
ES2714380T3 (es) 2019-05-28
PT1891388T (pt) 2019-04-08
AU2006254092A1 (en) 2006-12-07
RU2367858C1 (ru) 2009-09-20
BRPI0611010A2 (pt) 2011-02-22
JP5006872B2 (ja) 2012-08-22
DK1891388T3 (en) 2019-04-08

Similar Documents

Publication Publication Date Title
US8156755B2 (en) Refrigerator for storing vials and cartridge for use in the same
EP2799337B1 (en) Vertically mounted dry ice cooling compartment applied to a galley cart for temperature gradient reduction
US6660974B2 (en) Warming system and method for heating various items utilized in surgical procedures
US7240513B1 (en) Thermally-controlled package
US20060174648A1 (en) Insulated shipping container and method
US20220011042A1 (en) Controlled inventory refrigerated dispensing system
US20080164265A1 (en) Thermally-controlled package
US4831840A (en) Ice maker with covered ice tray
WO2005013778A2 (en) Refrigeration/retherma- lization food delivery system
EP1891388B1 (en) Refrigerator for storing vials and cartridge for use in the same
PL192956B1 (pl) Sposób oraz zespół pojemnika i paneli izolujących do transportowania lub przechowywania towarów, w szczególności produktów spożywczych w stanie zamrożonym i/lub schłodzonym
US4916921A (en) Ice maker with vertical cooling member
US20020184906A1 (en) Temperature controlled cabinet system and method employing a thermal barrier to thermally isolate the cabinet interior from the ambient environment
US20210190417A1 (en) Cooling plate assembly and method
WO2022263840A1 (en) Transport pods
US11274026B2 (en) Dispenser cartridge for the cooled storage and dispensing of liquid or semi-liquid foodstuffs and dispenser machine for the use of such a dispenser cartridge
EP2798990A1 (en) Mobile service cart with closed circulation system
US7640769B1 (en) Portable self-contained storage apparatus for biologicals
EP2092861B1 (en) Sales furniture
GB2608109A (en) A locker system, a docking station, and a transport locker pod.
CN219330543U (zh) 一种细胞制品低温运输箱
GB2577683A (en) A portable temperature-stable storage device
KR200287786Y1 (ko) 온냉 배식차
JP6638809B2 (ja) 保冷装置
GB2607965A (en) A dockable pod system, a docking station, and a temperature-controlled transport pod

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080103

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20161219

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20180910

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602006057145

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1081976

Country of ref document: AT

Kind code of ref document: T

Effective date: 20190115

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

Effective date: 20190401

Ref country code: PT

Ref legal event code: SC4A

Ref document number: 1891388

Country of ref document: PT

Date of ref document: 20190408

Kind code of ref document: T

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20190304

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190326

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2714380

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20190528

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190327

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1081976

Country of ref document: AT

Kind code of ref document: T

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190426

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602006057145

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20190927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190601

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20200529

Year of fee payment: 15

Ref country code: FI

Payment date: 20200527

Year of fee payment: 15

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181226

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20060601

REG Reference to a national code

Ref country code: FI

Ref legal event code: MAE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210601

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210630

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210630

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20230315

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20230526

Year of fee payment: 18

Ref country code: IT

Payment date: 20230612

Year of fee payment: 18

Ref country code: FR

Payment date: 20230509

Year of fee payment: 18

Ref country code: DK

Payment date: 20230526

Year of fee payment: 18

Ref country code: DE

Payment date: 20230509

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20230510

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20230703

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240514

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20240509

Year of fee payment: 19