EP1872743B1 - Assemblage de valve cardiovasculaire doté d'une station d'accueil redimensionnable - Google Patents

Assemblage de valve cardiovasculaire doté d'une station d'accueil redimensionnable Download PDF

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Publication number
EP1872743B1
EP1872743B1 EP07111254A EP07111254A EP1872743B1 EP 1872743 B1 EP1872743 B1 EP 1872743B1 EP 07111254 A EP07111254 A EP 07111254A EP 07111254 A EP07111254 A EP 07111254A EP 1872743 B1 EP1872743 B1 EP 1872743B1
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EP
European Patent Office
Prior art keywords
valve
tubular body
base member
diameter
valve assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP07111254A
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German (de)
English (en)
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EP1872743A1 (fr
Inventor
Ivan Vesely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ValveXchange Inc
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ValveXchange Inc
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Filing date
Publication date
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Publication of EP1872743A1 publication Critical patent/EP1872743A1/fr
Application granted granted Critical
Publication of EP1872743B1 publication Critical patent/EP1872743B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0004—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable
    • A61F2250/001—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof adjustable for adjusting a diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0082—Additional features; Implant or prostheses properties not otherwise provided for specially designed for children, e.g. having means for adjusting to their growth

Definitions

  • the present invention relates generally to a cardiovascular valve assembly, and more specifically relates to a cardiovascular valve assembly comprised of a resizable base member that remains in a patient, and a valve member that is detachably mountable to the resizable base member.
  • a valve member may require periodic replacement due to wear. Accordingly, the current valve member is detached from the permanent base member and a new valve member is mounted thereto. It may also be necessary to replace the current valve member because the patient has grown and requires a valve member having larger dimensions. In this regard, children need frequent valve member replacements as they grow to full adult size. However, existing base members have a fixed diameter, thus preventing a simple exchange of valve members with different dimensions.
  • One purpose of the present invention is to address the needs of a child patient who may have valve problems (e.g., pulmonary stenosis).
  • valve problems e.g., pulmonary stenosis
  • catheter deployable valves are permanent devices. There is no provision for replacing such valves percutaneously when the valve fails or needs to be replaced due to sizing issues. It is generally thought that a single percutaneous deployment of a valve will avoid the first surgery and allow the patient to mature and recover for a few years until it is time for the first revision surgery.
  • the present invention address the drawbacks of existing cardiovascular valve assemblies by providing a valve assembly including a resizable base member that is adaptable to receive valve members of various sizes.
  • WO 2006/127756 A2 which forms prior art pursuant to Art. 54(3) and (4) EPC, describes a component-based valve prosthesis that can be implanted during a surgical procedure.
  • the valve comprises a support structure and a valve member that may be connected to the support structure.
  • the support structure may take the form of a balloon-expandable stent.
  • the support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body.
  • US 2004/0030381 A1 describes a heart valve prosthesis having a frame that includes one outwardly extending annular flange adjacent to a suturing ring or a band comprising an inwardly extending annular flange that is capable of engagement with the annular flange of the frame.
  • US 6,454,799 B1 describes an expandable heart valve that includes an annular tissue-engaging base and a subassembly having an elastic wireform and a plurality of leaflets connected thereto.
  • the annular base and subassembly are separately stored and connected just prior to delivery to the host annulus.
  • a valve assembly comprising: a base member deformable to increase the dimensions thereof; and a valve member including a valve frame and a plurality of leaflets supported by the valve frame, said valve member detachably mountable to said base member.
  • a valve assembly comprising: (a) a base member deformable to increase the dimensions thereof, said base member including: a tubular body having an adjustable diameter, a plurality of mounting elements attached to the tubular body, a plurality of securing elements attached to the tubular body; and (b) a valve member detachably mountable to said base member, said valve member including: a valve frame and a plurality of leaflets supported by the valve frame, a plurality of coupling elements attached to the valve frame, each said coupling element engageable with a respective mounting element to detachably mount said valve member to said base member, and a plurality of fingers attached to the valve frame, each finger capturable by a respective securing element of the base member.
  • An advantage of the present invention is the provision of a cardiovascular valve assembly including a base member that is expandable to receive valve members of varying dimensions.
  • Still another advantage of the present invention is the provision of a cardiovascular valve assembly including an exchangeable valve member that is mountable to an expandable base member.
  • FIG. 1 illustrates a fully assembled valve assembly according to an embodiment of the present invention
  • FIG. 2 is an exploded side elevational view of a valve assembly according to the present invention, including an unexpanded base member and a valve member of a first dimension detached therefrom.
  • FIG. 3 is an exploded said elevational view of a valve assembly according to the present invention, including an expanded base member and a valve member of a second dimension detached therefrom;
  • FIG. 4 is a perspective view of a valve member according to the present invention, with leaflet components removed therefrom;
  • FIG. 5 is an enlarged perspective view of engagement means for attaching a valve member to a base member
  • FIG. 6 shows the inner surface of an unexpanded base member in a planar profile
  • FIG. 7 shows the inner surface of an expanded base member in a planar profile
  • FIG. 8 is an enlarged side view of a securing element of the base member, according to a first embodiment of the securing element
  • FIG. 9 is a perspective view of the securing element of FIG. 8 ;
  • FIG. 10 is an enlarged side view of a securing element of the base member, according to a second embodiment of the securing element
  • FIG. 11 is a perspective view of the securing element of FIG. 10 ;
  • FIG. 12 is an enlarged side view of a securing element of the base member, according to a third embodiment of the securing element
  • FIG. 13 is a perspective view of the securing element of FIG. 12 ;
  • FIG. 14 is an enlarged perspective view of engagement means for attaching a valve member to a base member, according to an alternative embodiment of the engagement means.
  • FIG. 1 illustrates a fully assembled cardiovascular valve assembly 10 according to a first embodiment of the present invention.
  • Valve assembly 10 is basically comprised of a replaceable valve member 20 and an expandable base member 100.
  • Valve member 20 is generally comprised of a valve frame 30 and a plurality of pericardial leaflets 22 supported by valve frame 30.
  • Base member 100 is permanently installed in a patient by conventionally known means.
  • Valve member 20 is detachably mountable to base member 100, as will be described in detail below. It should be understood that valve member 20 and base member 100 may take forms other than as illustrated herein.
  • Wireform 40 may be formed of a single continuous material that comprises wireform sections 42, or may be formed of individual discrete wireform sections 42 that are joined together at coupling elements 80.
  • Wireform 40 is preferably made of a medical grade metal wire with suitable elasticity, such as Algiloy, nitinol, stainless steel, platinum, gold, titanium, other biocompatible metals, and combinations thereof. It should be understood that a preferred material for wireform 40 has an elasticity such that the material returns to its original shape after being deformed. However, it is contemplated that a material that does not return to its original shape after deformation could also be suitably used.
  • Base member 100 is generally comprised of a tubular body 110 and a mounting element 180.
  • Tubular body 110 has a first end 112 and a second end (not shown), and a wall 116 disposed between first end 112 and the second end.
  • First end 112 is the outflow end, while the second end is the inflow end, or vice versa.
  • Wall 116 is formed by a plurality of intersecting elongate members 122 and 124. At least some of the elongate members 122, 124 intersect with one another at intersection points 126.
  • Body 110 has a first diameter and is deformable to expand to a second diameter larger than the first diameter.
  • Body 110 is expanded by application of a radially, outwardly extending force from the interior of body 110.
  • body 110 may be expanded to the second diameter by inflating a balloon (e.g., a balloon catheter) located within the interior of body 110.
  • the second diameter of body 110 is variable and dependent upon the amount of force applied to the body 110.
  • the plurality of elongate members 122, 124 may be a plurality of wires.
  • the wires may be fixedly secured to one another where the wires intersect with one another to form a wire mesh. It is contemplated that the plurality of elongate members 122, 124 may take forms other than as illustrated.
  • Elongate members 122, 124 are made of a material having the required strength and elastic characteristics to allow expansion of body 110 (e.g., allow plastic deformation) and to allow body 110 to retain an expanded configuration.
  • suitable materials for the fabrication of body 110 include silver, tantalum, stainless steel, gold, and titanium.
  • tubular body may include mechanical tabs, teeth and/or hooks to prevent body 110 from returning to a smaller diameter after expansion, such as that used in a ratchet or in some intravascular stents.
  • the plurality of elongate members 122, 124 are fixedly secured to one another at intersection points 126, thereby forming a mesh tube.
  • a wire mesh tube is formed where elongate members 122, 124 are wires. It will be appreciated that elongate members 122, 124 may be fixedly secured to one another in any conventional manner (e.g., by welding, soldering, or gluing).
  • mounting element 180 includes an upper section 182 and a lower section 184. Sections 182 and 184 define an outward facing notch 188. Notch 188 is dimensioned to receive tab 88 of coupling element 80. Similarly, inward facing recess 82 of coupling element 80 is dimensioned to receive upper section 182 of mounting element 180.
  • mounting elements 180 are attached to tubular body 110 at first end 112. For example, mounting elements 180 may be welded to the inner or outer surfaces of tubular body 110, or welded to the edge of first end 112.
  • FIG. 14 illustrates an engagement means 260 according to an alternative embodiment.
  • Engagement means 260 includes a coupling member 280 having a projecting element 282 (e.g., a locking pin with a spike) and a bulb portion 283, and a mounting element 290 having a recess 292.
  • Recess 292 is dimensioned to mate with projecting element 282 by receiving at least a portion of projecting element 282.
  • Surface 294 of recess 292 conforms to the outward facing surface of projecting element 282. It should be appreciated that engagement means 60 may take forms other than those illustrated herein.
  • Base member 100 also includes securing elements 140 for capturing fingers 50 of valve frame 30.
  • each securing element 140 is comprised of a pair of arms 142, having first and second ends 144, 146, and a flexible strap 152. Arms 142 are pivotally connected to each other at first ends 144 by fastening means (e.g., a rivet or pin).
  • Second ends 146 of arms 142 are pivotally connected by fastening means to the inner side of tubular body 110 at respective intersection points 126, as shown in FIGS. 8 and 9 .
  • Strap 152 is attached at opposite ends to arms 142 by fastening means. Strap 152 extends between the pair of arms 142, thereby forming an opening 154. Opening 154 is dimensioned to receive a finger 50 of valve frame 30.
  • FIGS. 10 and 11 illustrate a securing element 160 according to an alternative embodiment.
  • Securing element 160 is comprised of a pair of arms 142, as discussed above, and an annular band 162.
  • Band 162 is attached to arms 142 by the same fastening means that connects arms 142 together at first ends 144.
  • Band 162 defines an opening 164 dimensioned to receive a finger 50 of valve frame 30.
  • FIGS. 12 and 13 illustrate a securing element 170 according to yet another alternative embodiment.
  • Securing element 170 is comprised of an annular band 172 fastened directly to the inner side of tubular body 110. As illustrated, band 172 is welded directly to an elongate member 122 or 124, preferably at an intersection point 126. Band 172 defines an opening 174 dimensioned to receive a finger 50 of valve frame 30.
  • Engagement means 60 together with the securing elements, maintain valve member 20 in engagement with base member 100.
  • FIG. 2 there is shown an unexpanded base member 100 having a first diameter and a detached valve member 20 having the first diameter.
  • the diameter of valve member 20 is defined by the spacing between adjacent coupling elements 80.
  • base member 100 is expandable to increase the diameter of tubular body 110, thereby dimensioning base member 100 to receive a valve member 20 having a larger diameter.
  • FIG. 3 shows an expanded base member 100 having a second diameter and a detached valve member 20 having the second diameter, wherein the second diameter is larger than the first diameter.
  • the diameter of tubular body 110 may be progressively increased in stages.
  • body 110 has detectable limits for each stage of diameter expansion. These limits may be comprised of interlocking tabs that generate variable resistance to expansion that can be felt or measured, or markers that are visible on fluoroscopy. Alternatively, limits may be set by the maximum expanded diameter of the balloon that is used to dilate tubular body 110 to the next dilated diameter.
  • tubular body 110 in a planar provide (i.e., unrolled as a planar mesh sheet).
  • base member 100 is unexpanded (i.e., first diameter), while in FIG. 7 base member 100 is expanded (i.e., second diameter).
  • D and D' represent the distance between adjacent mounting elements 180.
  • H and H' represents the distance between mounting element 180 of base member 100 and strap 152 of securing element 140.
  • the aspect ratio D'/H' is maintained to be substantially equal to the aspect ratio D/H, as base member 100 is expanded to increase the diameter of tubular body 110.
  • arms 142 of securing element 140 articulate or pivot relative to each other in a downward direction away from first end 112 of body 110, as shown in FIG. 7 .
  • strap 152 is formed of a flexible material that allows movement of arms 142. The movement of arms 142 substantially maintains the aspect ratio regardless of the amount by which the diameter of tubular body 110 is increased.
  • Base member 100 may be expanded, for example, by use of a balloon catheter, in a procedure similar to the placement of intracoronary stents in the field of interventional cardiology.
  • the distance between mounting elements 180 increases from distance D ( FIG. 6 ) to a new distance D' ( FIG. 7 ).
  • the increased distance between mounting elements 180 allows a valve member 20 of larger dimensions to be coupled to base member 100.
  • the diameter of tubular body 110 is increased to accept a valve frame 30 having a larger diameter.
  • Securing element 160 ( FIGS. 10 and 11 ) operates in substantially the same manner as securing element 140 described above in order to substantially maintain the aspect ratio.
  • securing element 170 ( FIGS. 12 and 13 ) does not substantially maintain the aspect ratio as the diameter of tubular body 110 is increased, since band 172 is directly attached to body 110 as described above. Accordingly, for the embodiment of base member 100 having securing elements 170, fingers 50 of valve frame 30 may require an increased length in order to be captured by band 172 when base member 100 is unexpanded (i.e., tubular body 110 has a small diameter).
  • a base member 100 is installed into the body of a patient (e.g., a pulmonary artery) by conventionally known means. It is contemplated that base member 100 is delivered percutaneously and deployed in place by way of catheter-based tools. Base member 100 may also be delivered by way of minimally invasive surgery. After installation of base member 100, tubular body 110 may dilated to a small diameter during a first procedure. A valve member 20 having a small diameter valve frame 30 can be docked with base member 100 by insertion of fingers 50 into opening 154 defined by strap 152 and the engagement of coupling element 80 with mounting element 180, as described in detail above.
  • valve member 20 with the small diameter valve frame 30 will be useable by a child through the first few years of life. After the child outgrows the small diameter valve frame 30, valve member 20 is detached from base member 100 by disengaging coupling element 80 from mounting element 180 and removing fingers 50 from the opening 154 defined by strap 152.
  • FIG. 2 illustrates the removal of a valve member 20 having a small diameter valve frame 30.
  • tubular body 110 of base member 100 may be further dilated (e.g., with use of a balloon) to increase the diameter thereof.
  • the diameter of body 110 can be determined with good precision by use of the dilating balloon.
  • a valve member 20 having a larger diameter valve frame 30 may then be installed in a manner similar to the installation of the original valve member 20 having the small diameter valve frame 40.
  • FIG. 3 illustrates the installation of a valve member 20 having a large diameter valve frame 30 after dilation of tubular body 110 to increase the diameter thereof. It should be appreciated that the diameter of tubular body 110 can be sequentially increased to receive a series of valve members 20 having incrementally larger diameter valve frames 30.
  • Valve frame 30 can be made to incremental diameter sizes, thereby allowing valve member 20 to be readily fit to a base member 100 having a tubular body 110 of an increased diameter.
  • Valve member 20 can be repeatedly "upsized” as a child grows by repeatedly enlarging or dilating tubular body 110, and replacing the current valve member 20 with a new valve member 20 having a larger diameter valve frame 30.
  • cardiovascular valve assembly 10 of the present invention can take a child through the early stages of life onto adolescence and adulthood.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)

Claims (7)

  1. Assemblage de valve comprenant :
    un élément de base (100) comprenant :
    un corps tubulaire (110) expansible qui peut être déformé pour
    agrandir un diamètre de celui-ci,
    une pluralité d'éléments de montage (180) fixés au corps tubulaire (110), et
    un élément de valve (20) pouvant être monté de manière détachable sur l'élément de base (100), dans lequel l'élément de valve (20) comprend :
    un cadre de valve (30),
    une pluralité de lames (22) supportées par le cadre de valve (30),
    et
    une pluralité d'éléments d'accouplement (80) fixés au cadre de valve (30), chacun desdits éléments d'accouplement (80) pouvant être rattaché à un élément de montage (180) respectif dudit élément de base (100) pour monter de manière détachable ledit élément de valve (20) sur ledit élément de base (100),
    caractérisé par
    une pluralité d'éléments de fixation (140 ; 160 ; 170) fixés au corps tubulaire, lesdits éléments de fixation (140 ; 160 ; 170) étant mobiles par rapport au corps tubulaire (110) pour maintenir sensiblement un rapport d'aspect D/H alors que le diamètre du corps tubulaire (110) est augmenté, où D est la distance entre des éléments de montage (180) adjacents et H est la distance entre les éléments de montage (180) et les éléments de fixation (140 ; 160 ; 170),
    dans lequel la pluralité d'éléments de fixation (140 ; 160 ; 170) de l'élément de base (100) maintient l'élément de valve (20) en prise avec l'élément de base (100).
  2. Assemblage de valve selon la revendication 1, dans lequel ledit corps tubulaire (110) est un filet composé d'une pluralité d'éléments allongés (122, 124) se croisant, lesdits éléments allongés (122, 124) se croisant en des points d'intersection (126).
  3. Assemblage de valve selon la revendication 1, dans lequel ledit diamètre dudit corps tubulaire (110) est agrandi séquentiellement pour recevoir une série d'éléments de valve (20) ayant des cadres de valve (30) de diamètre incrémentalement plus grand.
  4. Assemblage de valve selon la revendication 1, dans lequel ledit élément de valve (20) comprend des doigts (50) s'étendant à partir du cadre de valve (30), lesdits doigts (50) étant capturés par ladite pluralité d'éléments de fixation (140 ; 160 ; 170) lorsque ledit élément de valve (20) est monté sur ledit élément de base (100).
  5. Assemblage de valve selon la revendication 4, dans lequel chacun desdits éléments de fixation (140 ; 160 ; 170) comprend :
    une paire de bras (142) reliés de manière pivotante audit corps tubulaire (110), lesdits bras (142) étant mobiles l'un par rapport à l'autre lorsque le diamètre dudit corps tubulaire (110) est augmenté ; et
    une sangle (152) s'étendant entre lesdits deux bras (142) pour définir une ouverture dimensionnée pour recevoir l'un desdits doigts (50).
  6. Assemblage de valve selon la revendication 4, dans lequel chacun desdits éléments de fixation (140 ; 160 ; 170) comprend :
    une paire de bras (142) reliés de manière pivotante audit corps tubulaire (110), lesdits bras (142) étant mobiles l'un par rapport à l'autre lorsque le diamètre dudit corps tubulaire (110) est ajusté ; et
    une bande (162) fixée à ladite paire de bras (142) pour définir une ouverture dimensionnée pour recevoir l'un desdits doigts (50).
  7. Assemblage de valve selon la revendication 4, dans lequel chacun desdits éléments de fixation (140 ; 160 ; 170) comprend :
    une bande (162) fixée audit corps tubulaire (110) pour définir une ouverture dimensionnée pour recevoir l'un desdits doigts (50).
EP07111254A 2006-06-29 2007-06-28 Assemblage de valve cardiovasculaire doté d'une station d'accueil redimensionnable Not-in-force EP1872743B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80610606P 2006-06-29 2006-06-29
US11/760,840 US20080004696A1 (en) 2006-06-29 2007-06-11 Cardiovascular valve assembly with resizable docking station

Publications (2)

Publication Number Publication Date
EP1872743A1 EP1872743A1 (fr) 2008-01-02
EP1872743B1 true EP1872743B1 (fr) 2009-08-05

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Application Number Title Priority Date Filing Date
EP07111254A Not-in-force EP1872743B1 (fr) 2006-06-29 2007-06-28 Assemblage de valve cardiovasculaire doté d'une station d'accueil redimensionnable

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Country Link
US (1) US20080004696A1 (fr)
EP (1) EP1872743B1 (fr)
AT (1) ATE438358T1 (fr)
CA (1) CA2592128C (fr)
DE (1) DE602007001836D1 (fr)

Cited By (19)

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US8226707B2 (en) 2008-07-21 2012-07-24 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US8613765B2 (en) 2008-02-28 2013-12-24 Medtronic, Inc. Prosthetic heart valve systems
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US9039756B2 (en) 2008-07-21 2015-05-26 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US9301860B2 (en) 2013-03-13 2016-04-05 Jenesis Surgical, Llc Articulated commissure valve stents and methods
US9700442B2 (en) 2013-11-11 2017-07-11 Edwards Lifesciences Cardiaq Llc Methods for manufacturing a stent frame
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
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US8961593B2 (en) 2008-02-28 2015-02-24 Medtronic, Inc. Prosthetic heart valve systems
US9364323B2 (en) 2008-07-21 2016-06-14 Jennifer K. White Repositionable endoluminal support structure and its applications
US8685080B2 (en) 2008-07-21 2014-04-01 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US8226707B2 (en) 2008-07-21 2012-07-24 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US8852261B2 (en) 2008-07-21 2014-10-07 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US9005272B2 (en) 2008-07-21 2015-04-14 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US9039756B2 (en) 2008-07-21 2015-05-26 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US9259314B2 (en) 2008-07-21 2016-02-16 Jenesis Surgical, Llc Repositionable endoluminal support structure and its applications
US9801714B2 (en) 2008-07-21 2017-10-31 Edwards Lifesciences Cardiaq Llc Repositionable endoluminal support structure and its applications
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US11419720B2 (en) 2010-05-05 2022-08-23 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US11413139B2 (en) 2011-11-23 2022-08-16 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11497602B2 (en) 2012-02-14 2022-11-15 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US10940001B2 (en) 2012-05-30 2021-03-09 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11389294B2 (en) 2012-05-30 2022-07-19 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US11617650B2 (en) 2012-05-30 2023-04-04 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9301860B2 (en) 2013-03-13 2016-04-05 Jenesis Surgical, Llc Articulated commissure valve stents and methods
US11389291B2 (en) 2013-04-04 2022-07-19 Neovase Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9700442B2 (en) 2013-11-11 2017-07-11 Edwards Lifesciences Cardiaq Llc Methods for manufacturing a stent frame
US11357622B2 (en) 2016-01-29 2022-06-14 Neovase Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US11464631B2 (en) 2016-11-21 2022-10-11 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11793640B2 (en) 2017-08-25 2023-10-24 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
US11491006B2 (en) 2019-04-10 2022-11-08 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
US11931254B2 (en) 2019-06-20 2024-03-19 Neovasc Tiara Inc. Low profile prosthetic mitral valve

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DE602007001836D1 (de) 2009-09-17
US20080004696A1 (en) 2008-01-03
CA2592128A1 (fr) 2007-12-29
EP1872743A1 (fr) 2008-01-02
ATE438358T1 (de) 2009-08-15
CA2592128C (fr) 2010-03-16

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