EP1859869A1 - Appareil électrique de dosage pour liquide - Google Patents

Appareil électrique de dosage pour liquide Download PDF

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Publication number
EP1859869A1
EP1859869A1 EP07008387A EP07008387A EP1859869A1 EP 1859869 A1 EP1859869 A1 EP 1859869A1 EP 07008387 A EP07008387 A EP 07008387A EP 07008387 A EP07008387 A EP 07008387A EP 1859869 A1 EP1859869 A1 EP 1859869A1
Authority
EP
European Patent Office
Prior art keywords
dosing device
mode
dosing
control
menu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP07008387A
Other languages
German (de)
English (en)
Other versions
EP1859869B1 (fr
Inventor
Peter Dipl.-Ing. Molitor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Priority to EP10011969.2A priority Critical patent/EP2283927B1/fr
Publication of EP1859869A1 publication Critical patent/EP1859869A1/fr
Application granted granted Critical
Publication of EP1859869B1 publication Critical patent/EP1859869B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0237—Details of electronic control, e.g. relating to user interface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/087—Ergonomic aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED

Definitions

  • the invention relates to an electronic dosing device for dosing liquids.
  • Electronic dosing devices for dosing liquids have a drive with an electric motor and a displacement device driven by this drive, which, e.g. a cylinder with a piston arranged therein displaceably comprises.
  • the displacer is e.g. communicating with a replaceable pipette tip.
  • an air cushion is displaced, which sucks liquid into the pipette tip or expels it.
  • positive displacement pipettes have a replaceable syringe that sucks or expels liquid.
  • Pipette tips and syringes are preferably disposable plastic disposable articles.
  • Known electronic dosing devices have a multiplicity of operating elements with which, in particular, the operating mode of the dosing device is selected, the respective parameters are set and the working of the dosing device is controlled.
  • the operation of the known metering devices is cumbersome. It is also disadvantageous that the control of the delivery and absorption of liquid via a single button, which must be actuated to trigger or stop the piston movement in a predetermined manner, so that the operation of electronic dosing deviates greatly from the operation of manual dosing.
  • the object of the invention is to provide an electronic dosing device which facilitates the operation of the user.
  • the change between the various menus is controlled by means of the electrical mode key and the electrical parameter key.
  • the navigation in the menus and the setting of parameters is done by means of the electrical control buttons.
  • the term "navigation" refers to the movement from menu item to menu item, for example, by a pointer pointing to the menu item or by highlighting the menu item is shown.
  • the electrical control keys are also used to control the movement of the displacer element. By operating the one control key, the navigation in the menus, the setting of parameters and the displacement of the displacer in one direction and actuation of the other control key, navigate the menus, set parameters and displace the displacer in the other Directed direction. With the help of the display device, the user can view the menus. If necessary. It can recognize the current operating status of the dosing device, eg a selected operating mode and set parameters.
  • the dosing device has a small number of operating elements. Due to the combination of a few controls with a display device an intuitive and self-explanatory operation is achieved by the user.
  • the recording of supernatants, the stopping of the recording and resuming the recording, the gel loading, stopping the delivery and resuming the delivery, repeating the Göblashubes for blowing out residual amounts of liquid, etc. allows or facilitates.
  • the metering device comes with few controls, simplifies the operations and allows a similar operation as in manual metering devices.
  • the metering device has an electrical power supply for supplying all the electrical equipment of the metering device, in particular for supplying the electric motor, the mode key, the parameter key, the control keys, the display device and the control device.
  • the power supply is e.g. a power supply, at least one battery (possibly with charger) or at least one battery.
  • the control device controls the display of particular operating modes of the metering related submenus and a multi-mode main menu by the display device according to the operation of the mode key and the parameter key.
  • the submenus concern e.g. one or more of the modes pipetting, dispensing, manual pipetting, calibration, set-up, titration, automatic dispensing, gel loading, pipetting and mixing.
  • the main menu shows all operating modes and allows a selection. The user can thus select an operating mode of the metering device with the help of the main menu.
  • the control device controls the change from a submenu relating to a specific operating mode of the metering device to a main menu relating to a plurality of operating modes of the metering device and / or the change from the latter said main menu in a specific mode of the dosing device concerning submenu with selectable menu items and / or the change from the aforementioned submenu in a same operating mode submenu in which a parameter of a selected menu item is adjustable and / or the change from the above submenu under acquisition a set parameter in the same operating mode of the metering concerned submenu with selectable menu items.
  • the mode key by operating the mode key, it is possible to go from a submenu for a particular mode to a main menu relating to several modes of operation, in particular all modes in which the metering device can operate.
  • the main menu the user can select an operating mode.
  • the mode key by pressing the mode key from the main menu, it is possible to change to a submenu for a specific operating mode in which individual menu items can be selected.
  • a change to a menu can be made in which parameters of selected menu items can be set.
  • it is possible to confirm or accept a set parameter by pressing the mode key and to return to the submenu in which menu items can be selected to set further parameters.
  • control device controls the display of certain operating modes of the dosing device submenus corresponding to the operation of a knob.
  • the Setting knob allows a quick change between different operating modes, whereby the submenu shows the set operating mode. If necessary, the submenu for the selected operating mode displays the applicable parameters of this operating mode.
  • the control device controls the change from a submenu relating to a specific operating mode of the metering device to a submenu with selectable menu items relating to the same operating mode and / or the starting of metering operations in the operating mode of the abovementioned one Submenus and / or starting dosing operations in a particular mode corresponding to a selected menu item from the main menu.
  • the parameter key By actuating the parameter key, it is thus possible to select menu items starting from a submenu relating to a specific operating mode and / or to start dispensing operations.
  • the relevant operating modes can be started by pressing the parameter key.
  • the controller upon actuation of the mode key, controls the change from a sub-menu of selectable menu items pertaining to a particular dispensing mode to a sub-menu relating to the same mode in which the parameter of a selected item is adjustable, and / or the change of the above Submenu under Transfer of a set parameter to the submenu concerning the same operating mode with selectable menu items.
  • the controller controls the movement of a pointer to various menu items and / or in a submenu with selectable menu items relating to a particular mode of operation, the movement of the pointer to various menu items and / or a submenu in which the parameter a selected menu item is adjustable, the setting of the parameter and / or after the start of a dosing the movement of the displacement element.
  • the pointer appears in the display of the display device. There he is always directed to a specific menu item. He is e.g. executed as an arrow or other graphic symbols.
  • the menu item may be highlighted, e.g. by a strongly contrasting presentation, a representation in another color, underlining etc.
  • the control keys are formed, for example, by a pair of juxtaposed keys which are independently operable.
  • the simultaneous operation of two control buttons can be evaluated as the control device as a false operation, for example, which remains without consequences.
  • the control keys are actuated by a rocker switch in one direction or the other, so that incorrect operations can be excluded. Furthermore, by means of the rocker switch in a particularly obvious way Navigating in the menus, setting parameters and displacing the displacer in the up and down direction controllable.
  • control device controls the display of the respective function of the mode key and the parameter key by means of the display device.
  • the display device displays, for example, if by pressing the mode key, selecting a submenu and confirming the parameter key to start a dosing in a particular mode is possible.
  • control device after actuation of a control key to control the displacement of the displacement element of the displacement device until the triggering of the displacement is stopped by the actuation of another key.
  • control device controls the displacement of the displacement element of the displacement device as long as the pressure on one of the control buttons stops and stops the displacement of the displacement element as long as the control buttons are relieved.
  • a control key has a second switching point and controls the control device upon actuation of the control button until reaching the second switching point, the displacement of the displacer of the displacer so that the displacer an Automatblashub performs. This facilitates the targeted execution of the Studentsblashub the user.
  • the displacer is e.g. a displacement chamber with a membrane-like wall whose volume can be changed by displacing the membrane.
  • the displacement device comprises the cylinder with a longitudinally displaceably arranged piston.
  • the metering device can be retrofitted with a pipette tip or syringe.
  • the metering device comprises a pipette tip or syringe.
  • the metering device has at least one holding device for a pipette tip or a syringe.
  • the holding device is, for example, a cone or cylinder, onto which a pipette tip with a corresponding opening can be pressed.
  • the holding device has gripping means for gripping a flange on a cylinder and a collar on a piston of a syringe, as for example in the EP 0 656 229 B1 are described, whose relevant embodiments are incorporated by reference in the present application.
  • the metering device is a single or multi-channel metering device.
  • a single channel dosing device works with a single pipette tip or syringe.
  • a Multi-channel dosing device works with multiple pipette tips or syringes.
  • Multi-channel metering devices may have a single displacement device that is communicably connectable to a plurality of pipette tips. However, they can also have a plurality of displacement devices, each displacement device communicating with a pipette tip.
  • the dosing device is a hand dosing device, i. a metering device which is arranged in a manageable housing.
  • the metering device has a display device on the housing head of a housing and the mode key, the parameter key and the pair of control keys below the display device. This arrangement allows a good visibility of the display device by the user and a simple operation of the controls.
  • the metering device has an elongate housing shaft and a housing head angled relative thereto.
  • An arrangement of the display device and the operating devices on the upper side of the housing head is particularly advantageous for the user.
  • the mode key and the parameter key are arranged side by side and / or the control keys one above the other.
  • at least one control key is arranged between the mode key and the parameter key.
  • a throw-off button below the Control buttons arranged.
  • control button which is arranged closest to the holding device, the second switching point for the triggering of the Matterblashubes.
  • This control button thus has obvious in the direction in which the Matterblashub is executed.
  • a metering device 1 designed as a handle housing 2 with an elongated housing shaft 3 and an angled by about 45 ° housing head 4 at the upper end.
  • the housing 2 has at the lower end a cone 5 for attaching a pipette tip. 6
  • a drive 7 is arranged with an electric motor 8. Further, there is a cylinder 9 with a longitudinally displaceably arranged piston 10 which is mechanically connected to the drive 7. The cylinder is connected via a connecting channel 11 with an opening at the end of the cone 5.
  • the housing head 4 has at the bottom a downwardly curved hook 12, which facilitates the secure holding of the metering device 1 on the housing shaft 3.
  • a Abwerfertaste 13 is arranged, which is mechanically connected to a Abwerferhülse 14, so that by pressing the Abwereftaste 13 a pipette tip 6 from the cone 5 can be abdrückbar.
  • a display device 16 On the top 15 or front side of the housing head 4 is a display device 16 and a display with a monitor 17, which is designed for example as an LCD or liquid crystal display.
  • a mode button 18 and a parameter button 19 are arranged side by side. In between are two control buttons 20, 21, wherein the upper control button 20 controls an upward movement and the lower control button 21 a downward movement and a Studentsblashub.
  • the control button 20 has only a single switching point.
  • the control button 21 has two switching points, wherein the reaching of the first switching point, the downward movement and the reaching of the second switching point triggers a Studentsblashub of the piston 10.
  • an electrical control device 22 is arranged on a circuit board, which is connected to the electric motor 8, the display device 16 and the keys 18 to 21.
  • the electrical control device 22 preferably comprises an electrical data processing device, e.g. a microcontroller.
  • an electrical power supply 23 is present in the housing head 4, which is formed for example by a plurality of batteries that are rechargeable by means of an external charger.
  • the electrical power supply 23 supplies the electrical components of the metering device 1 with electricity.
  • the electronic dosing device 1 is from a standby mode, in which it falls after a certain rest period, by pressing any Button 18 to 21 can be set to the normal operating state.
  • an on / off switch not shown, for switching on the normal operating state or switching off can be present.
  • the display device After switching on, the display device displays a submenu with the last set operating mode and the last set parameters of this operating mode. In Fig. 3.1 this is shown for the case that the last operation mode "pipetting" was set.
  • FIG. 3.2 The display after actuation of the parameter key 19 is shown in FIG. 3.2.
  • a pointer 24 is present, which is adjustable by means of the control buttons 20, 21 upwards and downwards.
  • the parameter to which the pointer 24 in FIG. 3.2 points can be changed after actuation of the mode key 18.
  • the change of the parameter is made by operating the control keys 20, 21, as shown in Fig. 3.3.
  • the change of this parameter is confirmed by pressing the mode key 18.
  • the pointer 24 can be adjusted by means of the control keys 20, 21 to a further parameter in order to change it.
  • the submenu for the set dosing operation is displayed with the current parameters, as shown in Fig. 3.1.
  • the pointer 24 is adjustable to a specific mode.
  • the menu is called, in which the respective operating mode is displayed with the applicable parameters.
  • the parameters can be set, as described above for the operating mode "Pipetting".
  • the parameter key 18 is pressed again.
  • the current functions of the mode key 18 and the parameter key 19 are respectively displayed in the respective main and submenus.
  • FIGS. 4 and 5 has, in addition to the above-described embodiment above the display 16, a rotary knob 25 for quickly setting the mode.
  • the housing head 4 is slightly longer to accommodate the knob 25 or to arrange ergonomically favorable. Otherwise, the construction of FIGS. 4 and 5 is identical to that of FIGS. 1 and 2.
  • the operation of the metering device 1 'of Fig. 4 and 5 largely corresponds to the operation of the metering device 1 of Fig. 1 to 3.
  • the knob 25 replaces the main menu of Fig. 3.4.
  • indications on different operating modes are arranged on the adjusting knob at different positions, e.g. printed.
  • the respective operating mode is set. This calls up the menu in which the respective operating mode is displayed with the applicable parameters, e.g. the menu shown in Fig. 3.1 for the operating mode "pipetting".
EP07008387.8A 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide Active EP1859869B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10011969.2A EP2283927B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006024051A DE102006024051A1 (de) 2006-05-23 2006-05-23 Elektronische Dosiervorrichtung zum Dosieren von Flüssigkeiten

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP10011969.2A Division-Into EP2283927B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide
EP10011969.2A Division EP2283927B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide

Publications (2)

Publication Number Publication Date
EP1859869A1 true EP1859869A1 (fr) 2007-11-28
EP1859869B1 EP1859869B1 (fr) 2014-08-13

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Family Applications (2)

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EP10011969.2A Active EP2283927B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide
EP07008387.8A Active EP1859869B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide

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Application Number Title Priority Date Filing Date
EP10011969.2A Active EP2283927B1 (fr) 2006-05-23 2007-04-25 Appareil électrique de dosage pour liquide

Country Status (5)

Country Link
US (1) US8096198B2 (fr)
EP (2) EP2283927B1 (fr)
JP (1) JP5047693B2 (fr)
CN (1) CN101078642A (fr)
DE (1) DE102006024051A1 (fr)

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WO2010034290A3 (fr) * 2008-09-23 2010-06-17 Ahn Biotechnologie Gmbh Pipette à course de piston électronique
DE102010047829A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Mechanische Pipette
DE102010047126A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Pipette
DE102010047826A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Elektronische Pipette
DE102010047828A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Laborgerät zum Behandeln von Flüssigkeiten
WO2012158783A1 (fr) * 2011-05-17 2012-11-22 Rainin Instrument, Llc Pipette électronique avec commande à deux axes
CN103316725A (zh) * 2012-03-20 2013-09-25 埃佩多夫股份公司 电动移液设备及其操作方法
DE102012102918A1 (de) 2012-04-03 2013-10-10 Eppendorf Ag Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes

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US8033188B2 (en) * 2007-09-17 2011-10-11 Integra Biosciences Corp. Pipettor software interface
EP2210667B1 (fr) * 2009-01-19 2019-05-08 Eppendorf Ag Dispositif de dosage avec éjecteur de pointe
ES2835181T3 (es) * 2009-04-27 2021-06-22 El Spectra Llc Instrumento de pipeta
DE102009051654B4 (de) 2009-10-30 2013-01-03 Eppendorf Ag Dosiervorrichtung für Flüssigkeiten und Verfahren zum Dosieren von Flüssigkeiten
JP2011115759A (ja) * 2009-12-07 2011-06-16 Fukae Kasei Kk ピペット装置
FI128560B (en) 2013-05-13 2020-08-14 Thermo Fisher Scientific Oy Electronic pipette
JP5791852B2 (ja) * 2013-05-14 2015-10-07 株式会社エー・アンド・デイ ピペット装置
TWI552808B (zh) * 2015-06-09 2016-10-11 緯創資通股份有限公司 吸管尖
EP3335795B1 (fr) * 2016-12-16 2019-03-27 Eppendorf AG Procédé de dosage de liquide au moyen d'une pipette et d'une seringue et pipette destinée à actionner une seringue pour le dosage de liquides
EP3851191A1 (fr) * 2020-01-17 2021-07-21 Eppendorf AG Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données

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DE9406304U1 (de) * 1994-04-18 1994-06-09 Zipperer M Cat Ingbuero Vorrichtung zum programmierbaren Dosieren von Flüssigkeiten aller Art
EP0864364A2 (fr) * 1997-03-14 1998-09-16 Becton, Dickinson and Company Méthode pour la programmation d'un dispositif de pipettage électronique
WO2000051739A1 (fr) 1999-03-05 2000-09-08 Rainin Instrument Co., Inc. Pipette electronique bilaterale et symetrique de faible poids, commandee par microprocesseur alimente par batterie et qui tient dans la main
WO2005052781A2 (fr) * 2003-11-27 2005-06-09 Gilson S.A.S. Pipette electronique
WO2005079988A1 (fr) 2004-02-25 2005-09-01 Thermo Electron Oy Pipette d'etalonnage

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010034290A3 (fr) * 2008-09-23 2010-06-17 Ahn Biotechnologie Gmbh Pipette à course de piston électronique
WO2012045415A1 (fr) 2010-10-04 2012-04-12 Eppendorf Ag Dispositif de laboratoire pour manipuler des liquides
WO2012045418A1 (fr) 2010-10-04 2012-04-12 Eppendorf Ag Pipette
DE102010047829A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Mechanische Pipette
DE102010047828A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Laborgerät zum Behandeln von Flüssigkeiten
DE102010047126A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Pipette
WO2012045416A1 (fr) 2010-10-04 2012-04-12 Eppendorf Ag Pipette mécanique
WO2012045417A2 (fr) 2010-10-04 2012-04-12 Eppendorf Ag Pipette électronique
DE102010047826A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Elektronische Pipette
WO2012158783A1 (fr) * 2011-05-17 2012-11-22 Rainin Instrument, Llc Pipette électronique avec commande à deux axes
CN103547371A (zh) * 2011-05-17 2014-01-29 瑞宁器材公司 具有双轴控制器的电子式吸量管
CN103547371B (zh) * 2011-05-17 2016-04-13 瑞宁器材公司 具有双轴控制器的电子式吸量管
EP2641656A1 (fr) * 2012-03-20 2013-09-25 Eppendorf AG Dispositif de pipetage électrique et procédé de fonctionnement d'un dispositif de pipetage électrique
CN103316725A (zh) * 2012-03-20 2013-09-25 埃佩多夫股份公司 电动移液设备及其操作方法
US9403163B2 (en) 2012-03-20 2016-08-02 Eppendorf Ag Electric pipetting apparatus, and method for operating an electric pipetting apparatus
CN103316725B (zh) * 2012-03-20 2017-03-01 埃佩多夫股份公司 电动移液设备及其操作方法
DE102012102918A1 (de) 2012-04-03 2013-10-10 Eppendorf Ag Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes
WO2013150064A1 (fr) 2012-04-03 2013-10-10 Eppendorf Ag Système d'appareil de laboratoire et appareil de laboratoire pour traiter des fluides et des matières solides et procédé pour faire fonctionner un appareil de laboratoire

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JP5047693B2 (ja) 2012-10-10
US20070276546A1 (en) 2007-11-29
CN101078642A (zh) 2007-11-28
EP1859869B1 (fr) 2014-08-13
DE102006024051A1 (de) 2007-12-06
JP2007316074A (ja) 2007-12-06
EP2283927B1 (fr) 2017-07-19
EP2283927A1 (fr) 2011-02-16
US8096198B2 (en) 2012-01-17

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