EP1853552A2 - Diastereoisomers of 4-hydroxyisoleucine and uses thereof - Google Patents

Diastereoisomers of 4-hydroxyisoleucine and uses thereof

Info

Publication number
EP1853552A2
EP1853552A2 EP06765601A EP06765601A EP1853552A2 EP 1853552 A2 EP1853552 A2 EP 1853552A2 EP 06765601 A EP06765601 A EP 06765601A EP 06765601 A EP06765601 A EP 06765601A EP 1853552 A2 EP1853552 A2 EP 1853552A2
Authority
EP
European Patent Office
Prior art keywords
compound
pharmaceutically acceptable
lactone
disorder
prodrug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06765601A
Other languages
German (de)
English (en)
French (fr)
Inventor
Claude Coquelet
Charles Mioskowski
Alain Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innodia Inc
Centre National de la Recherche Scientifique CNRS
Universite Louis Pasteur Strasbourg I
Original Assignee
Innodia Inc
Centre National de la Recherche Scientifique CNRS
Universite Louis Pasteur Strasbourg I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innodia Inc, Centre National de la Recherche Scientifique CNRS, Universite Louis Pasteur Strasbourg I filed Critical Innodia Inc
Publication of EP1853552A2 publication Critical patent/EP1853552A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP06765601A 2005-02-18 2006-02-17 Diastereoisomers of 4-hydroxyisoleucine and uses thereof Withdrawn EP1853552A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65441305P 2005-02-18 2005-02-18
PCT/IB2006/001758 WO2006117696A2 (en) 2005-02-18 2006-02-17 Diastereoisomers of 4-hydroxyisoleucine and uses thereof

Publications (1)

Publication Number Publication Date
EP1853552A2 true EP1853552A2 (en) 2007-11-14

Family

ID=37086084

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06765601A Withdrawn EP1853552A2 (en) 2005-02-18 2006-02-17 Diastereoisomers of 4-hydroxyisoleucine and uses thereof

Country Status (8)

Country Link
EP (1) EP1853552A2 (ja)
JP (1) JP2008530198A (ja)
CN (1) CN101128418A (ja)
AU (1) AU2006242851A1 (ja)
BR (1) BRPI0607140A2 (ja)
CA (1) CA2598491A1 (ja)
MX (1) MX2007009985A (ja)
WO (1) WO2006117696A2 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006131836A2 (en) * 2005-03-22 2006-12-14 Innodia Inc. Compounds and compositions for use in the prevention and treatment of obesity and related syndromes
WO2008154743A1 (en) * 2007-06-19 2008-12-24 Innodia Inc. Methods for the synthesis of 4-hydroxyisoleucine, stereoisomers and analogs thereof
US20110136911A1 (en) * 2007-12-20 2011-06-09 The Feinstein Institute For Medical Research Treatment of sepsis and inhibition of mif by d-t4
JP6800968B2 (ja) 2015-10-23 2020-12-16 ナビター ファーマシューティカルズ， インコーポレイテッド セストリン−ｇａｔｏｒ２相互作用のモジュレーターおよびその使用
JP7179015B2 (ja) 2017-04-26 2022-11-28 ナビター ファーマシューティカルズ， インコーポレイテッド Ｓｅｓｔｒｉｎ－ＧＡＴＯＲ２相互座用のモジュレーターおよびその使用
EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. POLYMORPHIC COMPOUNDS AND USES THEREOF
AU2020376950A1 (en) 2019-11-01 2022-06-09 Navitor Pharmaceuticals, Inc. Methods of treatment using an mTORC1 modulator
CN112089710B (zh) * 2020-08-07 2022-04-01 郑州大学 4-羟基异亮氨酸在制备抗肿瘤药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2797767B1 (fr) * 1999-08-27 2002-06-14 Centre Nat Rech Scient Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances
BRPI0415781A (pt) * 2003-10-27 2006-12-26 Innodia Inc método para o tratamento de diabetes em um paciente e kit farmacêutico
EP1657236A1 (en) * 2004-11-10 2006-05-17 Centre National De La Recherche Scientifique (Cnrs) Method for preparing diastereoisomers of 4-hydroxy isoleucine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006117696A2 *

Also Published As

Publication number Publication date
BRPI0607140A2 (pt) 2009-08-11
JP2008530198A (ja) 2008-08-07
WO2006117696A2 (en) 2006-11-09
CA2598491A1 (en) 2006-11-09
AU2006242851A1 (en) 2006-11-09
WO2006117696A3 (en) 2007-01-25
MX2007009985A (es) 2008-03-11
CN101128418A (zh) 2008-02-20

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Legal Events

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Effective date: 20071217

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Effective date: 20090901