EP1796824A4 - DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE - Google Patents

DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE

Info

Publication number
EP1796824A4
EP1796824A4 EP05766055.7A EP05766055A EP1796824A4 EP 1796824 A4 EP1796824 A4 EP 1796824A4 EP 05766055 A EP05766055 A EP 05766055A EP 1796824 A4 EP1796824 A4 EP 1796824A4
Authority
EP
European Patent Office
Prior art keywords
same
reaction device
thermal reaction
thermal
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05766055.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1796824A2 (en
Inventor
Federico Goodsaid
Marc A Unger
Jiang Huang
Emerson Quan
Robert Grossman
Phillip Lam
Hou-Pu Chou
Jake Kimball
Martin Pieprzyk
Geoffrey Facer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Standard Biotools Corp
Original Assignee
Fluidigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/837,885 external-priority patent/US7476363B2/en
Priority claimed from US10/876,046 external-priority patent/US20050145496A1/en
Priority claimed from US11/043,895 external-priority patent/US8105553B2/en
Priority claimed from US11/058,106 external-priority patent/US7867763B2/en
Application filed by Fluidigm Corp filed Critical Fluidigm Corp
Publication of EP1796824A2 publication Critical patent/EP1796824A2/en
Publication of EP1796824A4 publication Critical patent/EP1796824A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/004—Pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/004—Pinch valves
    • B01J2219/00403—Pinch valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP05766055.7A 2004-05-02 2005-05-02 DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE Withdrawn EP1796824A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10/837,885 US7476363B2 (en) 2003-04-03 2004-05-02 Microfluidic devices and methods of using same
US10/876,046 US20050145496A1 (en) 2003-04-03 2004-06-23 Thermal reaction device and method for using the same
US11/043,895 US8105553B2 (en) 2004-01-25 2005-01-25 Crystal forming devices and systems and methods for using the same
US11/058,106 US7867763B2 (en) 2004-01-25 2005-02-14 Integrated chip carriers with thermocycler interfaces and methods of using the same
PCT/US2005/015352 WO2005107938A2 (en) 2004-05-02 2005-05-02 Thermal reaction device and method for using the same

Publications (2)

Publication Number Publication Date
EP1796824A2 EP1796824A2 (en) 2007-06-20
EP1796824A4 true EP1796824A4 (en) 2016-10-19

Family

ID=35320754

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05766055.7A Withdrawn EP1796824A4 (en) 2004-05-02 2005-05-02 DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE

Country Status (3)

Country Link
EP (1) EP1796824A4 (ja)
JP (1) JP5502275B2 (ja)
WO (1) WO2005107938A2 (ja)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754257B1 (en) 2004-06-07 2013-12-25 Fluidigm Corporation Optical lens system and method for microfluidic devices
EP3714979A1 (en) 2005-05-09 2020-09-30 BioFire Diagnostics, LLC Self-contained biological analysis
US7913928B2 (en) 2005-11-04 2011-03-29 Alliant Techsystems Inc. Adaptive structures, systems incorporating same and related methods
JP2007189964A (ja) * 2006-01-20 2007-08-02 Toppan Printing Co Ltd 検査基板
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
BRPI0712655A2 (pt) 2006-06-08 2012-11-20 Koninkl Philips Electronics Nv dispositivo de sensor microeletrânico, mÉtodo para investigaÇço de pelo menos uma substÂncia alvo biolàgica, e, uso do dispositivo de sensor microeletrânico
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
BRPI0718473A2 (pt) * 2006-10-18 2013-12-03 Harvard College Bioensaio de fluxo direto e fluxo lateral baseado em meio poroso modelado, métodos de produção do mesmo, e métodos de uso do mesmo.
CA2669943C (en) * 2006-11-15 2016-05-31 Idaho Technology, Inc. High density self-contained biological analysis
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
JP2009042103A (ja) * 2007-08-09 2009-02-26 Sony Corp 基板、これを用いた反応処理装置並びに反応制御方法
CN101910415B (zh) * 2007-11-07 2015-02-25 不列颠哥伦比亚大学 微流体装置及其使用方法
US9157116B2 (en) 2008-02-08 2015-10-13 Fluidigm Corporation Combinatorial amplification and detection of nucleic acids
EP2265958A4 (en) 2008-03-27 2016-10-19 Harvard College MICROFLUIDIC SYSTEMS BASED ON PAPER
KR101510785B1 (ko) 2008-03-27 2015-04-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 저렴한 멀티 검사 진단 플랫폼으로서의 무명실
WO2009120963A2 (en) 2008-03-27 2009-10-01 President And Fellows Of Harvard College Paper-based cellular arrays
AU2009228091B2 (en) 2008-03-27 2015-05-21 President And Fellows Of Harvard College Three-dimensional microfluidic devices
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US8833430B2 (en) 2008-06-26 2014-09-16 President And Fellows Of Harvard College Versatile high aspect ratio actuatable nanostructured materials through replication
US8697363B2 (en) 2008-08-26 2014-04-15 Fluidigm Corporation Methods for detecting multiple target nucleic acids in multiple samples by use nucleotide tags
SG10201404683TA (en) * 2008-12-08 2014-10-30 Fluidigm Corp Programmable microfluidic digital array
WO2010088288A2 (en) 2009-01-28 2010-08-05 Fluidigm Corporation Determination of copy number differences by amplification
WO2010102279A1 (en) 2009-03-06 2010-09-10 President And Fellows Of Harvard College Microfluidic, electromechanical devices
DE102009015739A1 (de) * 2009-03-31 2010-10-07 Siemens Aktiengesellschaft Vorrichtung und Verfahren zur Aufnahme eines Sensors
US8691509B2 (en) 2009-04-02 2014-04-08 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
WO2013134742A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc Micro-tube particles for microfluidic assays and methods of manufacture
CN102713621B (zh) 2009-11-23 2016-10-19 西维克公司 用于施行化验的方法和设备
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
AU2011212916B2 (en) 2010-02-03 2015-07-02 President And Fellows Of Harvard College Devices and methods for multiplexed assays
CA2830533C (en) 2011-03-22 2020-02-18 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
GB201106548D0 (en) 2011-04-18 2011-06-01 Evitraproteoma Ab A method for determining ligand binding to a target protein using a thermal shift assahy
US9523693B2 (en) 2011-04-18 2016-12-20 Biotarget Engagement Interest Group Ab Methods for determining ligand binding to a target protein using a thermal shift assay
CN103635594B (zh) 2011-05-09 2018-02-13 富鲁达公司 基于探针的核酸检测
SG194745A1 (en) 2011-05-20 2013-12-30 Fluidigm Corp Nucleic acid encoding reactions
CN102320558B (zh) * 2011-09-13 2014-03-26 上海先进半导体制造股份有限公司 全硅基微流体器件的腔体的制造方法
DE102012100824A1 (de) * 2012-02-01 2013-09-05 Albert-Ludwigs-Universität Freiburg Gemultiplexte Digital PCR
EP3627140A1 (en) 2012-02-29 2020-03-25 Fluidigm Corporation Methods, systems, and devices for multiple single-cell capturing and processing using microfluidics
US9840732B2 (en) 2012-05-21 2017-12-12 Fluidigm Corporation Single-particle analysis of particle populations
US20140200167A1 (en) 2012-08-01 2014-07-17 Nanomdx, Inc. Functionally integrated device for multiplex genetic identification
WO2014020977A1 (ja) * 2012-08-03 2014-02-06 ソニー株式会社 核酸分析装置、核酸分析用マイクロチップ及び該装置におけるマイクロチップ搭載方法
EP3698874A1 (en) * 2014-03-11 2020-08-26 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making the same
US9373561B1 (en) 2014-12-18 2016-06-21 International Business Machines Corporation Integrated circuit barrierless microfluidic channel
KR102385794B1 (ko) * 2015-04-07 2022-04-11 셀 아이디 피티이 엘티디 Dc 히터
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US11117113B2 (en) 2015-12-16 2021-09-14 Fluidigm Corporation High-level multiplex amplification
CN113702269B (zh) 2016-01-21 2024-04-09 东京毅力科创株式会社 药液供给装置和涂敷显影系统
CA3038262A1 (en) * 2016-09-23 2018-03-29 ArcherDX, Inc. Fluidic system and related methods
WO2018060326A1 (en) 2016-09-29 2018-04-05 Qiagen Lake Constance Gmbh Sample container arrangement
JP2020530907A (ja) * 2017-08-14 2020-10-29 キマンテック，リミテッド・ライアビリティ・カンパニー 液体分配装置
CN109406442B (zh) * 2018-10-30 2021-01-05 桂林电子科技大学 一种快速测量蛋白质热变性温度的方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
WO2001096880A1 (en) * 2000-06-15 2001-12-20 Irm, Llc Automated precision object holder
WO2002028533A1 (en) * 2000-10-03 2002-04-11 California Institute Of Technology Combinatorial synthesis system
WO2002081729A2 (en) * 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
WO2003048295A1 (en) * 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US20040023371A1 (en) * 2002-07-30 2004-02-05 Adrian Fawcett Sample block apparatus and method for maintaining a microcard on a sample block
WO2004089810A2 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5241450A (en) * 1992-03-13 1993-08-31 The United States Of America As Represented By The United States Department Of Energy Three dimensional, multi-chip module
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
WO2003038363A2 (en) * 2001-10-29 2003-05-08 Chart Heat Exchangers Lp Heat exchangers
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
US6893613B2 (en) * 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
EP1567638A1 (en) * 2002-11-08 2005-08-31 Irm, Llc Apparatus and methods to process substrate surface features

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
WO2001096880A1 (en) * 2000-06-15 2001-12-20 Irm, Llc Automated precision object holder
WO2002028533A1 (en) * 2000-10-03 2002-04-11 California Institute Of Technology Combinatorial synthesis system
WO2002081729A2 (en) * 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
WO2003048295A1 (en) * 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US20040023371A1 (en) * 2002-07-30 2004-02-05 Adrian Fawcett Sample block apparatus and method for maintaining a microcard on a sample block
WO2004089810A2 (en) * 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same

Also Published As

Publication number Publication date
JP2007537847A (ja) 2007-12-27
WO2005107938A3 (en) 2006-01-12
JP5502275B2 (ja) 2014-05-28
EP1796824A2 (en) 2007-06-20
WO2005107938A2 (en) 2005-11-17

Similar Documents

Publication Publication Date Title
EP1796824A4 (en) DEVICE FOR THERMAL REACTIONS AND METHOD FOR THEIR USE
EP1861512A4 (en) THERMAL REACTION DEVICE AND USE METHOD THEREFOR
EP1710696A4 (en) SEMICONDUCTOR DEVICE AND METHOD FOR THEIR ACTIVATION
EP1755733A4 (en) METHOD AND DEVICES FOR THERMAL TREATMENT
TWI346995B (en) Semiconductor device and method for producing the same
GB2431481B (en) Part positioning method and device for the method
IL191556A0 (en) Solar system and method for the operation thereof
EP1941820A4 (en) PISTON ROTATION PROCESS AND DEVICE THEREFOR
EP1899766A4 (en) THERMAL DEVELOPMENT SYSTEM AND METHOD OF USING SAME
GB2433267B (en) Special reaction method and special reaction apparatus
ZA200709770B (en) Method and device
PL1816101T3 (pl) ­­­­Piec przemysłowy z urządzeniem do reformingu parowego i stosujący go sposób reformingu parowego
EP1966826A4 (en) SEMICONDUCTOR COMPONENT AND METHOD FOR THEIR FORMING
PL1600277T3 (pl) Urządzenie chłodzące i sposób chłodzenia
GB0518218D0 (en) Thermal energy system and apparatus
GB2433724B (en) Printing device and printing method using the same
EP1685721A4 (en) METHOD AND DEVICE FOR DIGITAL-RADIO FREQUENCY CONVERSION
GB2457613B (en) Nano-base device and method
SG117529A1 (en) Thermal anneal process for strained-si devices
GB0619862D0 (en) Method and device for fastening fastening member
GB0412475D0 (en) Device and method
EP1870176A4 (en) COOLING METHOD AND COOLING DEVICE
SG2013006333A (en) Thermal reaction device and method for using the same
EP1752529A4 (en) METHOD AND DEVICE FOR TEMPERATURE CONTROL
GB2411216B (en) Fixing device and method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070323

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: B01J 3/00 20060101AFI20070910BHEP

Ipc: G01N 21/00 20060101ALI20070910BHEP

Ipc: G01N 31/22 20060101ALI20070910BHEP

Ipc: G01N 15/06 20060101ALI20070910BHEP

Ipc: B01J 3/02 20060101ALI20070910BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: QUAN, EMERSON

Inventor name: GOODSAID, FEDERICO

Inventor name: UNGER, MARC, A.

Inventor name: HUANG, JIANG

Inventor name: LAM, PHILLIP

Inventor name: KIMBALL, JAKE

Inventor name: FACER, GEOFFREY

Inventor name: CHOU, HOU-PU

Inventor name: GROSSMAN, ROBERT

Inventor name: PIEPRZYK, MARTIN

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: FLUIDIGM CORPORATION

RIC1 Information provided on ipc code assigned before grant

Ipc: B01L 7/00 20060101ALI20160421BHEP

Ipc: B01L 3/00 20060101ALI20160421BHEP

Ipc: B01J 19/00 20060101ALI20160421BHEP

Ipc: G01N 21/00 20060101AFI20160421BHEP

Ipc: G01N 31/22 20060101ALI20160421BHEP

Ipc: B01L 9/00 20060101ALI20160421BHEP

Ipc: G01N 15/06 20060101ALI20160421BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20160919

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 31/22 20060101ALI20160913BHEP

Ipc: G01N 15/06 20060101ALI20160913BHEP

Ipc: B01L 7/00 20060101ALI20160913BHEP

Ipc: B01L 9/00 20060101ALI20160913BHEP

Ipc: G01N 21/00 20060101AFI20160913BHEP

Ipc: B01L 3/00 20060101ALI20160913BHEP

Ipc: B01J 19/00 20060101ALI20160913BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20171113

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20211201