EP1792656B1 - Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten - Google Patents

Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten Download PDF

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Publication number
EP1792656B1
EP1792656B1 EP20060124369 EP06124369A EP1792656B1 EP 1792656 B1 EP1792656 B1 EP 1792656B1 EP 20060124369 EP20060124369 EP 20060124369 EP 06124369 A EP06124369 A EP 06124369A EP 1792656 B1 EP1792656 B1 EP 1792656B1
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EP
European Patent Office
Prior art keywords
cuvette
cuvettes
array
dimensional
holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP20060124369
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English (en)
French (fr)
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EP1792656A1 (de
Inventor
Manfred Kansy
Thomas Zumstein
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F Hoffmann La Roche AG
Weidman Plastics Technology AG
Original Assignee
F Hoffmann La Roche AG
Weidman Plastics Technology AG
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Publication date
Application filed by F Hoffmann La Roche AG, Weidman Plastics Technology AG filed Critical F Hoffmann La Roche AG
Priority to EP10180535A priority Critical patent/EP2283923A2/de
Priority to EP20060124369 priority patent/EP1792656B1/de
Publication of EP1792656A1 publication Critical patent/EP1792656A1/de
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Publication of EP1792656B1 publication Critical patent/EP1792656B1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50855—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates using modular assemblies of strips or of individual wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates

Definitions

  • the invention concerns an integrally built, linear array of cuvettes made of a plastic material, every cuvette of the array having the same shape and dimensions, and neighboring cuvettes being connected to each other by a single web. Furthermore, the invention provides also a two-dimensional array of cuvettes and a system comprising two or more two-dimensional arrays of cuvettes.
  • EP 1232792 describes a cuvette array 11 comprising cuvettes 12 with an open lower end 13, means for removably connecting 14 and means for positioning the cuvettes 15 in the cuvette holder as shown in Figure 1A .
  • FIG. 1B shows a partial cross-section through a cuvette holder 16 with a cuvette array 11 of Figure 1A .
  • the positioning means 15 prevent an accurate placement of a steel matrix 17 (see Figure 1B ).
  • the steel matrix concisely locks up with the lower ends of the cuvettes 12 which form the welding contour 19.
  • the distance of the lower end 18 of the inlayed steel matrix 17 and the welding contour 19 is to low for accurate welding and/or punching of the layer.
  • the present invention provides an integrally built, linear array of cuvettes made of a plastic material, as specified in independent claim 1.
  • the present invention is further directed to a two-dimensional array as specified in claim 4 and to a system as specified in claim 12.
  • Advantageous embodiments are the subject of the respective dependent claims.
  • This invention is based on the observation that these positioning means are of disadvantage when welding a layer at the lower open end of the cuvettes.
  • a steel matrix is imposed on the cuvettes.
  • the steel matrix comprises wholes whose position and dimensions correspond with the position and dimension of the cuvettes in the array so that the steel plate may fit on the cuvettes.
  • a layer is laid on the open lower ends of the cuvettes and welded, whereby the lower ends form the welding contour.
  • a knife in dimension and form equivalent to the steel matrix punches the layer so that only the layer welded to cuvettes remains. The steel matrix stops the knife of cutting through the cuvette array.
  • the main advantages of the invention are that it allows to perform the welding process steps accurately and efficiently.
  • a cuvette array 21 without positioning means allows to accurately position a steel matrix 17 below welding contour 29 (lower ends of cuvettes 22) so that a proper welding and cutting is possible.
  • Figures 2 and 3 show an integrally built, linear array 21 of cuvettes 22 made of a plastic material.
  • Every cuvette of array 21 has the same shape and dimensions and neighboring cuvettes are connected to each other by a single web 25, 26.
  • Each of these single webs 25, 26 is flexible and has a curved shape.
  • the symmetry axis Y-Y of every cuvette 22 which forms part of array 21 of cuvettes lies substantially in one and the same plane A-A which is a symmetry plane of cuvette array 21.
  • the upper part of an intermediate cuvette 22 of array 21 is connected by a first single web 25 to a neighboring cuvette 23 which lies on one side of intermediate cuvette 22 and is connected by a second single web 26 to a neighboring cuvette 24 which lies on the opposite side of intermediate cuvette 22.
  • the single webs 25, 26 are flexible and therefore facilitate the insertion of the cuvettes in a cuvette holder, e.g. cuvette holder 42 described hereinafter, in spite of variations of the length of cuvette array 21 which are due to different shrinkage coefficients of the different materials used for manufacture of cuvette arrays 21 by injection molding.
  • These single webs 25, 26 may lie on either of two opposite sides of the plane A-A. This means that two successive single webs may lie on the same side of the plane A-A, or on the opposite side of the plane A-A. However, it is preferred that at least to single webs lie on opposite sides of the plane A-A.
  • At least two of the cuvettes of the array 21 have means for removably connecting the cuvettes to cuvette holder 42 described hereinafter. These means are an integral part of the cuvette. Preferably, these connecting means are latches 31 and 32.
  • the distribution of cuvettes with connecting means over the array is equitable. If two cuvettes have connecting means preferably the first and the last cuvettes has each connecting means, or second and the last but one cuvette has each connecting means, or the third and the last but two cuvette has each connecting means, and so on.
  • the first cuvette, the third cuvette, the fourth, the fifth, the sixth and the eighth cuvette has each connecting means.
  • Figure 3 shows a cross-section of one of the cuvettes, e.g. cuvette 22 of cuvette array 21.
  • the cuvette has an upper chamber 27 and a lower chamber 28 which have a common symmetry axis Y-Y which passes through the centers of both chambers.
  • Upper chamber 27 and lower chamber 28 have each a substantially cylindrical shape. The cross-section of upper chamber 27 at the central part thereof is larger than the cross-section of lower chamber 28.
  • Lower chamber 28 has an open lower end 33.
  • Upper chamber 27 has an open top end 34 and an annular bottom wall 35. This bottom wall has a central circular opening 36 which connects said upper chamber 27 with lower chamber 28.
  • the inner surface 37 of bottom wall 35 is part of a conical surface the cross-section of which forms an angle of about 80 degrees with the symmetry axis Y-Y of the cuvette, so that there is an abrupt change of cross-section between said upper chamber 27 and said lower chamber 28.
  • the cuvette array 21 is made by injection molding of a selected first plastic material which is particularly suitable for being used in combination with a second selected material of which a foil shaped layer is made. This layer is adapted to be closely attached to at least one cuvette of the array of cuvettes for covering at least one opening of the cuvette.
  • the same plastic material may be used for said first plastic material and said second plastic material.
  • the attachment of the foil shaped layer to one or more cuvettes can be effected e.g. by gluing the layer and the one or more cuvettes or by a welding process. Preferred is the attachment of the foil shaped layer by a welding process.
  • the foil attached to one individual cuvette is attached only to this individual cuvette and has no connection with any other cuvette or with a foil attached to a different cuvette.
  • the attachment of the layer to the cuvette must ensure a medium tight connection (liquid and/or gas tight connection) of these components.
  • foil shaped layer Possible uses of such a foil shaped layer include e.g. its use as a filter and/or as a transparent closure (e.g. transparent to ultraviolet irradiation), which must not necessarily have the function of a filter.
  • a transparent closure e.g. transparent to ultraviolet irradiation
  • the filtration process can be effected by use of vacuum or pressure applied to the medium contained in each cuvette of a cuvette array.
  • Suitable materials for a foil shaped layer usable as a filter and having a thickness in a range of 10 to 200 micrometer are for instance: polyvinylidenfluorid (PVDF), polycarbonat (PC), polysulfon (PSU), regenerated cellulose, polytetrafluorethylen (PTFE), PET, cyclic olefin copolymers (COC) and filter paper.
  • PVDF polyvinylidenfluorid
  • PC polycarbonat
  • PSU polysulfon
  • PTFE polytetrafluorethylen
  • PET cyclic olefin copolymers
  • COC cyclic olefin copolymers
  • FIG. 5 such a foil shaped layer is adapted to be closely attached to the lower end of the cuvette.
  • Figure 5 shows a cuvette 22 and a foil shaped layer 71 which is closely attached to cuvette 22 for covering the opening of this cuvette at the lower end 33 thereof.
  • the injection molding apparatus for manufacturing the cuvette array is preferably so configured and dimensioned that injection molding of different materials having different shrinkage coefficients can be carried out with one and the same apparatus.
  • the material of which this layer is made is so selected that properties of the layer are suitable for use with the material of which the cuvettes are made.
  • the materials of the cuvette array and of the foil shaped layer are so selected that they are particularly well adapted for and thereby enable optimization of a particular process carried out with the assembly of cuvette array and foil shaped layer.
  • Such processes are e.g. filtration, diffusion, concentration determination and "microspotting".
  • cuvettes made of a hydrophilic material are suitably combined with ultrafiltration membranes for carrying out ultrafiltrations in an optimal way.
  • Diffusion processes through artificial membranes are preferably carried out with hydrophobic filtration membranes, which are suitable for being combined by a melting process with cuvette material having similar hydrophobic properties.
  • Filtration processes require hydrophilic or lipophilic properties of the cuvettes and of the filtration membrane attached thereto, and the selection of the materials of these components depends from the properties of the substance to be filtered.
  • fragments are deposited by microspotting on the foil which is attached to the lower end of the cuvettes of cuvette array 21.
  • cuvette array 21 celluloseacetate, polycarbonate, polyvinylidene fluoride (PVDF), polysulfones, polystyrene, polypropylene (PP) or cyclic olefin copolymers (COC). Materials with similar shrinkage coefficient (in connection with injection molding) and melting properties may also be used for manufacturing cuvette array 21.
  • PVDF polyvinylidene fluoride
  • PP polypropylene
  • COC cyclic olefin copolymers
  • Figure 6 shows a top view of a cuvette holder 42 which can be used to hold a plurality of the above described cuvette arrays 21 to form a two-dimensional cuvette array 41.
  • Figure 7 shows a cross-section through a plane B-B of cuvette holder 42 in Figure 6 .
  • cuvette holder 42 is of substantially rectangular shape and has four centering ribs located each on the outer surface of one of the corners of cuvette holder 42.
  • Figure 8 shows a top view of a two-dimensional cuvette array 41 according to the invention.
  • Figure 9 shows a cross-section through a plane C-C of two-dimensional cuvette array 41 in Figure 8 .
  • a two-dimensional array 41 of cuvettes comprises a cuvette holder 42 having a matrix array 43 of openings 44 for receiving cuvettes 22 of at least one linear cuvette array 21 having the above described features.
  • Each of the cuvettes 22 of cuvette array 21 has a shape and dimensions that snugly fits, also with connecting means, into one of openings 44 of cuvette holder 42.
  • Cuvette holder 42 is so configured and dimensioned that two-dimensional array 41 is adapted to be used in a centrifuge. As shown by Figure 9 , cuvette holder 42 snugly fits into a holder plate 49 of a centrifuge.
  • Figure 10 shows a cuvette holder 42 with a cuvette array 21 and a steel matrix 17 which is imposed on the cuvettes 22 of the cuvette array 21.
  • the steel matrix 17 is imposed on the cuvettes as shown in Figure 10 .
  • the steel matrix 17 comprises holes whose position and dimensions correspond with the position and dimension of the cuvettes 22 in the array so that the steel plate 17 may fit on the cuvettes 22.
  • a layer is laid on the open lower ends of the cuvettes and welded, whereby the lower ends form the welding contour 29.
  • a knife in dimension and form equivalent to the steel matrix 17 punches the layer so that only the layer welded to cuvettes remains.
  • the function of the steel matrix 17 is to stop the knife of cutting through the cuvette array 21.
  • two or more two-dimensional cuvette arrays e.g. arrays 141 and 151 each of which has the structure described in EP1232792 can be stacked on each other to form a three-dimensional cuvette array.
  • the components of such an array are so configured and dimensioned that cuvettes having the same relative position in their respective holders are accurately positioned one above the other with coincidence of their symmetry axis, one of said cuvettes taking the position of an upper cuvette 61 and the other cuvette taking the position of a lower cuvette 62.
  • each upper cuvette 61 lies within the upper chamber of the corresponding lower cuvette 62 and the lower end of the upper cuvette 61 is at a predetermined distance from the bottom wall of the upper chamber of the lower cuvette 62.
  • a two-dimensional cuvette array 141 which has the structure described in EP 1232792 , can be stacked also on a standard holder plate 48 for a standard multiwell plate.
  • a system comprising one or more two-dimensional arrays 41 of cuvettes having the above-described structure are used to perform simultaneously diffusion, filtration or detection process steps on a plurality of liquid samples, wherein said samples are e.g. genes, gene fragments, drug substance or precursors of drugs.
  • such a system comprises a first two-dimensional cuvette array and a second two-dimensional cuvette array, said cuvette arrays are stacked on each other, and the cuvette holders and the cuvettes of said two-dimensional cuvette arrays are so configured and dimensioned that cuvettes having the same relative position in their respective holders are accurately positioned one above the other with coincidence of their symmetry axes, one of the cuvettes taking the position of an upper cuvette and the other cuvette taking the position of a lower cuvette.
  • a portion of the lower part of the upper cuvette lies within the upper chamber of the lower cuvette and the lower end of the upper cuvette is at a predetermined distance from the bottom wall of the upper chamber of the lower cuvette.
  • Figures 13A to 13E show a top view of cuvette array 21 with preferred arrangements of the single webs 15,16.
  • Figures 14A to 14G show a cross-section through plane A-A of the cuvette arrays 21, with preferred arrangements of the connecting means 31,32.

Claims (13)

  1. Einstückige Reihe (21) von Küvetten (22) aus einem Kunststoffmaterial, wobei jede Küvette der Reihe die gleiche Form und Grösse hat und benachbarte Küvetten durch einen einzelnen Steg miteinander verbunden sind, wobei jede Küvette der Reihe eine Symmetrieachse (Y-Y) aufweist und die Symmetrieachse (Y-Y) jeder Küvette, die Bestandteil der Reihe (21) von Küvetten ist, in einer Ebene (A-A) liegt, die sich entlang der Länge der Küvettenreihe erstreckt, wobei
    a) jede Küvette eine obere Kammer (27) und eine untere Kammer (28) hat, die beide eine im Wesentlichen zylindrische Form haben und eine gemeinsame Symmetrieachse (Y-Y) aufweisen, die durch die Mitte beider Kammern geht, wobei der Querschnitt der oberen Kammer (27) in ihrem zentralen Bereich grösser ist als der Querschnitt der unteren Kammer (28), und wobei die obere Kammer (27) eine ringförmige Bodenwand (35) mit einer zentralen kreisförmigen Öffnung (36) aufweist, welche die obere Kammer (27) mit der unteren Kammer (28) verbindet, und wobei die ringförmige Bodenwand (35) eine Innenfläche (37) aufweist, die Teil einer konischen Fläche ist, deren Querschnitt einen Winkel von etwa 80 Grad mit der Symmetrieachse (Y-Y) der Küvette bildet,
    b) die Küvetten ein offenes unteres Ende (33) haben,
    c) eine Lage (71) dazu ausgebildet ist, an mindestens einer Küvette der Küvettenreihe eng anliegend befestigt zu werden zum Abdecken mindestens einer Öffnung der Küvette,
    d) mindestens zwei Küvetten (22) Mittel (31, 32) aufweisen zum lösbaren Verbinden der Küvetten (22) mit einem Küvettenhalter mit Öffnungen, und
    e) jede Küvette mittels eines einzelnen Stegs mit der benachbarten Küvette verbunden ist, wobei der einzelne Steg flexibel und gekrümmt ist und aufeinander folgende Stege auf jeder von einander gegenüberliegenden Seiten der Ebene (A-A) angeordnet sein können,
    dadurch gekennzeichnet, dass jede der Küvetten (22) der Reihe (21) eine Form und Grösse hat, die genau in eine der Öffnungen des Küvettenhalters passt, und dass die Reihe (21) es erlaubt eine Stahlmatrize (17) unterhalb einer Schweisskontur (29) am unteren Ende der Küvetten (22) präzise zu positionieren.
  2. Einstückige Küvettenreihe gemäss Anspruch 1, wobei die Küvettenreihe aus einem ausgewählten ersten Kunststoffmaterial hergestellt ist, welches sich für die Verwendung in Kombination mit dem gleichen oder einem zweiten ausgewählten Material besonders eignet, aus dem die folienförmige Lage (71) hergestellt ist, wobei die folienförmige Lage dazu ausgebildet ist, an jeder Küvette (22) der Küvettenreihe zum Abdecken mindestens einer Öffnung jeder Küvette (22) eng anliegend befestigt zu werden.
  3. Einstückige Küvettenreihe gemäss Anspruch 2, wobei das erste Kunststoffmaterial und das zweite Kunststoffmaterial COC sind.
  4. Zweidimensionale Anordnung (41) von Küvetten umfassend
    (a) einen Küvettenhalter (42) mit einer Matrix-Anordnung (43) von Öffnungen (44) zum Aufnehmen von Küvetten (22), und
    (b) mindestens eine Küvettenreihe (21) gemäss einem der Ansprüche 1 bis 3, wobei jede Küvette (22) der mindestens einen Küvettenreihe (21) eine Form und Grösse hat, die genau in eine der Öffnungen (44) des Küvettenhalters (42) passt.
  5. Zweidimensionale Küvettenandordnung gemäss Anspruch 4, wobei der Küvettenhalter und die Küvetten der mindestens einen Küvettenreihe so ausgebildet und dimensioniert sind, dass zwei oder mehrere Küvettenhalter, welche jeweils mindestens eine Küvettenreihe tragen, so gestapelt werden können, dass Küvetten mit der gleichen Relativposition in ihren entsprechenden Haltern exakt eine über der anderen positioniert sind mit zusammenfallenden Symmetrieachsen, wobei eine der Küvetten die Position einer oberen Küvette einnimmt während die andere Küvette die Position einer unteren Küvette einnimmt und ein Abschnitt des unteren Teils der oberen Küvette innerhalb der oberen Kammer der unteren Küvette liegt, und wobei das untere Ende der oberen Küvette in einem vorgegebenen Abstand von der Bodenwand der oberen Kammer der unteren Küvette angeordnet ist.
  6. Zweidimensionale Küvettenanordnung gemäss Anspruch 4 oder Anspruch 5, ferner umfassend eine Folie, die am unteren Ende jeder Küvette befestigt ist zum Abdecken der Öffnung der Küvette an ihrem unteren Ende.
  7. Zweidimensionale Küvettenanordnung gemäss Anspruch 6, wobei die Folie ein Filter ist.
  8. Zweidimensionale Küvettenanordnung gemäss Anspruch 6, wobei die Folie transparent ist.
  9. Zweidimensionale Küvettenanordnung gemäss Anspruch 6, wobei die Folie Gene oder Genfragmente trägt die auf der Folie durch Mikrospotten aufgebracht sind.
  10. Zweidimensionale Küvettenanordnung gemäss Anspruch 4 oder Anspruch 5, wobei der Küvettenhalter eine im Wesentlichen rechteckige Form aufweist und vier Zentrierrippen hat, die jeweils auf der Aussenfläche einer der Ecken des Küvettenhalters angeordnet sind.
  11. Zweidimensionale Küvettenanordnung gemäss Anspruch 4 oder Anspruch 5, wobei der Küvettenhalter so ausgebildet und dimensioniert ist, dass die zweidimensionale Küvettenanordnung zur Verwendung in einer Zentrifuge angepasst ist.
  12. System zum gleichzeitigen Durchführen von Diffusions- oder Filtrations-Verfahrensschritten an einer Vielzahl flüssiger Proben, wobei das System eine oder mehrere zweidimensionale Küvettenanordnungen (41) gemäss einem der Ansprüche 4 bis 10 umfasst.
  13. System gemäss Anspruch 12, umfassend eine erste zweidimensionale Küvettenanordnung gemäss Anspruch 4 und eine zweite zweidimensionale Küvettenanordnung gemäss Anspruch 4, wobei die Küvettenanordnungen übereinander gestapelt sind, und wobei der Küvettenhalter und die Küvetten der ersten und zweiten zweidimensionalen Küvettenanordnungen so ausgebildet und dimensioniert sind, dass die ersten und zweiten zweidimensionalen Küvettenanordnungen so gestapelt werden können, dass Küvetten mit der gleichen Relativposition in ihren entsprechenden Haltern exakt eine über der anderen positioniert sind mit zusammenfallenden Symmetrieachsen, wobei eine der Küvetten die Position einer oberen Küvette einnimmt während die andere Küvette die Position einer unteren Küvette einnimmt, und wobei ein Abschnitt des unteren Teils der oberen Küvette innerhalb der oberen Kammer der unteren Küvette liegt und das untere Ende der oberen Küvette in einem vorgegebenen Abstand von der Bodenwand der oberen Kammer der unteren Küvette angeordnet ist.
EP20060124369 2005-11-30 2006-11-20 Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten Not-in-force EP1792656B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10180535A EP2283923A2 (de) 2005-11-30 2006-11-20 Lineare Küvettenanordnung ohne Positionierungsmittel
EP20060124369 EP1792656B1 (de) 2005-11-30 2006-11-20 Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten

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EP05111522 2005-11-30
EP20060124369 EP1792656B1 (de) 2005-11-30 2006-11-20 Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten

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EP10180535.6 Division-Into 2010-09-28

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EP1792656A1 EP1792656A1 (de) 2007-06-06
EP1792656B1 true EP1792656B1 (de) 2011-11-02

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EP20060124369 Not-in-force EP1792656B1 (de) 2005-11-30 2006-11-20 Integrierte lineare Anordnung von Küvetten, zweidimensionale Anordnung von Küvetten und System mit zwei oder mehreren zweidimensionalen Anordnungen von Küvetten

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